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Jumina Jumina

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia

Author-ID : 3959825

Chemical Engineering, Chemistry & Bioengineering Chemistry

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Articles

Synthesis of Polyurethane/Silica Modified Epoxy Polymer Based on 1,3-Propanediol for Coating Application Lutviasari Nuraini; Evi Triwulandari; Muhammad Ghozali; Muhammad Hanafi; Jumina Jumina
Indonesian Journal of Chemistry Vol 17, No 3 (2017)
Publisher : Universitas Gadjah Mada

Studies on the synthesis of polyurethane/silica modified epoxy polymer using 1,3-propanediol has been conducted. Synthesis of polymers made by reaction of tolonate and 1,3-propanediol (ratio NCO/OH=2.5) as the building blocks of polyurethane with diglycidyl ether bisphenol A (DGEBA) epoxy and catalyst dibutyltin dilaurate (DBTL).The total weight of the polyurethane used was 20% (w/w) of the total epoxy. Based on Fourier Transform Infrared (FTIR) and 1H-Nuclear Magnetic Resonance (1H-NMR) spectra indicated the existence of a new bond that is formed from the reaction of isocyanate group and hydroxyl group, where the hydroxyl groups derived from epoxy and 1,3-propanediol. The addition of silica (5, 10, and 15% w/w to epoxy) into the epoxy-modified polyurethane has been carried out through sol-gel reaction of tetraethyl orthosilicate (TEOS). The isocyanate conversion rate for the addition of silica 5, 10, and 15% are 95.69; 100, and 100%, respectively. The morphology and element identification by Scanning Electron Microscopy/Energy Dispersive X-Ray Analysis (SEM/EDX), showed that Si element has been successfully added in the polymer. From the tensile strength and elongation analysis, also thermal stability analysis using Thermal Gravimetric Analyzer (TGA), the increase of silica amount into the polyurethane modified epoxy did not significantly affect to thermal properties, but decrease the tensile strength of the polymer.

Synthesis and Kinetic Study of the Urea Controlled Release Composite Material: Sodium Lignosulfonate from Isolation of Wood Sawdust-Sodium Alginate-Tapioca Arif Cahyo Imawan; Yehezkiel Steven Kurniawan; Muhammad Fernadi Lukman; Jumina Jumina; Triyono Triyono; Dwi Siswanta
Indonesian Journal of Chemistry Vol 18, No 1 (2018)
Publisher : Universitas Gadjah Mada

A synthesis and kinetic study of the urea controlled-release composite material based on isolated Na-lignosulfonate, Na-alginate and tapioca was carried out. This experiment’s aims were to isolate Na-lignosulfonate from wood sawdust and to applicate this isolated Na-lignosulfonate, along with tapioca and Na-alginate as urea control release composite material. A kinetic study of urea released from the composite materials was also conducted. Na-lignosulfonate was isolated by Kraft lignin method to give a brown solid yield of 16.92% and was characterized by FT-IR spectrophotometer and SEM-EDX. The composite materials were synthesized by blending urea as the active compound with composite material as the carrier compound. Three types of material were prepared: complete material (A), low-concentration Na-lignosulfonate material (B) and material without tapioca (C). The composite material had a spherical form with 0.79 mm radius and 2.16 mm swollen radius. Urea content inside material was 40.425 mg urea/g material. The urea diffusivity coefficient for material A, B, and C were 7.27 x 10–6; 15.50 x 10–6 and 0.94 x 10–6 m2 h–1, respectively. Modelling analysis showed the experiment obeyed around only 15% of the Korsmeyer–Peppas model, but there was good correlation (80%) with the unsteady-state diffusion model.

Development of C-Arylcalix[4]resorcinarenes and C-Arylcalix[4]pyrogallolarenes as Antioxidant and UV-B Protector Jumina Jumina; Dwi Siswanta; Abdul Karim Zulkarnain; Sugeng Triono; Priatmoko Priatmoko; Emmy Yuanita; Nela Fatmasari; Ikhsan Nursalim
Indonesian Journal of Chemistry Vol 19, No 2 (2019)
Publisher : Universitas Gadjah Mada

Indonesia is rich with essential oils such as anise and clove leave oils. In respect to explore the potential utilization of these resources, it has been conducted the transformation of p-hydroxybenzaldehyde and vanillin (4-hydroxy-3-methoxy benzaldehyde) respectively derived from anise oil and clove leaves oil to a series of C-arylcalix[4]resorcinarenes and C-arylcalix[4]pyrogallolarene macrocycles. Treatment of these aldehydes with resorcinol in the presence of HCl in absolute ethanol at reflux for 8 h afforded C-4-hydroxyphenylcalix[4]resorcinarene (3a) and C-4-hydroxy-3-methoxy phenyl-calix[4]resorcinarene (3b) in good yields. When the aldehydes were treated with pyrogallol under the similar condition, the products were C-4-hydroxyphenyl calix[4]pyrogallolarene (3c) and C-4-hydroxy-3-methoxyphenylcalix[4]pyrogallolarene (3d) which were also obtained in excellent yields. Treatment of these calix[4]resorcinarenes and calix[4]pyrogallolarenes with cinnamoyl chloride and benzoyl chloride in pyridine afforded the corresponding cinnamate esters and benzoate esters in high yields. The resulted C-arylcalix-[4]resorcinarenes and C-arylcalix[4]pyrogallol arenes were subjected to antioxidant activity test using DPPH method and showed strong activity with IC50 values of 15–80 μg/mL. In terms of the synthesized calix cinnamates, the compounds showed UV-B absorption with SPF values of 15–30 at a concentration of 25 ppm which demonstrate their potential to be applied as a UV-B protector. Furthermore, these compounds were also tested for their photostability on the UV-B region and the results showed that the compounds were still unstable under irradiation for 30 min.

