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Tingkat pengetahuan dan sikap ibu terkait makanan tambahan dengan status gizi balita di Kecamatan Woyla Barat Maharani Maharani; Sri Wahyuni; Diah Fitrianti
AcTion: Aceh Nutrition Journal Vol 4, No 2 (2019): AcTion Vol 4 No 2 Tahun 2019
Publisher : Jurusan Gizi Politeknik Kesehatan Kemenkes Aceh

The double burden of nutrition is very worrying for children in Indonesia. Indonesia has a prevalence of malnutrition of 13,8% and 3,1% was overweight of children, while in Aceh that is 16,8% and 2,9% of overweight. One of the factors is the arrangement of additional food that is not patterned. The purpose of this study was to examine the relationship between mother's knowledge and attitudes about supplementary food and nutritional status in infants. The study was an analytic survey using a cross sectional approach. Samples were taken as many as 86 toddlers with a simple random technique. Data collection using questionnaires and anthropometric measurements. Knowledge and attitude data are processed according to percentage values, and nutritional status data are processed according index to WFA. The statistical test is chi-square at CI:95%. The results showed that mothers' knowledge and attitudes about supplementary food were still not good, and there were still many toddlers with the best nutritional status. Other results show the relationship between maternal knowledge (p=0,000) and maternal attitudes (p=0,019) regarding supplementary food with nutritional status in toddlers in Woyla Barat District. Conclusions, poor mother's knowledge and attitude about supplementary feeding is related to the high problem of malnutrition and over nutrition. Suggestions, counseling is needed related to providing good and nutritious supplementary food, as well as monitoring the nutritional status of children continuously both in the WFA, HFA and WFH indexs.Beban ganda masalah gizi sangat mengkhawatirkan anak-anak di Indonesia. Indonesia mempunyai prevalensi kekurangan gizi sebesar 13,8% dan 3,1% balita gizi lebih, sedangkan di Aceh yaitu sebesar 16,8% dan 2,9% anak gizi lebih. Salah satu faktor penyebab yaitu pengaturan makanan tambahan yang tidak terpola. Tujuan penelitian untuk mengukut hubungan pengetahuan dan sikap ibu tentang makanan tambahan dengan status gizi pada balita di. Penelitian bersifat survey analitik dengan menggunakan pendekatan cross sectional. Sampel diambil sebanyak 86 balita dengan teknik acak sederhana. Pengumpulan data menggunakan kuesioner dan pengukuran antropometri. Data pengetahuan dan sikap diolah menurut nilai persetase, dan data status gizi diolah menurut indeks BB/U. Uji statistik yaitu chi-square pada CI:95%. Hasil penelitian menunjukan pengetahuan dan sikap ibu tentang makanan tambahan masih kurang baik, serta masih banyak balita yang bestatus gizi kurang. Hasil lainnya menunjukkan hubungan antara pengetahuan ibu (p= 0,000) dan sikap ibu (p= 0,019) tentang makanan tambahan dengan status gizi pada balita di Kecamatan Woyla Barat Kabupaten. Kesimpulan, pengetahuan dan sikap ibu yang kurang baik tentang pemberian makannan tambahan berhubungan dengan tingginya masalah gizi kurang dan kelebihan gizi. Saran, perlu dilakukan penyuluhan terkait pemberian makanan tambahan yang baik dan bergizi, serta pemantauan status gizi anak secara terus menerus baik pada indeks BB/U, TB/U dan BB/TB.

Genistein To Decrease Matrix Metalloproteinase-2 (Mmp-2) And Matrix Metalloproteinase-9 (Mmp-9) Levels In Peritoneal Fluid Of Endometriosis On Mice Model Maharani Maharani; Endang Sri wahyuni; Sutrisno Sutrisno
JKM (Jurnal Kebidanan Malahayati) Vol 8, No 1 (2022): Vol. 8 No. 1, Januari 2022
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v8i1.5847

