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All Journal Folia Medica Indonesiana JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of Stem Cell Research and Tissue Engineering Jurnal Rekonstruksi dan Estetik

Hutagalung, Magda Rosalina

Department Of Plastic Reconstructive And Aesthetic Surgery, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya, Indonesia.

Author-ID : 4224540

Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

Published : 17 Documents Claim Missing Document

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Wound Pattern Profile in Deceased Victims of Traffic Accidents in Raden Said Sukanto Bhayangkara Hospital Jakarta from January 2017 until December 2018 Evan Boedi Dewanto; Ahmad Yudianto; Magda Rosalina Hutagalung
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.79-82

Highlights:1. Traffic accidents can cause different types of wounds.2. Traffic accident victims were predominantly male at the age of 26-45 years old. 3. The most found wounds were abrasions and the most affected area were head and neck. AbstractIntroduction: A traffic accident is an incident that happens on the road, such as a car crash that started on the road and leads to injury or death or damaged properties in the surrounding environment. Traffic accident injuries have a different pattern from any other events or violence, such as a mechanical injury due to friction with asphalt. The wounds that are usually found on the victims are abrasion, laceration, contusion, and wounds with fracture. About 70% of traffic accidents in Indonesia are happening in Java. The aim of this study was to determine the wound patterns of victims of traffic accidents, particularly deceased victims recorded in the Forensic Department of Raden Said Sukanto Bhayangkara Hospital Jakarta from January 2017 until December 2018.Methods: This was a descriptive study using secondary data. Consecutive sampling methods were used by using an external examination form obtained from the Forensic Department of Raden Said Sukanto Bhayangkara Hospital Jakarta from January 2017 until December 2018. Age, gender, and wound patterns such as abrasion, laceration, contusion, and wounds with fracture data were taken.Results: 67 cases of traffic accidents were recorded. Male victims were the most common victims (87.5%) within the age of 26–45 years old (42.18%). Abrasions were the most common wounds found (44.92%) and head and neck region were the most affected area (44.09%).Conclusion: The deceased victims of traffic accidents were mostly males aged 26–45 years old. The most common wound found were abrasions and the most affected areas were head and neck region.

Decubitus Ulcer Patients Profile in Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018 Azmil Permatasari; Magda Rosalina Hutagalung; Nuniek Nugraheni Sulistiawaty; Agus Susanto Budi
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.46-50

Highlights:1. Decubitus ulcers can be caused by prolonged immobilization and constant pressure on the body.2. Decubitus ulcer patients were dominated by females, aged 46-65 years old, and the most common comorbidity history was patients with limb weakness. AbstractIntroduction: Continuous pressure on the area of the skin, especially in areas with bone protrusion can cause decubitus ulcers. Decubitus ulcers can occur to anyone, both children and adults, male or female, especially in people who experience daily immobility in a bed or wheelchair. Many treatments are performed in order to prevent decubitus ulcers to not becoming a more dangerous condition. This study aimed to determine the profile of pressure ulcers in Dr. Soetomo General Hospital Surabaya.Methods: This was a cross-sectional descriptive retrospective study. Secondary data were collected from 25 medical records of pressure ulcer patients in the Outpatient Clinic Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018. The data such as age, gender, risk factors, comorbidities history, and management were taken. The calculation was performed using Microsoft Excel.Results: The majority of patients with pressure sores at the Outpatient Clinic Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018 were dominated by female patients aged 46-65 years old (24%), with the most common risk factor being immobilization (96%). Patients’ history showed that most patients with decubitus ulcers suffered from a weakness in the limbs (13%). The most common treatment was wound bed preparation (46%) and education (46%).Conclusion: Pressure ulcers most often occurred in women aged 41-65 years or the elderly. Most patients experienced immobilization as a risk factor for pressure ulcers. These patients were dominated by those who had a history of illness with limb weakness. The therapy applied to patients with pressure sores was the preparation of wound beds and education to the patient.

