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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Buletin Udayana Mengabdi Jurnal Farmasi Udayana JPSCR : Journal of Pharmaceutical Science and Clinical Research
Ni Putu Eka Leliqia
Program Studi Farmasi, FMIPA, Universitas Udayana
Chemistry Dentistry Education Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES

 1 
PENGARUH pH DAN LAMA PENYIMPANAN TERHADAP STABILITAS KIMIA STANDAR (+)-KATEKIN Ni Putu Eka Leliqia; Yanita Ristanti Purwitadewi; I Made Agus Gelgel Wirasuta
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 5 (2015): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/10.24843/IJLFS.2015.v05.i01.p01

Abstract

(+)-Catechin was a potential compound to be isolated and developed into natural antioxidant product, but it was unstable because it was easy to be oxidized and formed quinone metabolite. This became a problem in its development and isolation process. Factors that can influence the oxidation process of (+)-catechin were pH condition and storage time. Therefore, this research was conducted to know pH and storage time influence towards the (+)-catechin stability. Observation was done in two parameters which was the acid-base pH (pH 1,64-10) and the storage time for 8 days. The influence of both the parameters towards (+)-catechin standard stability was observed by the quinone metabolite formation from (+)-catechin oxidation reaction result. (+)-catechin was declared as unstable if quinone metabolite was formed by absorbance measurement in its maximum wavelength, 409nm with spectrophotometry method. The obtained result showed that (+)-catechin standard was stable in pH 1.64-6 for 8 days storage and was unstable in pH 7-10 showed by the formation of quinone metabolite for 2-8 days storage.
PENGARUH pH DAN LAMA PENYIMPANAN TERHADAP STABILITAS KIMIA STANDAR (+)-KATEKIN Ni Putu Eka Leliqia; Yanita Ristanti Purwitadewi; I Made Agus Gelgel Wirasuta
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 5 (2015): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/10.24843/IJLFS.2015.v05.i01.p01

Abstract

(+)-Catechin was a potential compound to be isolated and developed into natural antioxidant product, but it was unstable because it was easy to be oxidized and formed quinone metabolite. This became a problem in its development and isolation process. Factors that can influence the oxidation process of (+)-catechin were pH condition and storage time. Therefore, this research was conducted to know pH and storage time influence towards the (+)-catechin stability. Observation was done in two parameters which was the acid-base pH (pH 1,64-10) and the storage time for 8 days. The influence of both the parameters towards (+)-catechin standard stability was observed by the quinone metabolite formation from (+)-catechin oxidation reaction result. (+)-catechin was declared as unstable if quinone metabolite was formed by absorbance measurement in its maximum wavelength, 409nm with spectrophotometry method. The obtained result showed that (+)-catechin standard was stable in pH 1.64-6 for 8 days storage and was unstable in pH 7-10 showed by the formation of quinone metabolite for 2-8 days storage.
UJI SKRINING DAN DETERMINASI KODEIN DENGAN TLC SPEKTROFOTODENSITOMETRI Pande Made Nova Armita Sari; Ni Putu Eka Leliqia
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 3 (2013): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A current research of screening and determination of codeine using Al-TLC Spectrophotodensitometry has been carried out. The separation was performed using TAEA mobile phase. Screening and confirmation were investigated by comparing hRfc of the analyte and hRfc those on data library. Combination hRfc vs correlation also been used as confirmation method, which can be enhanced by spectrum shift reaction using HCl 10% and KOH 0,1 M. The validation parameters were precission, linierity, limit of detection and quantitation (LOD & LOQ) and recovery.   TAEA mobile phase performed a good separation among morphine, codeine, caffeine, papaverine and bromhexine standards, which gave Rs value > 1. Test of linierity using regression gave correlation value > 0,99 . LOD and LOQ of Al-TLC were 137.85 ng and 459.63 ng. The recovery of codeine in human plasma using isopropanol as the precipitating agent was 77.1% ± 4.9 (6.5%).
Co-Authors A.A. Bagus Yoga Saputra Adiluhur M. A. Cahyadi M.F. Chanjaya ,C. Cokorda Istri Sri Arisanti Coky N. W. C. Dewa Ayu Swastini Dewantari A. A. I. S. H Dewi, A.A.A.P.K. Diarini A. S. Era S.Y., I Ketut Gede Gilang Gama Harta I Made Agus Gelgel Wirasuta I. D. M. R Taradipta I.B.D Esa I.M.K.A Suyadnya I.N.K. Widjaja IG.Y Prayadnya IK.A.Y. Murti Irmayanti N.M.F. Jaya, I. G. N. I. P Junior, I.K.P. K. Megayanti L.P.F. Larasanty Maryadhi N. M. D. D. Maryadhi N.M.D.D. Moeliono A.P. N. L. P. V. Paramita N.K.I.P Dewi N.L.P.A Pratiwi N.W.W Citradewi Ni Kadek Warditiani Ni Putu Linda Laksmiani Oka M. P. A. S. Putra P.A. Pramana, P.A. Savitri, Pande Made Nova Armita Sari, Pande Made Nova Pande Putu Ayu Sukmawati Pustiari, P. A. Putu Oka Samirana R. Wirayanti Rupadani, N.L.D Satiawan, I. P. J Sumartin N.W.E. Susanti, N.M.P Taradipta, I. D. M. R. Utami N. L. W. S. Utami, L. N. S. Viviandari, I D. A. A Wahyuni, N.N.S Wedana JS S. M. Widjaja I.N.K. Wijayanti N. P. A. D. Wijayanti, N. P. A. D. Yan Ramona Yanita Ristanti Purwitadewi