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All Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indonesian Archives of Biomedical Research (InABR)
Safira Raissa Dwi Putri
Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Medication Adherence in Type 2 Diabetes Mellitus Patients with Diabetic Ulcer: Systematic Literature Review: English Safira Raissa Dwi Putri; Sony Wibisono Mudjanarko; Bambang Hermanto
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.293 KB) | DOI: 10.55392/indarcbiores.v1i2.13

Abstract

Background: Patient non-adherence to diabetes medication can worsen the patient's condition and increase the risk of diabetes complications such as diabetic ulcers. A sufficient level of medication adherence can prevent diabetic complications. This study aimed to determine the level of medication adherence of type 2 DM patients with diabetic ulcers. Review: This research uses a systematic literature review with a PRISMA chart as a research design guideline. Researchers searched three databases, namely PubMed, Google Scholar, and ScienceDirect, using predefined keywords. The search resulted in 2,763 literatures then 11 literatures that met the criteria were taken. The number of respondents obtained amounted to 1,082 people. Characteristics of type 2 DM patients with diabetic ulcers: respondents were female, aged under 60 years, had diabetes for more than five years, used oral medication, insulin, or combination, could have normal or excess BMI, and possibly had hypertension or neuropathy. The result from systematic literature review obtained seven pieces of literature that had a low medication adherence level, two pieces of literature showed no correlation between medication adherence and the incidence of diabetic ulcers in type 2 DM patients, and two pieces of literature had a sufficient level of medication adherence. Summary: The level of medication adherence in type 2 DM patients with diabetic ulcers varies. However, more literature contains results in low medication adherence of type 2 Diabetes Mellitus patients with diabetic ulcers, so it needs to be improved in the future. Keywords: diabetic ulcer, medication adherence, type 2 diabetes mellitus
In Silico Analysis Effect of Potential Antidiabetic from Dandang Gendis Extract on Aldose Reductase, Glucokinase, and GSK3β for Type 2 Diabetes Mellitus Safira Raissa Dwi Putri; Irda Bella; Siti Khaerunnisa; Nurlaili Susanti; Arifa Mustika
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42288

Abstract

Introduction: Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Various epidemiological studies have shown a trend of increasing incidence and prevalence of diabetes mellitus in various parts of the world. Therefore, diabetes mellitus is currently a global health threat. Dandang gendis (Clinacanthus nutans) is a widely used plant as a traditional herbal treatment in Indonesia, and it has been proven that the ethanol extract of dandang gendis leaves shows an antidiabetic effect. This research aims to determine the compatibility among the flavonoid compounds in C. nutans with Aldose reductase, glucokinase, and GSK3β target drugs for type 2 diabetes mellitus using in silico method.Methods: 45 compounds were obtained from multiple sources. The screening method used Lipinski’s rule of five and Pyrx until 8 compounds were selected. Avogadro, AutoDock 4.2, and Biovia Discovery Studio 2016 were used for molecular docking and visualization analysis.Results: Molecular docking results demonstrate that the ligand-protein interaction’s binding energy was -7.31 to 35.25 kcal/mol for 1AH3, -7.55 to 0.15 kcal/mol for 1V4S, and -7.99 to -2.85 kcal/mol for 3D0E.Conclusion: We can conclude that flavonoid compounds Apigenin, Vitexin, 3,3-di-O-Methylellagic Acid, and Clinacoside C show a high binding affinity with Aldose Reductase, Glucokinase, and GSK3β proteins and have the potential to be oral antidiabetic drug compounds for Diabetes Mellitus. However, its binding affinity has not been able to exceed that of the native ligand of the protein. Further research is needed to determine the significant efficacy and potential as an antidiabetic.
Co-Authors Arifa Mustika Bambang Hermanto Irda Bella Nurlaili Susanti Siti Khaerunnisa Sony Wibisono