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All Journal Medicina E-Jurnal Medika Udayana Oto Rhino Laryngologica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Perikanan Pantura Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports

Eka Putra Setiawan

2Departemen Ilmu Kesehatan Telinga Hidung Tenggorok–Bedah Kepala Dan Leher (THT-KL), Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia

Author-ID : 376869

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Other

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Hubungan derajat obstruksi hidung pada pasien deviasi septum dengan disfungsi tuba Eustachius Yudianto, Sony; Ratnawati, Luh Made; Setiawan, Eka Putra; Sutanegara, Sari Wulan Dwi
Oto Rhino Laryngologica Indonesiana Vol 44, No 1 (2014): Volume 44, No. 1 January - June 2014
Publisher : PERHATI-KL

Latar belakang: Deviasi septum diduga sebagai salah satu predisposisi terjadinya disfungsi tuba Eustachius, terutama di telinga ipsilateral pada sisi hidung yang tersumbat. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara derajat obstruksi hidung pada pasien deviasi septum nasi dengan disfungsi tuba Eustachius. Metode: Diskriptif dan analitik pada penelitian yang kami lakukan di poliklinik THT-KL RSUP Sanglah Denpasar, diikuti 58 orang yang terbagi dalam kelompok disfungsi tuba Eustachius sebanyak 29 responden dan kelompok fungsi tuba Eustachius normal sebesar 29 responden. Hasil: Analisis penelitian didapatkan hubungan yang bermakna yaitu derajat obstruksi hidung kanan pada pasien deviasi septum meningkatkan risiko kejadian 2,85 kali lebih tinggi dengan terjadinya disfungsi tuba Eustachius kanan. Pada sisi kiri juga didapatkan hubungan yang bermakna yaitu derajat obstruksi hidung kiri pada pasien deviasi septum meningkatkan risiko kejadian 2,17 kali lebih tinggi dengan dengan terjadinya disfungsi tuba Eustachius kiri. Pada derajat sumbatan hidung diketahui pada sisi kanan dan pada sisi kiri dengan hasil responden yang mengalami sumbatan hidung derajat berat secara bermakna meningkatkan risiko terjadinya disfungsi tuba Eustachius pada sisi yang sama dengan nilai (p< 0,05). Kesimpulan: Pada penelitian ini didapatkan hubungan yang bermakna antaraderajat obstruksi hidung pada pasien deviasi septum yang meningkatkan risiko terjadinya disfungsi tuba Eustachius pada sisi yang sama.Kata kunci: Disfungsi tuba Eustachius, obstruksi hidung, deviasi septum nasi. ABSTRACTBackground: Septal deviation is suspected as one of the predisposing factor in Eustachian tube dysfunction, especially in the ipsilateral ear on the side of the obstructed nose. Purpose: To find out the relationship between the degree of nasal obstruction in septal deviation patient with Eustachian tube dysfunction. Method: Descriptive analytic studies that we conducted in ENT clinic Sanglah Hospital that divided 58 people into 29 respondents as the Eustachian tube dysfunction group and 29 others as the normal Eustachian tube function group. Result: We found prevalence of right Eustachian tube dysfunction in 21 respondents and the prevalence on the left Eustachian tube dysfunction in 8 respondents, which was on the same side with the obstructed nose in the case group as measured byPNIF. Bivariate analysis found a significant relationship that increased the risk of occurence was 2,85 times higher in septal deviation patients with right obstructed nose with the right Eustachian tube dysfunction. The left side also showed a significant association 2,17 times. Degree of nasal obstruction performed analysis known on the right side and on the left side showed that respondents with severe degrees of nasal obstruction significantly increased the risk of Eustachian tube dysfunction on the ipsilateral side (p<0,05). Conclusion: In this study we have significant association between the degree of nasal obstruction in septal deviation patients which increased the risk of Eustachian tube dysfunction incidence on the ipsilateral side.Keywords: Eustachian tube dysfunction, nasal obstruction, nasal septal deviation.