Latar Belakang: Matrix metalloproteinases (MMPs) mempengaruhi progesivitas endometriosis, dalam invasi, perkembangan dan metastasis endometriosis. Penururan kadar MMP-2 dan MMP-9 merupakan terapi yang tepat untuk kasus endometriosis menggunakan terapi hormonal alami yaitu genistein.Tujuan: Penelitian ini bertujuan untuk mengetahui pemberian genistein dapat menurunkan kadar MMP-2 dan MMP-9 dalam cairan peritoneal mencit (Mus musculus) model endometriosis.Metode: Penelitian ini merupakan penelitian eksperimental yang dilakukan di Laboratorium Fisiologi Reproduksi Embriologi Fakultas Kedokteran Hewan Universitas Airlangga Surabaya dan Laboratorium Fisiologi Fakultas Kedokteran Universitas Brawijaya Malang. Sampel menggunakan mencit (Mus musculus) model endometriosis. Penelitian dibagi menjadi 8 kelompok, yaitu : kontrol negatif, kontrol positif dan perlakuan pemberian genistein dosis 50 mg/hari, 100 mg/hari, 200 mg/hari, 300 mg/hari, 400 mg/hari, 500 mg/hari. Pengukuran kadar MMP-2 dan MMP-9 menggunakan ELISA kit. Data hasil pengamatan dianalisis dengan uji ANOVA, Tukey dan Regresi.Hasil: Genistein mampu menurunkan kadar MMP-2 terendah pada dosis 50 mg/hari (5.61±0.69 ng/mL), 100 mg/hari (4.91±0.59 ng/mL) dan 400 mg/hari (4.95±0.32 ng/mL) bila dibandingkan dengan perlakuan dosis yang lain. Genistein mampu menurunkan kadar MMP-9 terendah pada dosis 50 mg/hari (1.69±0.45 ng/mL), 100 mg/hari (1.29±0.32 ng/mL), 200 mg/hari (1.84±0.25 ng/mL) dan 400 mg/hari (1.42±0.11 ng/mL) bila dibaningkan dengan perlakuan dosis yang lain.Kesimpulan: Genistein dapat menurunkan kadar MMP-2 dan MMP-9 dalam cairan peritoneal mencit (Mus musculus) model endometriosis.Saran: Perlu studi lanjut untuk melihat pengaruh genistein pada hewan coba kelinci Kata Kunci: Endometriosis, Genistein, MMP-2, MMP-9 ABSTRACT Background: Matrix metalloproteinases (MMPs) affect the progression of endometriosis, in the invasion , development , and metastasis of endometriosis. Reducing levels of MMP-2 and MMP-9 is an appropriate therapy for endometriosis cases using natural hormonal therapy, namely genistein.Purpose: To know the effect of genistein on the level of MMP-2 and MMP-9 in peritoneal fluid of endometriosis mice model.Method: The design of this study was experimental, had been performed in Reproductive Physiology and Embryology Laboratory, Veterinary Medical Faculty of Airlangga University Surabaya and Physiology Laboratory, Medical Faculty of Brawijaya University Malang. The animal model was divided the 8 groups: negative group ,positive group, and treated group with genistein doses of 50 mg/day, 100 mg/day, 200 mg/day, 300 mg/day, 400 mg/day, and 500 mg /day (human dose). The measurement of MMP-2 and MMP-9 levels using ELISA kits. Thedata were analyzed with ANOVA, Tukey, and Regression tests.Result: Genistein was able to decrease the MMP-2 level in the lowest dose 50 mg/day (5.61±0.69 ng/mL), 100 mg/day (4.91±0.59 ng/mL) and 400 mg/day (4.95±0.32 ng/mL) when compared with other treatment dose. Genistein was able to decrease the MMP-9 level in the lowest dose 50 mg/day (1.69±0.45 ng/mL), 100 mg/day (1.29±0.32 ng/mL), 200 mg/day (1.84±0.25 ng/ mL) and 400 mg/day (1.42±0.11 ng/mL) when compared with other treatment doses.Conclusion: Genistein may decrease MMP-2 and MMP-9 levels in peritoneal fluid of endometriosis mice model.Suggestion: Further study is needed to see the effect of genistein on rabbit experimental animals. Keywords: Endometriosis, Genistein, MMP-2, MMP-9

