Risnandya Primanagara
Fakultas Kedokteran Universitas Swadaya Gunung Jati

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ANTIDIABETIC EFFECT OF COMBINED Muntingia calabura L. LEAF EXTRACT AND METFORMIN ON RATS Nugroho, Adhy; Primanagara, Risnandya; Basyir, Pahmi Budiman Sahputra
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Diabetes mellitus is a disease that causes blood glucose levels to increase. There are several therapies that can be done to reduce blood glucose levels in diabetes such as metformin, biguanides medicine and kersen (Muntingia calabura L.) leaves as an alternative. Treatment with combination of both is expected to further reduce blood glucose levels. This study aims to measure the effectiveness of the combination of metformin and Muntingia calabura L. leaf extract on blood glucose levels. Methods: This was an experimental research with pretest-posttest control group. The samples were 24 Sprague-Dawley rats divided into 4 groups, first group (K1) negative control was given only aquadest, second group (K2) positive control (+) was given 45 mg/kgBW metformin, third group (K3) was treated with 300 mg/kgBW Muntingia calabura leaf extract, and the fourth group (K4) was given the combination of 300 mg/kgBW Muntingia calabura leaf extract and  45 mg/kgBW metformin. Blood glucose levels were measured and analyzed using paired t-test and one-way ANOVA. Results: The combination of 300 mg/kgBW of Muntingia calabura extract and 45 mg/kgBB of metformin reduces 131.77 ± 3.57 mg/dl of blood glucose levels (p<0.05). This result is better than only metformin (92.68 ± 3.10 mg/dl) or only Muntingia calabura leaf extract (91.70 ± 4.40 mg/dl). There is a possibility that the synergistic effect of Muntingia calabura leaf extract and metformin caused the increased effectivity in reducing blood sugar level.Conclusion: The combination of Muntingia calabura and metformin is more effective in reducing blood glucose levels compared to a single dose of metformin or Muntingia calabura L. extract alone.
CALCULATING COLONY OF Candida spp. AMONG CHILDREN WITH INTELLECTUAL DISABILITY IN CIREBON Oktaviani, Dhini; Amanah, Amanah; Suhaeni, Eni; Primanagara, Risnandya
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Children and adults with Intellectual Disability and Autism Spectrum Disorders (ASD) have decreased intestinal permeability and enzyme activity, causing gastrointestinal (GI) problems that are more frequent and more severe than in children from the general population. The immune system which is part of the intestinal barrier in children with Intellectual Disability (ID) experiences various disorders and becomes more susceptible to fungal invasion, such as Candida spp. This present study aims to calculate the colony of Candida spp. in the digestive tract of Children with Intellectual Disability (ID) in the city of Cirebon.Method: This is an observational study with cross-sectional design using purposive sampling. The study was conducted in November 2018-February 2019. The sample (ID) group consists of 31 individuals from Special Needs School and 60 individuals from National elementary school (non-ID) in the city of Cirebon. The inclusion criteria were children ages 6-12 years and the exclusion criteria were children under antifungal treatment and children under cytotoxic or immunosuppressive drugs.  The fecal samples from the ID group and non-ID were examined at the Laboratory of the Faculty of Medicine, Universitas Swadaya Gunung Jati Cirebon, Indonesia using Digital Colony counter. Collected data were stored and analyzed using computer aided Statistical program. Mann-Whitney analysis of variance techniques were used to test the hypotheses. Results: The results showed that there are significant differences in the colonies of Candida spp. between the ID group and non-ID group. Median colony of Candida spp. in the ID group is 39.00 with mean colony of 126.90 while the median colony of non-ID group is 3.00 with mean colony of 40.93 (p<0.001).Conclusion: There are significant differences between the Candida spp. colonies in the ID group with the non-ID.
EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Fauziah, Sri Utami; Primanagara, Risnandya; Pratamawati, Tiar M; Nauphar, Donny
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus).Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative.Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus).Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses.