Chondroregenerative Potential of Platelet-Rich Fibrin (PRF)-Impregnated Decelulrized Bovine Cartilage Scaffold Implanted Subcutaneously Putu Ardhy Parama Widyatmika; Muhammad Sjaifuddin Noer; Magda Rosalina Hutagalung
Folia Medica Indonesiana Vol. 58 No. 4 (2022): December
Publisher : Universitas Airlangga

Highlights: This research compared the hondroregenerative potential between bovine cartilage scaffold with platelet-rich fibrin (BCPRF) and autologous cartilage. The formation of newly-regenerated chondrocyte, the thickness of type II collagen, and the rate of cartilage resorption following the subcutaneous implantation were assessed. BCPRF is highly biocompatible and can be developed as an alternative to alloplastic porous polyethylene (Medpor) implant material. Abstract: The invention of alternative implants with regenerative potential comparable to autologous cartilage continues to be encouraged due to high morbidity of the donor site related to autologous harvesting process. This research attempted an invention of alternative implant using tissue engineering techniques in the form of endogenous regeneration by combining decellularized bovine cartilage scaffold with platelet-rich fibrin (BCPRF) that was implanted subcutaneously. The study aimed to compare the chondroregenerative potential between BCPRF and autologous cartilage in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen produced, and the rate of cartilage resorption following the subcutaneous implantation. This study was conducted in a pretest-posttest control group design using New Zealand white rabbits. Forty-eight experimental samples were divided into two groups, then treated with subcutaneous implantation of BCPRF and autologous cartilage respectively. The results were evaluated after six weeks of implantation. Thirty-nine samples were evaluated. There was a significant difference found from both groups in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen (p=0.000), and the implant resorption rate (p=0.000). The microscopic images demonstrated a superior chondroregenerative potential in the group receiving implantation of autologous cartilage compared to the group receiving BCPRF. The chondroregenerative potential for autologous cartilage and BCPRF differed significantly in terms of the formation of newly-regenerated chondrocyte, the deposition of type II collagen matrix, as well as the resorption rate.

MODIFIED CLEFT LIP EVALUATION PROFILE (MCLEP) INDEX FOR UNILATERAL CLEFT LIP REPAIR OUTCOME ASSESSMENT IN SURABAYA CLP CENTER Robertus Arian Datusanantyo; Hutagalung, Magda Rosalina; Rizaliyana, Sitti
Jurnal Rekonstruksi dan Estetik Vol. 5 No. 1 (2020): Jurnal Rekonstruksi dan Estetik, June 2020
Publisher : Universitas Airlangga

Highlights: The study revealed that there were no notable variations in the ultimate scores, regardless of whether the cleft lip was complete or an alveolar cleft was present. If the palate cleft was not present, unilateral cleft lip repair yielded considerably superior results, showing enhancements in both total lip and nose scores. Abstract: Introduction: Cleft lip and/or palate is the most common craniofacial congenital anomaly encountered by the plastic surgeon. Both reconstruction and outcome assessment are challenging. This study aimed to assess the outcome of unilateral cleft lip repair in the Surabaya CLP Center. Methods: All patients who underwent unilateral cleft lip repair in 2017 were included in the study. Those without complete photographs at minimally 52 weeks after surgery were excluded. The photographs of patients taken at least one-year post-surgery were assessed using a modified cleft lip evaluation profile (MCLEP) index. The data were then analyzed using statistical software. Results: There were 38 subjects included in the study. There was no significant difference in the final scores obtained based on completeness of the cleft lip and the presence of alveolar cleft. The total nose score was significantly better in the left side cleft (p = 0.002). When palate cleft was absent, the total lip score (p= 0.038), the total nose score (p = 0.008), and total score (p = 0.000) were also significantly better. Conclusion: The unilateral cleft lip repair in CLP Center Surabaya yielded good and symmetrically acceptable results. The study failed to observe the different outcomes of unilateral cleft lip repair based on completeness of the cleft lip and the presence of alveolar cleft. However, the unilateral cleft lip repair outcome was significantly better in the absence of palate cleft.