Separation of Pb(II) Ion with Tetraacetic Acid Derivative of Calix[4]arene by Using Droplet-based Microreactor System Yehezkiel Steven Kurniawan; Mizuki Ryu; Ramachandra Rao Sathuluri; Wataru Iwasaki; Shintaro Morisada; Hidetaka Kawakita; Keisuke Ohto; Masatoshi Maeki; Masaya Miyazaki; Jumina Jumina
Indonesian Journal of Chemistry Vol 19, No 2 (2019)
Publisher : Universitas Gadjah Mada

In this study, the microreactor system was investigated and compared with the batch-wise system as rapid and effective extractive Pb(II) separation over Fe(III), Cu(II) and Zn(II) with tetraacetic acid calix[4]arene. By using a microreactor system, the Pb(II) extraction percentages reached the maximum of 73, 89 and 100% in 8 sec residence time at equilibrium pH of 2.00, 2.25 and 2.50, respectively. The stripping percentage was 92% at 8 sec residence time by using a microreactor system with 2.0 M HNO3 as a stripping reagent. Complete separation of Pb(II) over Fe(III), Cu(II) and Zn(II) ions with the tetraacetic acid calix[4]arene in a competitive metal system was achieved at pH 2.00. However, the batch system required 24 h to reach the equilibrium for both extraction and stripping processes. The results suggested that the microreactor system enhanced the Pb(II) extraction and stripping rate up to 104 times faster than the batch-wise system.

The Origin, Physicochemical Properties, and Removal Technology of Metallic Porphyrins from Crude Oils Jumina Jumina; Yehezkiel Steven Kurniawan; Dwi Siswanta; Bambang Purwono; Abdul Karim Zulkarnain; Agustinus Winarno; Joko Waluyo; Johan Syafri Mahathir Ahmad
Indonesian Journal of Chemistry Vol 21, No 4 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.62521

Crude oil is an indispensable energy feedstock for daily activities, although some amounts of metallic porphyrins components with undesired characteristics have been identified. These constituents are assumed to originate from the geochemical process of chlorophyll and heme derivatives. In addition, their chemical structures have been thoroughly characterized using spectroscopy techniques, while several analytical methods were adopted in the detection and concentration quantification in the crude oils. The metallic porphyrins have several demerits, including the deactivation of used catalysts, contamination of the treated petrochemical products, and corrosion of the industrial equipment. Also, the removal process is considered challenging due to the strong interaction with the asphaltene fraction of crude oil. This review article, therefore, provides brief information on the origin, physicochemical properties, and possible removal technology of metallic porphyrins from crude oil samples. Besides, a better understanding of chemistry contributes a useful insight towards the development and establishment of better futuristic processing technology.

Computational Design of Thioxanthone Derivatives as Potential Antimalarial Agents through Plasmodium falciparum Protein Inhibition Faris Hermawan; Jumina Jumina; Harno Dwi Pranowo; Eti Nurwening Sholikhah; Muthia Rahayu Iresha
Indonesian Journal of Chemistry Vol 22, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.69448

Plasmodium falciparum (P. falciparum) is the most fatal among the other Plasmodium parasites that infect humans with the malaria disease. Currently, the resistance of P. falciparum against some antifolate drugs has become a severe problem. On the other hand, xanthone and thioxanthone derivatives have been reported to have remarkable antimalarial activity. However, molecular docking studies have not evaluated thioxanthone derivative compounds as antimalarial agents. Accordingly, this research investigated the binding pose and inhibition mechanism of several thioxanthone derivatives against P. falciparum proteins DHFR (PDB ID: 1J3K) and DHODH (PDB ID: 1TV5) through molecular docking study. The compound structures were geometrically optimized using Gaussian 09 software and docked to the receptors using AutoDock4 software. The results showed that the free binding energy of thioxanthone derivatives ranged between -6.77 to -7.50 and -8.45 to -9.55 kcal mol–1 against pfDHFR and pfDHODH, respectively, with RMSD values of less than 2 Å. Compound F (4-iodo-3,4-dihydroxy-thioxanthone) gave the most substantial free binding energy against both proteins. Furthermore, the hydrogen bond interaction of compound F was the same as the native ligands of pfDHFR and pfDHODH. These results suggested that compound F has a more robust interaction in pfDHFR and pfDHODH. Thus, it is promising to further evaluate the compound as a candidate for a new antimalarial agent.