BILATERAL OTOMYIASIS IN A CHILD WITH CHRONIC SUPPURATIVE OTITIS MEDIA W, Suwandara; M, Sudipta; Setiawan, Eka Putra
Medicina Vol 43 No 2 (2012): Mei 2012
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.415 KB)

Myiasis is a disease that is rarely found in humans. The most often areas are the skin, nose, trachea, mouth, eye, ear and paranasal sinuses. Auriclar myiasis also known as otomyiasis is the presence of larval infestation on the human ear. In general, otomyiasis frequently in children, but can also be found in adult who have mental retardation or cerebral palsy. We reported a case of a boy who has otomyiasis with chronic suppurative otitis media in Sanglah Hospital, Denpasar and has done manage by evacuation of maggots, ear toilet using NaCl 0.9% and concomitant suction, topical and oral antibiotic.

KARAKTERISTIK PENDERITA RINOSINUSITIS KRONIS YANG RAWAT JALAN DI POLI THT-KL RSUP SANGLAH DENPASAR TAHUN 2016 Putu Krisna Yama Dewi; Eka Putra Setiawan; Sari Wulan Dwi Sutanegara
E-Jurnal Medika Udayana Vol 7 No 12 (2018): Vol 7 No 12 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.785 KB)

Rinosinusitis kronis (RSK) merupakan suatu masalah kesehatan yang berakibat dalam beban biaya kesehatan yang besar untuk masyarakat. Rinosinusitis kronis adalah peradangan pada mukosa hidung dan sinus paranasal. Angka kejadian RSK di Indonesia masih sangat tinggi, data yang diperoleh dari DEPKES RI tahun 2003 menyebutkan bahwa penyakit hidung dan sinus paranasal berada pada urutan ke-25 dari 50 pola penyakit peringkat utama atau sekitar 102.817 penderita rawat jalan di rumah sakit. Tujuan penelitian ini untuk mengetahui karakteristik penderita rinosinusitis kronis yang rawat jalan di Poli THT-KL RSUP Sanglah Denpasar tahun 2016. Penelitian ini merupakan penelitian deskriptif retrospektif yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Data yang diperoleh berupa data sekunder rekam medis pasien periode April – Desember 2016 yang dipilih secara total sampling dengan jumlah sampel sebanyak 53 penderita. Data kemudian diolah dan disajikan dalam bentuk tabel, diagram pie, serta diagram batang dengan menggunakan program microsoft excel dan word. Hasil penelitian menunjukkan bahwa dari 53 pasien, rata-rata berusia 41,2 ± 15,8 tahun dengan proporsi terbanyak yaitu rentangan usia 46-60 tahun sejumlah 20 penderita (37,7%). Jenis kelamin terbanyak laki-laki sejumlah 32 penderita (60,4%). Pekerjaan terbanyak yaitu pegawai swasta sejumlah 23 penderita (43,4%). Keluhan utama yang paling sering pada gejala mayor yaitu hidung tersumbat sebanyak 37 penderita (69,8%), sedangkan pada gejala minor yaitu sakit kepala sebanyak 13 penderita (24,5%). Penyakit penyerta terbanyak yaitu kelainan anatomi sejumlah 42 penderita (79,3%). Keterlibatan jumlah sinus terbanyak yaitu single rinosinusitis sejumlah 24 penderita (45,3%), serta sinus yang sering terkena yaitu sinus maksila sebanyak 48 penderita (90,6%). Kata kunci: Karakteristik Penderita, Rinosinusitis Kronis, Rawat Jalan

Pengaruh bising lalu lintas terhadap penurunan fungsi pendengaran pada juru parkir di kota Denpasar Ni Ketut Susilawati; Wayan Sudana; Eka Putra Setiawan
Oto Rhino Laryngologica Indonesiana Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v40i2.3