ANTIDIABETIC EFFECT OF COMBINED CINNAMOMUM CASSIA EXTRACT AND METFORMIN IN RATS Assajad, Jibril Ali Syariati; Sanif, Muhammad Edial; Primanagara, Risnandya
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Diabetes mellitus is a group of metabolic diseases characterized with hyperglycemia. This metabolic dysregulation can lead to complications in many organs and even lead to death. Diabetes mellitus can be treated by giving metformin or Cinnamomum cassia. Treatment with a combination of both is expected to better reduce blood glucose levels. This study measured the effectiveness of the combination of metformin and Cinnamomum cassia extract to blood glucose.Methods: This study used Pre-Post-Test control group design using 24 random male white rats divided into 4 groups using Simple random sampling. All groups were induced by alloxan of 150 mg/kg BW, Group 1 was given aquades, group 2 was given metformin of 45 mg/kg BW, group 3 was given Cinnamomum cassia extract 200 of mg/kg BW, and group 4 was given a combination of metformin of 45 mg/kg BW extract Cinnamomum cassia of 200 mg/kg BW. Afterwards, the collected data was analyzed using paired T test and one way ANOVA along with the corresponding post-hoc.Results: The results of this study indicate the effect of administering a combination of cinnamon extract of 200 mg/kg BW and metformin of 45 mg/kg BW to blood glucose levels (p <0.05) with a glucose decrease value of 122.80 ± 2.77 mg/dl better than a single dose of metformin with a glucose reduction value of 92.68 ± 3.10 mg/dl and Cinnamomum cassia extract with a glucose decrease value of 107.16 ± 4.80 mg/dl. This is because there is a different mechanism between cinnamon extract and metformin.Conclusion: In this study, three treatments showed a different decrease in blood sugar levels. Administration of a combination of Cinnamomum cassia extract of 200 mg/kg BW and metformin of 45 mg/kg BW caused the highest decrease. These results provide an opportunity for better treatment of diabetes.
Hubungan Durasi Penggunaan Gadget Untuk Sosial Media Dan Game Online Terhadap Miopia Pada Siswa SMA Negeri 1 Kota Cirebon Amelya Chandra Pitriani; Risnandya Primanagara; Witri Pratiwi
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 7, No 1 (2021): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
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ABSTRAKLatar Belakang: WHO (World Health Organization) telah menetapkan miopia sebagai salah satu prioritas utama untuk mengendalikan dan mencegah kebutaan di dunia pada tahun 2020 Estimasi jumlah orang dengan gangguan penglihatan di seluruh dunia pada tahun 2010 adalah 285 juta orang atau 4,24% populasi. Penggunaan gadget dalam waktu yang lama akan menyebabkan kerusakan pada lensa mata. Tingginya penggunaan gadget terhadap sosial media dan game online yang dapat menyebabkan masalah mata, sehingga dapat menimbulkan kejadian miopia. Penelitian ini bertujuan untuk menganalisis hubungan durasi penggunaan gadget untuk sosial media dan game online terhadap miopia pada SMA Negeri 1 Kota Cirebon.Metode: Penelitian ini observasional analitik dengan desain cross sectional. Pengambilan data dilakukan dengan menggunakan kuesioner, yang dilakukan di SMA Negeri 1 Kota Cirebon pada bulan Februari 2020 dan melibatkan 114 orang. Pengambilan data dilakukan dengan menggunakan kuesioner.Hasil: Hasil analisis menunjukkan bahwa tidak terdapat hubungan antara durasi penggunaan gadget untuk sosial media dengan kejadian miopia (p = 0,233) serta tidak terdapat hubungan antara durasi penggunaan gadget untuk bermain game dengan kejadian miopia (p = 0,808).Simpulan: Tidak terdapat hubungan antara durasi penggunaan gadget baik untuk sosial media dan maupun untuk bermain game dengan kejadian miopia pada siswa SMA N 1 Kota Cirebon.Kata Kunci: miopia; gadget; media sosial; gameABSTRACTBackground: WHO (World Health Organization) has set myopia as one of the top priorities for controlling and preventing blindness in the world because estimated number of people with visual impairments worldwide in 2010 was 285 million people or 4.24% of the population. Using gadgets for a long time will cause damage to the lens of the eye. The high use of gadgets for social media and online games can cause eye problems, such as myopia. This study aims to analyze the relationship between the duration of the use of gadgets for social media and online games to myopia in students of SMA Negeri 1 Kota Cirebon. Methods: An analytic observational