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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Journal of Pharmacopolium Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Dunia Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Nursing and Health (JNH) Akper Yakpermas Banyumas Jurnal Ilmiah Farmasi Akademi Farmasi Jember Jurnal Pengabdian Masyarakat Jurnal Sosial dan Sains Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT
Desy Nawangsari
Universitas Harapan Bangsa
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Isolation and Phisicochemical Characterization of Microcristalline Cellulose from Ramie (Boehmeria nivea L. Gaud) Based on Pharmaceutical Grade Quality Nawangsari, Desy; Yohana Chaerunisaa, Anis; Abdassah, Marline; Sriwidodo, Sriwidodo; Rusdiana, Taofik; Apriyanti, Linda
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.191 KB) | DOI: 10.24198/ijpst.v5i3.15040

Abstract

Microcrystalline cellulose is the most used material for medicine, which able to be found in fibrous plants. Microcrystal celluloses are being used as filler or binder in dosage formulas in tablets and capsules. This research aimed to produce microcrystalline cellulose from ramie based on pharmaceutical grade parameters. Research method include hemp fiber preparation, α-cellulose isolation, microcrystalline cellulose production, and microcrystalline cellulose characterization which compare with Avicel® PH 102 . Result shown microcrystalline cellulose yield is 57.26%. The result of physicochemical characterization that can comply the specifications of pharmaceutical grade as a pharmaceutical excipient.  Keywods :  Microcrystalline cellulose, Ramie, physicochemical, pharmaceutical grade.
ISOLASI DAN KARAKTERISASI SELULOSA MIKROKRISTAL DARI AMPAS TEBU (SACCHARUM OFFICINARUM L.) Nawangsari, Desy
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9150

Abstract

Microcrystalline cellulose is the result of isolation from alpha cellulose. Woody plants are generally the source of microcrystalline cellulose production. One of the natural ingredients that can be used to make microcrystalline cellulose is bagasse (Saccharum officinarum L.). Bagasse contains 37.65% of cellulose which can be isolated by the delignification stage using a base solution, the process of bleaching and hydrolysis of alpha cellulose by high temperature heating using dilute dilute acid. The yield of microcrystalline cellulose from bagasse 26.03% and fulfilling the characterization based on the literature.
UJI STABILITAS SEDIAAN SALEP EKSTRAK ETANOL RIMPANG KENCUR (Kaempferiae galanga L.) DALAM BERBAGAI BASISt Of Ethanol Extract Ointment of Kaempferiae galanga L. Rhizome Extract In Various Bases Nawangsari, Desy; Sunarti, Sunarti
Journal of Pharmacopolium Vol 4, No 2 (2021)
Publisher : P3M STIKes Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jop.v4i2.737

Abstract

Kencur (Kaempferiae galanga L.) merupakan jenis tanaman rempah dan obat yang telah dikenal secara luas oleh masyarakat Indonesia. Secara empiris kencur digunakan sebagai penambah nafsu makan, infeksi bakteri, obat batuk, disentri, ekspektoran, masuk angin, sakit perut serta meredakan peradangan (inflamasi). Manfaat kencur sebagai anti inflamasi memerlukan pengembangkan dalam bentuk sediaan farmasi untuk meningkatkan penggunaannya. Salah satu sediaan farmasi yang dapat memudahkan dalam penggunaannya adalah salep. Pembuatan salep secara umum dibagi menjadi 4 basis. Penelitian ini bertujuan untuk mengevaluasi sifat fisik dan stabilitas dari salep dengan berbagai basis yang digunakan.Hasil penelitian ini menunjukkan perbedaan tipe basis salep yang digunakan pada formulasi salep ekstrak rimpang kencur berpengaruh pada sifat fisik sediaan yang dihasilkan. Warna, pH, daya sebar dan daya lekat dari sediaan salep berbeda-beda untuk tiap jenis basis yang digunakan, tetapi bau dan homogenitas sediaan yang dihasilkan sama.  Hasil ujian stabilitas fisik menunjukan salep ekstrak rimpang kencur dengan basis tercuci air termasuk stabil selama penyimpanan dengan (p value > 0,05).
FORMULASI SEDIAAN MASKER ANTIOKSIDAN DARI EKSTRAK TEH HIJAU (CAMELLIA SINENSIS) desi nawangsari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.03 KB) | DOI: 10.35960/vm.v10i2.451

