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All Journal Jurnal Kedokteran dan Kesehatan Bioma : Jurnal Biologi Indonesia Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Abdi Insani Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Mitra Kesehatan Proceeding Muhammadiyah International Public Health and Medicine Conference
Maya Uzia Beandrade
Program Studi S1 Farmasi, STIKes Mitra Keluarga Bekasi Timur
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Formulasi dan Karakterisasi SNEDDS Ekstrak Jinten Hitam (Nigella Sativa) dengan Fase Minyak Ikan Hiu Cucut Botol (Centrophorus Sp) serta Uji Aktivitas Imunostimulan Maya Uzia Beandrade
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 3, No 1 (2018)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.925 KB) | DOI: 10.20961/jpscr.v3i1.15506

Abstract

Jinten hitam (Nigella sativa) mengandung senyawa timokuinon yang berefek sebagai imunostimulan. Ekstrak jinten hitam dikembangkan menjadi SNEDDS (Self-nanoemulsifying Drug Delivery System) karena masalah kelarutan. Penelitian dilakukan untuk mengetahui karakteristik SNEDDS ekstrak jinten hitam yang meliputi viskositas, ukuran tetesan nanoemulsi, extract loading, dan stabilitas. Pengujian aktivitas imunostimulan SNEDDS meliputi rasio sel makrofag dan indeks fagositosis.SNEDDS ekstrak jinten hitam dioptimasi dengan metode Simplex Lattice Design menggunakan Design Expert 7.1.5., selanjutnya SNEDDS optimal diuji ukuran tetesan nanoemulsi dan zeta potensial, viskositas, serta uji stabilitas. Uji aktivitas imunostimulan dilakukan dengan metode biolatex assay terhadap tikus Sprague Dawley sebanyak 5 tikus/kelompok selama 15 hari dengan pemberian satu kali sehari yaitu kontrol positif (ekstrak meniran 7,2 mg/tikus), kelompok perlakuan yaitu ekstrak jinten hitam dengan dosis 200 mg/kgBB serta SNEDDS ekstrak jinten hitam (200 mg/kgBB), kelompok plasebo berupa formula SNEDDS tanpa ekstrak jinten hitam, dan kontrol normal, selanjutnya dihitung rasio dan indeks fagositosis makrofag.SNEDDS ekstrak jinten hitam optimal mengandung 15% minyak ikan hiu cucut botol, 67,344% surfaktan (10,102% croduret 50 ss dan 57,242% tween 80), 17,656% PEG 400 sebagai ko-surfaktan dengan hasil ukuran tetesan nanoemulsi 16,3 nm, PI sebesar 0,202, zeta potensial -43,5 mV, dan viskositas antara 234,69 – 255,71 cP. Hasil extract loading sistem SNEDDS mencapai 600 mg ekstrak/g sistem. SNEDDS stabil setelah penyimpanan selama 90 hari pada suhu kamar dan uji freeze-thawing. SNEDDS ekstrak jinten hitam dengan dosis 200 mg/kgBB dapat meningkatkan rasio sel makrofag dan indeks fagositosis dibandingkan dengan ekstrak jinten tanpa formulasi (P<0,05).
Edukasi Penggunaan Suplemen Vitamin A, Iodium, Zink, dan Zat Besi dalam Pencegahan Stunting Reza Anindita; Intan Kurnia Putri; Maya Uzia Beandrade; Dede Dwi Nathalia; Melania Perwitasari
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 4, No 4 (2022)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v4i4.6460