Background: Noise pollution or noise is an unwanted sound which is disturbing to human beings.However small or soft the sound, if it is undesirable it is considered as noise. Noise induced hearingloss is a sensorineural hearing loss that is commonly encountered second to presbycusis. Purpose: Toknow the effect of traffic noise exposure on hearing impairment to the employees of the Parking DistrictCompany of the Denpasar city and to improve diagnostic detection on hearing impairment caused bynoise. Method: A cross sectional study was conducted at the Parking District Company office. Thepopulations of this study were the employees of the Parking District Company. Samples of this study were the employees who were exposed to traffic noise and control samples were an employee who was unexposed. Samples were selected by simple random sampling. Results: From 40 parking attendants,27 persons (67.5%) aged above 35 years old. The parking attendants who had been working for ten to fifteen years were 36 persons (90%) and no history using ear protection when working. Seven persons(17.5%) had referred DPOAE upon examination with increase hearing threshold on audiogram result.In this study the parking attendants who had hearing deficit induced by noise were 7 persons (17.5%)and only one person (2.5%) in control group. There was a statistically significant effect of traffic noiseto hearing function deficit (p<0.05). Conclusion: Traffic noise has effect in hearing function deficit onthe parking attendants.ORLI Vol. 40 No. 2 Tahun 2010Key words: NIHL, parking attendant, audiometry, DPOAE.

PENGARUH PEMBERIAN DOSIS PROBIOTIK YANG BERBEDA PADAPAKAN KOMERSIL TERHADAP PERTUMBUHAN IKAN LELE DUMBO(Clariasgariepinus) PEMELIHARAAN PADAT TEBAR TINGGI Setiawan Eka Putra; Endah Sri Redjeki; Sa’idah Luthfiyah
Jurnal Perikanan Pantura (JPP) Vol 1 No 2 (2018): SEPTEMBER 2018
Publisher : Universitas Muhammadiyah Gresik

African catfish (Clarias gariepinus) is one type of freshwater fish that has high economic value. African catfish with intensive cultivation are hampered by the high cost of feed that is not in accordance with the selling price of African catfish. An alternative effort that can be done is the addition of probiotics to feed which is expected to reduce feed costs. Probiotics are living microorganisms in fish culture that can prevent disease, thereby increasing production and can reduce economic losses. This study aims to analyze the effect of probiotics on the growth of absolute weight and daily growth rate of African catfish. The method used was Completely Randomized Design (RAL) with 4 treatments namely 0, 2, 4 and 6 ml / kg of feed and repeated 3 times. Activities carried out in this study include preparation of containers, seed stocking, fish sampling, feed preparation, feeding and water management. The variables observed were absolute weight growth and daily growth rate. The results showed that the addition of probiotics to commercial feed significantly affected the growth of weight and daily growth rate of African catfish

KEJADIAN OTITIS EKSTERNA PADA MASYARAKAT PENEBEL TABANAN DAN YANGAPI BANGLI YANG BERKUNJUNG KE BAKTI SOSIAL STAF MEDIS FUNGSIONAL TELINGA HIDUNG TENGGOROKAN FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA - RUMAH SAKIT UMUM PUSAT SANGLAH PADA TAHUN 2012 Putu Teguh Aryanugraha; Eka Putra Setiawan
Intisari Sains Medis Vol. 5 No. 1 (2016): (Available online: 1 April 2016)
Publisher : DiscoverSys Inc.

Indonesia is a tropical country which in some places have there own temperature and humidity criteria factors predisposing to otitis externa is usually triggered by the growth of fungi that are responsible for the onset of otitis externa. The research was conducted in two places, namely in the village of Penebel Tabanan and the village of Yangapi Bangli. The aim to determine the prevalence of otitis externa, especially in people who follow social events in the village Penebel and Yangapi. This research was carried out by quantitative descriptive design with a population that is affordable and Yangapi Penebel villagers who come to charity ENT Division Sanglah Hospital. The incidence of OE in the village Penebel was 6 of 66 patients and in the village Yangapi was 3 of 96 patients. Variants OE in the village of the same Penebel lot of male patients men and women with a lifespan of 41 years and above, whereas the incidence in the village OE Yangapi more on men with an age range 21-30 years. At this research showed otitis externa patients who come to social event in both villages were 9 people from 162 patients who came to the social event ENT Division Sanglah Hospital.

