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All Journal Indonesian Journal of Tropical and Infectious Disease Journal of General Procedural Dermatology and Venereology Indonesia
rachmah diana putri, rachmah diana
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Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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EVALUATION OF ANTI PCL-1 ANTIBODY TITER IN A GROUP OF HEALTHY SCHOOL CHILDREN WHO LIVE IN LEPROSY ENDEMIC AREA FROM 2007–2010 putri, rachmah diana; amiruddin, M. dali; tabri, farida; Adriaty, Dinar; Wahyuni, ratna; iswahyudi, iswahyudi; agusni, indropo; izumi, shinzo
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 3 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.13 KB) | DOI: 10.20473/ijtid.v1i3.2184

Abstract

The "Iceberg phenomene” has been used to explain this situation which indicate that these new leprosy cases is originated from Subclinical Leprosy. Fifty eight healthy school children who live in Jeneponto Regency, a leprosy endemic area in South Sulawesi were recruited. The first examination was performed in 2007 and sera samples were kept in deep freeze refrigerator. In 2010 these children were re-examined for clinical leprosy and sera were collected again. ELISA study was performed simultaneously to these 58 pairs of sera (2007 & 2010) for measuring the titer of IgM anti PGL-1 antibody (ELISA) and the level 605u/ml was regarded as cut off value. After three years evaluation, none of these children showed any clinical signs of leprosy, but 20 of 22 ( 90.9%) children were remained sero-positive and only 2 (9.1%) became sero-negatives. In other sites, 5 children that previously sero-negatives became sero-positives after 3 years. Eight of 10 (80%) children who showed sero (+) with high titer (>1.000u/ml) in 2007, were also remained in high titer. The mean titer of 2007 was 627.8 u/ml, and after3 years became 723.9 u/ml (p<0.05). Although there is no progression from Subclinical to Manifest Leprosy cases among these children, the number of sero (+) cases were increased and the mean titer of IgM anti PGL-1 antibody was significantly increased.. The majority who previously showed high anti PGL-1 antibody titer, remained in high level. This study support the "iceberg phenomene” theory in Leprosy.
The efficacy of tranexamic acid in melasma: A review Sari, Ninda; Putri, Rachmah Diana; Syahrir, Syahriani; Agustina, Agustina; Bulqiah, Mikyal
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Melasma is a common acquired pigmentary condition presenting as dark macules or patches on sun-exposed areas of the face. Conventional treatments rely on topical bleaching agents and sun protection, while additional adjuvant options such as chemical peels, dermabrasion, and laser procedures are often applied. However, recurrence is frequent, and overall therapeutic success remains modest, significantly affecting patient quality of life. Recently, tranexamic acid (TXA) has gained attention as a novel therapeutic approach. This review provides an overview of the available evidence on the efficacy of TXA, used as monotherapy or in combination regimens, for the management of melasma. Discussion: TXA has been investigated for administration via several routes, including oral, intradermal, and topical. The pathophysiology of melasma involves not only abnormal melanogenesis but also enhanced dermal vascularity and angiogenic activity. TXA acts by interfering with the plasminogen–plasmin system, thereby altering keratinocyte–melanocyte signaling and reducing melanogenesis. In addition, it demonstrates anti-angiogenic effects, leading to reduced vessel density and erythema. Clinical data suggest oral TXA generally yields superior outcomes compared to intradermal or topical approaches, although study results remain heterogeneous, particularly in trials combining multiple therapies. Conclusion: TXA appears to be a promising therapeutic option for melasma, with potential use as a stand-alone intervention or in combination with other modalities. Combination regimens often produce better clinical improvement than monotherapy. Nonetheless, standardized guidelines for the optimal use of TXA in melasma treatment remain lacking.
Co-Authors Agustina DINAR ADRIATY Farida Tabri INDROPO AGUSNI ISWAHYUDI ISWAHYUDI M. dali amiruddin, M. dali Mikyal Bulqiah, Mikyal Ratna Wahyuni Sari, Ninda SHINZO IZUMI Syahriani Syahrir