study with a cross sectional was done. The data was collected using questionnaire from SMA Negeri1 Cirebon, which is 114 students were recruited, in February 2020. Results: The gender of the subjects of this study was relatively balanced between men and women, the current age was 16 years, the age when subject first used the gadget was 11-15 years, and majority had myopia. The analysis showed that there was no relationship between the duration of using gadgets for social media with the myopia (p = 0.233) and there was no relationship between the duration of using gadgets for gaming with the myopia (p = 0.808). Conclusion: There is no relationship between the duration of the use of gadgets for social media and for playing games with the myopia in students of SMA N 1 Kota Cirebon.Keywords: myopia; gadget; social media; game
HUBUNGAN ANTARA TINGKAT STRES DAN KUALITAS TIDUR TERHADAP TEKANAN DARAH PADA MAHASISWA TINGKAT AKHIR FAKULTAS KEDOKTERAN UNSWAGATI TAHUN AKADEMIK 2015/2016 Dindin Hardi Gunawan; Taufik Budi Permana; Yandri Naldi; Risnandya Primanagara
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 5, No 1 (2019): Tunas Medika Jurnal Kedokteran & Kesehatan
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ABSTRAKLatar Belakang : Mahasiswa tingkat akhir disibukkan dengan berbagai kegiatan yang dapat menjadi tekanan para mahasiswa sehingga dapat menimbulkan stresor negatif dan mempengaruhi tingkat stres. Tugas dan perkembangan mahasiswa dalam fase dewasa muda dapat tercapai dan mencapai titik maksimal ketika mahasiswa terpenuhi kebutuhan-kebutuhan dasarnya. Kebutuhan dasar yang paling mudah terpenuhi adalah kebutuhan akan tidur. Tingkatan stres dan kualitas tidur merupakan masalah yang muncul pada remaja dan dewasa muda khususnya dialami oleh mahasiswa tingkat akhir yang dapat mempengaruhi tekanan darah.Tujuan : Mengetahui hubungan antara tingkat stres dan kualitas tidur terhadap tekanan darah pada mahasiswa tingkat akhir Fakultas Kedokteran Unswagati Cirebon tahun akademik 2015/2016.Metode : Jenis penelitian observasional analitik dengan pendekatan cross sectional. Data primer dengan menggunakan kuisoner baku dan pemeriksaan tekanan darah untuk menilai hubungan antara tingkat stres dan kualitas tidur terhadap tekanan darah dengan jumlah sampel sebanyak 72 responden yang di lakukan pada Mahasiswa tingkat akhir Fakultas Kedokteran Unswagati Cirebon tahun akademik 2015/2016. Analisis data menggunakan Rank Spearman.Hasil : Hasil menunjukkan ada hubungan bermakna antara tingkat stres dan kualitas tidur dengan tekanan darah dengan nilai r masing-masing adalah 0.392 (p-value 0,001) dan 0.316 (p-value 0,007).Kesimpulan : Ada hubungan bermakna antara tingkat stres dan kualitas tidur dengan tekanan darah pada mahasiswa tingkat akhir Fakultas Kedokteran Unswagati Cirebon tahun akademik 2015/2016 dengan kekuatan korelasi lemah.Kata Kunci : Tingkat stres, kualitas tidur, tekanan darah.ABSTRACTBackground: The last year students busy with various activities that can be a pressure that can lead to university students and the negative stressors affect stress level. Tasks and student development in young adult phase can be achieved and reaches its maximum when the students met basic needs. The most basic requirement is fulfilled is the need for sleep. Stress level and sleep quality is a problem in adolescents and young adults in particular experienced by a graduate student who can influence blood pressure.Objective: To determine the correlation between stress level and sleep quality on blood pressure in the last year students of Faculty of Medicine Unswagati Cirebon academic year 2015/2016.Methods: an observational study with cross sectional analytic. Primary data using standard questionnaires and blood pressure checks to assess the association between stress level and sleep quality on blood pressure with a 72 total sample of the Faculty of Medicine Student level Unswagati Cirebon academic year 2015/2016. Analysis of the data using the Rank Spearman.Results: The results showed no significant correlation between stress level and sleep quality with high blood pressure by value r 0392, respectively (p-value 0.001) and 0316 (p-value 0.007). Conclusion: There is a significant correlation between stress level and sleep quality with the blood pressure in their last year of the Faculty of Medicine Unswagati Cirebon academic year 2015/2016 with the strength of the correlation is weak.Keywords: level of stress, sleep quality, blood pressure.