Abstract

Stunting telah menjadi masalah kesehatan nasional sekaligus prioritas kesehatan global yang mampu mempengaruhi kualitas Sumber Daya Manusia (SDM) sebagai generasi masa depan bangsa Indonesia. Oleh sebab diperlukan upaya penanganan masalah stunting seperti peningkatan komunikasi perubahan perilaku melalui kegiatan pengabdian masyarakat (PKM) berupa edukasi mengenai stunting sebagai salah satu perwujudan strategi penurunan stunting sesuai Peraturan Persiden Nomor 72 Tahun 2021 tentang percepatan penurunan stunting di Indonesia. Tujuan PKM ini memberikan edukasi kepada masyarakat mengenai pemberian suplemen vitamin A, Iodium, Zink, dan Zat Besi sebagai upaya perwujudan program pencegahan stunting untuk mempercepat penurunan angka stunting. Kegiatan ini dilakukan pada tanggal 16 April 2022. Kegiatan ini dilakukan saat pandemi COVID-19 sehingga mewajibkan kebijakan pertemuan secara daring. Tahap kegiatan ini meliputi persiapan, pelaksanaan, dan evaluasi. Tahap persiapan dimulai dari penyusunan materi dalam bentuk power point, video, dan poster. Tahap Pelaksanaan berupa pre-test, pemaparan materi, sesi diskusi/Tanya jawab, post-test, dan pemberian reward (penghargaan) bagi peserta terbaik. Semua kegiatan dilaksanakan secara daring (online) melalui aplikasi zoom meeting. Target peserta antara lain Institusi pendidikan, Pemerintahan, siswa-siswi SMA/SMK, masyarakat umum, dan praktisi kesehatan. Tahap evaluasi dilakukan menganalisis semua data secara deskriptif mengenai jumlah peserta, asal peserta, nilai pre-test dan post test. Hasil kegiatan ini antara lain jumlah peserta yang mengikuti PKM sebanyak 60 dengan peserta sebanyak 96% berasal dari Jawa Barat (Bekasi). Rata-rata nilai pre-test ke post-test meningkat dari 62 menjadi 83 atau mengalami peningkatan sebesar 55 %. Kesimpulan PKM ini adalah masyarakat mampu memahami materi edukasi yang dibuktikan dengan ketepatan menjawab pertanyaan seperti fungsi, dampak, sumber, dan dosis pemberian vitamin A, Zink, Iodium, dan zat Besi untuk mencegah potensi stunting.    Stunting has become a national health problem as well as a global health priority that can affect the quality of Human Resources for the future generation of the Indonesian nation. Therefore, efforts to tackle stunting problems are needed, such as increasing behavior change communication through community service activities in the form of education about stunting as a manifestation of stunting reduction strategies according to Presidential Regulation Number 72 of 2021 concerning the acceleration of stunting reduction in Indonesia. The purpose of this PKM is to provide education to the public regarding the provision of vitamin A, Iodine, Zinc, and Iron supplements as an effort to realize the stunting prevention program to accelerate the reduction of stunting rates. This activity was carried out on April 16, 2022. This activity was carried out during the COVID-19 pandemic, thus requiring an online meeting policy. This activity stage includes preparation, implementation, and evaluation. The preparation stage begins with the preparation of materials in the form of power points, videos, and posters. The implementation stage is in the form of a pre-test, material presentation, discussion/question-answer session, post-test, and awarding of the best participants. All activities are carried out online through the Zoom Meeting application. Target participants include educational institutions, government, high school/vocational high school students, the general public, and health practitioners. The evaluation stage was carried out by analyzing all data descriptively regarding the number of participants, the origin of participants, and pre-test and post-test scores. The results of this activity included the number of participants who took part in PKM as many as 60 with 96% of participants coming from West Java (Bekasi). The average value of pre-test to post-test increased from 62 to 83 or increased by 55%. This PKM concludes that the community can understand educational materials as evidenced by the accuracy of answering questions such as the function, impact, source, and dose of vitamin A, zinc, iodine, and iron to prevent stunting potential.
Gambaran Histologi Pankreas Tikus dengan Diabetes Melitus Tipe 2 yang Diberikan Tablet Kedelai Detam II Maya Uzia Beandrade; Ria Amelia; Wahyu Nuraini Hasmar
Jurnal Kedokteran dan Kesehatan Vol 18, No 2 (2022): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jkk.18.2.240-248

