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All Journal AcTion: Aceh Nutrition Journal JKM (Jurnal Kebidanan Malahayati) Journal SAGO Gizi dan Kesehatan Asian Journal of Health Research Asian Journal of Fertility, Endocrinology, and Reproduction
Maharani Maharani
Jurusan Kebidanan Poltekkes Kemenkes Aceh
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Comparison of the Effects of Dienogest and Leuprolide Acetat on Serum Interferon (IFN-Æ”) Levels in a Mouse Model of Endometriosis (Mus musculus) Maria Antonia Barbara Batu Mali; Siskanita Nur Fitriana; Sutrisno Sutrisno; Husnul Khotimah; I Wayan Arsana Wiyasa; I Wayan Agung Indrawan; Maharani Maharani
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.111

Abstract

Introduction: Endometriosis is a medical condition in which there is abnormal growth of tissue resembling the endometrium outside the uterus. It can cause symptoms of pain and/or infertility. The current medical therapy focuses on reducing estradiol levels or stimulating progesterone response. One of the most effective options for medical treatment is the use of GnRH analogs. Dienogest have a direct anti-inflammatory effect on endometriotic stromal cells. However, a comparison of the anti-inflammatory effects of these drugs on IFN-Æ” has not been previously investigated. Therefore, this study aims to compare the effects of reducing IFN-Æ” by both Dienogest and Leuprolide Acetat in a mouse model. Material and Methods: This study employed a post-test only control group design and involved 4 groups, namely the negative control group, positive control group, and two treatment groups: one group administered Dienogest at a dosage of 0.0052 milligrams per day for 14 days, and the other administered Leuprolide Acetat at a dosage of 0.00975 milligrams once every 5 days for a period of 14 days. Serum IFN-Æ” levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). The data were subsequently analyzed using IBM SPSS 25 with One-Way ANOVA test. Results: This study demonstrated that Leuprolide Acetat significantly decreased serum levels of IFN-Æ”, whereas Dienogest actually increased the levels . Conclusion: In a mouse model of endometriosis (Mus musculus), Leuprolide Acetat effectively reduced the levels of IFN-Æ” (pro-inflammatory). Conversely, Dienogest increased the levels of IFN-Æ” (anti-inflammatory) in the mouse model of endometriosis.
Postpartum Depression and Breastfeeding Success among Postpartum Mothers: A Systematic Review Maharani
Asian Journal of Health Research Vol. 5 No. 1 (2026): Volume 5 No 1 (April) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i1.345

Abstract

Introduction: Postpartum depression is a frequent maternal mental health concern that can disrupt confidence, responsiveness, and daily care during the early postpartum period. Breastfeeding success is not limited to exclusive breastfeeding, but also includes early initiation, continuation, maternal satisfaction, and breastfeeding self-efficacy. This systematic literature review synthesized recent evidence on the relationship between postpartum depression and breastfeeding success among postpartum mothers.    Methods: A PRISMA-guided review was conducted using Scopus as the target database. The search combined terms for postpartum depression, postnatal depression, maternal depression, breastfeeding, exclusive breastfeeding, lactation, breastfeeding self-efficacy, mother, maternal, and postpartum. English language open-access articles published from 2020 to 2026 were screened. Forty-five studies met the eligibility criteria and were synthesized narratively.     Results: The evidence consistently indicated that postpartum depressive symptoms were associated with lower exclusive breastfeeding, early cessation, reduced breastfeeding self-efficacy, and more negative breastfeeding experiences. Longitudinal, cross-sectional, review, and intervention studies also showed that social support, maternal stress, breastfeeding pressure, prenatal planning, and midwife-led support shaped this association.    Conclusion: Postpartum depression and breastfeeding success should be addressed as integrated maternal outcomes. Midwifery practice needs routine psychological screening, lactation counseling, partner involvement, and non-judgmental support for mothers who breastfeed, combine feeding, or discontinue breastfeeding. 
Effectiveness of the SIMPOL Web-Based Educational Intervention for Village Midwives in Improving Polio Immunization Coverage: A Quasi-Experimental Study Ita Susanti; Erlia Rosita; Maharani Maharani
Asian Journal of Health Research Vol. 5 No. 2 (2026): Volume 5 No 2 (August) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i2.360