ORTHOGNATHIC SURGERY COMBINED WITH ORTHODONTIC TREATMENT IN A PATIENT WITH BILATERAL CLEFT LIP, PALATE AND ALVEOLUS, WITHOUT ALVEOLAR BONE GRAFT: A CASE REPORT Siswanto, Yudi; Hutagalung, Magda Rosalina; Sjamsudin, Jusuf; Indri Lakhsmi Putri
Jurnal Rekonstruksi dan Estetik Vol. 3 No. 1 (2018): Jurnal Rekonstruksi dan Estetik, June 2018
Publisher : Universitas Airlangga

Highlights: The orthognathic surgery combined with orthodontic intervention, leads to positive functional and aesthetic outcomes in individuals diagnosed with bilateral cleft lip and palate. It emphasizes the continued importance of adhering to the standard protocol, including alveolar bone grafting before permanent canine eruption, to achieve optimal outcomes. Abstract: Introduction: The incidence of cleft lip and palate is 8 in every 10,000 live births. A patient with this condition experiences a deficiency in maxillary growth. Maxillary hypoplasia leads to malocclusion and skeletal disharmony. Orthognathic surgery at skeletal maturity is the standard procedure at the end of the protocol to correct maxillary hypoplasia resulting in malocclusion not correctable with orthodontics alone. Case Illustration: We report the result of orthognathic surgery performed on a 23 year old male with complete bilateral cleft lip, palate, and alveolus. We proceeded with bimaxillary surgery despite the alveolar cleft. We also recorded a neglected alveolar cleft in which he should have had undergone alveolar bone graft prior to the current procedure. The pre-maxillary segment was stabilized with miniplate followed by Le Fort 1 advancement and mandibular setback guided by an occlusal wafer. Malar augmentation was done by onlay bone grafts. Mandibulo-maxillary fixation was maintained. Postoperatively, a good occlusion and better facial harmony were achieved. He was planned to undergo a septorhinoplasty in the near future. Discussion: Despite adequate treatments following the protocol recommended by many centres, some patients developed some degree of maxillary hypoplasia. A quarter of this population need osteotomies and Le Fort I maxillary osteotomy is the most common procedure to correct retrognathic maxilla. Conclusion: Orthognathic surgery combined with orthodontic treatment in a patient with bilateral cleft lip and palate provided good functional and aesthetic result. However, this procedure cannot replace the standard protocol of having an alveolar.

DETEKSI KADAR TRANSFORMING GROWTH FACTOR (TGF-β) PADA LUKA AKUT Wulandari, Pratidina; Hutagalung, Magda Rosalina; David Sontani Perdanakusuma
Jurnal Rekonstruksi dan Estetik Vol. 6 No. 1 (2021): Jurnal Rekonstruksi dan Estetik, Juni 2021
Publisher : Universitas Airlangga

Highlights: Peningkatan kadar TGF-β dalam fase proliferasi luka dapat berperan dalam stimulasi fibroblas untuk menghasilkan lebih banyak kolagen dalam pembentukan jaringan parut. Kadar TGF-β pada luka akut kulit tikus menunjukkan adanya peningkatan yang signifikan dari fase inflamasi ke fase proliferasi dengan nilai p=0,003. Abstrak: Latar Belakang: TGF-β merupakan faktor pertumbuhan yang paling dominan dalam peningkatan sintesis kolagen, memiliki peran utama pada penyembuhan luka dengan menstimulasi fibroblas sehingga menimbulkan penyembuhan dan berperan serta dalam pembentukan parut, baik itu parut normal maupun abnormal seperti parut hipertrofik dan keloid. Penelitian ini bertujuan untuk mengukur kadar TGF-β pada fase penyembuhan luka. Metode: Penelitian eksperimental ini menggunakan randomized post test only control group design. Dua belas luka akut kulit tikus dirandomisasi menjadi dua kelompok, dimana kelompok 1 diambil spesimen pada hari ke-5 dan kelompok 2 pada hari ke-21 dan dilakukan pemeriksaan ELISA untuk mengukur kadar TGF-β. Hasil: Pengukuran kadar TGF-β pada luka akut kulit tikus didapatkan jumlah yang meningkat secara signifikan dari hari ke-5 (fase inflamasi) ke hari ke-21 (fase proliferasi) dengan nilai p=0,003. Kesimpulan: Terjadi peningkatan kadar TGF- β pada akhir fase proliferasi atau awal fase remodelling. Hal ini menyebabkan peningkatan proliferasi fibroblas untuk mensintesis kolagen yang nantinya dapat menjadi parut hipertrofik dan keloid.