Uji daya hambat sediaan tetes telinga ekstrak daun â€œTebel-Tebelâ€ (Hoya carnosa) terhadap bakteri gram positif dan gram negatif penyebab Otitis Media Supuratif Kronik (OMSK) aktif tipe benigna secara in-vitro di RSUP Sanglah, Bali, Indonesia I Wayan Lolik Lesmana; Eka Putra Setiawan; I Made Jawi
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: The recent Chronic Suppurative Otitis Media (CSOM) management by antibiotic Chloramphenicol 1% ear drop seems to be ineffective due to the bacterial resistance, ototoxic effects, and the idiosyncratic response. Traditional medicine from Hoya carnosa leaf as ear drops has been suggested for alternative medicine because of its antibacterial properties. This study aims to evaluate the inhibition test of Hoya carnosa leaf-extract towards gram-positive and gram-negative bacteria causeMethods: An experimental study with a completely randomized post-test control group design has been conducted to the American Type Culture Collection (ATCC), which consists of Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa dan Enterobacter spp. The Hoya carnosa leaf extract in-ear drop emulsion has been divided into 3 concentrations, such as 1%, 3%, and 5% w/v by simple random technique. As a positive control used Chloramphenicol 1% and as a negative control using 96% ethanol. Each treatment was repeated 5 times and data were analyzed by SPSS version 17 for Windows.Results: There was a significant difference in inhibitory diameter (IH) from ear drop dosage of (Hoya carnosa) leaf emulsions to Streptococcus pyogenes bacteria in concentrations of 3% and 5% (p<0.05). There was a significant difference from the inhibitory drug resistance (DDH) ear drop emulsion preparation leaf extract "tebel-tebel" (Hoya carnosa) concentrations of 1%, 3% and 5% with Cholrampenicol 1% against Streptococcus pyogenes bacteria (p<0.05)Conclusion: There was a significant difference in inhibitory diameter (DDH) and inhibitory drug resistance from Hoya carnosa leaf emulsions ear drops to Streptococcus pyogenes bacteria.Â Latar Belakang: Penatalaksanaan Otitis Media Supuratif Kronis (OMSK) saat ini dengan antibiotik Kloramfenikol tetes telinga 1% tampaknya tidak efektif karena adanya resistensi bakteri, efek ototoksik, dan respon idiosinkratik. Obat tradisional dari daun Hoya carnosa sebagai obat tetes telinga telah disarankan untuk pengobatan alternatif karena sifat antibakterinya. Penelitian ini bertujuan untuk mengevaluasi uji daya hambat ekstrak daun Hoya carnosa terhadap bakteri penyebab gram positif dan gram negatifMetode: Telah dilakukan penelitian eksperimental dengan rancangan acak kelompok kontrol post-test pada American Type Culture Collection (ATCC) yang terdiri dari Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa dan Enterobacter spp. Ekstrak daun Hoya carnosa dalam emulsi tetes telinga dibagi menjadi 3 konsentrasi yaitu 1%, 3% dan 5% b / v dengan teknik acak sederhana. Sebagai kontrol positif digunakan Kloramfenikol 1% dan sebagai kontrol negatif menggunakan etanol 96%. Tiap perlakuan diulang sebanyak 5 kali dan data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Terdapat perbedaan bermakna dalam uji diameter daya hambat (DDH) antara dosis tetes telinga emulsi daun Hoya carnosa terhadap bakteri Streptococcus pyogenes pada konsentrasi 3% dan 5% (p <0,05). Ada perbedaan yang bermakna antara ekstrak daun â€œtebel-tebelâ€ (Hoya carnosa) sediaan emulsi tetes telinga konsentrasi 1%, 3% dan 5% dengan Cholrampenicol 1% terhadap bakteri Streptococcus pyogenes (p <0,05).Kesimpulan: Ada perbedaan yang bermakna pada diameter hambat (DDH) dan resistensi obat penghambat emulsi daun Hoya carnosa tetes telinga terhadap bakteri Streptococcus pyogenes.