Abstract

Introduction: Polio is a disease caused by the enterovirus (poliovirus) that attacks the brain's nervous system, causing paralysis in children. Although Indonesia has been a polio-free country since 2014, vigilance against the re-emergence of polio virus cases must still be increased by increasing polio immunization coverage. The use of website-based SIMPOL (Polio Immunization Education) media is one of the best alternatives for village midwives in delivering counseling. This greatly assists the government's program in increasing polio immunization coverage. Website-based media has the ability to disseminate information quickly, practically, and easily accessed, making it easier for village midwives to deliver counseling. Thus, the website-based counseling process is believed to increase public awareness to immunize their children. The purpose of this study is to evaluate the effectiveness of the SIMPOL Web-Based Educational Intervention for Village Midwives in Improving Polio Immunization Coverage. Material and Methods: This study employs a quasi-experimental design with a one-group pretest-posttest approach. Results: The mean village-level complete polio immunization coverage increased from 31.05% at baseline to 70.82% following implementation of the SIMPOL web-based educational intervention. This represented a statistically significant increase of 39.78 percentage points (95% CI: 37.58–41.97; t(23) = 37.44, p < 0.001). Conclusion: The SIMPOL web-based educational intervention was associated with a significant improvement in complete polio immunization coverage. Integrating SIMPOL into routine health education delivered by village midwives may strengthen polio immunization programs in primary healthcare settings.
Flavonoids Extract of Phaleria macrocarpa Fruit Extract Ameliorated Inflammation Markers In Endometriosis Mice Models Sutrisno Sutrisno; Maharani Maharani; Gema Alya Salsabila; Ani Khoirinda; Leni Ria Ariana; Ana Paramita Prastiwi; Maria Antonia Barbara Batu Mali
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.38

Abstract

Introduction: Endometriosis is an abnormal endometriosis growth in the outside of uterus, which performed pelvic pain and high inflammatory markers. This study investigated the potential endometriosis therapeutic agents of flavonoid compounds from P. macrocarpa in decreasing IGF-1, IL-33, IL-2, IL-10, IFN-Ɣ, and MUC1 levels in the endometriosis mice model. Methods: Forty female mice, weight 20 – 30 grams, 6 – 8 weeks old, were classified into 8 groups (Normal, Endometriosis (EM), EM +3.75; EM + 7.5; EM +11.25; EM + 15; EM + DNG; and EM + LA). Endometriosis mice models were induced by injecting cyclosporin, followed by adenomyosis tissue that was injected intramuscularly and ethynyl estradiol. Endometriosis mice were treated as group as for 14 days. The peritoneal fluid of all animal models was collected and analyzed by using ELISA. Result: Administrated of PME 7.5 mg/mice/day for 14 days increase IL-10. The PME decreased IL-2 significantly and improved the IL-2 levels as well as normal mice. PME also reduced IL17A, IGF1, IL-33 and lowered IL-4, IFN y, and Mucin1 levels. Conclusion: Phaleria macrocarpa fruit extract altered inflammation marker protein of endometriosis mice model for 14 days and potentially for endometriosis therapeutic agents.
5-O-methyl genistein of Phaleria macrocarpa Revealed a Potential Therapeutic Compound for Endometriosis Sutrisno; Maharani Maharani
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.39

Abstract

Introduction: Endometriosis is a gynecological disease characterized by pelvic pain and high inflammation in women. Phaleria macrocarpa fruit contains six flavonoids involved Eriodictyol, Glycitin, 5-O-methylgenistein, Catechin 7-O-beta-D-xyloside, 8-Prenylnaringenin, and Naringenin. In vivo experiment performed that flavonoid from Phaleria macrocarpa fruit potential as therapeutic agents for endometriosis. However, the mechanism of flavonoids from Phaleria macrocarpa was limited information. This study performed the endometriosis therapeutic mechanism of flavonoids from Phaleria macrocarpa through molecular docking. Methods In silico experiment was carried out of this study, canonical SMILES of six identified flavonoids from Phaleria macrocarpa were predicted the anti-inflammatory, antineoplastic, and antioxidant properties. Then, the highest biological properties was redocked with AKT, COX-2, AHR, and ESR by using Molegro Virtual Docker version 5.0. Result: According to the bioactivity prediction, six flavonoids of Phaleria macrocarpa performed antiinflammatory property ranged 0.599 – 0.751, low anti-inflammatory intestinal NSAID agent, and antineoplastic (uterine, cervical, and ovarian cancers). 5-O-methylgenistein showed highest breast cancer – resistant protein inhibitor. Molecular docking performed interaction of 5-O-methylgenistein and inhibited COX-2, AHR, ESR, and AKT. 5-O-methylgenistein induced apoptosis by caspase – 3 interactions. A proposed mechanism of 5-O-methylgenistein in endometriosis was reducing pain, inducing apoptosis, preventing cancer cell initiation, inhibiting proliferation and oncogenic cell. Conclusion: 5-O-Methylgenistein performed a promising plant constituent for endometriosis therapy.
Co-Authors Ana Paramita Prastiwi Ani Khoirinda Ardina Rezky Noeraini Diah Fitrianti Endang Sriwahyuni Erlia Rosita Gema Alya Salsabila Gita Nawangtantrini Handi Wiradharma Husnul Khotimah I Wayan Agung Indrawan Ita Susanti Leni Ria Ariana Maria Antonia Barbara Batu Mali Maria Antonia Barbara Batu Mali maya yunita Nina Rini Suprobo Pande Made Dwijasa Rizzatul Khumairoh Siskanita Fitriana Siskanita Nur Fitriana Sri Andarini Sri Wahyuni steven christian susianto Sutrisno Sutrisno Sutrisno Sutrisno Sutrisno Sutrisno Sutrisno Sutrisno Sutrisno Sutrisno Wiyasa, I Wayan Arsana Yulia Fitri