PENGARUH PLATELET RICH FIBRIN PADA PROSES EPITELISASI LUKA DONOR SKIN GRAFT: STUDI META ANALISIS Zarasade, Lobredia; Hutagalung, Magda Rosalina; Saputro, Iswinarno Doso; Putri, Nadia Tamara
Jurnal Rekonstruksi dan Estetik Vol. 6 No. 1 (2021): Jurnal Rekonstruksi dan Estetik, Juni 2021
Publisher : Universitas Airlangga

Highlights: Bukti preklinik yang dianalisis tidak berpengaruh signifikan dari pemberian platelet-rich fibrin (PRF) pada donor skin graft terhadap kecepatan epitelisasi. Praktisi medis perlu mempertimbangkan dengan hati-hati penggunaan PRF dalam prosedur donor skin graft. Abstrak: Latar Belakang: Kehilangan kulit yang terlalu luas perlu jaringan penutup untuk mengatasinya, salah satu pilihan untuk menutup luka tersebut dengan melakukan tindakan skin grafting. Berdasarkan data IRJ Bedah Plastik Rekonstruksi dan Estetik RSUD Dr. Soetomo dalam 1 tahun (2017-2018) didapatkan pada 26 dari 50 kasus donor skin graft mengalami penyembuhan yang lebih dari waktu penyembuhan normal. Metode penyembuhan luka telah mengalami perkembangan beberapa tahun terakhir, salah satunya mulai dikenal peran platelet-rich fibrin (PRF). Metode: Penelitian ini merupakan penelitian dengan desain meta-analisis yang bersifat kuantitatif. Sumber data dari penelitian ini melalui penelusuran literatur di pencarian elektronik dengan menggunakan keyword pencarian literature. Database yang digunakan adalah Medline dan Pubmed antara tahun 2005-2020. Hasil: Seleksi literatur didapatkan lima studi, dengan tiga studi subjek menggunakan donor split thickness skin graft dan dua studi menggunakan donor free gingival graft. Dalam tiga studi menyebutkan pemberian platelet-rich fibrin (PRF) dapat mempercepat waktu penyembuhan dan epitelisasi. Hasil meta analisis menunjukkan tidak ada perbedaan antara kelompok pemberian platelet-rich fibrin (PRF) dan kelompok kontrol dalam proses epitelisasi pada donor skin graft (summary effect 1,30, 95% CI -0,42–3,02). Kesimpulan: Bukti-bukti preklinik berdasarkan studi meta-analisis ini menunjukkan bahwa tidak ada pengaruh signifikan terhadap pemberian platelet-rich fibrin (PRF) pada donor skin graft dalam kecepatan epitelisasi.