PENGARUH FLAVONOID EKSTRAK MAHKOTA DEWA (PHALERIA MACROCARPA) TERHADAP PENINGKATAN INDEKS APOPTOSIS PADA PERITONEAL MENCIT MODEL ENDOMETRIOSIS Maharani Maharani; Sutrisno Sutrisno
JKM (Jurnal Kebidanan Malahayati) Vol 7, No 4 (2021): Vol.7 No.4 Oktober 2021
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v7i4.4606

Background: Endometriosis is one of the main reproductive problems today because the incidence is quite high. The development and progression of endometriosis cells results from an abnormal balance between cell proliferation and apoptosis. Cell apoptosis is triggered by an imbalance between positive signals (cell growth factors) and negative signals (DNA damage) in endometriosis. The anti-cancer effect of Mahkota Dewa has been shown to suppress cancer growth and inhibit cancer cell invasion through inhibition of proliferation and anti-apoptotic activity, Purpose: This study aimed to determine the effect of giving flavonoid extract from Mahkota Dewa fruit on the apoptotic index in endometriosis model mice. Methods: This research is an experimental study conducted at the Laboratory of the Faculty of Veterinary Medicine, Airlangga University, Surabaya. The sample used mice (Mus musculus) endometriosis model. The study was divided into 6 groups: negative control, positive control and treatment with the flavonoid extract of the Mahkota Dewa fruit at a dose of 3.75 mg/day, 7.5 mg/day, 11.25 mg/day and 15 mg/day. Measurement of apoptotic index using Tunel kit immunohistochemistry. Observational data were analyzed by ANOVA dan Tukey. Results: There was significant difference in the mean apoptotic index of the five groups of observational samples, the mean value of the apoptotic index was found between the KP group (7.96 ± 1.02) and the group given flavonoid extract from the Mahkota Dewa fruit group P1 at a dose of 3.75 mg (5.36 ± 0.91), P2 dose 7.5 mg (3.4 ± 0.49), P3 dose 11.25 mg (3.88 ± 0.59), P4 dose 15 mg (3.96 ± 0.75). Conclusion: The administration of flavonoid extract of the Mahkota Dewa fruit had a significant effect on increasing cell apoptotic index in endometriosis model mice.Suggestion Further study is needed to see the effect of flavonoid extract of Mahkota Dewa on rabbit experimental animals. Keywords: endometriosis, flavonoid extract of Mahkota Dewa fruit, apoptotic index ABSTRAK Latar Belakang: Endometriosis menjadi salah satu masalah reproduksi utama saat ini karena angka kejadian cukup tinggi. Perkembangan dan progresi sel endometriosis akibat terjadinya abnormalitas keseimbangan antara proliferasi dan apoptosis sel. Apoptosis sel dipicu karena adanya ketidakseimbangan antara sinyal positif (faktor pertumbuhan sel) dan sinyal negatif (kerusakan DNA) pada kondisi endometriosis. Efek anti kanker mahkota dewa terbukti dapat menekan pertumbuhan kanker dan menghambat terjadinya invasi sel kanker melalui penghambatan aktivitas proliferasi dan anti apoptosis.Tujuan: Penelitian ini bertujuan untuk mengetahui efek pemberian flavonoid ekstrak dari buah mahkota dewa terhadap indeks apoptosis pada mencit model endometriosis.Metode: Penelitian ini merupakan penelitian eksperimental yang dilakukan di Laboratorium Fakultas Kedokteran Hewan Universitas Airlangga Surabaya. Sampel menggunakan mencit (Mus musculus) model endometriosis. Penelitian dibagi menjadi 6 kelompok, yaitu : kontrol negatif, kontrol positif dan perlakuan pemberian ekstrak flavonoid buah mahkota dewa dosis 3,75 mg/hari, 7,5 mg/hari, 11,25 mg/hari dan15 mg/hari. Pengukuran indeks apoptosis menggunakan imunohistokimia Tunel kit. Data hasil pengamatan dianalisis dengan uji ANOVA dan Tukey. Uji statistik dikatakan bermakna bila p<0,05.Proses penghitungan dilakukan dengan bantuan piranti lunak (soft-ware) SPSS for windows 19.0.Hasil: Terdapat perbedaan yang bermakna rerata indeks apoptosis kelima kelompok sampel pengamatan didapatkan nilai rerata indeks apoptosis antara kelompok K- (7.96 ± 1.02) dengan kelompok pemberian ekstrak flavonoid dari buah mahkota dewa kelompok P1 dosis 3,75 mg (5.36 ± 0.91), P2 dosis 7,5 mg (3.4 ± 0.49), P3 dosis 11,25 mg (3.88 ± 0.59), P4 dosis 15 mg (3.96 ± 0.75).Kesimpulan: Pemberian ekstrak flavonoid buah mahkota dewa memberikan pengaruh yang signifikan terhadap peningkatan indeks apoptosis sel pada mencit model endometriosis.Saran Perlu studi lanjut untuk melihat pengaruh flavonoid ekstrak mahkota dewa pada hewan coba kelinci. Kata Kunci: endometriosis, flavonoid ekstrak buah mahkota dewa, indeks apoptosis