Korelasi merokok, Usia, Riwayat Keluarga, dan Obesitas dengan Kejadian Hipertensi pada Laki-Laki Usia 35-65 Tahun Ardi Aprilman; Edial Sanif; Risnandya Primanagara
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 6, No 1 (2020): Tunas Medika Jurnal Kedokteran & Kesehatan
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ABSTRAKLatar Belakang: Hipertensi adalah salah satu penyebab kematian tertinggi di dunia. Prevalensi hipertensi di Indonesia telah mencapai angka 25,8%. Faktor yang dapat menyebabkan hipertensi diantaranya Merokok, Usia, Riwayat Keluarga, dan Obesitas. Tujuan: Untuk mengetahui korelasi dari kebiasaan merokok, Usia, Riwayat Keluarga, dan Obesitas dengan kejadian hipertensi. Metode: Metode penelitian yang digunakan adalah Observasional dengan menggunakan desain Cross sectional. Populasi adalah laki-laki usia 35-65 tahun di wilayah kerja puskesmas Larangan kota Cirebon. Jumlah sampel 330 responden yang diambil dengan menggunakan teknik Accidental Sampling. Data diperoleh menggunakan kuesioner, kemudian dianalisis secara univariat dan bivariat dengan uji data Spearman dengan interval kepercayaan 5%. Hasil: dari uji spearman penelitian ini, variabel yang berhubungan dengan kejadian hipertensi adalah merokok dengan nilai (p=0,000 r=0,507) korelasi kuat arah positif, Usia dengan nilai (p=0,000 r=0,346) korelasi cukup arah positif, Obesitas dengan nilai (p=0,002 r=-0,167) korelasi arah negatif. Sedangkan variabel yang tidak berhubungan adalah Riwayat Keluarga dengan nilai (p=894 r=-0,085). Kesimpulan: Kebiasaan merokok dan Faktor Usia merupakan faktor resiko yang mempengaruhi kejadian Hipertensi.Kata Kunci: Hipertensi, merokok, Usia, Riwayat Keluarga, Obesitas ABSTRACT Introduction: Hypertension is a highest cause of death in the world. Prevalence of hypertension in Indonesia has reached 25, 8 %. Factors that can cause hypertension include smoking habits, age, family history, and obesity. Objective: To know correlation of smoking habits, age, family history, and obesity with hypertension case. Method: The method that is used is Observational with the design is Cross sectional. The populations are men age 35-65 years old in work field in Larangan Public Health Center Cirebon. There are 330 sample respondents which were taken by using Accidental Sampling technic. The data was taken by using questionnaire then it was analyzed through univariate and bivariate by Spearman’s data test with the belief interval is 5%. Result: Spearmann’s correlation Test results showed variables that has a relation with hypertension   are smoking habit (p=0,000 r=0,507) with positive strong correlation, age (p=0,000 r=0,346) with positive sufficient correlation, obesity  (p=0,002 r=-0,167) with negative correlation. While variables that doesn’t have relation Alt hypertensin are family history (p=894 r=-0,085). Conclusion: smoking habit and age are risk factors that have influence on hypertension insidence.Keywords: Hypertension, smoking, Age, Family History, Obesity.                     
