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AKTIVITAS ANTIJAMUR KRIM EKSTRAK ETANOL DAUN JAMBU MONYET (Anacardium occidentale L.) DAN KULIT BATANG RAMBUTAN (Nephelium lappaceum) TERHADAP Candida albicans Devi Nisa Hidayati; Ulya Felasufah; Amaliyah Ayu Nurfitriani; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Ethanol extract of Anacardium occidentale and rambutan bark (Nephelium lappaceum) proved to have antifungal activity agains Candida albicans. Efforts to improve comfort and ease of use then made in the form of cream formulation.The aim of study is to know the antifungal activity of cream with various concentration of Anacardium occidentaleleaf extract and rambutan bark againstCandida albicans. Extraction of ethanol extractAnacardium occidentale leaf (EAOL) and rambutan bark (ERB) used maceration method. Solvents used ethanol 70% and ethanol 96%, respectively. Formulation cream of EAOL and ERB was maked 3 formulation. Formulation cream EAOL with concentration of variations extract are FI (10,5%), FII (12,5%), FIII (14,5%). Formulation cream ERB with concentration of varions extract are FI (10%), FII (15%), FIII (20%). Antifungal activity was determined in the cream using agar diffusion method and zone of inhibitionwere analyzed using descriptive. The results showed that antifungal activity against Candida albicans of cream EAOL concentration 14,5% with zone of inhibition is 7,16 ± 0,28 mm and cream ERB concentration 20% with zone of inhibition is 9,5 ± 0,5 mm. Kata Kunci : Antifungal, Anacardium occidentale, Nephelium lappaceum, Formulation ofcream

PENGARUH VARIASI KONSENTRASI PEKTIN KULIT BUAH JERUK BALI (Citrus maxima MERR.) SEBAGAI SUSPENDING AGENT TERHADAP SIFAT FISIK SUSPENSI MAGNESIUM HIDROKSIDA yulias ninik windriyati; ika kurnaningsih; mufrod mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTSuspention is the most effective liquid dosage form for magnesium hydroxide because the compound relatively insoluble in water. Pectin as suspending agent has been used to inhibit sedimentation of suspension. The aim of this research is to know physical and chemical characteristic of pectin from Bali Citrus Peels and the influence of difference concentration of pectin and storage duration to physical characteristic of magnesium hydroxide suspensions. Pectin powder was extracted from Bali Citrus Peels with 70% ethanol. Magnesium hidroxide suspensions were made in three formulas with pectin concentration 0.75%, 1.00% and 1.25%. The suspensions was tested for their physical characteristic such as particle sizes, viscosity, sediment volume, redispersibility and fluidity (easiness to be poured) for 4 weeks. The result of this research shown that the pectin from Bali Citrus Peels can be used as suspending agent. The pectin powder has 15.26% water content, pH 3 and no amylum. The viscosity of mucilago was 33.33 cP for 0.75% concentration of pectin, 37.17 cP for 1.00%, and 40.50 cP for 1.25% respectively at the time of preparation. The difference concentration of pectin and its storage duration significantly affected particle sizes, viscosity, redispersibility and fluidity, while sediment volumes had influenced until the end of first week. Keywords: Pectin made of Bali Citrus Peels, Physical Characteristic and Suspensions

EVALUASI KARAKTERISTIK FISIKA-KIMIA SEDIAAN KRIM DAN LOTION EKSTRAK KULIT BUAH NANAS (Ananas comosus L.Merr) Elya Zulfa; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTIn previous research, ethanolic extract of pineapple peel (EEPP) has activity as a sunscreen because of the content of flavonoids. EEPP can be formulated in the form of creams and lotions to facilitate use on the skin. This study aims to evaluate the physical chemistry characteristics of EEPP creams and lotions. Creams and lotions were made in 3 formulas based on variations in FI extract concentrations (15.0%), FII (17.5%), FIII (20.0%), base controls and positive controls (preparations on the market). The cream obtained was evaluated for physical chemical characteristics including organoleptic, homogeneity, adhesion and dispersion, viscosity, pH and SPF values which were analyzed descriptively. cream with varying concentrations of green, the distinctive smell of pineapple, homogeneous and in accordance with the pH of the skin. Increasing the concentration of EEPP in the preparation has an effect on increasing viscosity, adhesion but decreasing the dispersion. Whereas the lotion shows greenish color, aromatic odor and semisolid texture and is easily applied. The increase in EEPP in lotion affects the increase in pH, adhesion, but decreasing the dispersion.Keywords: Creams, lotions, sunscreen, pineapple fruit skin

