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All Journal HAYATI Journal of Biosciences JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Global Health research Indian Journal of Forensic Medicine & Toxicology Jurnal Rekonstruksi dan Estetik The International Journal of Medical Science and Health Research
David Sontani Perdanakusuma
Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Identification of Single Nucleotide Polymorphism on Bone Morphogenetic Protein 2 Gene in Non-Syndromic Cleft Lip/ Palate Patient Mala Kurniati; RM Coen Pramono D; Agung Sosiawan; David Sontani Perdanakusuma; Hari Basuki Notobroto; Andra Rizqiawan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16954

Abstract

Cleft lip/palate (CL/P) is one of the most common birth defects in humans. Haploinsufficiency in genesBone Morphogenetic Protein (BMP) 2 is thought to play an important role in the incidence of CL/P. Thisstudy aimed to identify changes in the nucleotide (Single Nucleotide Polymorphism/SNP) BMP 2 rs235768A>T gene in CL/P patient in Indonesia. Seventy samples of DNA that were successfully amplified andrestricted consisted of patient and control samples with the three of which were used for sequencing. Basedon the analysis using restriction enzymes and Finch TV and Bioedit software programs, this study identifieda change from nucleotide A to nucleotide T which is a mutation missense (Serine-Arginine/TCA-TCT).Based on the results of the Fisher’s exact test, there was difference in genotype frequency between the CL/Pgroup and the control. Meanwhile, there was no difference in allele frequencies between the two groups. Theallele frequency T has a higher value than the frequency of the allele A.
Profile of Working-Age Patients with Keloid and Hypertrophic Scar at Dr. Soetomo General Hospital Surabaya in 2014-2017 Fania Ayu Wardani; David Sontani Perdanakusuma; Diah Mira Indramaya
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 2 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I22021.84-89

Abstract

Introduction: Keloid and hypertrophic scar are pathological scars resulting from excessive accumulation of collagen in wound healing process. Data about profiles of keloid and hypertrophic scar are rarely found in Indonesia. Therefore, it is necessary to conduct research related to keloid and hypertrophic scar. This study aimed to provide valuable data for further research.Methods: This was descriptive retrospective study evaluating 105 patients treated for keloid and hypertrophic scar from 2014 to 2017 using medical records of working-age patients.Results: Mostly in patients between 17-25 years old (40%). Comparison between male and female patients were 1.07:1 (keloid) and 1.09:1 (hypertrophic scar). As many as 10.71% of patients of keloid and 17.39% patients of hypertrophic scar were private employees. 23.21% patients with keloid and 23.91% patients of hypertrophic scar were Javanese. 14.29% patients of keloid and 19.57% patients of hypertrophic scar tend to have daily indoor activities. 17.86% patients of keloid and 26.09% patients of hypertrophic scar felt dark-skinned toned. Most keloid scars were caused by traumatic lesions (32.14%), located on the chest (19.54%), and treated by corticosteroid injection. Hypertrophic scar mostly caused by burn injury (54.35%), located on the face (29.55%), and treated by excision surgery.Conclusion: Both keloid and hypertrophic scars were mostly developed in 17-25 years old, male, private employees, Javanese ethnic, dark skin tone patients, with daily indoor activities, caused by traumatic lesion and located on the chest, earlobe, and hand, treated by corticosteroid injection (keloid). Meanwhile, hypertrophic scars are mostly caused by a burn injury on the face and treated by excision surgery.
The Incidence Pattern of Electrical Burns at the Department of Plastic Surgery Dr. Soetomo General Academic Hospital, Surabaya, from January 2014 to December 2017 Merilyne Merilyne; David Sontani Perdanakusuma; Linda Astari
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 1 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I12023.26-29

