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All Journal Jurnal Kesehatan Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional Jurnal Ilmiah Manuntung Jurnal Inovasi Kebijakan GEMASSIKA: Jurnal Pengabdian Kepada Masyarakat Indian Journal of Forensic Medicine & Toxicology Action Research Literate (ARL) Indonesian Journal of Pharmacology and Therapy Jurnal Info Kesehatan
Maria Hilaria
Poltekkes Kemenkes Kupang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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PEMBERDAYAAN MASYARAKAT SEBAGAI APLIKASI GERAKAN MASYARAKAT CERDAS MENGGUNAKAN OBAT (GEMA CERMAT ) Hilaria, Maria; Maakh, Yorida F
GEMASSIKA: Jurnal Pengabdian Kepada Masyarakat Vol 3, No 2 (2019): NOPEMBER
Publisher : P3M STIKES Aisyiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.099 KB) | DOI: 10.30787/gemassika.v3i2.362

Abstract

The use of drugs is said to be rational if the patient receives a drug that is in accordance with his clinical needs, in doses according to his needs and in an adequate period of time. One of the efforts to increase public knowledge in order to be able to carry out safe and appropriate replication with the activities of Gema Cermat (Smart Society Using Medicines Movement. The target and outcome of community service carried out through over-the-counter self-medication training will be produced by the community, especially hamlet 01, Baumata village has the knowledge and skills in choosing to choose over-the-counter drugs for self-medication. The method of implementing the activity is a form of socialization using a two-way interactive method, namely how to provide information dissemination carried out by giving information from students and lecturers on material translation using power point, giving leaflet introduction to drugs and giving samples in the form of drugs that are classified as over-the-counter drugs. Before the education level of knowledge is sufficient (38%) and less 62%. After education, the level of knowledge is good 11%, enough 73% and less 16%. There was an increase in people's knowledge about drugsThe use of drugs is said to be rational if the patient receives a drug that is in accordance with his clinical needs, in doses according to his needs and in an adequate period of time. One of the efforts to increase public knowledge in order to be able to carry out safe and appropriate replication with the activities of Gema Cermat (Smart Society Using Medicines Movement. The target and outcome of community service carried out through over-the-counter self-medication training will be produced by the community, especially hamlet 01, Baumata village has the knowledge and skills in choosing to choose over-the-counter drugs for self-medication. The method of implementing the activity is a form of socialization using a two-way interactive method, namely how to provide information dissemination carried out by giving information from students and lecturers on material translation using power point, giving leaflet introduction to drugs and giving samples in the form of drugs that are classified as over-the-counter drugs. Before the education level of knowledge is sufficient (38%) and less 62%. After education, the level of knowledge is good 11%, enough 73% and less 16%. There was an increase in people's knowledge about drugs
PENGARUH PENAMBAHAN AMILUM GEWANG (CORYPHA UTAN LAMARCK) SECARA INTRAGRANULAR DAN EKSTRAGRANULAR TERHADAP SIFAT FISIK TABLET PARACETAMOL DENGAN METODE GRANULASI BASAH Hilaria, Maria; Octavia, Devi Ristian
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.439 KB)

Abstract

Gewang (Corypha utan Lamk) is a member of a palm tree that grows wild in most parts of Indonesia. The gewang plant is rich in starch which is thought to be used as an additional ingredient in making Paracetamol tablets with wet granulation methods. This study aims to determine the effect of starch supplementation on the physical properties of Paracetamol tablets. This research is a type of experimental research. Tablets are made in three formulas based on variations in the ratio of starch gewang intragranular and extragranular. Comparison of three formulas intragranular and extragranular, namely: FI (100%: 0%), FII (75%: 25%), FIII (0%: 100%). Tablets are made in wet granulation method with starch binder. Homogeneous dry granules then tested for physical properties of granules include: flow time, stationary angle, and tapping. Furthermore, pressing and tablets obtained were tested for the physical and chemical properties of tablets including weight uniformity and hardness. Statistical analysis of the physical quality of tablets was carried out by the Kolmogorov-Smirnov data normality test, followed by the dendan One Way Anova. The results showed that the use of starch gewang intragranular, extragranular and intragranular and extragranular combinations affected the physical properties of tablets. The method of adding extragranular starch starch to formula 3 produced tablets with effective tablet fragility, which was to meet the physical properties of tablets.  
KAJIAN ETNOFARMAKOLOGI SUKU MARAE TERHADAP PENGOBATAN TRADISIONALDI DESA KEWAR KECAMATAN LAMAKNEN KABUPATEN BELU Ni Nyoman Yuliani; Maria Hilaria; Elisma Elisma; Jefrin Sambara
Jurnal Kesehatan The 1st Alauddin Pharmaceutical Conference and Expo (ALPHA-C) 2019
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v0i0.11457