FORMULASI TABLET HISAP EKSTRAK ETANOLIK DAUN KEMANGI (Ocimum sanctum L.) DENGAN VARIASI PEMANIS MANITOL DAN LAKTOSA Devi Nisa Hidayati; Lusyana Setiawati Marwan; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Holy basil leaves (Ocimum sanctum L.) traditionally used by the people as a stomatitis aphtosa medication. Bacteria could cause stomatitis aphtosa. Flavonoids in holy basil leaves had antibacterial activity. The usage of holy basil leaves traditionally were not practice so formulated more acceptable such lozenges. Acceptability is influenced by a taste. This study aims was to determine sweeteners variations which is mannitol and lactose from the lozenges formulation of holy basil leaves extract on the physical properties and the level of consumer acceptance taste. Holy basil leaves extract made by maceration method using 70% ethanol. Lozenges made within 5 based on the variation concentration of mannitol and lactose are FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%), dan FV (0%:100%) and manufactured by wet granulation method. The granules obtained were tested for physical properties include flowability, angle of repose, and compressibility. The tablets obtained were tested for physical properties including weight uniformity, hardness, friability, dissolve time, responsive taste test, and the active substance with TLC methods. The data obtained were analyzed statistically using one way ANOVA and Kruskal Wallis, except acceptability taste analyzed descriptionally. The results showed that all formulas provide lozenges which conform the quality specification. Lozenges most accepted by the respondents was formula I. Keywords: holy basil leaves, lozenges, mannitol, lactose

PENGARUH KOMBINASI BASIS PEG 400 DAN BASIS PEG 4000 DALAM FORMULASI SALEP EKSTRAK DAUN SUKUN (Artocarpus altilis) TERHADAP AKTIVITAS ANTIBAKTERINYA Sella_Arbi Nur_Ullya Dewi; Dewi Andini_Kunti Mulangsri; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBreadfruit leaves contain flavonoid compounds that can inhibit the growth of Staphylococcus aureus bacteria. Breadfruit leaf extract is practical and effective formulated in ointment preparations. The base combination of PEG 400 and PEG 4000 decreases the melting point of PEG 4000, so that it is compatible and can increase the penetration of drugs in the skin. The objective of this study to determine the breadfruit leaf extract ointment with a combination of PEG 400 and PEG 4000 bases as well as antibacterial activity against Staphylococcus aureus bacteria. Breadfruit leaf extract (BLE) was obtained by maceration with 70% ethanol. Salve preparations were made into III formulas with variations in base concentrations of PEG 400 and PEG 4000, namely (F1) 75%: 25%, (F2) 50%: 50%, (F3) 25%: 75%, using the fusion method. Antibacterial activity test used agar well diffusion method. Kruskal Wallis test and Mann Whitney test used for analyzed data from antibacterial activity test. The ointment of Breadfruit leaves extract showed the color of brown ointment, semi-solid form, distinctive aroma of breadfruit leave. All of three ointment formulas have antibacterial activity indicated by the formation of inhibitory zones around the well. All of three ointment formulas have significant differences which means the combination of PEG 400 and PEG 4000 can affect antibacterial activity of BLE ointment. The higher of the concentration PEG 4000 compared PEG 400 caused inhibiton zone become smaller that means the potency of antibacterial decreased. The formula has the greatest antibacterial activity in the FI is 8,02mm.Keywords: breadfruit leaves, ointment, PEG 400 and PEG 4000, antibacterial

