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All Journal Pharmacon PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia HERBAPHARMA : Journal of Herb Farmacological Jurnal Ilmiah JKA (Jurnal Kesehatan Aeromedika) Pena : Jurnal Ilmu Pengetahuan dan Teknologi FORTE JOURNAL PENA ABDIMAS : Jurnal Pengabdian Masyarakat Jurnal Farmasetis Masyarakat Pariwisata: Journal of Community Services in Tourism Joong-Ki Journal of Clinical Pharmacy and Pharmaceutical Science Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Ulil Albab Joong-Ki
Muhammad Walid
Fakultas Farmasi, Universitas Pekalongan
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan

 1 
Daya Hambat Staphylococcus Aureus Terhadap Ekstrak Metanol Daun Sirsak (Annona Muricata L.) Amjad Mohammad Nadlif; Muhammad walid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 3 (2024): May : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i3.365

Abstract

The use of antibiotics can cause drug resistance if their use is not appropriate, so alternative treatment from plants is needed, one of which is soursop leaves (Annona muricata L.). Chemical substances contained in soursop leaves can prevent development until they can kill bacteria, one of which is flavonoids. The purpose of this study was to determine whether soursop leaf methanol extract (Annona muricata L.) at concentrations of 25%, 50%, 75% can inhibit the growth of Staphylococcus aureus bacteria and can determine at what concentration soursop leaf extract (Annona muricata L.) can effectively inhibit Staphylococcus aureus. The simplisia extract was done by maceration strategy using methanol as a solvent. The antibacterial testing method uses the disc diffusion method and uses clindamycin as a positive control and distilled water as a negative control. The results showed that Annona muricata L. extract can provide antibacterial action at concentration variants of 25%, 50% and 75% which is characterized by the presence of transparent areas with an average diameter of 8.97mm, 11.36 mm and 13.3mm respectively with positive control with a diameter of 23.25 and negative control with a diameter of 0 mm. Soursop leaf methanol extract (Annona muricata L.) is able to suppress the growth of Staphylococcus aureus bacteria with the most effective concentration variant of 75%.
Daya Hambat Bakteri Staphylococus Aureus Pada Ekstrak Metanol Daun Jambu Biji Merah (Psidium Guajava L. Var. Pomifera) Muhammad Irfan Zidni; Muhammad Walid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 3 (2024): May : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i3.366

Abstract

Staphylococcus aureus infection is one of the causes of increasing number of diseases and deaths. It is estimated that currently around 2-3% of the general population has MRSA in their bodies. People with MRSA on their bodies are estimated to have a 64% higher chance of dying. The purpose of this study was to determine the antibacterial activity of red guava leaves against Staphylocoocus aureus bacteria and to determine the amount of inhibition of methanol extract from red guava leaves against the activity of Staphylocoocus aureus bacteria. This type of research is experimental research The object of this study is the inhibitory power of Staphylococcus aureus bacteria in methanol extract of red guava leaves. The sample used in this study was methanol extract of red guava leaves. This research was conducted using maceration extraction method with the solvent used is methanol. The measurement results showed that red guava leaf methanol extract at concentrations of 25%, 50%, 75% and 100% had an inhibitory zone on the antibacterial activity of Staphylococus aureus. The greatest bland result at a concentration of 50% of 0.49 mm. The lowest inhibitory power is at a concentration of 75% of 0.26 mm.
Uji Efektivitas Analgetik Ekstrak Etanol Daun Sirih Merah (Piper crocatum) pada Mencit Putih (Mus musculus L) yang Diinduksi dengan Asam Asetat Hasna Adwa Salsabila Nursantoso; Muhammad Walid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1118

Abstract

This study explored the analgesic effectiveness of ethanol extract of red betel leaf (Piper crocatum) in white rats (Mus musculus L.) induced with acetic acid. A total of 15 rats were divided into five groups with different treatments, and the number of twitching movements as a pain response was measured for one hour. The extract was prepared using 96% ethanol solvent, and the analgesic effect was analyzed using the writhing test method. The results showed that the extract contained flavonoids, alkaloids, tannins, and saponins, which might contribute to its analgesic properties. It was found that the higher the dose of extract administered, the greater the inhibition of pain that occurred, with a dose of 800 mg/kgBB showing optimal analgesic effectiveness, almost equivalent to paracetamol as a positive control. Statistical analysis showed significant differences between treatment groups, with doses of 200 mg/kgBB and 400 mg/kgBB showing lower effectiveness. This study recommends further exploration of the therapeutic benefits of red betel leaf extract and formulation development for wider medical applications.
Uji Efektivitas Ekstrak Etanol Herba Krokot (Portulaca Oleracea L) pada Mencit Putih (Mus Musculus) dengan Induksi Asam Asetat Marissa Aulia; Muhammad Walid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1119

Abstract

Pain is the body's response to tissue damage that is often addressed using analgesic compounds. Purslane plants (Portulaca oleracea L) are known to contain flavonoids, saponins, tannins, and alkaloids that have potential as analgesics. This study aims to test the analgesic effectiveness of purslane ethanol extract by writhing test method using white mice (Mus musculus) induced by 1% acetic acid. A total of 15 mice were divided into 5 treatment groups, namely negative control, positive control (paracetamol), and three groups with doses of purslane extract 200 mg/kgBB, 400 mg/kgBB, and 800 mg/kgBB. The number of writhes was observed every 15 minutes for 1 hour, and the percentage of protective power was calculated. The results showed that the dose of 800 mg/kgBB gave the highest analgesic effect with a percent protection power of 65.28%, followed by doses of 400 mg/kgBB (52.4%) and 200 mg/kgBB (30.6%). The highest analgesic effect was achieved at a dose of 800 mg/kgBB, almost equivalent to the positive control. This shows the significant potential of purslane ethanol extract as an analgesic agent.
Co-Authors Adi Prayoga Amjad Mohammad Nadlif Anita Mursiany Dewanti Novela Putri Dewi Azizah Famila Mutiananda Fatkhiya, Musa Fitri Hasna Adwa Salsabila Nursantoso Izzatulmumtaz, Nazhara Jenie Sacharissa Davita Khafid Mahbub Luluk Izzati Mahfur Isfa Mahfur, Mahfur Marissa Aulia Marta Widhi Astuti Mey Prawesti Miftakhul Jannah Muhamad Najibufahmi Muhammad Irfan Zidni Nofiyan Ahmad Krisdianto Nur Cholis Endriyatno Nur Fatoni Reyhan Hartanto Akbar Riska Amalia Ristiyanti Dwi Anggraini Silfi Arini Durri