Abstract

Abstract Research has been carried out on the formulation of maskantioxidant preparations containing green tea leaf extract. The study begins with testing the antioxidant activity of ethanol extract of green tea leaves with a free radical reduction method of 1,1-diphenyl-2-picrylhydrazyl using visible spectrophotometry. Testing of antioxidant activity showed that the ethanol extract of green tea leaves gave an IC50 value of 3.17µg / mL. Formulations of gel masks made were F0 (base without active substances), F1 (base + concentration of ethanol extract of green tea leaves for IC50 (0,000317%)), F2 (base + concentration of ethanol extract of green tea leaves for 50xIC50 (0, 0158%)), F3 (base + concentration of ethanol extract of green tea leaves for 100xIC50 (0.0317%)), F4 (base + concentration of ethanol extract of green tea leaves for IC50), F5 (base + concentration of ethanol extract of green tea leaves worth IC50), F6 (base + concentration of ethanol extract of green tea leaves for IC50. Evaluation of gel mask preparations include, organoleptic examination and homogeneity, pH, viscosity, dry time of preparation and testing of antioxidant stability. F2 provides better and higher free radical reduction activity than products on the market. F4, F5, F6 shows an increase in free radical reduction activity. Keywords: Green tea leaves (Camellia sinensis L.), DPPh, IC50 gel mask.
EVALUASI SEDIAAN MASKER ANTIOKSIDAN DARI EKSTRAK DAUN TEH HIJAU (CAMELLIA SINENSIS) desi nawangsari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.358 KB) | DOI: 10.35960/vm.v10i2.452

Abstract

Abstract Green tea (Camellia sinensis L.) has the main efficacy as an antioxidant and contains polyphenol compounds in green tea leaves with the main component of polyphenol fraction namely Epigallocatechin-3-gallate (EGCG) which has strong activity to prevent free radicals that cause premature aging. Research has been carried out on the formulation of maskantioxidant preparations containing green tea leaf extract. The study begins with testing the antioxidant activity of ethanol extract of green tea leaves with a free radical reduction method of 1,1-diphenyl-2-picrylhydrazyl using visible spectrophotometry. Testing of antioxidant activity showed that the ethanol extract of green tea leaves gave an IC50 value of 3.17µg / mL. Formulations of gel masks made were F0 (base without active substances), F1 (base + concentration of ethanol extract of green tea leaves for IC50 (0,000317%)), F2 (base + concentration of ethanol extract of green tea leaves for 50xIC50 (0, 0158%)), F3 (base + concentration of ethanol extract of green tea leaves for 100xIC50 (0.0317%)), F4 (base + concentration of ethanol extract of green tea leaves for IC50), F5 (base + concentration of ethanol extract of green tea leaves worth IC50), F6 (base + concentration of ethanol extract of green tea leaves for IC50. Evaluation of gel mask preparations include, organoleptic examination and homogeneity, pH, viscosity, dry time of preparation and testing of antioxidant stability. F2 provides better and higher free radical reduction activity than products on the market. F4, F5, F6 shows an increase in free radical reduction activity. Keywords: Green tea leaves (Camellia sinensis L.), DPPh, IC50 gel mask.
Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C Desy Nawangsari
Viva Medika Vol 12 No 02 (2019): Viva Medika: Jurnal Kesehatan, Kebidanan, dan keperawatan
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (499.805 KB) | DOI: 10.35960/vm.v11i02.464

Abstract

Avicel® PH is branded name from microcrystalline cellulose that is generally used in pharmaceutical preparations. Avicel® PH are being used as filler or binder in dosage formulas in tablets especially for direct compression because having a good flowing rate and a good compressibility. This study aims to compare the influence of the use Avicel® PH 101 and Avicel® PH 102 as a filler on of preparations a tablet of ascorbic acid. A method of the research was conducted by making granule of ascorbic acid tablet with the variation filler, then the granule was evaluate in .The results showed Avicel® PH 102 as a filler produce granule which better seen from the flowability, static angle of repose, carr’s index and hausner ratio .
PREPARASI DAN ISOLASI MIKROKRISTAL DARI AMPAS TEBU (Saccharum officinarum L.) Desy Nawangsari; Rani Pranbandari; Fenny Permatasari
Viva Medika Vol 13 No 01 (2019): VOLUME 13/NOMOR 01/SEPTEMBER/2019
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (511.347 KB) | DOI: 10.35960/vm.v12i01.487

Abstract

Selulosa mikrokristal merupakan hasil isolasi dari alfa selulosa. Selulosa mikrokristal banyak digunakan dalam bidang farmasi. Salah satu bahan alam yang dapat dimanfaatkan untuk membuat selulosa mikkrokristal adalah ampas tebu. Ampas tebu mengadung 45,96% selulosa yang dapat diisolasi dengan tahapan delignifikasi menggunakan larutan basa, proses pemutihan serta hidrolisis alfa selulosa dengan pemanasan suhu tinggi menggunakan larutan asam encer. Rendemen selulosa mikrokristal dari ampas tebu 26,03%.
ISOLASI DAN IDENTIFIKASI RIMPANG TEMULAWAK (Curcuma xanthorrohza Roxb.) DAN BUNGA LAVENDER (Lavandula angustifolia Mill.) rani prabandari; desy Nawangsari; Kukuh Yunianto Sumargo
Viva Medika Vol 13 No 01 (2019): VOLUME 13/NOMOR 01/SEPTEMBER/2019
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.447 KB) | DOI: 10.35960/vm.v12i01.488