EVALUASI SIFAT FISIKA KIMIA DAN TANGGAP RASA TABLET HISAP DEKOKTA DAUN MENGKUDU (Morinda citrifolia L.) DENGAN VARIASI PEMANIS M. Fatchur Rochman; Mufrod Mufrod; Feyzar Habib Reynaldo; Ayuk Siti Fatimah; Yayang Rusyta Dewi
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTNoni leaf (Morinda citrofolia L.) has antioxidant compounds that can inhibit and counteract free radicals. Decocta Noni leaf to make more practice preparation of lozenges. This study aims to evaluate the physical chemical characteristics and taste response of lozenges with variations of sweeteners to cover the bitter taste of Noni leaves. Decocta mengkudu leaf is obtained by boiling at 90C for 30 minutes. Suction tablets made 9 formulas based on variations of sweeterners sucrose-water sweetener, sorbitol-sucrose-sugarcane water, and aspartame-sucrose-sugarcane water. The suction tablet is made by molding mixture method. Evaluation of physical chemical characteristics including hardness and solubility were analyzed statistically using one-way ANOVA with 95% confidence level, followed by tukey test, weight uniformity, taste response and thin layer chromatography analyzed descriptively. The results of the study was showed that influenced the increase in hardness and dissolution time and the results of the requirements physical lozenges The results of the TLC test of lozenges and decocytes showed an RF value close to Quercetin. The taste response test results showed formula I with variations of sugarcane-sucrose water sweetener, formula III with variations in sorbitol-sucrose-sugarcane-water sweetener and sugarcane water aspartame-sucrose was the most preferred by respondents of 85% - 95%.Keywords: leaf of morinda citrifolia l., lozenges, sorbitol, aspartame, sucrose, sugarcane water

AKTIVITAS ANTIBAKTERI SALEP EKSTRAK DAUN SUKUN (Artocarpus altilis) DENGAN DUA MACAM KOMBINASI BASIS SALEP TERHADAP BAKTERI Stapylococcus aureus Dewi Andini Kunti Mulangsri; Heru Fitranto; Yana Astiana; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Breadfruit leaves (Artocarpus altilis) was contain compound of flavonoids, tannins and phenol that the ability as antibacterial against Staphylococcus aureus bacteria. The extracts of breadfruit leaves formulated became ointment that made practice to used. The combine of ointment bases can obtain of good consistency like the combine of adeps lanae with vaselin album and cera flava with vaselin album. The aims of this study to know the profile of antibacterial activity of the breadfruit leaves extract ointment with two kind of the combine of ointment bases. The breadfruit leaves extract has obtained by maceration method used etanol 70% solvents. The breadfruit leaves ointment was made by melting method with combination bases A is adeps lanae:vaselin album as F1 (13.5%:76.5%), F2 (45%:45%) dan F3 (76.5%:13.5%), while combination B is cera alba:vaselin album as F1 (85.5%:4.5%), F2 (81%:9%), F3 (76.5%:13.5%). antibacterial activity assay was used well diffusion method and analyzed descriptively. The research result that the all formulas has breadfruit flavor, smooth texture and brown color. Two variatons of combination bases ointment has antibacterial activity against Staphylcoccus aureus bacteri with formed of inhibition zone around the well. Keywords: Breadfruit leaves extract, ointment, antibacterial, combination of ointment bases

FORMULASI SIRUP EKSTRAK ETANOL DAUN PARE (Momordica charantia L.) DENGAN GELATIN SEBAGAI PENGENTAL DAN AKTIVITAS MUKOLITIKNYA Ririn Lispita Wulandari; Eli Mahmud; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTEthanol extract of bitter melon leaves at a concentration of 5% has been shown to have mucolytic activity. For ease of use that is made of dosage forms syrup. Thickening agent serves to increase the viscosity and resist settling process resulting in a stable syrup. Gelatin has the ability to improve settling extract better than other thickening. This study aims to determine the effect of variations in the concentration of gelatin to the physical-chemical properties and activity of ethanol extract syrup mukolitik pare leaves the cow intestine mucus in vitro. Extraction of leaf bitter melon is done by percolation. EEDP was made into three syrup formulas using 1% (FII), 2% (FIII), 3% (FIV) gelatin thickener. There is also syrup without extract and gelatin (FI) as a control. The four syrup formulas were examined for physical chemical properties (organoleptic, homogeneity, pH, viscosity), and tested their mucolytic activity. Data on the results of activity tests in the form of viscosity were analyzed by Kruskal-Wallis followed by Mann-Whitney. Data from organoleptic examination, homogeneity, Ph were analyzed descriptively, while viscosity with Linear Regression. The results showed that EEDP syrup with a gelatin concentration of 1%; 2%; 3% have mucolytic activity. The results of examination of the physico-chemical properties of FII, III, and IV syrups have the same taste and color, sweet and bitter, and are greenish black in color, while FI syrup is sweet and yellowish in color. Homogeneous FI syrup, FIII and FIV syrup are evenly distributed, while FII syrup has coarse particles. Fourth pH normal syrup formula. Increased concentration of gelatin (1%; 2%; 3%) can increase the viscosity of syrupKeywords: ethanol extract of bitter melon leaves, syrup, gelatin

