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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Tropical and Infectious Disease Cermin Dunia Kedokteran
Farida Tabri
Dept, of Dermato-Venereology, Hasanuddin Medical Faculty, Makassar
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE TO CHILDREN WHO LIVE IN LOW AND HIGH ALTITUDE IN LOW LEPROSY ENDEMIC AREA OF SOUTH SULAWESI Rachmawati, Rachmawati; Mataallo, Timurleng Tonang; Adam, Safruddin; Adam, A. M.; Amin, Safruddin; Tabri, Farida; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1373.847 KB)

Abstract

Background: The intensity of Mycobacterium leprae exposure to people who live in leprosy endemic area could be measured by serological study and detection of the bacilli in the nose cavity. Different geographical altitude might have some influences to this exposure since the bacilli prefer to live in warm areas. Aim: A combined serological and PCR study of leprosy was conducted in Selayar island, South Sulawesi to 80 school children (40 from low land and 40 from highland altitudes) in order to compare the exposure intensity between the two areas. Method: Anti PGL-1 IgM antibody (ELISA) and PCR study to detect M.leprae in the nasal cavity were performed simultaneously from each person. Result: Seropositive cases were found in 23/40 children from low land compared to 16/40 children from high land, but statistically no significant difference (p>0.05). PCR positive for M.leprae in the nasal cavity only found in 1/40 children, both in low and high altitude. Conclusion: It is concluded that although the existence of M.leprae in nasal cavity is minimal, the intensity of exposure to this bacilli still high as indicated by serological study.
Infeksi Cacing Tidak Berpengaruh terhadap Kadar Transforming Growth Factor (TGF)-β dan Kejadian Dermatitis Atopik pada Anak Mukhasin, Nadiah Soleman; Wahyuni, Sitti; Ilyas, Faridha S; Amin, Safruddin; Satriono, R; Tabri, Farida
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1063.152 KB) | DOI: 10.21776/ub.jkb.2015.028.03.10

Abstract

Infeksi cacing melalui kemampuannya memacu proliferasi sel T regulator dilaporkan dapat mempengaruhi manifestasi klinik dari alergi. Selain Interleukin (IL)-10, Transforming Growth Factor (TGF)-β merupakan sitokin yang di lepaskan oleh sel T regulator. Penelitian ini bertujuan untuk melihat pengaruh infeksi cacing terhadap kejadian dermatitis atopik (DA) melalui TGF-β. Penelitian ini dilakukan di beberapa rumah sakit pendidikan Fakultas Kedokteran Universitas Hasanuddin. Dermatitis atopik (DA) didiagnosis dengan menggunakan kriteria William, ada dan beratnya infeksi cacing diperiksa dengan metode Kato Katz dan kadar TGF-β serum diukur menggunakan metode ELISA.  Sebanyak 80 anak usia 2-7 tahun berpartisipasi pada penelitian ini. Partisipan dibagi menjadi kelompok DA (30 anak) dan non-DA (50 anak). Persentasi infeksi cacing adalah 21,2% (17/80) dengan intensitas infeksi yang ringan. Infeksi cacing tidak mempengaruhi kadar TGF-β, demikian juga infeksi cacing serta kadar TGF-β tidak mempengaruhi kejadian DA. Penelitian ini menyimpulkan bahwa infeksi cacing dengan intensitas ringan tidak mempengaruhi kadar TGF-β maupun kejadian DA pada anak di Makassar.Kata Kunci: Dermatitis atopik, infeksicacing, TGF-β
COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE TO CHILDREN WHO LIVE IN LOW AND HIGH ALTITUDE IN LOW LEPROSY ENDEMIC AREA OF SOUTH SULAWESI Rachmawati, Rachmawati; Mataallo, Timurleng Tonang; Adam, Safruddin; Adam, A. M.; Amin, Safruddin; Tabri, Farida; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol. 4 No. 4 (2013)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1373.847 KB) | DOI: 10.20473/ijtid.v4i4.220