Abstract

Highlights:1. Electrical burns may progress even when the source has been removed.2. The most common age group to suffer from electrical burns was the 26–35 years old group.3. There was a significant association between electrical burns and the productive age of male employees who work in the private sector. AbstractIntroduction: Burns are direct or indirect damage to the skin tissue and can reach internal organs. This study aimed to investigate the incidence pattern of electrical burn patients at the Department of Plastic Surgery Dr. Soetomo General Academic Hospital, Surabaya, from 1 January 2014 to 31 December 2017, focusing on the age, gender, and occupation aspect of the patients.Methods: This was a descriptive retrospective study evaluating 50 patients treated for electrical burns from 1 January 2014 to 31 December 2017 using the patients’ medical records. The parameters assessed were age, gender, occupation, cause of injury, and annual incident. The data was collected from the medical records Dr. Soetomo General Academic Hospital, Surabaya.Results: Most electrical injuries occurred in May, as many as 12 (24%) patients. There were 49 (98%) male and 1 (2%) female patients. The patients ranged from 8–60 years old, with 17 (34%) patients in the 26-35 age group. 76% of patients were private employees. Work accidents caused approximately 82% of electrical injuries.Conclusion: There was a significant association between electric burns with males at productive age and working as private employees. Many electric accidents occurred while working, especially in May.
DETEKSI KADAR TRANSFORMING GROWTH FACTOR (TGF-β) PADA LUKA AKUT Wulandari, Pratidina; Hutagalung, Magda Rosalina; David Sontani Perdanakusuma
Jurnal Rekonstruksi dan Estetik Vol. 6 No. 1 (2021): Jurnal Rekonstruksi dan Estetik, Juni 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.088 KB) | DOI: 10.20473/jre.v6i1.28225

Abstract

Highlights: Peningkatan kadar TGF-β dalam fase proliferasi luka dapat berperan dalam stimulasi fibroblas untuk menghasilkan lebih banyak kolagen dalam pembentukan jaringan parut. Kadar TGF-β pada luka akut kulit tikus menunjukkan adanya peningkatan yang signifikan dari fase inflamasi ke fase proliferasi dengan nilai p=0,003. Abstrak: Latar Belakang:  TGF-β merupakan faktor pertumbuhan yang paling dominan dalam peningkatan sintesis kolagen, memiliki peran utama pada penyembuhan luka dengan  menstimulasi  fibroblas  sehingga  menimbulkan  penyembuhan  dan berperan  serta  dalam  pembentukan  parut,  baik  itu  parut  normal  maupun abnormal seperti parut hipertrofik dan keloid. Penelitian ini bertujuan untuk mengukur kadar TGF-β pada fase penyembuhan luka. Metode: Penelitian eksperimental ini menggunakan randomized post test only control  group  design.  Dua  belas  luka akut  kulit tikus  dirandomisasi  menjadi dua  kelompok,  dimana  kelompok  1  diambil  spesimen  pada  hari  ke-5  dan kelompok  2  pada  hari  ke-21  dan  dilakukan  pemeriksaan  ELISA  untuk mengukur kadar TGF-β. Hasil: Pengukuran kadar TGF-β pada luka akut kulit tikus didapatkan jumlah yang meningkat secara signifikan dari hari ke-5 (fase inflamasi) ke hari ke-21 (fase proliferasi) dengan nilai p=0,003. Kesimpulan: Terjadi  peningkatan  kadar  TGF- β  pada  akhir  fase  proliferasi atau  awal  fase  remodelling.  Hal  ini  menyebabkan  peningkatan  proliferasi fibroblas  untuk  mensintesis  kolagen  yang  nantinya  dapat  menjadi  parut hipertrofik dan keloid.
CHRONIC WOUNDS : RISK FACTORS AND EVIDENCE-BASED INTERVENTION Pinem, Veronica Abebia Beginanta; David Sontani Perdanakusuma; Evy Ervianti; Mikiyas Gifawosen Teferi; Harith Ali Al-Taie
Jurnal Rekonstruksi dan Estetik Vol. 10 No. 1 (2025): Jurnal Rekonstruksi dan Estetik, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jre.v10i1.66610

Abstract

Highlights: Identifies key risk factors for chronic wounds and the underexplored role of genetics and immune dysregulation in healing. Explores advanced interventions like smart bandages and bioengineered skin, while addressing accessibility challenges. Highlights the potential of personalized medicine and digital health in improving patient-centered wound care.   Abstract: Introduction: Chronic wounds are a pervasive and escalating public health issue, characterized by their inability to progress through the typical phases of healing, resulting in prolonged tissue damage and patient morbidity.  Common types include diabetic, pressure, arterial, and venous ulcers. Factors like comorbidities, infection, poor circulation, and inadequate care delay healing. This review aims to explore the risk factors for chronic wounds and evaluate evidence-based interventions to optimize treatment outcomes, thereby improving patient care and reducing healthcare costs.   Methods: A thorough literature review was performed using peer-reviewed journals and reliable medical databases, focusing on articles from the past 10 years for relevance. The search used keywords like "chronic wounds," "risk factors," "management," and "evidence-based interventions," selecting studies that addressed the epidemiology, causes, and treatment of chronic wounds. Results: The review identified major risk factors for chronic wounds, such as diabetes, poor circulation, neuropathy, infection, and aging. Effective treatments discussed include advanced dressings, debridement, negative pressure wound therapy, and skin grafts. A multidisciplinary, patient-focused approach was found to improve healing outcomes. Conclusion: Understanding  the risk factors of chronic wounds and applying evidence-based, personalized treatments can significantly improve healing outcomes. Ongoing research and innovation are essential to address gaps in care and enhance patient management.
Case Report: Recurrent Keloid Excision with Tension Reduction Suture and Adjuvant Closed Incision Negative Pressure Wound Therapy Ananda Rahmadanti Perdanakusuma; David Sontani Perdanakusuma
The International Journal of Medical Science and Health Research Vol. 15 No. 4 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/nvgwkb29