Perbandingan Efektivitas Ekstrak Daun Seledri (Apium graveolens L.) dengan Allopurinol Terhadap Penurunan Kadar Asam Urat pada Tikus Putih Jantan (Rattus novergicus) dibuat Hiperuresemia Fitriani Fitriani; Ismi Cahyadi; Risnandya Primanagara
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 4, No 2 (2018): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
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ABSTRAK                  Latar Belakang : Hiperurisemia yang berkepanjangan dapat menyebabkan gout atau pirai. Allopurinol merupakan obat pilihan utama untuk menurunkan kadar asam urat, namun jika dikonsumsi terus menerus dapat mengakibatkan efek samping. Oleh sebab itu, diperlukan alternatif terkandung dalam daun seledri yang mampu menghambat pembentukan asam urat. Tujuan : Untuk mengetahui perbandingan efektivitas ekstrak daun seledri (Apium graveolens L) dengan allopurinol terhadap penurunan kadar asam urat tikus putih jantan (Rattus norvegicus) dibuat hiperuresemia. Metode : Penelitian eksperimental dengan rancangan pretest dan posttest control group design. Penelitian ini menggunakan empat kelompok yaitu dua kelompok kontrol K(N) diberi makan standar dan K(-) diberi makan tinggi purin serta dua kelompok perlakuan (P1 diberi ekstrak daun seledri 10mg/200grBB dan P2 diberi allopurinol 3,6mg/kgBB). Hasil : Pada kelompok K(N) mengalami  perubahan  bermakna  yaitu  nilai p=0,010 (p<0,05). Kelompok K(-) mengalami perubahan bermakna yaitu nilai p=0,004 (p<0,05). Kelompok (P1) mengalami perubahan dengan nilai p=0,000 (p<0,05). Kelompok (P2) mengalami perubahan dengan nilai p=0,000 (p<0,05). Simpulan : Pemberian allopurinol lebih efektif dalam menurunkan kadar asam urat darah dibandingkan pemberian ekstrak daun seledri.                  Kata Kunci : Allopurinol, Asam Urat, Daun Seledri.ABSTRACTBackground : Long term hyperuricemia can lead to gout. Allopurinol is the first choice treatment to reduce uric acid concentration, but if consumed continuously it can lead to various side effects. Therefore, there is a need for an alternative that can inhibit the formation of uric acid, which is found in celery leaves. Goal : To effectivity comparison between celery (apium graveolens L)  leaves extract  and allopurinol towards uric acid reduction in hyperuricemia created male white rat (Rattus novergicus).Method : Experimental research with pretest and posttest control group design. This research used four groups which were two control groups K(N) who were given a standard diet and K (-) who were given a high purine diet, as well as two treatment groups (P1 group were given 10mg/200grBW celery leaves and P2 were given 3,6mg/kgBW allopurinol). Results : K(N) group had a significant difference with p=0,010 (p<0,05). K(-) group had a significant difference with p=0,004 (p<0,05). (P1) group showed difference with p=0,000(p<0,05). (P2) group showed difference with p=0,000(p<0,05). Conclussion : Allopurinol treatment is more effective in reducing uric acid concentration than celery leaves treatment. Keywords : Allopurinol, Uric Acid, Celery Leaves.