FORMULASI KOMBINASI PEMANIS SUKROSA DAN ASPARTAM TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK ETANOL DAUN PARE (Momordica charantina L.) Dewi Andini KuntiMulangsri; Wahyu Setianingsih; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 13 No 2 Desember 2016
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Daun Pare telah digunakan sebagai obat batuk oleh masyarakat dan memiliki rasa sangat pahit. Mempertimbangkan acceptabilitas dan kemudahan dalam pemakaian maka ekstrak etanol daun pare dibuat sediaan tablet hisap dengan kombinasi pemanis Sukrosa dan Aspartam. Penelitian ini bertujuan untuk mengetahui karakteristik fisik tablet hisap ekstrak etanol daun Pare dengan kombinasi pemanis Sukrosa dan Aspartam, serta penerimaan rasa oleh responden. Ekstrak etanol daun pare dibuat secara maserasi menggunakan pelarut etanol 70%. Tablet hisap dibuat dalam 5 formula berdasarkan kombinasi pemanis sukrosa dan aspartam yaitu FI (sukrosa 10% : aspartam 0%), FII (sukrosa 6% : aspartam 4%), FIII (sukrosa 5% : aspartam 5%), FIV (sukrosa 4% : aspartam 6%), FV (sukrosa 0% : aspartam 10%). Metode granulasi basah digunakan untuk pembuatan tablet hisap. Granul diuji sifat fisik meliputi kecepatan alir, sudut diam dan kompresibilitas. Tablet hisap yang diperoleh diuji sifat fisik meliputi keseragaman bobot, kekerasan, kerapuhan, dan waktu larut serta tanggapan rasa. Data hasil uji granul dibandingkan dengan pustaka yang diacu. Data kerapuhan dan waktu larut dianalisa secara statistik menggunakan uji Kruskal-wallis. Data keseragaman bobot tablet dan kekerasan dianalisa menggunakan uji ANOVA satu jalan, untuk keseragaman bobot tablet dilanjutkan dengan uji Tukey, dengan taraf kepercayaan 95%. Data tanggapan rasa dianalisis secara deskriptif. Hasil yang diperoleh menunjukkan bahwa kombinasi pemanis sukrosa dan aspartam menghasilkan tablet hisap ekstrak etanol daun pare yang memenuhi persyaratan fisik dan terdapat perbedaan pada FI dan FIII, FII dan FIII dari keseragaman bobot. Tablet hisap FIV memiliki tingkat penerimaan rasa oleh responden sebesar 85%. Kata kunci : Ekstrak Etanol Daun Pare, Tablet hisap, Sukrosa, Aspartam ABSTRACT The bitter melon leaves has been used as a cough medicine by the community and the taste has a very bitter. The consider of acceptability and easy to use of the ethanol extract of bitter melon leaves made preparations lozenges with a combination of sweetener sucrose and aspartame. This study aims to determine the physical characteristics lozenges of ethanol extract of bitter melon leaves with a combination of sweetener sucrose and aspartame, and flavor acceptance by the respondent. The ethanol extract of bitter melon leaves made by maceration using ethanol 70% as solvent. Lozenges made in 5 formula based on a combination of sweeteners sucrose and aspartame are FI (sucrose 10%: aspartame 0%), FII (sucrose 6%: aspartame 4%), FIII (sucrose 5%: aspartame 5%), FIV (sucrose 4 %: aspartame 6%), FV (sucrose 0%: 10% of aspartame). The wet granulation method used for manufactured of lozenges. The granules tested physical properties include the flow rate, angle of repose and compressibility. Lozenges was tested physical properties include uniformity of weight, hardness, friability, time of solubility and hedonic test. Data from the granul assay compared with a standard reference. Data of fragility and time of solubility analyzed using the Kruskal-Wallis test statistically. Data of uniformity of weight and hardness were analyzed using one way ANOVA test, and for uniformity of weight followed by Tukey's test, with a level of 95%. Data hedonic were analyzed descriptively. 40 The results showed that the combination of sweetener sucrose and aspartame on the lozenges of ethanol extract of bitter melon leaves are requirements of physical and there is a difference the uniformity of weight in FI and FIII, FII and FIII. The lozenges of FIV have a taste that acceptance by 85% of respondents. Keywords : Extract ethanol of bitter melon leaves, Lozenges, Sucrose, Aspartam

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Journal : Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)