Abstract

Ethnopharmacology is a part of ethnobotany that studies specifically the use of plants for treatment by certain traditional ethnic groups/communities. Ethnopharmacology becomes the spearhead in the search for new active components/substances present in plants. While ethnopharmacology studies are studies of the use of plants that function as medicines or herbs produced by local residents for treatment. The tribe studied in this study is the Marae tribe, which examines the traditional herbs or herbs used by the Marae tribe in treating the illness, this type of research is a descriptive research and using a sampling technique that is purposive sampling. This research was conducted in an interview. The results of this study found 29 types of traditional medicinal plants used by the Marae tribe society in traditional medicine. Many traditional plants have the same regional name as Indonesia, and the most common use of plants is leaves with a percentage (38%), compared to others namely, bark (28%), fruit (24%), rhizome (6%), and interest (4%) the way of utilization used by Marae tribe society including boiling (72%), pounding (17%), chewing (7%), and smeared (4%). The properties of the plants used are high blood pressure, broken bones, diabetes, malaria, ulcers, vomiting blood, bleeding, appendicitis and lungs
Potential of Miana Leaf Extract as Expectorant (Profile Place of Growing, Antioxidant, Sputum Contaminants, Antibacterial, MIC, MKC Expectorant) Sesilia Rante Pakadang; Santi Sinala; Alfrida Monica Salasa; St Ratnah; Sisilia Teresia Rosmala Dewi; Maria Hilaria
Majalah Obat Tradisional Vol 25, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.52500

Abstract

Research has been conducted on the treatment of phlegm cough with miana leaf extract in vitro (effective dose of miana leaf extract as an expectorant and antibacterial agent causing cough with phlegm). The study aims to compare the antioxidant activity of miana leaves from 3 locations where it grows, determine the types of contaminant bacteria in the sputum of cough sufferers, determine the minimum value of inhibitor concentration (MIC) and MKC of miana leaves against the test bacteria causing cough with phlegm, determine the effective dose of miana leaves that can used as a reference for coughing up phlegm and proving the potential of miana leaves as a sputum thinner. Miana leaf extraction is done by the juicer method. Antioxidant activity testing uses the DPPH method. Determination of test bacteria is done by isolating and identifying contaminant bacteria in the sputum sample of cough with phlegm. Testing the effectiveness of miana leaves against test bacteria is determined by the liquid dilution method. Expectorant activity testing was determined by measuring the viscosity of mucus viscosity of cow intestine treated with miana leaf extract. The results found that antioxidant activity was influenced by the location where miana leaves grew with an antioxidant potential of IC72 0.072 mg/ml - 0.76 mg/ml. Contaminant bacteria from sputum samples of cough patients are Streptococcus pneumonia, Klebsiella pneumonia, Staphylococcus aureus, Staphylococcus epidermidis and Enterobacter agglomerans. MIC values for contaminant bacteria are 0.1% - 0.75% and MKC values are found between 0.25% - 1.75%. miana leaf extract has the potential as a sputum thinner at a concentration of 0.01% - 0.1%. The recommended dose of miana leaf extract as a cough with phlegm is 1.75% w/v.
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol Ni Nyoman Yuliani; Jefrin Sambara; Maria Hilaria; Harlinda Harlinda
Indonesian Journal of Cancer Chemoprevention Vol 7, No 2 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss2pp68-73

