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All Journal Juke JK Unila (Jurnal Kedokteran Universitas Lampung) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Majority
Efrida Warganegara
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Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Determining type of Extended-Spectrum B-Lactamase Enzyme (ESBL) from Escherichia coil resistance Cephalosporine of third Generation in RSUD Abdoel Moeloek Bandar Lampung Efrida Warganegara; Ety Apriliana
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

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Pengaruh Pemberian Kalsium Terhadap Panjang Kranium Fetus Tikus Putih (Rattus Norvegicus) Setelah Pemberian Etanol Reni Zuraida; Nurlis Mahmud; Efrida Warganegara; Radinal Mauludi
JUKE Unila Vol 2, No 1 (2012)
Publisher : Fakultas Kedokteran Universitas Lampung

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Calcium is an essential element in the human body primarily on bone metabolism processes. Calcium is needed to activate the osteoblast in producing bone matrix. Calcium metabolism in human body could be inhibited by ethanol. Someone who consumes ethanol will suffer hypocalcemia. Consequently activating process of the osteoblast producing of bone matrix will be imbalanced and bone structure will be abnormal. The purpose of this study was to determine the effect of calcium supplementation on the length of white rat fetus cranium in organogenesis phase of Sprague Dawley strain that had been treated by ethanol. This study uses an experimental research design using 20 rats (Rattus norvegicus) of Sprague Dawley strain pregnant females aged 10-16 weeks which randomly selected were divided into five groups. The results showed that the average cranium length from analysis of one way ANOVA p value = 0.000. Post Hoc LSD cranium length with five groups compared with each other p = 0.000. Can be concluded that the existence of the effect of calcium supplementation on the length of white rat (Rattus norvegicus) fetus cranium that had been treated by ethanol
Pneumonia Nosokomial (Hospital-acquired, Ventilator-associated, dan Health Care-associated Penumonia) Efrida Warganegara
Jurnal Kedokteran Universitas Lampung Vol 1, No 3 (2017): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v1i3.1729

Abstract

Pneumonia merupakan suatu peradangan parenchym paru-paru, mulai dari bagian alveoli sampai bronhus, bronchiolus, yang dapat menular, dan ditandai dengan adanya konsolidasi, sehingga mengganggu pertukaran oksigen dan carbon dioksida di paru-paru. Pengklasifikasian yang lebih praktis untuk Pneumoia adalah menurut sifat aquisisinya, seperti yangsering digunakan yaitu Community-assosiated Pneumonia (CAP), Hospital-associated Pneumonia (HAP) atau Health careassociated Pneumonia (HCAP) dan Ventilator-associated Pneumonia (VAP). Hospital-acquired pneumonia (HAP) adalah suatu Pneumonia yang terjadi 48 jam atau lebih setelah pasien masuk rumah sakit, dan tidak dalam masa inkubasi ataudiluar suatu infeksi yang ada saat masuk rumah sakit. HAP merupakan penyebab paling umum kedua dari infeksi diantara pasien di Rumah Sakit, dan sebagai penyebab utama kematian karena infeksi (mortalitas-rate sekitar 30-70%), dan diperkirakan 27-50% berhubungan langsung dengan pneumonia. Mikroba yang paling bertanggung jawab untuk HAP adalah Streptococcus pneumonia, Staphylococcus aureus (MSSA dan MRSA), Pseudomonas aeruginosa, Gram negatif batang yang tidak memproduksi ESBL dan yang memproduksi ESBL (Enterobacter sp., Escherichi coli, Klebsiella pneumonia). Dalam proses patogenesis terjadinya pneumonia, paru-paru memiliki mekanisme pertahanan yang kompleks dan bertahap. Manifestasi klinik dari pneumonia adalah demam, menggigil, berkeringat, batuk (produktif, atau non produktif, atauproduksi sputum yang berlendir dan purulent), sakit dada karena pleuritis dan sesak. Diagnosis dari pneumonia nosokomial adalah melalui anamnese, gejala-gejala dan tanda-tanda klinik (non spesifik), pemeriksaan fisik, pemeriksaan radiologis, pemeriksaan laboratorium dan khususnya pemeriksaan mikrobiologis. Sesudah diagnosa HAP ditegakkan, penting untuk segera memulai terapi, sebab bila terlambat ini merupakan cara mengatasi infeksi yang buruk.Kata Kunci : Hospital-acquired pneumonia (HAP), Pneumonia, Tatalaksana
Pengaruh Aktivitas Fisik Intensitas Sedang terhadap Penurunan Kadar Glukosa Darah Sewaktu pada Laki-Laki Obesitas Dian Syafitri; Khairun Nisa Berawi; Efrida Warganegara
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 7, No 1 (2022)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.889 KB) | DOI: 10.30829/jumantik.v7i1.10170