Abstract

Kondisi hiperglikemia pada penyakit diabetes mellitus tipe 2 dapat menyebabkan kematian sel baik pada sel β pankreas maupun sel lain. Pencegahan kematian sel tersebut diperlukan untuk mencegah terjadinya komplikasi pada DMT2. Salah satu cara pencegahannya melalui konsumsi zat antioksidan. Kacang kedelai hitam varietas detam II memiliki kandungan senyawa flavonoid tinggi dan berperan dalam antioksidan. Penelitian dilakukan selama 9 bulan dari bulan Februari- Oktober 2020 di Laboratorium Farmakologi dan Sitohistoteknologi STIKes Mitra Keluarga. Metode penelitian yang digunakan yaitu Randomized Controlled Pretest-posttest design. Kelompok sampel terbagi menjadi 5 kelompok yaitu kontrol negatif, positif, perlakukan dengan kadar tablet 500 mg/BB, 750 mg/BB, 1.000mg/BB, pembuatan preparat dengan metode paraffin dan pewarnaan HE. Hasil pewarnaan menunjukkan perbaikan jaringan pankreas yang optimum terdapat pada kelompok tikus yang diberikan tablet kedelai hitam varietas detam II 750 mg/BB. Hasil penelitian ini menunjukkan kedelai hitam varietas detam 2 memiliki kemampuan  mencegah kerusakan sel akibat kondisi stress oksidatif.
Reevaluation of methanol extract from Phoenix dactylifera var. sukkari fruit’s potential against acne-inducing bacteria Reza Anindita; Intan Kurnia Putri; Maya Uzia Beandrade; Dede Dwi Nathalia; Melania Perwitasari
Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Vol 5, No 2 (2022): December
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/biolokus.v5i2.1363

Abstract

One of the natural ingredients that is often developed as an antibacterial product is the date palm (Phoenix dactylifera). However, scientific evidence regarding the effectiveness of the antibacterial compounds contained in dates needs to be evaluated, considering that several previous studies have reported that dates are more dominant as antioxidants than as antibacterials. Therefore, it is necessary to reevaluate the antibacterial ability of the methanolic extract of the sukkari variety date palm against the three test bacteria that cause acne, namely P. acnes, S. epidermidis and S. aureus. This research aimed to determine the sensitivity of the three bacteria tested in response to the methanol extract of the sukkari dates. This research design is experimental. The samples tested were sukkari and the tested bacteria were P. acnes, S. epidermidis and S. aureus. Dates were extracted by maceration method and made in concentrations of 50%, 60%, 70%, 80% and 90%. Positive control was chloramphenicol antibiotic while negative control was sterile distilled water. All treatments including control (+) and (-) were given to the test bacteria using the Kirby Baeur method to see the diameter of the zone of inhibition of the test bacteria growth. The data was processed in tabular form and compared with the 2016 CLSI standard to see the sensitivity response of the test bacteria. Results of this research is the sukkari dates extract with concentrations of 50%, 60%, 70%, 80% and 90% was able to inhibit the growth of P. acnes, S. epidermidis and S. aureus bacteria with an interval of 7.0-10.0 mm in diameter of the zone of inhibition. All the tested bacteria showed a sensitivity response in the resistant category, so the sukkari dates fruit extract is not the main choice to be developed as a natural anti-acne product.
EDUKASI TENTANG PENTINGNYA SUPLEMENTASI PROBIOTIK UNTUK MENJAGA IMUNITAS DI MASA PANDEMI COVID-19 Reza Anindita; Dede Dwi Nathalia; Melania Perwitasari; Intan Kurnia Putri; Maya Uzia Beandrade
Jurnal Abdi Insani Vol 9 No 4 (2022): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v9i4.619

Abstract

The community death rate due to Covid-19 is 2.58%. This percentage places Indonesia as the second highest CFR Covid-19 score in Southeast Asia. The highest death rate was in the age group > 65 years, which was 48.7%. Therefore, efforts to deal with Covid-19 are needed through education in Community Service activities (PKM) in the form of the importance of consuming probiotics to maintain endurance during the Covid-19 pandemic. The purpose of this PKM is to provide education about types of probiotics as a supplement to prevent Covid-19. Education also informs about the proper rules regarding the consumption of probiotics as an effort to increase endurance during the Covid-19 pandemic. This method of activity was adapted to the COVID-19 pandemic which required online meeting policies. The preparatory stage is carried out by compiling interesting and communicative material in the form of attractive and communicative power points, videos and posters. The implementation phase is carried out online in the form of a webinar. The evaluation evaluation stage is carried out by looking at the number of participants who are actively participating in the PKM webinar. Publication of PKM activities is carried out through Instagram and WhatsApp social media. Specifically on WhatsApp, a group of SMA/SMK teachers was created to facilitate the dissemination of information about Mitra Keluarga STIKes PKM activities. The number of participants who took part in this PKM webinar was 142 people. As for this PKM, the community was able to understand educational material as evidenced by the average pre-test and post-test scores of the 142 participants in this activity sequentially increasing from 58 to 81 with a percentage increase of 55%. The conclusion from this activity is that the community is able to understand educational material in online PKM webinars. The material is the effectiveness of consuming probiotics in preventing Covid-19.
KANDUNGAN HIDROKUINON DALAM LOTION PEMUTIH YANG BEREDAR DI WILAYAH CIKARANG DENGAN METODE SPEKTROFOTOMETRI UV-VIS shandra megasari; Melania perwitasari; Maya Uzia Beandrade; Reza Anindita
Jurnal Mitra Kesehatan Vol. 5 No. 1 (2022): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v5i1.150