Abstract

Indonesia has  biodiversity potential to be developed as medicinal plants, such as basil leaves (Ocimum sanctum L.). Basil was reported to have a very high antioxidant activity in vitro. The aim of this study was to determine the effect of basil leaves (Ocimum sanctum L.) infusion to liver based Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) value in each dose. 18 rats were divided into 6 groups.,  control group,  negative control group treated with CMC Na 0.5%,  positive control group treated with Curcuma 3.6 mg / 200gBB, groups of 4-6 consecutive given a 80 mg  dose infusion basil / 200 gBB, 160 mg / 200 gBB, 320 mg / 200 gBB for 8 consecutive days, on the day of the 4th and 8th all treatment groups induced by toxic doses of paracetamol (500 mg / 200 gBB) except the normal control group 1, The research data in the form of enzyme activity of AST and ALT were analyzed using parametric and nonparametric ANOVA, and Friedman test with the level of trust  then followed by SNK test and Bnj test. The statistical test result with a 95% of level of trust that shown basil infuse with a dose of 80mg / 200gBB, 160mg / 200gBB, 320mg / 200gBB have hepatoprotective effects in rats induced by paracetamol 500mg / 200gBB. Based on the result of changes in average levels of AST on the fourth day and the eighth day of the three treatment infusion, infusion at a dose of 160 mg / 200gBB most effectively reduce average levels of AST and a group that has the average AST closest to the control group is positive, but infusion at a dose of 320mg / 200gBB the group that has the closest average ALT positive control group.Keywords : hepatoprotective, Ocimum sanctum L, Paracetamol
Effect of Propolis Extract to Heal The Burns in New Zealand Rabbit Maria Hilaria; Elisma Elisma; Adrianus L. Uhe
Indonesian Journal of Cancer Chemoprevention Vol 7, No 2 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss2pp54-59

Abstract

Propolis contains arginine (amino acids), ferulic acid (a derivative compound cinnamic which promotes the formation of collagen), flavonoids (phenolic compounds), and other compounds that can prevent the growth of bacteria, virus, and fungi. The purpose of this study was to measure the most concentration of propolis extracts that effective to heal burns of New Zealand rabbit's.  This was an experimental study with the post-test only control group design. As many as 15 male white rabbits were divided into 5 groups which treated by  propolis extract  with concentration of 50%, 75%, 100%, positive control by bioplacenton and negative control with propylene glycol. The macroscopic observation was done with detached necrosis tissue and the growth of collagen tissue as the parameter. Data were analyzed by using the one-way ANOVA and continued by the SNK test. The results of this study indicated that the propolis extracted have potency on healing burn wound with the significance of 0.00 (p≤0,05). In the concentration of 100%, extract of propolis has  potency on healing burn wound that proportionates with bioplacenton with the significance value of 1.000 (p≥0,05). It is concluded that by increasing dose, the healing time of burn wound will be shortened.Keywords : Propolis, healing burns, rabbit
Subcronic Toxicity and Hepatoprotector Potential of Miana Leaf Extract on White Rat Which Indicated by Anti Tuberculosis Drugs Sesilia Rante Pakadang1 , Santi Sinala1 , Sisilia Teresia Rosmala Dewi1 , Heri Soemantoro2 , Maria H
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10753

Abstract

Damage to liver function is the most common cause of patients or doctors stopping treatment. Anti tuberculosis (OAT) drug-induced hepatotoxicity is mainly caused by oxidative stress caused by drugs and metabolites. Subchronic toxicity is one of the conditions for testing long-term used drugs such as OAT. The research aims to determine the potential of miana leaf extract (EDM) as a hepatoprotector and prevent toxicity due to OAT administration. The study used 5 groups of Wistar rat test animals namely K1 (normal mice given placebo); K2 (OAT-induced mice given placebo); K3 (OAT-induced mice given Makassar EDM); K4 (OAT-induced mice given EDM Kupang); K5 (OAT-induced mice given Silymarin). Tests on mice were carried out after 30 days of treatment with parameters SGOT, SGPT, total bilirubin, creatinine and liver histopathology. The results showed that EDM has the potential as a hepatoprotector by preventing an increase in SGOT, SGPT and total bilirubin so as to avoid liver damage due to OAT induction. EDM has the potential to prevent toxicity due to the administration of OAT with creatinine parameters.
Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Puskesmas Oebobo Kota Kupang Ni Nyoman Yuliani; Anita Rae; Maria Hilaria; Marce Takubessi
Jurnal Inovasi Kebijakan Vol 5 No 1 (2020): Jurnal Inovasi Kebijakan
Publisher : Badan Penelitian dan Pengembangan Daerah Kota Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37182/jik.v5i1.49

