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Quality of life epilepsy in childhood: Comparison between well-controlled epilepsy and non epilepsy Soeroyo Machfudz, Fita Wirastuti Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Quality of life is an important parameter in assessing the efficacy of medical interventions. Chronic diseases such asepilepsy, have a significant impact on quality of life. Childhood epilepsy is often associated with low achievement inschool, physical limitations, and disturbed social functions. The purpose of this study was to compare the quality oflife of well-controlled epileptic children with non epileptic children. This research was conducted with cross-sectionalstudy design with respondents aged 5-18 years old. All respondents were well-controlled epileptic and non epilepticchildren who were admitted to the Pediatric Polyclinic of Dr. Sardjito General Hospital, Yogyakarta, Indonesia in theperiod of March until June 2010. Measurement of quality of life was conducted by filling out the questionnairePediatrics Quality of Life (PedsQL) that directly obtained from the children who were accompanied by their parent.Lower total score of PedsQL showed better quality of life. The results showed that mean total score of PedsQL onwell-controlled epileptic children (38.31Â±1.6) was higher than non epileptic children (8.84Â±0.90). Prevalence ratioof controlled epileptic children was 2.69 (95% CI: 2.01-3.58). In conclusion, well-controlled epileptic children hadlower quality of life than non epileptic children. The factors that affect quality of life of well-controlled epilepticchildren were duration of suffering from epilepsy and age at diagnosis of epilepsy.Key words: quality of life â well-controlled epileptic children - PedsQL â physical function â emotional functionsocialfunction

Hereditary ovalocytosis - molecular analysis of hereditary Southeast Asian Ovalocytosis (SAO) in Bangka, South Sumatra. Suryono Yudha Patria, Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Background: Southeast Asian Ovalocytosis (SAO) is a hereditary asymptomatic hemolytic disease characterized by oval form erythrocytes. This morphology is rigid and related with resistency to several strains of malaria parasites. The underlying molecular genetic abnormalities include heterozygous state for mutant band 3 protein, a membrane anion transporters protein.Objectives: To characterize the SAO in Bangka, South Sumatra in molecular level, by analyzing the DNA genome of three generation family with polymerase chain reaction (PCR).Methods: The DNA genome extracted from dried blood filter paper was used as template PCR. A pair of primers was synthesized in accordance with exon 11 of band 3 gene. The PCR product was studied under UV after electrophoresis on EtBr stained 3% agarose gel.Results: Both mutant alleles showed as smaller band compared to normal allele in all 6 heterozygote SAO persons, but not in the normal 8 cases. Deletions were predicted removing nine amino acids of band 3 protein. The mutant protein was possibly carried by the ancestor from China.Conclusions: Hereditary ovalocytosis in Bangka, Sumatra Selatan was caused by specific mutation on band 3 gene which is common mutation occurred in SAO patients.Keywords: Bangka ovalocytosis - SAO - Band 3 protein - EPB3 gene deletion - PCR

Quality of life epilepsy in childhood: Comparison between well-controlled epilepsy and non epilepsy Fita Wirastuti Suryono Yudha Patria Soeroyo Machfudz
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.668 KB)

Quality of life is an important parameter in assessing the efficacy of medical interventions. Chronic diseases such asepilepsy, have a significant impact on quality of life. Childhood epilepsy is often associated with low achievement inschool, physical limitations, and disturbed social functions. The purpose of this study was to compare the quality oflife of well-controlled epileptic children with non epileptic children. This research was conducted with cross-sectionalstudy design with respondents aged 5-18 years old. All respondents were well-controlled epileptic and non epilepticchildren who were admitted to the Pediatric Polyclinic of Dr. Sardjito General Hospital, Yogyakarta, Indonesia in theperiod of March until June 2010. Measurement of quality of life was conducted by filling out the questionnairePediatrics Quality of Life (PedsQL) that directly obtained from the children who were accompanied by their parent.Lower total score of PedsQL showed better quality of life. The results showed that mean total score of PedsQL onwell-controlled epileptic children (38.31±1.6) was higher than non epileptic children (8.84±0.90). Prevalence ratioof controlled epileptic children was 2.69 (95% CI: 2.01-3.58). In conclusion, well-controlled epileptic children hadlower quality of life than non epileptic children. The factors that affect quality of life of well-controlled epilepticchildren were duration of suffering from epilepsy and age at diagnosis of epilepsy.Key words: quality of life – well-controlled epileptic children - PedsQL – physical function – emotional functionsocialfunction

Hereditary ovalocytosis - molecular analysis of hereditary Southeast Asian Ovalocytosis (SAO) in Bangka, South Sumatra. Suryono Yudha Patria Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.476 KB)

Background: Southeast Asian Ovalocytosis (SAO) is a hereditary asymptomatic hemolytic disease characterized by oval form erythrocytes. This morphology is rigid and related with resistency to several strains of malaria parasites. The underlying molecular genetic abnormalities include heterozygous state for mutant band 3 protein, a membrane anion transporters protein.Objectives: To characterize the SAO in Bangka, South Sumatra in molecular level, by analyzing the DNA genome of three generation family with polymerase chain reaction (PCR).Methods: The DNA genome extracted from dried blood filter paper was used as template PCR. A pair of primers was synthesized in accordance with exon 11 of band 3 gene. The PCR product was studied under UV after electrophoresis on EtBr stained 3% agarose gel.Results: Both mutant alleles showed as smaller band compared to normal allele in all 6 heterozygote SAO persons, but not in the normal 8 cases. Deletions were predicted removing nine amino acids of band 3 protein. The mutant protein was possibly carried by the ancestor from China.Conclusions: Hereditary ovalocytosis in Bangka, Sumatra Selatan was caused by specific mutation on band 3 gene which is common mutation occurred in SAO patients.Keywords: Bangka ovalocytosis - SAO - Band 3 protein - EPB3 gene deletion - PCR

Neonatal outcomes in In vitro fertilization (IVF) pregnancies Muhammad Buchori; Suryono Yudha Patria; Tunjung Wibowo; Ita Fauzia Hanoum
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

small-for-gestational age (SGA), and low birth weight (LBW) rates are approximately twiceas high in IVF pregnancies than in natural pregnancies. The IVF procedures have becomemore routine in recent years in Indonesia, but there have been few assessments ofneonatal outcomes. The study aimed to evaluate the risk of preterm birth, SGA, and LBWin IVF infants. This was a retrospective cohort study performed in Dr. Sardjito GeneralHospital, Yogyakarta from January 2012 to December 2016. Pre-coded questionnaireswere used to collect data from medical records. The relative risk of preterm birth, SGA,and LBW among IVF infants were calculated and compared to naturally conceived infants.A total sampling method was used for the IVF infants and a simple random samplingmethod was used for naturally conceived infants, who were born on the same day as aninfant in the IVF group.A total of 108 infants were recruited, consisting of 54 IVF infants and 54 naturallyconceived infants. The IVF infants had increased risk of preterm birth (RR = 2.0; 95%CI0.52 - 7.58) and LBW (RR = 1.25; 95%CI 0.53 - 2.92). However, the IVF infants didnot have an increased risk of SGA (RR = 1.0; 95%CI 0.21 - 4.73). In conclusion, therisk of preterm birth and LBW in IVF infants are higher than in naturally conceived infants,but not statistically significant. However, there is no increased risk of SGA in IVF infants.

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