Abstract

Essential oils are fragrance agents in plants. Essential oils have a volatile component in some plants with certain characteristics. At present, essential oils have been used as perfume, cosmetics, food additives and medicine. Empiric ethnopharmacology studies on aromatherapy plants show that Indonesia has 49 types of aromatic plants from 22 types of tribes, 12 of which are empirically used as aromatherapy with calming and refreshing effects (Sangat 1996 in Rahmawati, 2010). One example of aromatherapy used is the ginger rhizome (Curcuma xanthorrihza Roxb) and Lavender Flower (Lavandula angustifolia Mill.). This study aims to isolate and identify the essential oils of Temulawak rhizome (Curcuma xanthorrihza Roxb) and Lavender Flowers (Lavandula angustifolia Mill.). The essential oil isolation step uses the Steam Water Distillation method, after which the essential oil obtained is identified to ensure its purity. The results showed that Temulawak essential oil and Lavender essential oil were carried out using the water distillation method, obtained levels of 2.3% and 1.8%. Essential oils in Temulawak were identified by testing their physical properties which include specific gravity, solubility in ethanol 90%, solubility in chloroform and oil in NaCl. The identification results obtained in the Temulawak rhizome and Lavender plants are specific gravity 0.9436 and 0.8221. Solubility in ethanol 90% with a volume ratio of 1: 3.7 mL and 1: 3.3 mL. solubility in chloroform of 1: 3.3 mL and 1: 3.3 mL. on the addition of NaCl in the oil oil reduction occurs.
Isolasi dan Karakterisasi Selulosa Mikrokristal dari Ampas Tebu (Saccharum officinarum L.) Desy Nawangsari
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9150

Abstract

Microcrystalline cellulose is the result of isolation from alpha cellulose. Woody plants are generally the source of microcrystalline cellulose production. One of the natural ingredients that can be used to make microcrystalline cellulose is bagasse (Saccharum officinarum L.). Bagasse contains 37.65% of cellulose which can be isolated by the delignification stage using a base solution, the process of bleaching and hydrolysis of alpha cellulose by high temperature heating using dilute dilute acid. The yield of microcrystalline cellulose from bagasse 26.03% and fulfilling the characterization based on the literature.
Review Artikel: Aktivitas Antibakteri dari Ekstrak Biji Mangga Arumanis (Mangifera indica L. Var. Arumanis) Nur Khasanah; Desy Nawangsari; Sunarti Sunarti
Jurnal Dunia Farmasi Vol 5, No 1 (2020): Edisi Desember
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v5i1.4704

Abstract

Pendahuluan: Tingginya masalah resistensi antibiotik di indonesia disebabkan karena penggunaan antibiotik yang tidak rasional sehingga diperlukan adanya antibakteri dari bahan alam yang dapat menghambat pertumbuhan bakteri dengan minimal efek samping. Salah satu bahan alam yang dapat digunakan sebagai antibakteri yaitu biji mangga arumanis (Mangifera indica L.Var. Arumanis).Sifat antibakteri pada biji mangga arumanis (Mangifera indica L.Var. Arumanis) disebabkan karena adanya senyawa fenolik berupa flavonoid, alkaloid, tanin, terpenoid, saponin, dan juga senyawa gallotanin.Tujuan:Untuk mengetahui aktifitas antibakteri ekstrak biji mangga arumanis dan bakteri apa saja yang dapat dihambat dengan mengetahui nilai MIC. Metode: Metode yang digunakan dalam penelitian ini yaitu metode PICO. Hasil: Dari literatur review biji mangga arumanis (Mangifera indica L.Var. Arumanis) terbukti dapat menghambat bakteri gram positif dan negatif dengan penghambatan lebih besar pada bakteri positif. Dengan nilai MIC sebesar 0.03mg/mL yang terbukti dapat menghambat bakteri Methicillin Resistan Staphylococcu aureus.Kesimpulan:Ekstrak biji mangga arumanis dapat menghambat bakteri gram positif dan negatif dengan nilai MIC dimulai dari 0.03mg/mL.
Co-Authors Adita Silvia F Adita Silvia Fitriana Aditya Silvia Fitriana Alfaeni Salmatuzzahro Alviony Trista Hapsari dina febrina Dwi Mustikasari Dwi Syaji Wahyuningtias Ega Angelia Narki Fenny Permatasari Fionaliasti Fionaliasti Galih Samodra Ikhwan Yuda Kusuma Isti Nurfaizah Khamdiyah Indah Kurniasih Kukuh Yunianto Sumargo Liana Febrianti Lina Umami LINDA APRIYANTI, LINDA Made Suandika Marline Abdassah, Marline Mely Nastiti Natasha Faruqi Andrian Putri Nur Khasanah Pegi Erawati Peppy Octaviani Rafi Firman Khaqiqi Rani Prabandari Rani Prabandari Rani Pranbandari Restu Maulana Rizky Widya Ayuning Tias Sriwidodo Sriwidodo, Sriwidodo Sunarti Sunarti Taofik Rusdiana umi sangadah Vidia Putri Kusumandari Yeni Pratiwi Yohana Chaerunisaa, Anis