Abstract

Pendahuluan: Lotion merupakan sediaan kosmetik yang banyak digunakan untuk memutihkan kulit, namun masih banyak lotion yang tidak memiliki nomor izin edar BPOM yang dijual belikan secara bebas. Hidrokuinon salah satu zat yang banyak ditambahkan sebagai pemutih di kosmetika terutama yang tidak memiliki izin edar. Efek penggunaan hirokuinon dapat mengiritasi kulit hingga dapat menyebabkan kanker kulit. Peraturan Badan Pengawas Obat dan Makanan No. 23 tahun 2019 menetapkan penggunaan hidrokuinon untuk kosmetika telah dilarang namun masih diperbolehkan untuk penggunaan pewarna kuku. Metode: Metode penelitian ini menggunakan metode non eksperimental, untuk analisis kualitatif menggunakan pereaksi FeCl3 sedangkan untuk uji kuantitatif digunakan metode spektrofotometer UV-Vis. Hasil:Panjang gelombang maksimum hidrokuinon yang diperoleh adalah 294 nm, dengan persamaan kurva baku didapat y= 0,0279 x +  0,2002 dengan r2 = 0,9972. Pada sampel L2, L3 dan L5 terkandung hidrokuinon dengan kadar pada sampel L2 yaitu 2,44% ± 0,023, L3 1,27% ± 0,002 dan L5 2,57% ± 0,001. Kesimpulan: Sebanyak 3 dari 5 sampel lotion positif terkandung hidrokuinon dan tidak sesuai dengan persyaratan yang ditentukan oleh BPOM.
POTENSI ANTIOKSIDAN INFUSA BUNGA TELANG (Clitoria ternatea), ROSELLA (Hibiscus sabdariffa) DAN DAUN STEVIA (Stevia rebaudiana) SEBAGAI ANTIDIABETES Melania Perwitasari; Sinta Nuriyah Awaliyah; Intan Kurnia Putri; Nofria Rizki Amalia Harahap; Ariska Deffy Anggarany; Reza Anindita; Maya Uzia Beandrade; Dede Dwi Nathalia
Jurnal Mitra Kesehatan Vol. 5 No. 2 (2023): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v5i2.194

Abstract

Reactive Oxygen Species (ROS) can induce oxidation that caused aging and degenerative diseases such as Diabetic Mellitus. To prevent the incident of degenerative disease, antioxidant needed that found in many herbs, especially colored herbs. Butterfly pea, Rosella flower, and Stevia leaf known as herbs contains phenolic and flavonoid. This constituent are responsible as antioxidant activity. Many people consume the herbs by brewing with hot water as infused water. The purpose of this research is to determine antioxidant activity of infused Butterfly pea, Rosella flower, and Stevia leaf by FRAP method. This is non experiment method descriptive with dry herbs of Butterfly pea, Rosella flower, and Stevia leaf infused extract as sample. The research was conducted in September 2022-February 2023 at STIKes Mitra Keluarga Laboratory. The antioxidant activity is expressed as % FRAP activity. Based on the experiment, it knows that % FRAP activity of Butterfly pea, Rosella flower, and Stevia leaf consecutive 55,29% ± 0,0, 69,17% ± 0,12 , 61,55% ± 0,04.
EPIDEMIOLOGY OF PITYRIASIS VERSICOLOR IN ELEMENTARY SCHOOL CHILDREN IN THE BANTAR GEBANG, BEKASI Anindita, Reza; Eka Wahyu Wulandari; Maulin Inggraini; Melania Perwitasari; Maya Uzia Beandrade; Dede Dwi Nathalia; Intan Kurnia Putri
Muhammadiyah International Public Health and Medicine Proceeding Vol. 3 No. 1 (2023): PROCEEDING MUHAMMADIYAH INTERNATIONAL PUBLIC HEALTH AND MEDICINE CONFERENCE - T
Publisher : Fakultas Kesehatan Masyarakat Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61811/miphmp.v3i1.449