Potensi antibakteri tetes telinga ekstrak daun Anredera Cordifolia terhadap Pseudomonas aeruginosa penyebab Otitis Media Supuratif Kronis (OMSK) Ni Putu Oktaviani Rinika Pranitasari; Eka Putra Setiawan; I Wayan Lolik Lesmana
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Chronic Suppurative Otitis Media (CSOM) is a chronic inflammation of the middle ear and mastoid mucosa characterized by perforation of the tympanic membrane and persistent discharge from the middle ear. The high resistance rate to CSOM pathogen brings hope for the development of natural-based drugs. The Binahong plant (Anredera cordifolia) has been known for a long time and is widely used as a traditional herb by Indonesian people. Flavonoid, saponins and alkaloids compounds from Binahong leaf extracts in several studies reveal its antibacterial activity. This study aims to determine the antibacterial activity of Binahong leaf extract ear drops against Pseudomonas aeruginosa, CSOM pathogen in-vitro. Methods: This is an experimental study with a post-test only control group design by testing antibacterial activity of binahong leaf extract at 1%, 3% and 5% concentrations into Pseudomonas aeruginosa American Type Culture Collection (ATCC) 9027. Chloramphenicol 1% was used as a positive control and ethanol 96% as a negative control. Data were analyzed using SPSS version 20 for Windows. Results: The minimum Inhibitory Zone Diameter (IZD) in the treatment groups A1, A2, A3 and A4 was the same, namely 0.00 mm and the maximum IZD in the treatment groups A1, A2, A3, A4 was also the same, which was 0.00 mm, so that the average IZD of the treatment groups A1, A2, A3, A4 was 0.00 mm. Meanwhile, in the A4 treatment group, the minimum IZD was 11.00 mm and the maximum IZD was 12.00 mm, so the average IZD was 11.20 mm. Conclusion: Antibacterial activity of the Binahong (Anredera cordifolia) leaf extract ear drops at 1%, 3% and 5% concentrations showed weak inhibitory response to Pseudomonas aeruginosa bacteria. Latar Belakang: Otitis media supuratif kronis (OMSK) adalah inflamasi kronis mukosa telinga tengah dan mastoid ditandai perforasi membran timpani dan keluarnya cairan dari telinga tengah yang menetap. Tingginya angka resistensi terhadap bakteri penyebab OMSK membawa harapan bagi pengembangan obat yang berbahan dasar alam. Tanaman Binahong (Anredera cordifolia) telah dikenal sejak dahulu dan banyak digunakan sebagai tanaman obat oleh masyarakat di Indonesia. Senyawa flavonoid, saponin dan alkaloid yang terkandung pada daun Binohong diketahui memiliki aktifitas antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri tetes telinga ekstrak daun Binahong terhadap Pseudomonas aeruginosa penyebab OMSK secara in-vitro. Metode: Penelitian ini merupakan penelitian eksperimental dengan rancangan post-test only control group design yaitu menguji aktivitas antibakteri berupa diameter daerah hambat (DDH) sediaan tetes telinga ekstrak daun Binahong konsentrasi 1%, 3% dan 5% terhadap Pseudomonas aeruginosa ATCC-9027. Sebagai kontrol positif digunakan Chloramphenicol 1% dan sebagai kontrol negatif digunakan ethanol 96% Data dianalisis menggunakan SPSS versi 20 untuk Windows. Hasil: Diameter daerah hambat (DDH) minimal pada kelompok perlakuan A1, A2, A3 dan A4 adalah sama, yaitu 0,00 mm dan DDH maksimal pada kelompok perlakuan A1, A2, A3, A4 juga sama, yaitu sebesar 0,00 mm, sehingga rerata diameter daerah hambat kelompok perlakuan A1, A2, A3, A4 adalah 0,00 mm. Sedangkan pada kelompok perlakuan A4, DDH minimal adalah 11,00 mm dan DDH maksimal sebesar 12,00 mm, sehingga rerata DDH adalah 11,20 mm. Kesimpulan: Aktivitas antibakteri sediaan tetes telinga ekstrak daun Binahong (Anredera cordifolia) pada konsentrasi 1%, 3% dan 5% menunjukkan respon hambat lemah terhadap pertumbuhan bakteri Pseudomonas aeruginosa.