Abstract

Background: Keloid management presents significant clinical challenges due to the very high recurrence rate after single surgical excision, reported to reach 50-100%. This failure is primarily caused by mechanical tension on the post-closure wound, which reactivates the fibroproliferative cascade. Closed Incision Negative Pressure Wound Therapy (ciNPWT) emerges as a promising adjuvant therapy because it directly targets this mechanical tension. This case report aims to present the effectiveness of a combination of excision, tension reduction sutures, and ciNPWT in high-risk recurrent keloids. Methods: A 16-year-old male patient with a recurrent keloid on the right upper arm underwent a wide excision procedure and tension reduction suture technique. After wound closure, a ciNPWT dressing was applied over the incision line and connected to a portable device. Continuous negative pressure therapy of −125 mmHg was maintained for 7 days post-operation. Results: The surgical procedure and post-operative care proceeded smoothly without complications such as infection or wound dehiscence. After 7 days, the surgical wound appeared clean and tightly closed with minimal edema. At the 3-month follow-up, the scar appeared calm, flat, and aesthetic, with no clinical signs of keloid recurrence. The patient reported high satisfaction and resolution of itching complaints. Discussion: The success of managing this case strongly validates the fundamental theory that mechanical tension is the primary trigger for keloid recurrence. The applied approach—through surgical excision followed by a tension reduction suture technique—directly targets this crucial factor. Furthermore, the application of ciNPWT as an adjuvant therapy functions as an effective external "mechanical splint." Its role is to neutralize residual tension on the wound and actively disrupt the profibrotic mechanotransduction cascade that triggers fibrosis. This mechanomodulatory strategy fundamentally addresses the root cause of keloid pathology, offering significant advantages over other adjuvant therapies that do not directly and specifically target the tension factor. Conclusion: The combination of surgical excision, tension reduction suture technique, and adjuvant ciNPWT application proved to be a highly effective and rational management strategy for recurrent keloids. This multimodal approach successfully addresses the tension factor—identified as the primary etiology—thus precisely breaking the recurrence cycle. By fundamentally targeting its root cause, this strategy can be a superior therapeutic option for cases with a high risk of recurrence.
Characteristics of Patients with Abnormal Scars Managed at a Tertiary Hospital in Indonesia: A Descriptive Study Shafira Irmalia; David Sontani Perdanakusuma; Dwi Murtiastutik
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 1 (2026): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I12026.28-34

Abstract

Highlights: Burn scars were the leading cause of abnormal scars. Surgery was the primary treatment for abnormal scars.   Abstract Introduction: Human skin is prone to damage, resulting in abnormal scarring that can adversely affect individuals and society. This study aimed to examine the frequency, characteristics, and treatment options of patients with abnormal scars treated at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from 2019 to 2023. Methods: This was a descriptive retrospective study that utilized 48 medical records of patients with abnormal scars at the Department of Plastic Reconstructive and Aesthetic Surgery, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from 2019 to 2023. Data analysis was performed using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) for Windows version 25.0. The variables in this study included demographic characteristics, etiology of the scar, region, size, and management of abnormal scars. Results: Of 48 patients, the highest incidence was in 2023 (29.2%). The majority of patients were female (60.4%) and aged 15-49 years old (41.7%). Burns were the primary etiology of scars (35.4%), and most scars measured over 20 cm² (34.5%). Surgical treatment was the most common management option (54.7%). Conclusion: Patients with abnormal scars are most frequently affected by burn scars. A significant proportion of these individuals present with extensive hypertrophic keloid scars, for which surgical intervention is the most often used therapeutic method.
Comparative Analysis of Bioactive Compounds in Stingless Bee Honey from Wetland and Non-Wetland Vegetation Nanang Miftah Fajari; Siti Hamidah; Eko Suhartono; Agung Pranoto; David Sontani Perdanakusuma; Nuvita Hasrianti; Laily Agustina; Kevin Prasetya Raharjo
HAYATI Journal of Biosciences Vol. 33 No. 4 (2026): July 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.4.1016-1029