Early Breastfeeding Initiation Effect in Stunting: A Systematic Review Steven Christian Susianto; Nina Rini Suprobo; Maharani Maharani
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Introduction: Stunting has been a global burden worldwide, resulting in severe outcomes, including inadequate brain development until mortality. Early breastfeeding initiation as a global strategy affects the success of continuous breastfeeding that influences the children’s growth and development. This study aimed to provide a literature review on how early breastfeeding initiation might help children avoid stunting. Methods: We searched articles published from 2017 to 2022 in PubMed, Science Direct, Cochrane, and the Indonesia Database with keywords “Early breastfeeding initiation” OR “Early breastfeeding” OR” Early Initiation Breastfeeding” AND “stunting.” All data were gathered and analyzed. Results: A total of 12 articles from 6690 articles met the inclusion, exclusion, and eligibility criteria. The mean of early breastfeeding initiation was 61,82%, with the lowest study in Chimborazo and Tungurahua, Ecuador, and stunting was 33,07% as the highest prevalence was in Chimborazo and Tungurahua, Ecuador, while the lowest in Saharawi refugee camps, Algeria. The mean prevalence of children who did not get early breastfeeding initiation and stunting occurred at 40,85%, and eight studies reported that early breastfeeding initiation was associated with stunting. Conclusion: Early breastfeeding initiation can lower stunting risk in children. Early breastfeeding initiation ensures children obtain enough colostrum that enhances the children’s immunity and probability of exclusive breastfeeding, ensuring children obtain adequate nutritional intake and prevent stunting.

Black-Eyed Pea Diet Alleviates High-Density Lipoprotein Cholesterol In Menopausal Women; Randomized Clinical Trial Study Handi Wiradharma; Pande Made Dwijasa; Maharani Maharani
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Introduction: Menopause is defined as the last menstruation cycle in women. Estrogen concentration in menopausal women was decreased and altered the lipid metabolism profiles. Menopausal women reportedly have a high risk of cardiovascular disease, arthritis, diabetes mellitus, and stroke. This study focused on the effect of the black-eyed pea diet on the lipid profiles in menopausal women. Material and Methods: A randomized clinical study was performed to analyzedd the effect of the black-eyed pea diet on lipid profiles. Fifty-four menopausal women were selected as respondents and classified into two groups, black-eyed pea diet and placebo. Black-eyed pea diet treatment was performed by consuming black-eyed powder containing 67.5 mg of isoflavones and were monitored in week – 0 and week – 12 after treatment. Lipid profile of black-eyed pea diet and placebo in 12 weeks monitoring showed no significant value. After 12 weeks of treatment, total cholesterol and triglyceride were higher than before treatment. Results: Interestingly, the black-eyed pea diet increased the HDL and lowered the LDL after 12 weeks of treatment. Conclusion: This study concluded that black-eyed pea improved lipid profile, especially in elevating HDL level and decreasing LDL level in 12 weeks consumption.