Uji toksisitas akut dan subkronik ekstrak daun binahong (Anredera cordifolia) pada mencit Balb/C betina I Wayan Lolik Lesmana; Eka Putra Setiawan; Ni Putu Oktaviani Rinika Pranitasari
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: The antibacterial potential of Binahong leaf extract has been known but has not been studied further, especially against disease-causing bacteria in the Ear, Nose and Throat (ENT) field. The antibacterial activity is made possible by the presence of flavonoid compounds, saponins and alkaloids. This study aims to test the acute toxicity in determining the LD50 value and the subchronic toxicity test in the phytopathological examination of liver and kidney function in female Balb/C mice. Methods: Experimental research was conducted on acute and subchronic toxicity of binahong leaf extract in mice. An acute toxicity test was carried out by giving a single dose of Binahong leaf extract, starting at a dose of 5 mg/kgBW and increasing until 2 mice died or 1 mouse showed symptoms of toxicity. After 28 days of offering Binahong leaf extract, blood serum was taken to check kidney and liver function, while the kidneys and then histopathological examinations were carried out. Data were analyzed with SPSS version 20 for Windows. Results: There was a significant difference in SGPT levels in the group that received binahong extract treatment at a dose of 250 mg/kgBW (24.08±3.08/L), 500 mg/kgBW (26.84±1.47/L), and 1000 mg/kgBW (30.38±0.68/L) compared to the control group (18.18±0.46/L) (p<0.05). Significant differences were also found in BUN and SC levels measurement compared to the control group (p<0.05). However, significant differences in SGOT levels were only found in the binahong extract group at a dose of 500 mg/kgBW (44.88±2.88/L) and 1000 mg/kgBW (58.18±2.56/L) compared to the control (37 ,48±0.44 /L) (p<0.05). Conclusion: There were significant differences in the levels of SGPT, SGOT, BUN, and SC after the administration of various doses of binahong leaf extract in female Balb/C mice. Latar Belakang: Potensi antibakteri ekstrak daun Binahong telah diketahui namun belum diteliti lebih jauh terutama terhadap bakteri penyebab penyakit di bidang Telinga Hidung dan Tenggorok (THT). Aktivitas antibakteri tersebut dimungkinkan oleh adanya kandungan senyawa flavonoid, saponin dan alkaloid. Penelitian ini bertujuan untuk menguji toksisitas akut dalam menentukan nilai LD50 dan uji toksisitas subkronik berupa pemeriksaan fungsi hepar dan ginjal secara biokimia dan histopatologi pada mencit Balb/C betina. Metode: Penelitian eksperimental dilakukan terhadap toksisitas akut dan subkronik ekstrak daun Binahong pada mencit. Uji toksisitas akut dilakukan dengan memberikan ekstrak daun Binahong dosis tunggal mulai dari dosis 5 mg/kgBB dan ditingkatkan sampai didapatkan ≥ 2 ekor mencit yang mati atau ≥ 1 ekor mencit menunjukkan gejala toksisitas. Setelah 28 hari pemberian ekstrak daun Binahong, dilakukan pengambilan serum darah untuk diperiksa fungsi ginjal dan hepar, sedangkan organ ginjal dan hepar selanjutnya akan dilakukan pemeriksaan histopatologi. Data dianalisis dengan SPSS versi 20 untuk Windows. Hasil: Terdapat perbedaan yang bermakna kadar SGPT pada kelompok yang mendapatkan perlakuan ekstrak binahong dengan dosis 250 mg/kgBB (24,08±3,08 µ/L), 500 mg/kgBB (26,84±1,47 µ/L), dan 1000 mg/kgBB (30,38±0,68 µ/L) dibandingkan dengan kelompok kontrol (18,18±0,46 µ/L) (p<0,05). Perbedaan yang bermakna juga ditemukan pada pengukuran kadar BUN dan SC dibandingkan dengan kelompok kontrol (p<0,05). Akan tetapi perbedaan bermakna kadar SGOT hanya ditemukan pada kelompok ekstrak binahong dengan dosis 500 mg/kgBB (44,88±2,88 µ/L) dan 1000 mg/kgBB (58,18 ± 2,56 µ/L) dibandingkan dengan kontrol (37,48±0,44 µ/L) (p<0,05). Simpulan: Terdapat perbedaan yang bermakna pada kadar SGPT, SGOT, BUN, dan SC pasca pemberian berbagai dosis ekstrak daun binahong pada mencit Balb/C betina.