Adsorption of Pb(II) on Calix[4]arene Derivatives: Kinetics and Isotherm Studies Busroni Busroni; Dwi Siswanta; Jumina Jumina; Sri Juari Santosa; Chairil Anwar
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70665

This study aims to investigate the application of two calix[4]arene derivatives named 5,11,17,23-tetra-(t-butyl)-25,26,27,28-tetrahydroxycalix[4]arene (TBCA) and 5,11,17,23-tetra-(t-butyl)-26,27,28-tribenzoyloxycalix[4]arene (TBMTCA) as adsorbents of Pb(II) from aqueous solution in a batch system. Adsorption was carried out by varying pH solution, exposure time, and concentration. The kinetics was evaluated based on the adsorption in various exposure times using the Lagergren and Ho equations, while the isotherms were analyzed based on the adsorption in various Pb(II) concentrations using the Langmuir and Freundlich equations. Furthermore, the isotherm model showed the Pb(II) adsorption of TBCA and TBMTCA followed Langmuir model with a capacity of 137.29 and 128.46 mg/g, respectively. Based on the adsorption capacity, both adsorbents are the potential for the removal of heavy metal cations from polluted water.

Synthesis, Cytotoxicity Evaluation and Molecular Docking Studies of Xanthyl-Cinnamate Derivatives as Potential Anticancer Agents Muthia Rahayu Iresha; Jumina Jumina; Harno Dwi Pranowo; Eti Nurwening Sholikhah; Faris Hermawan
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.76164

A new series of xanthyl-cinnamate hybrid compounds (4a-d) have been synthesized and screened through in vitro assay against four human cancer cell lines, i.e., HeLa, T47D, A549, and WiDr. The results revealed that xanthone hybridization with cinnamic acid increases the selectivity of the compounds with SI values of 2.75–209.03 compared to its parent oxygenated-xanthone. Compound 1,3-dihydroxyxanthen-6-yl cinnamate (4c) showed high cytotoxic activity against WiDr cell lines with an IC50 value of 39.57 µM. Molecular docking studies revealed the possible binding modes of all hybrid compounds with EGFR protein. A complex of 3,6-dihydroxyxanthen-1-yl cinnamate (4d)-EGFR, as the best binding model, exhibited higher predicted EGFR inhibitory activity than erlotinib and oxygenated-xanthone with a ΔG and Ki value of -35.02 kJ/mol and 0.74 µM, respectively. Compounds 4c and 4d were chosen as the most potent derivates from the study.

Synthesis of Calix[4]resorcinarene Derivatives as Antimalarial Agents through Heme Polymerization Inhibition Assay Rizky Riyami Putri; Harno Dwi Pranowo; Yehezkiel Steven Kurniawan; Hana Anisa Fatimi; Jumina Jumina
Indonesian Journal of Chemistry Vol 23, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.81452

Malaria is an endemic disease in tropical countries, including Indonesia, with a high annual mortality rate. Because of that, serious attention shall be given to find new antimalarial agents that are highly active for medical treatment. In this work, we designed and synthesized three calix[4]resorcinarene derivatives and evaluated them as antimalarial agents through in vitro heme polymerization inhibitory assay. The calix[4]resorcinarenes were prepared from resorcinol and corresponding aldehyde derivatives in ethanol media through a cyclo-condensation reaction. The calix[4]resorcinarene products were obtained in 31.1–85.1% yield. The synthesized compounds were subjected to structure elucidation using spectroscopy techniques. The antimalarial activity of calix[4]resorcinarene with aromatic substituent (IC50 = 0.198 mg/mL) was higher than the aliphatic ones (IC50 = 0.282–0.814 mg/mL). It was found that all calix[4]resorcinarenes in this work exhibited stronger antimalarial activity than chloroquine diphosphate as the positive control (IC50 = 1.157 mg/mL). The calix[4]resorcinarenes could interact with hydrogen bonding, thus inhibiting the heme polymerization process. These findings demonstrate that calix[4]resorcinarene derivatives are potential antimalarial agents to be developed for effective medical treatment in the near future.

Co-Authors Abdul Karim Zulkarnain Agustinus Winarno Arif Cahyo Imawan Bambang Purwono Busroni, Busroni Chairil Anwar Dwi Siswanta Emmy Yuanita Eti Nurwening Sholikhah Evi Triwulandari Faris Hermawan Hana Anisa Fatimi Harno Dwi Pranowo Harno Dwi Pranowo Harno Dwi Pranowo Hidetaka Kawakita Ikhsan Nursalim Johan Syafri Mahathir Ahmad Joko Waluyo Keisuke Ohto Lutviasari Nuraini Masatoshi Maeki Masaya Miyazaki Mizuki Ryu Muhammad Fernadi Lukman Muhammad Ghozali Muhammad Hanafi Muthia Rahayu Iresha Muthia Rahayu Iresha Nela Fatmasari Priatmoko Priatmoko Ramachandra Rao Sathuluri Rizky Riyami Putri Shintaro Morisada Sri Juari Santosa Sugeng Triono Triyono Triyono Wataru Iwasaki Yehezkiel Steven Kurniawan Yehezkiel Steven Kurniawan Yehezkiel Steven Kurniawan

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