Abstract

. Pharmaceutical services are integrated activities to identify, prevent and resolve problems related to drugs. Patient satisfaction is a level of satisfaction that arises as a result of the health service performance obtained after the patient has compared it with what he expected. This research was conducted with the aim of knowing the level of patient satisfaction with pharmaceutical services at the Oebobo Health Center in March - April 2018. This type of research is a non-experimental study with a descriptive design (survey research), the type of research is purposive sampling using a questionnaire sheet as a research instrument, then the average percentage of patient satisfaction was calculated and classified. Data analysis of the results of research conducted by researchers on 345 respondents showed that the level of patient satisfaction with each variable was: 84% reliability, 85% responsiveness, 86% confidence, 85% empathy and 82% performance variables, thus, on average Level of Patient Satisfaction with Pharmaceutical Services at Oebobo Community Health Center, Kupang City March-April 2018 as a whole is 84% with satisfaction classification, which is very satisfied.
Antiplasmodial activity of faloak bark (Sterculia quadrifida, R.Br.) extract from East Nusa Tenggara, Indonesia Priska Ernestina Tenda; Maria Hilaria; Arba Pramundita Ramadani
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1975

Abstract

The current development of antimalarial drug resistance encourages researchers to discover and develop novel antimalarials. One of its alternatives for antimalarial discovery is using medicinal plants remembering the success of artemisinin. Sterculia quardrifida R. Br. bark, locally name as faloak, is an endemic medicinal plant from East Nusa Tenggara that has been used traditionally to treat malaria. However, its antimalarial activity has not been investigated, yet. This study was aimed to evaluate the antiplasmodial activity of ethanolic extract of faloak bark against Plasmodium falciparum in vitro. Using FCR-3 P. falciparum strain, the ethanolic extract was evaluated on various concentration (1, 10, 50, and 100 μg/mL, respectively). The IC50 value was determined by the relationship between concentration and percentage of growth inhibition. The result showed that the percentage of inhibition of P. falciparum was concentration dependent, higher concentration resulting on higher percentage of inhibition with the IC50 42.399 ± 9.517 μg/mL. It can be concluded that the ethanolic extract of faloak bark have moderate antiplasmodial activity against P. falciparum in vitro.
PROFIL TINGKAT KEPUASAN PASIEN RAWAT JALAN UMUM TERHADAP PELAYANAN KEFARMASIAN DI RSUD KEFAMENANUBULAN JULI TAHUN 2011 NI NYOMAN YULIANI; JEFRIN SAMBARA; MARIA HILARIA; MARIA ELISABETH MANIKIN
JURNAL INFO KESEHATAN Vol 11 No 2 (2013): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Satisfaction is a goal that is often applied/designed to measure the gap between the quality of service they received with the expected quality of service. Level ofpatient satisfactionwas measured by five dimensions ofquality of the service, namely reliability(Reability), Responsiveness (responsivenes), empathy(Emphaty), confidence(Assurance), andappearance(Tangible). This study was conducted to determine the level of patient satisfaction with the level of reliability, level of responsiveness, level of confidence, the level of empathy, and the rate of appearance of pharmaceutical services at the District General Hospital Kefamenanu. The research was done by filling the question naire by the patientis then calculated presentation of the patient'slevel of satisfaction indicators studied. Based on the calculation of the level of patient satisfaction indicators at responsiveness of 40.75% gave values some what satisfied, 44.5% reliability give satisfied, 45.25% confidence give satisfaction, delivering value empathy39.05% satisfied, 41% give the appearance of satisfied.
Co-Authors ADRIANUS L UHE Adrianus L. Uhe Alfrida Monica Salasa Anita Rae Arba Pramundita Ramadani Bimantoro, Afwan Devi Ristian Octavia Dimas Prayogo Pangestu Elisma Elisma Harlinda Harlinda Maakh, Yorida Febry Makoil, Samuel David I. MANIKIN, MARIA ELISABETH Marce Takubessi MARIA ELISABETH MANIKIN Najib, Mohd Nadzri Bin Mohd NI NYOMAN YULIANI Ni Nyoman Yuliani Ni Nyoman Yuliani Octavia, Devi Ristian Priska Ernestina Tenda Rahmat, Emanuel G. A. Ratnah, St. SAMBARA, JEFRIN Santi Sinala Sesilia Rante Pakadang Sisilia Teresia Rosmala Dewi Slahayu Niken Purwandini Soeharto, Faizal R. Tenda, Priska E. UHE, ADRIANUS L