Abstract

Pityriasis versicolor (PV) is a disease caused by a superficial fungus, namely Malassezia furfur. This disease is chronic with skin appearance that has characteristics in the form of well-defined skin lesions and white (hypopigmentation) and pink to brownish (hyperpigmentation). PV disease causes itching and a psychological impact in the form of a decrease in self-confidence. The purpose of this study was to determine the percentage of PV incidence in elementary school children at the Garbage Disposal Site, Bantar gebang, Bekasi, West Java. This type of research is quantitative and descriptive with a cross-sectional design. The research sample consisted of 87 elementary school students in grades 1 and 2 who were selected based on inclusion criteria, namely the presence of hypopigmented and hyperpigmented lesions. The examination was carried out microscopically with the solatip method using 10% KOH. Data analysis was performed by using descriptive statistical tests. The results of this study showed that there were 35 (40%) students who were positively infected with PV, which was confirmed by the presence of spores and hyphae of the fungus M. furfur. The age most affected by PV is 7 years old, with a percentage of 17 (49%) students, while the percentage of the sex most affected by PV is male, with as many as 23 (53%) students. The study concludes that the prevalence of children in grades 1 and 2 at Yayasan Dinamika Indonesia Elementary School around the Bantargebang landfill, Bekasi, West Java, is in the middle category. The factors that influence the incidence of PV in this study are outdoor activities, which cause the facial area to sweat easily, and lack of personal hygiene.
Reproducibility of antibacterial effects of ethanol extracts from Piper crocatum Ruiz & Pav., and Piper betle L. (Piperaceae), against common acne, Propionibacterium acnes (Gilchrist, 1900) Douglas & Gunter, 1946 (Propionibacteriaceae) Anindita, Reza; Fatmawati, Mita; Inggraini, Maulin; Intan Kurnia Putri; Maya Uzia Beandrade
Bioma Vol. 21 No. 1 (2025): Bioma
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/bioma.v21i1.50131

Abstract

Red and green betel leaf plants are useful as medicine but need to be tested for antibacterial ability to be used as raw materials for making anti-acne serum. This study aims to determine the antibacterial effect of red and green betel leaves on the sensitivity response of Propionibacterium acnes bacteria. This experimental study used samples of red and green betel leaves with procedures including sample preparation, maceration, qualitative phytochemical screening, and testing of antibacterial compounds in ethanol extracts of 70%, 80%, 90% and 100% samples using the Kirby Baeur method. Positive control was clindamycin 30 µg antibiotic and negative control was sterile distilled water. The yield of thick extracts of red and green betel leaves was 13.5% and 15%. The administration of 70%, 80%, 90%, and 100% thick extract of red betel leaves was able to inhibit Propionibacterium acnes with inhibition zone diameters of 16 mm, 18 mm, 18.5 mm, and 19 mm while green betel was 18 mm, 18 mm, 21 mm, 23 mm. The administration of thick extracts of red and green betel leaves is effective in inhibiting the growth of P. acnes and has the potential to be used as raw material for anti-acne serum formulations.
Co-Authors , Intan Kurnia Putri Amelia, Ria Ariska Deffy Anggarany, Ariska Deffy Dwi Nathalia, Dede Eka Wahyu Wulandari Fatmawati, Mita Hasmar, Wahyu Nuraini Inggraini, Maulin Intan Kurnia Putri Intan Kurnia Putri Intan Kurnia Putri Melania Perwitasari Melania Perwitasari Melania Perwitasari, Melania Nofria Rizki Amalia Harahap Reza Anindita Anindita shandra megasari Sinta Nuriyah Awaliyah Syah, Muh Nur Hasan