TATALAKSANA MANAJEMEN OPERATIF PADA PASIEN SINDROM PARRY-ROMBERG DI RSUD DR. SOETOMO SURABAYA Setya, Aldy Mulia Hati; Saputro, Iswinarno Doso; Hutagalung, Magda Rosalina; Rizaliyana, Sitti
Jurnal Rekonstruksi dan Estetik Vol. 6 No. 1 (2021): Jurnal Rekonstruksi dan Estetik, Juni 2021
Publisher : Universitas Airlangga

Highlights: Tatalaksana Sindrom Parry-Romberg pada pasien melibatkan rekonstruksi wajah dengan menggunakan free flap dari otot Gracilis. Dilakukan terapi berupa obat-obatan golongan kortikosteroid, retinoid, antioksidan, dan imunosupresan untuk mengendalikan gejala dan perkembangan penyakit pada Sindrom Parry-Romberg. Abstrak: Latar Belakang: Sindrom Romberg yang juga memiliki sinonim dengan Sindrom Parry-Romberg (juga dikenal sebagai atrofi hemifasial progresif) adalah penyakit langka yang ditandai oleh penyusutan yang progresif serta degenerasi jaringan di bawah kulit, biasanya penyakit ini terjadi pada satu sisi wajah (atrofi hemifasial) tetapi kadang-kadang meluas ke bagian lain dari tubuh. Sebuah mekanisme autoimun dicurigai menjadi salah satu penyebab dari penyakit ini, dan sindrom ini diduga merupakan varian dari skleroderma lokal, untuk penyebab pasti patogenesis dari penyakit yang didapat ini hingga saat ini masih belum dapat ditentukan. Ilustrasi Kasus: Pasien perempuan berusia 23 tahun mengeluhkan ketidaksimetrisan wajah antara sisi kanan dan sisi kiri yang telah dialaminya selama 8 tahun, tetapi keluhan tersebut tidak mengalami perburukan dalam setahun terakhir.Tidak ada riwayat trauma. Dari anamnesis, tidak ada gejala seperti rasa baal atau kesemutan pada wajah sisi kanan, dan tidak ada riwayat penyakit serupa dalam keluarga pasien. Pemeriksaan fisik menunjukkan adanya atrofi pada musculus region Frontotemporal sisi kanan hingga cheek dextra. Pemeriksaan intraoral mengindikasikan oklusi gigi yang normal.Hasil pemeriksaan Saraf Cranial ke-7 (nervus fasialis) menunjukkan fungsi yang normal, termasuk kemampuan mengangkat alis, mengkerutkan dahi, mencucu, dan tersenyum pada kedua sisi wajah. Pemeriksaan mata menunjukkan visus yang baik pada mata kanan dan kiri, gerak bola mata yang normal, dan tidak ada penglihatan ganda. Pembahasan: Dilakukan tatalaksana berupa rekonstruksi dengan free flap dari otot Gracillis tungkai kanan pasien untuk sisi kanan wajah pasien yang di anastomosis dari arteri dan vena temporalis superior. Selain menggunakan free flap gracillis, Sindrom Parry-Romberg juga dapat menggunakan terapi lainnya seperti obat-obatan golongan kortikosteroid (topical dan intralesi), retinoid, anti-oksidan, dan imunosupresan. Kesimpulan: Pengobatan Sindrom Parry-Romberg dapat melibatkan berbagai pendekatan, termasuk prosedur bedah rekonstruksi dan penggunaan obat-obatan tertentu. Pilihan terapi harus dibicarakan antara pasien dan tim medis yang merawat untuk memastikan perencanaan pengobatan yang paling sesuai untuk kasus ini

CHONDROREGENERATIVE POTENTIAL ON SUBCUTANEOUS IMPLANTATION OF PLATELET-RICH FIBRIN (PRF)-IMPREGNATED DECELLULARIZED BOVINE CARTILAGE SCAFFOLD Widyatmika, Putu Ardhy Parama; Noer, M. Sjaifuddin; Hutagalung, Magda Rosalina
Journal of Stem Cell Research and Tissue Engineering Vol. 7 No. 2 (2023): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v7i2.52555