Abstract

Background: The intensity of Mycobacterium leprae exposure to people who live in leprosy endemic area could be measured by serological study and detection of the bacilli in the nose cavity. Different geographical altitude might have some influences to this exposure since the bacilli prefer to live in warm areas. Aim: A combined serological and PCR study of leprosy was conducted in Selayar island, South Sulawesi to 80 school children (40 from low land and 40 from highland altitudes) in order to compare the exposure intensity between the two areas. Method: Anti PGL-1 IgM antibody (ELISA) and PCR study to detect M.leprae in the nasal cavity were performed simultaneously from each person. Result: Seropositive cases were found in 23/40 children from low land compared to 16/40 children from high land, but statistically no significant difference (p>0.05). PCR positive for M.leprae in the nasal cavity only found in 1/40 children, both in low and high altitude. Conclusion: It is concluded that although the existence of M.leprae in nasal cavity is minimal, the intensity of exposure to this bacilli still high as indicated by serological study.
EVALUATION OF ANTI PCL-1 ANTIBODY TITER IN A GROUP OF HEALTHY SCHOOL CHILDREN WHO LIVE IN LEPROSY ENDEMIC AREA FROM 2007–2010 putri, rachmah diana; amiruddin, M. dali; tabri, farida; Adriaty, Dinar; Wahyuni, ratna; iswahyudi, iswahyudi; agusni, indropo; izumi, shinzo
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 3 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.13 KB) | DOI: 10.20473/ijtid.v1i3.2184

Abstract

The "Iceberg phenomene” has been used to explain this situation which indicate that these new leprosy cases is originated from Subclinical Leprosy. Fifty eight healthy school children who live in Jeneponto Regency, a leprosy endemic area in South Sulawesi were recruited. The first examination was performed in 2007 and sera samples were kept in deep freeze refrigerator. In 2010 these children were re-examined for clinical leprosy and sera were collected again. ELISA study was performed simultaneously to these 58 pairs of sera (2007 & 2010) for measuring the titer of IgM anti PGL-1 antibody (ELISA) and the level 605u/ml was regarded as cut off value. After three years evaluation, none of these children showed any clinical signs of leprosy, but 20 of 22 ( 90.9%) children were remained sero-positive and only 2 (9.1%) became sero-negatives. In other sites, 5 children that previously sero-negatives became sero-positives after 3 years. Eight of 10 (80%) children who showed sero (+) with high titer (>1.000u/ml) in 2007, were also remained in high titer. The mean titer of 2007 was 627.8 u/ml, and after3 years became 723.9 u/ml (p<0.05). Although there is no progression from Subclinical to Manifest Leprosy cases among these children, the number of sero (+) cases were increased and the mean titer of IgM anti PGL-1 antibody was significantly increased.. The majority who previously showed high anti PGL-1 antibody titer, remained in high level. This study support the "iceberg phenomene” theory in Leprosy.
Profil Penyakit Kulit Penduduk Perkampungan Terapung Kepulauan Tihi-tihi dan Selangan, Bontang, Kalimantan Timur, Indonesia Santoso, Fenny Leets; Anwar, Anis Irawan; Tabri, Farida; Amin, Safruddin; Adriani, Anni; Idrus, Idrianti; Arsyad, Andi Anwar
Cermin Dunia Kedokteran Vol 51 No 2 (2024): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i2.872

Abstract

Introduction: Tihi-tihi and Selangan Islands, floating village areas in Bontang, East Kalimantan, are remote areas in Indonesia, which can only be accessed by sea route. The research was conducted to describe skin diseases in those islands. Method: Retrospective observational cross-sectional and descriptive analysis study on floating communities in Tihi-tihi and Selangan Island, Bontang Lestari Village, South Bontang District, Bontang City, East Kalimantan, Indonesia. Results: The study was conducted on 95 subjects, mostly female (53%), and the largest age group was 26-45 years (29%), followed by the 5-11 years group (24%). Skin infection diseases (58.96%) were dominated by scabies (67.9% of the skin infection disease group). The second highest was allergic contact dermatitis (41%) from the non-infection group. There is an association between age and disease group (p<0.05), with an odds ratio of 3.164. Conclusion: Skin diseases in Tihi-tihi and Selangan Islands are dominated by scabies, followed by allergic contact dermatitis. The pediatric age group is at a three-fold greater risk of developing skin infections than non-infection skin diseases.
Co-Authors A. M. Adam, A. M. Anis Irawan Anwar Anni Adriani Arsyad, Andi Anwar DINAR ADRIATY Faridha S Ilyas Idrus, Idrianti INDROPO AGUSNI ISWAHYUDI ISWAHYUDI M. dali amiruddin, M. dali Nadiah Soleman Mukhasin R Satriono rachmah diana putri, rachmah diana Rachmawati Rachmawati RATNA WAHYUNI Safruddin Adam, Safruddin Safruddin Amin Santoso, Fenny Leets SHINZO IZUMI Sitti Wahyuni Timurleng Tonang Mataallo, Timurleng Tonang