Phaleria macrocarpa Flavonoid as a Potent MMP-1 Inhibitor for Endometriosis Therapy: In silico Study Maharani; Sutrisno
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Introduction: Endometriosis is a gynaecological disorder in women and causes infertility. Several therapeutic were developed to reduce endometriosis cases, one of them was matrix metalloproteinase (MMP) inhibitor. This study investigated the potential activity of the flavonoids in Phaleria macrocarpa fruit as MMP1 inhibitors for endometriosis. Methods: In silico modelling was used in this study. Six flavonoid structures were retrieved from PubChem NCBI database. A targeted protein, MMP1 was taken out from Protein Data Bank with ID 1CGE and predicted the active sites. Six flavonoids and MMP1 was interacted by molecular docking using Molegro virtual Docker version 5 and analyzed using PyMol 2.2 and Discovery Studio version 21.1.1. Three-dimensional complex structure of flavonoids – MMP1 showed interaction in the same active sites and performed an amino acid residue Glu219 as catalytic site. Results: Six flavonoids of Phaleria macrocarpa were divided into two patterns and generated varied binding energy. Glycitin and Catechin 7-O-beta-D-xyloside showed low score of binding energy and depicted similar structure with four aromatic rings. 8-Prenylnaringenin performed lower binding energy than naringenin, eriodictyol, and 5-O-methylgenistein. Conclusion: In silico analysis suggested that six flavonoids compounds is potent as MMP1 inhibitor and might be interfered endometriosis pathophysiology. In vivo and in vivo investigations are required for further analysis.

The Analysis Of Factors Related To The Prevalence Of Chronic Energy Deficiency (Ced) In Pregnant Women Maya Yunita; Yulia Fitri; Maharani Maharani
JKM (Jurnal Kebidanan Malahayati) Vol 9, No 1 (2023): Volume 9 No.1 Januari 2023
Publisher : Program Studi Kebidanan Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v9i1.8965

Latar Belakang: Angka kematian ibu Indonesia Tahun 2018 menunjukkan bahwa AKI adalah sebesar 305 kematian ibu per 100.000 kelahiran hidup. Ibu meninggal akibat komplikasi yang terjadi dari buruknya status gizi ibu dan pada akhirnya berdampak kepada kondisi kesehatannya begitu juga dengan kondisi janin yang dilahirkan. Prevalensi KEK wanita hamil usia subur (15-49 tahun) di indonesia adalah sebesar 17.3%.Tujuan Penelitian: Untuk melakukan review pada beberapa literature terkait faktor-faktor yang berhubungan dengan Kejadian Kekurangan Energi Kronik (KEK) pada Ibu Hamil.Metode Penelitian: Penelitian ini menggunakan metode literature review. Artikel dikumpulkan dengan melakukan penelusuran/ pencarian jurnal menggunakan Google Search atau bibliografi dari artikel yang ditelusur dan google scholarly. Literature review ini menggunakan literature terbitan tahun 2016-2019 yang dapat diakses fulltext dalam format pdf.Hasil literature review: Hasil penelitian menunjukkan bahwa Ada hubungan yang signifikan antara umur, ada hubungan pendapatan keluarga, ada hubungan pengetahuan, ada hubungan pendidikan, dan ada hubungan paritas dengan kejadian KEK pada ibu hamil.Kesimpulan dan Saran: Penelitian diatas menunjukkan adanya hubungan antara umur, pendapatan keluarga, pengetahuan, pendidikan, dan ada hubungan paritas dengan kejadian KEK pada ibu hamil.Saran diharapkan kepada lahan penelitian, penelitian ini dapat menjadi bahan masukan dalam mengambil kebijakan dalam mengatasi kejadian kekurangan energi kronik (KEK) pada ibu hamil. Kata kunci: Ibu hamil KEK, Umur, Pendapatan Keluarga, Pengetahuan, Pendidikan, Paritas. ABSTRACT Background: Indonesia's maternal mortality rate in 2018 shows that the MMR is 305 maternal deaths per 100,000 live births. The high maternal mortality rate is due to complications that occur from the poor nutritional status of the woman and ultimately impact her health condition as well as the condition of the fetus being born. The prevalence of pregnant women with CED of childbearing age (15-49 years) in Indonesia is 17.3%.Objectives: To review some literature related to factors associated with the prevalence of Chronic Energy Deficiency (CED) in Pregnant Women.Research Methods: This study uses the literature review method. Articles are collected by conducting a journal search using Google Search or a bibliography of the articles searched with Google Scholar. This literature review uses literature published in 2016-2019, which can be accessed in full-text in pdf format.Results: The results of the study show that there is a significant relationship between age, family income, knowledge, education, and parity with the incidence of CED in pregnant women.Conclusions: The above research shows a relationship between age, family income, knowledge, and education, and there is a relationship between parity and the incidence of CED in pregnant women.Suggestion The research field is expected to be used as input for policymaking in overcoming the incidence of chronic energy deficiency (CED) in pregnant women. Keywords: Chronic Energy Deficiency (CED); Pregnant women; Factors related to CED