The discovery of alternative implants with regenerative potential comparable to autologous cartilage continues to be encouraged because of the high donor site morbidity rate. This research tries to make an alternative implant that uses the concept of tissue engineering techniques in the form of endogenous regeneration by combining Decellularized Bovine Cartilage scaffold with Platelet-Rich Fibrin (BCPRF) which is implanted subcutaneously. The aim of this study was to compare the potential for chondroregeneration between BCPRF and autologous cartilage as assessed by chondrocyte cell formation, type 2 collagen thickness, and implant resorption rate in subcutaneous implantation. Using the research design method is a pretest-posttest control group design using New Zealand white rabbits. Forty eight experimental samples were divided into 2 groups which were treated with BCPRF and autologous cartilage implantation. Results were evaluated after 6 weeks. Evaluation was carried out on 39 samples. Microscopy showed better potential for autologous cartilage chondroregeneration than BCPRF with significant differences in the number of chondrocytes formed, the thickness of type 2 collagen (p=0.000), and the rate of implant resorption (p=0.000). In conclusion, the potential for chondroregeneration of autologous cartilage and BCPRF is significantly different in terms of the number of chondrocytes formed, the thickness of type 2 collagen, and the rate of implant resorption.

EFFICACY OF AMNIOTIC MEMBRANE MESENCHYMAL STEM CELL THERAPY FOR BURN WOUNDS: META-ANALYSIS STUDY Bermani, Bayu Fasi; Budi, Agus Santoso; Hutagalung, Magda Rosalina
Jurnal Rekonstruksi dan Estetik Vol. 5 No. 1 (2020): Jurnal Rekonstruksi dan Estetik, June 2020
Publisher : Universitas Airlangga

Highlights: The healing potential of stem cell therapy for burn wounds, primarily attributed to angiogenesis and anti-inflammatory effects. AM-MSC therapy has a beneficial impact on burn wound healing, particularly by promoting angiogenesis and reducing inflammation. Abstract: Introduction: Burn injury is a trauma with high morbidity and mortality that requires special management from the start. stem cells have generated great hopes for the treatment of numerous conditions including burns. The Metaanalysis was performed for these preclinical studies to assess the efficacy and possible mechanisms of Amniotic Membrane Mesenchymal Stem Cell (AM- MSC) in treating burn wounds. Methods: Seven studies identified by searching PubMed, MEDLINE, databases from inception to October 2020. In addition, a manual search of references of studies was performed to obtain potential studies. Stata 16 was used for all data analysis. Results: The overall meta-analysis showed that AM-MSC therapy significantly improved burn healing rate (SMD 3.34, 95% CI 1.82 to 4.86), irrespective of transplant type, burn area, and treatment method in the control group. Conclusions: Meta-analysis showed that AM-MSC therapy exerts appears to exert a positive effect in burn wound healing, mainly through angiogenesis and anti- inflammatory actions. There is, therefore, justification for continued efforts to evaluate variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness. the use of stem cells as an adjunct to first- line therapies in burns.

Co-Authors Agus Santoso Budi Agus Santoso Budi, Agus Santoso Agus Susanto Budi Ahmad Yudianto Arista, Timotius Hansen Azmil Permatasari Bermani, Bayu Fasi David Sontani Perdanakusuma Evan Boedi Dewanto Indri Lakhsmi Putri, Indri Lakhsmi Iswinarno Doso Saputro Jusuf Sjamsudin Lupitasari, Ciptomurti Mesang, Williams Muhammad Sjaifuddin Noer Noer, M. Sjaifuddin Nuniek Nugraheni Sulistiawaty Prasetyo, Arif Tri Putri, Nadia Tamara Putu Ardhy Parama Widyatmika Rizaliyana, Sitti Robertus Arian Datusanantyo Setiawati, Rosy Setya, Aldy Mulia Hati Suarta, I Dewa Gde Daniswara U H, Muhammad Aulia Wahdini, Siti Isya Widyatmika, Putu Ardhy Parama Wulandari, Pratidina Yudi Siswanto Zarasade, Lobredia

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