RANCANG BANGUN SISTEM INFORMASI TERINTEGRASI AUDIOVISUAL UNTUK OSCE (OBJECTIVE STRUCTURED CLINICAL EXAMINATION) Risnandya Primanagara; M. Duddy Satrianugraha; Catur Setiya Sulistiyana
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 2, No 1 (2015): Tunas Medika Jurnal Kedokteran & Kesehatan
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Sistem Informasi menjadi penunjang di era modern, termasuk di dunia medis dalam bidang pendidikan kedokteran. Dalam pendidikan kedokteran, Sistem Informasi  digunakan dalam membantu kelancaran pendidikan kedokteran, baik untuk pengajaran, pengujian hingga penilaian. Metoda pengujian dalam Pendidikan kedokteran salah satunya adalah OSCE (Objective Structured Clinical Examination). Pelaksanaan OSCE membutuhkan sumber daya yang besar. Sistem Informasi diintegrasikan dengan sistem audio visual diterapkan untuk meningkatkan efisiensi sumber dayanya didesain untuk pelaksanaan OCSE di fakultas Kedokteran Unswagati. Kemudian desain yang dibuat diujicobakan dalam lingkup sendiri dengan harapan bahwa penerapan Sistem Informasi terintegrasi audiovisual, menjadikan pelaksanaan OSCE  reliabel, valid dan efisien
Hubungan Frekuensi Antenatal Care dan Lama Waktu Bekerja dengan Pemberian ASI Eksklusif (Studi di Wilayah Kerja Puskesmas Kalitanjung Kota Cirebon) Risnandya Primanagara; Haidar Imam Ali Shidiq
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 2, No 4 (2015): Tunas Medika Jurnal Kedokteran & Kesehatan
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ABSTRAKLatar Belakang: Mengetahui rendahnya angka pemberian ASI eksklusif di Kota Cirebon bahwa dari 6.361 bayi pada tahun 2012 hanya 944 (14,8%) bayi yang diberikan ASI eksklusif. Selain itu, berdasarkan Survey Demografi dan Kesehatan Indonesia (SDKI) menjabarkan bahwa cakupan pelayanan Antenatal Care di indonesia tahun 2011 sebesar 82% masih tertinggal dengan negara ASEAN yang lainnya. Survey Demografi Kesehatan Indonesia (SDKI) 2007 menunjukan bahwa 57 % tenaga kerja di indonesia adalah wanita. Tujuan: Menganalisis hubungan frekuensi Antenatal Care dan lama waktu bekerja terhadap pemberian ASI eksklusif di wilayah kerja Puskesmas Kalitanjung Kota Cirebon. Metode: Metode yang digunakan adalah survei analitik secara cross sectional. Sampel diambil dengan teknik purposive sampling sebanyak 44 orang. Data diambil menggunakan kuesioner melalui wawancara terstruktur. Uji statistik yang digunakan adalah uji Risk Association dengan menggunakan Prevalence Rate dan 95% Confidence Interval. Hasil: Dari 44 responden didapatkan 26 (59,1%) responden memberikan ASI Eksklusif dan 18 (40,9%) resonden tidak memberikan ASI Eksklusif. Melalui uji Risk Association terdapat hubungan yang bermakna antara frekuensi Antenatal Care (P= 0,001, RP = 3,400 (95% CI 1,871-6,177), lama waktu bekerja (P = 0,031, RP = 2,143 (95% CI 1,095-4,195) terhadap ASI Eksklusif. Simpulan: Frekuensi Antenatal Care dan lama waktu bekerja mempunyai hubungan bermakna terhadap pemberian ASI Eksklusif. Kata Kunci: ASI Eksklusif, Antenatal Care, Lama Waktu Bekerja ABSTRACTBackground: Knowing the low rate of exclusive breastfeeding in Cirebon city that 6,361 babies in 2012 only 944 (14.8%) babies were exclusively breastfeeding. In addition, based on the Indonesian Demographic and Health Survey (IDHS) outlines that Indonesia Antenatal Care coverage in 2011 by 82% still left with the other ASEAN countries. Indonesian Demographic Health Survey (IDHS) in 2007 showed that 57% of workers in Indonesia are women. Objective: To analyze correlation between Antenatal Care frequency and work duration with exclusive breastfeeding in Kalitanjung public Health Center Working area Cirebon city. Methods: The method used is the cross sectional analytical survey. Samples were taken by using purposive sampling as many as 44 people. Data collected using a structured questionnaire interviews. The statistical test used is the Risk Association by using the Prevalence Rate and 95% Confidence Interval. Results: Of the 44 respondents found 26 (59.1%) of  respondents provide exclusive breastfeeding and 18 (40.9%) respondents not exclusive breastfeeding. Through the Association of Risk test there a significant correlation between Antenatal Care frequency (P = 0.001, RP = 3.400 (95% CI 1.871 to 6.177), and work duration (P = 0.031, RP = 2.143 (95% CI 1.095 to 4.195) with exclusive breastfeeding. Conclusion: Antenatal Care frequency and work duration thave a significant correlation with exclusive breastfeeding. Key Words: Exclusive breastfeeding, Antenatal Care, work duration.