Literature Review: The Effect Of Giving Purple Sweet Potato On Haemoglobin (Hb) Levels Maharani Maharani; Ardina Rezky Noeraini
JKM (Jurnal Kebidanan Malahayati) Vol 9, No 2 (2023): Volume 9 No.2 April 2023
Publisher : Program Studi Kebidanan Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v9i2.9407

Latar Belakang: Angka kejadian anemia pada ibu hamil sekitar 38,2 juta jiwa di dunia, sedangkan di Asia tenggara terdapat 11,5 juta ibu hamil yang mengalami anemia. Prevalensi anemia pada ibu hamil di Indonesia mengalami peningkatan yaitu pada tahun 2013 sebanyak 37,1% meningkat menjadi 48,9% pada tahun 2018. Untuk menangani kejadian anemia saat hamil, ibu dapat mengkonsumsi makanan yang mengandung zat besi salah satunya ubi jalar ungu, setiap 100 gr mengandung 0,7 mg zat besi.Tujuan: Untuk melakukan review pada beberapa literatur terkait pengaruh ubi jalar terhadap perubahan kadar Haemoglobin (Hb) pada ibu hamil dengan Anemia.Metode: Penelitian ini menggunakan studi literature review yang mengkaji pengaruh ubi jalar terhadap kadar Hb. Penelitian ini menggunakan data sekunder berupa artikel sebanyak empat artikel yang kemudian direview. Pengumpulan data menggunakan metode dokumentasi. Sumber Jurnal yang digunakan diperoleh dari Google Scholar dan Blossom Journal of Midwifery. Analisis data dilakukan dengan tiga tahap, yaitu kompilasi, analisis dan simpulan yang sesuai dengan rumusan dalam penelitian ini.Hasil: Hasil penelitian menunjukkan bahwa tiga artikel signifikan menunjukkan ubi jalar berpengaruh terhadap kadar Hb dan satu artikel pada ibu dengan menggunakkan air rebusan daun ubi jalar.Kesimpulan: Empat artikel yang direview, tiga diantaranya menunjukkan perubahan yang signifikan terhadap kadar Hb setelah di intervensi dengan ubi jalar.Saran: Peneliti berharap agar ibu hamil bisa memanfaatkan manfaat ubi jalar untuk memperbaiki kadar Hb terutama bagi ibu hamil dengan anemia. Kata kunci: Anemia, Kadar Hb,Ubi Jalar ABSTRACT Background: Anemia in pregnant women affects approximately 38.2 million women worldwide, with 11.5 million pregnant women suffering from anemia in Southeast Asia. The prevalence of anemia in pregnant women in Indonesia has increased from 37.1% in 2013 to 48.9% in 2018. To deal with the incidence of anemia during pregnancy, mothers can consume foods that contain iron, one of which is purple sweet potato, in which every 100 grams contains 0.7 mg of iron.Purpose: To review some of the literature related to the effect of sweet potatoes on changes in hemoglobin (Hb) levels in pregnant women with anemia.Methods: This study used a literature review to examine the effect of sweet potatoes on Hb levels. This study uses secondary data in the form of four articles, which are then reviewed. Data collection uses the documentation method. Journal sources used were obtained from Google Scholar and the Blossom Journal of Midwifery. Data analysis was carried out in three stages, namely compilation, analysis, and conclusions according to the formulation in this research.Results: The result showed that three significant articles showed that sweet potatoes had an effect on Hb levels, and one article focused on mothers using sweet potato leaf-boiled water.Conclusion: Conclusion in this study four articles were reviewed, three of which showed significant changes in Hb levels after intervention with sweet potatoes.Suggestions: Researchers hope that pregnant women can take advantage of the benefits of sweet potatoes to improve Hb levels, especially for pregnant women with anemia. Keyword: Anemia, Haemoglobin Levels, Sweet Potato