Abstract

Stingless bee honey (SBH) produced by the stingless bee species Heterotrigona itama in South Kalimantan is a biologically active natural product with therapeutic potential. This study examines differences in bioactive compounds—molecules that affect living organisms—between SBH from wetland and non-wetland vegetation. The goal is to show how a terrestrial landscape influences functional properties. Using untargeted metabolomics, a technique for surveying many small molecules without preselection, via LC-HRMS (Liquid Chromatography-High-Resolution Mass Spectrometry), we identified 141 distinct metabolites (small molecules involved in metabolism), with 23 compounds present in all samples. These shared metabolites support the mitigation of obesity, wound healing, cardiovascular health, neuroprotection, and gastrointestinal function. Hierarchical cluster analysis, a statistical method for grouping data, using retention time (the time a compound takes to pass through the system), area (the size of the signal on the detector), and molecular weight, revealed distinct compositional clusters between wetland- and non-wetland-derived SBH, suggesting vegetation type shapes metabolite profiles. Wetland SBH contained 198 compounds, while non-wetland samples had 193. These findings highlight how ecological origin modulates the bioactive compounds in SBH and influences their use in nutraceuticals (foods with health benefits) and functional foods. By establishing a metabolomic baseline for SBH, this work advances understanding of its region-specific health benefits and underscores the importance of ecosystem-conscious apiculture (beekeeping) in optimizing bioactive yield.
Relationship Between Dried Amnion Sheet and Dry Powdered Amnion with Changes in Wound Area in Acute Wounds Ferdinand Ferdinand; Afriwardi Afriwardi; David Sontani Perdanakusuma; Hirowati Ali
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6906

Abstract

Dried sheet amnion has long been used as a wound treatment that provides better results than standard general care. In addition to dried amnion sheet, dry powdered amnion preparations have begun to be used for wound care. This study aims to evaluate the effectiveness of dry powdered amnion compared to dried amnion sheets in wound healing, and to compare both treatments with standard acute wound care. Sixty-three healthy Wistar rats were randomly divided into three groups: dried amnion sheet treatment group, dry powdered amnion treatment group, and standard wet wound care control group. The research procedure began with the administration of anesthesia using penthotal at a dose of 10mg/kgBW intramuscularly. The backs of the rats were shaved and a 2x1cm wound was designed using a GOAL razor blade after disinfection with 10% betadine solution and 1:30 savlon. Wounds were made on the backs of the rats, and treatments were given according to the group. The wound area was evaluated at time points 6 hours after treatment, day 2 and day 5. Statistical analysis was performed to compare the effectiveness of the treatments. Both treatments with dry powdered amnion and dried amnion sheets significantly reduced the wound area compared to the control group. However, treatment with dried amnion sheets showed higher efficacy in reducing wound area compared to treatment with dry powdered amnion. Statistical analysis confirmed significant differences in wound area reduction between groups. Dry powdered amnion and dried amnion sheets were effective in reducing wound area compared to standard wet wound care. Treatment with dried amnion sheets showed greater efficacy than treatment with dry powdered amnion.
Co-Authors Afriwardi Afriwardi Agung Pranoto Agung Sosiawan Ananda Rahmadanti Perdanakusuma Andra Rizqiawan Diah Mira Indramaya Dwi Murtiastutik Eko Suhartono Evy Ervianti Fania Ayu Wardani Ferdinand Ferdinand Hari Basuki Notobroto Harith Ali Al-Taie Hirowati Ali Hutagalung, Magda Rosalina Kevin Prasetya Raharjo Laily Agustina Linda Astari, Linda Mala Kurniati Merilyne Merilyne Mikiyas Gifawosen Teferi Nanang Miftah Fajari Nuvita Hasrianti Pinem, Veronica Abebia Beginanta RM Coen Pramono D Shafira Irmalia Siti Hamidah Wulandari, Pratidina