Abstract

Obesity is a problem that concerns the world. The increasing of obese prevalence is relate to the risk of comorbidities that occurs through the insulin resistance mechanism. Moderate intensity physical activity can prevent insulin resistance and increase insulin sensitivity. The method is numerical comparative analytic research with a quasi-experimental design and the method of taking the repetitive measurement data (pre test - post test design) with a control group. Total of the samples are 30 people, divided into positive control groups (K1), negative control group (K2) and the treatment group (P). Analysis using Paired T-Test shows the value of p = 0.087 in group P1, p = 0.058 in group P2 and p = 0,000 in group P. Analysis using One Way Anova shows the value of p= 0.002 between P and K1, p= 0.085 between P and K2, p= 0.474 between K1 and K2. There is a statistically significant effect of moderate-intensity physical activity in the form of 30 minutes of brisk walking on lowering blood glucose levels in obese men. Keywords: Blood glucose level, insulin resistance, moderate intensity of physical activity, obesity.
Uji Aktivitas Antibakteri Formulasi Gel Ekstrak Daun Kelor (Moringa oleifera) terhadap Staphylococcus aureus Astara Ginarana; Efrida Warganegara; Oktafany
MAJORITY Vol 9 No 2 (2020): MAJORITY
Publisher : Majority

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Abstract

Staphylococcus aureus is one of the bacteria that is pathogenic to humans and is most often transmitted from hand to hand. Moringa leaf gel as an alternative as an antibacterial. The purpose of this research is to determine the antibacterial activity of Moringa oleifera leaf extract in gel formulation against Staphylococcus aureus. This type of research is an experimental laboratory with the method of sump on Mueller Hinton Agar media. Moringa oleifera leaf extract was obtained from the Organic Chemistry Laboratory of the University of Lampung with maceration techniques using 96% ethanol. Gel formulations were made at Cendikia Farma Husada Pharmacy Vocational School Bandar Lampung. Moringa oleifera leaf extract is divided into several concentrations namely 5%, 10%, 20%, 40% and 80%. As a negative control, distilled water gel and positive control were erythromycin (Erymed®) gel. The data obtained is based on the results of the measurement of the inhibition zone formed around the sump and measured by the calipers. Data were tested by One Way ANOVA. The results of this study indicate that the diameter of the inhibitory zone formed in the Moringa oleifera leaf extract in gel formulation in concentration of 5%, 10%, 20%, 40% and 80%. Sequentially, namely 5.85 mm, 10.00 mm, 11.00 mm, 15.40 mm and 21.05 mm. In the negative control group it was 0 mm and positive control was 32.20 mm (p value = 0,000). There is an antibacterial activity of Moringa oleifera extract in gel formulation against Staphylococcus aureus.
Prevalensi Kolonisasi Bakteri Methicillin-Resistant Staphylococcus aureus (MRSA) di Ruang Intensive Care Unit (ICU) Rumah Sakit Umum Daerah Abdul Moeloek Bandar Lampung Hasril Mulya Budiman; Tri Umiana Soleha; Efrida Warganegara; Dwi Indria Anggraini
MAJORITY Vol 9 No 1 (2020): MAJORITY
Publisher : Majority

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Abstract

Methicillin-Resistant Staphylococcus aureus (MRSA) is a bacterium Staphylococcus aureus which has a resistance to methicillin and some beta-lactam antibiotics. MRSA can colonize as normal flora in some parts of the human body, such as the nose, skin, hands, perineum, and other parts of the body. Intensive Care Unit (ICU) is the high risk areas for MRSA transmission. The purpose of this study was to determine the prevalence of MRSA in ICU of Regional General Hospital Abdul Moeloek Bandar Lampung. The method used in this study was cross sectional. The primary data used in this research were obtained by collecting a nasal and hand swab of patients treated in the ICU at one time and then identify the MRSA bacteria in laboratory to determine its prevalence. The results of bacterial identification on the nose and hand specimen showed 15 out of 40 samples tested positive for MRSA (37.50%). The results of the identification of bacteria MRSA shows the prevalence of MRSA colonization of the nose specimen at 17.50%, hand amounted to 32.50%, and which are both positive at 12.50%. Based on the research that has been done, it can be concluded there is a prevalence of colonization of the MRSA bacteria in ICU of Regional General Hospital Bandar Lampung Abdul Moeloek is 37.50%.
Co-Authors Astara Ginarana Dian Syafitri Dwi Indria Anggraini Ety Apriliana Hasril Mulya Budiman Khairun Nisa Nurlis Mahmud Oktafany Radinal Mauludi Reni Zuraida Tri Umiana Soleha