Literature review: Peran bidan terhadap keberhasilan pemberian ASI Eksklusif Maharani Maharani; Rizzatul Khumairoh
Jurnal SAGO Gizi dan Kesehatan Vol 4, No 2 (2023): Juni
Publisher : Politeknik Kesehatan Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v4i2.1106

Background: exclusive breastfeeding in Aceh in 2021 (66.66%) has increased compared to 2020 (65.43%), but there has not been a significant increase. Efforts are needed to increase exclusive breastfeeding. Exclusive breastfeeding is one way of good growth and development. In addition, midwives play an important role in the success of exclusive breastfeeding. Midwives are responsible for exclusive breastfeeding education and care for breastfeeding mothers during pregnancy, starting from the first breastfeeding to breastfeeding mothers. Midwife support can also give mothers the confidence to continue giving exclusive breastfeeding to their babies.Objectives: to review several journals about the role of midwives in the success of exclusive breastfeeding.Methods: this research is a descriptive analysis. This research in literature review held ini may-june 2021. The keywords used are the role of the midwife and exclusive breastfeeding. Literature sources were obtained from the Google Scholar, Science Direct, and Pubmed publication databases with the last five years limitation A total of 224 articles were obtained with these keywords, then were selected in stages according to predetermined criteria. Retrieved 10 articles published in 2015-2020. The articles obtained were compiled, analyzed, and concluded by looking for similarities, dissimilarities, giving views, comparing and summarizing.Results: literature studies show that there is a relationship between the role of the midwife and the success of exclusive breastfeeding. Providing education, information and assessment about exclusive breastfeeding is the responsibility of midwives to mothers starting from the period of pregnancy, the beginning of breastfeeding until the baby is 6 months old.Conclusion: the midwife has a role in the success of exclusive breastfeeding

Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice Siskanita Fitriana; Sri Andarini; Sutrisno Sutrisno; Gita Nawangtantrini; Maharani Maharani
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.109

Introduction : Herbal medications are increasingly being used to treat a wide range of illnesses. Phaleria macrocarpa, often known as the crown of the gods, is a plant rich in flavonoids that is frequently used in herbal therapy. The goal of this study was to see what effect a flavonoid-rich extract from phaleria macrocarpa has on the livers of mice. Material and Methode : This study used adult female mice aged 6-8 weeks and weighing 20-30 gr as experimental animals, which were divided into four groups: the control group was given distilled water, group 2 was given a flavonoid dose of 500 mg/kg/day, group 3 was given a flavonoid dose of 1000 mg/kg/day, and group 4 was given a flavonoid dose of 2000 mg/kg/day. The flavonoid-rich extract of Phaleria macrocarpa was administered for 28 days. On the 29th day, the mice were necropsied, followed by surgery and examination of the mice's livers. Result : The flavonoid-rich extract of phaleria macrocarpa at a dose of 500 mg/kg body weight/day resulted in no changes in the weight or histological structure of the liver (p>0.05). Hydropic degeneration and necrosis were observed in the group administered the flavonoid-rich extract of phaleria macrocarpa at doses of 1000 and 2000 mg/kg body weight/day. Conclusion : The administration of a flavonoid-rich extract from Phaleria macrocarpa at a level of 500 mg/kg body weight/day caused no harm in the liver of mice. The use of more than 500 mg/kg body weight/day over an extended period of time has hazardous effects and is not recommended.

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