Deep Neck Abscess with Concurrent Orbital and Subgaleal Extension Secondary to Odontogenic Infection: A Case Report Pande Agus Parta Prananda; Putu Dian Ariyanti Putri; I Made Wiranadha; I Dewa Gede Arta Eka Putra; Eka Putra Setiawan; Sari Wulan Dwi Sutanegara
Archives of The Medicine and Case Reports Vol. 6 No. 3 (2025): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v6i3.744

Deep neck infections (DNIs) originating from odontogenic sources are common, but extensive spread involving concurrent orbital and subgaleal spaces is rare. DNIs can lead to life-threatening complications, particularly in patients with comorbidities like diabetes mellitus (DM) and chronic kidney disease (CKD), which impair immune function. This report details a complex case of DNI with unusual superior extension. A 44-year-old male with poorly controlled type 2 DM and CKD presented with a two-day history of rapidly progressing left facial, submandibular, parotid, and orbital swelling, associated with fever, trismus, and severe pain, originating from a carious mandibular molar. CT imaging confirmed an extensive abscess involving the left masticator, submandibular, sublingual, parotid, and parapharyngeal spaces, with contiguous spread to the left preseptal orbital space and the fronto-temporo-parietal subgaleal space. Multidisciplinary management involved urgent surgical drainage of the submandibular and subgaleal abscesses, odontectomy of the offending molar, broad-spectrum intravenous antibiotics (Citrobacter amalonaticus and Proteus hauseri identified on culture), intensive glycemic control, hemodialysis, and supportive care. In conclusion, this case highlights the potential for aggressive craniofacial spread of odontogenic DNIs, particularly in immunocompromised individuals. Concurrent orbital and subgaleal extension represents a rare and serious complication. Prompt diagnosis with imaging, aggressive multidisciplinary surgical and medical management, including addressing underlying comorbidities, were crucial for a successful outcome.

Co-Authors Agus Rudi Asthuta Anak Agung Wira Ryantama Endah Sri Redjeki I Dewa Gede Arta Eka Putra I Gde Ardika Nuaba I Ketut Suanda I Made Jawi I Made Wiranadha I Wayan Lolik Lesmana I Wayan Lolik Lesmana Komang Andi Dwi Saputra Luh Made Ratnawati Luh Sartika Sari Made Lely Rahayu Ni Ketut Susilawati Ni Putu Oktaviani Rinika Pranitasari Pande Agus Parta Prananda Putu Dian Ariyanti Putri Putu Krisna Yama Dewi Putu Teguh Aryanugraha Sari Wulan Dwi Sutanegara Sa’idah Luthfiyah Steven Yohanis Latupeirissa Sudipta M Sutanegara, Sari Wulan Dwi Suwandara W Wayan Lolik Lesmana Wayan Sudana Yudianto, Sony

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