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FRUCTOSE ALTERS THE EXPRESSION OF TYPE B LEPTIN RECEPTOR IN HYPHOTALAMUS AND INTESTINUM OF Rattus Novergicus Rachmawati, Ermin; Kristanti, Risma Aprinda; Susanti, Nurlaili
Journal of Islamic Medicine Vol 2, No 2 (2018): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Background: Several epidemiological dataâ€™s reported significant correlation between fructose consumption and diabetes mellitus type 2 by inducing insulin resistance. Leptin resistance induced by fructose was proposed as one novel mechanism that induce insulin resistance but the exact mechanism remains unclear. Â We hypothesize that fructose diminish the type b leptin receptors in hypothalamus and intestine.Aim: This study was aimed to elucidate fructose effect on the expression of leptin receptor type b in hypothalamus and intestine of Rattus novergicus.Method: twenty eight rats were used and divided into 4 groups: Group 1 was control, group 2 was given fructose 10%, group 3 was given fructose 30% and group 4 was given fructose 55% for 2 months. At the end of treatment, the animal were sacrificed and then the hypothalamus and intestine were collected. The expression of type b leptin receptor were measured by immunohistochemistry technique with primary antibody from Bioss antibodies type Leptin receptor polyclonal antibody bs-0109R using Staining kit Skytec Laboratories and DAB chromogen. A positive expression can be seen as a brown colour in cell cytoplasm and counted in 100 cell. The expression then analysed using SPSS 18 with anova one way tes (p0,05) followed by post hoc test after the data showed normality and homogeneity using Saphiro wilk and Levene test (p0,05).Result: There was significant differences in type b leptin receptors found in hypothalamus between each group (p0.05). The significant differences also could be seen in the expression between control and group fructose 30 and 50% in intestinal cell (p0.05).Conclusion: the consumption of Fructose 55% for 2 months attenuates the expression of type b leptin receptors in hypothalamus and intestine of Rat novergicus.Â

PERAN IBU MENYUSUI YANG BEKERJA DALAM PEMBERIAN ASI EKSKLUSIF BAGI BAYINYA Susanti, Nurlaili
EGALITA EGALITA (Vol 6, No 1
Publisher : Pusat Studi Gender UIN Maulana Malik Ibrahim Malang

Exclusive breastfeeding is defined as an infantâ€™s consumption of human milk without complementary foods for the first six months of life. Breastfeeding has many benefits and advantages for infants. Breast milk suffice infantâ€™s necessary for energy, protein, vitamin and mineral. In addition, breast milk protect infants from susceptibility to infectious disease. Increase vulnerability to nutritional problems in infants recently due to the replacement of breast milk with formula milk in a manner and amount that can not satisfy infantâ€™s need. Many problems were encountered in efforts to provide exclusive breastfeeding, one of which is the number of breastfeeding mothers who must return to work after the leave ends. Therefore, mothers need knowledge and skill to provide exclusively breastfeeding on theirinfants during work.Air Susu Ibu (ASI) Eksklusif adalah pemberian ASI tanpa makanan pendamping sampai bayi berusia 6 bulan. ASI memiliki banyak sekali manfaat dan keunggulan bagi bayi. ASI memenuhi kebutuhan sumber energi, protein, vitamin dan mineral utama bagi bayi. Selain itu, ASI memiliki kandungan yang menjaga bayi dari kerentanan terhadap penyakit infeksi. Meningkatnya masalah kerawanan gizi pada bayi akhir-akhir ini,salah satunya disebabkan penggantian ASI dengan susu formula, dengan cara dan jumlah yang tidak dapat memenuhi kebutuhan bayi. Beberapa kendala yang muncul dalam upaya pemberian ASI eksklusif ini, diantaranya adalah banyaknya ibu menyusui yang harus kembali bekerja setelah masa cutiÂ berakhir. Oleh karena itu, dibutuhkan pengetahuan dan keterampilan bagi ibu agar dapat memberikan ASI eksklusif pada bayi selama ditinggal bekerja.

VAKSINASI LANSIA UPAYA PREVENTIF MENINGKATKAN IMUNITAS AKIBAT PROSES PENUAAN Susanti, Nurlaili
El-Hayah : Jurnal Biologi Vol 4, No 2 (2014): EL-HAYAH (Vol 4, No 2, Maret 2014)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v4i2.2629

Advancement in health sciences and technologies gives positive impact to improve life expectancy, but the other hand it can increases elderly population with all consequences. Old age is associated with high morbidity and mortality due to their susceptibility to suffer several diseases caused by lacking immunity, especially infectious diseases. Moreover, the occurrence of multiple morbidities, such as heart disease and vulnerability to stress, are the main confounding factors that may impact to immune functions of elderly. Aging affects both cellular and humoral responses of the innate and adaptive immune systems and causes decreasing the number of immune cells, their viability, functional capacity and their responses against pathogens that entering the body. Strategies for preventing these diseases would have a clear impact on improving healthy aging. Thus, vaccination strategies for elderly population are needed. Vaccines should be developed to take into consideration the peculiar age-induced variations of immune responsiveness

SUPLEMENTASI TEPUNG PORANG (Amorphophallus muelleri Blume) SEBAGAI Nutraceutical DALAM MANAJEMEN DIABETES MELLITUS TIPE 2 Susanti, Nurlaili
El-Hayah : Jurnal Biologi Vol 5, No 1 (2014): EL-HAYAH (VOL 5, NO 1, September 2014)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v5i1.3035

Diabetes is a group of metabolic diseases characterized by hyperglycemia. Type 2 Diabetes is most commonly type which accounts for 90-95% of those, resulting from defects in insulin secretion and insulin action. Management of type 2 diabetes should combine pharmacological therapy with both diet modification and increasing physical activity. Nutraceutical was known to have important role. A kind of Araceae family, Porang (Amorphophallus muelleri Blume), has a main content of glucomannan. Glucomannan is a water-soluble polysaccharide, high fibers and low calories. Various studies suggest the benefit effects of glucomannan in type 2 diabetes mellitus to improve blood glucose level and lipid profiles. Its mechanism is postulated to be associated with the intrinsic physical effects of soluble fiber in the gastrointestinal tract and fermentation by microflora in the large intestine that trigger production of several gut hormones. Short Chain Fatty Acids, product of fiber fermentation, can improve insulin sensitivity through competition with free fatty acids and increasing expression of GLUT 4 in insulin sensitive tissues. Therefore, glucomannan from Porang has a great potential to be a nutraceutical for the management of type 2 diabetes mellitus.

EFEKTIFITAS KOMPRES DINGIN DAN HANGAT PADA PENATALEKSANAAN DEMAM Nurlaili Susanti
SAINSTIS SAINSTIS (Vol 1, No 1
Publisher : Lembaga Penelitian dan Pengembangan Universitas Islam Negeri Maulana Malik Ibrahim Malang.

Fever is a symptom that accompanies some infectious and non infectious diseases. Fever cause metabolic consequences such as dehydration, increasing oxygen consumption and metabolic rate. Treatment of fever can reduce patient discomfort and another symptoms such as fatigue, myalgia, diaphoresis and chills.In addition to antipyretic, the use of physical methods to reduce fever has been widely applied. Physical methods of cooling are the treatment of choice for hyperthermia, but their value in the treatment of fever remains uncertain. Fever treated with tepid-water sponging and combined with antipyretic drugs are more effectively than those treated with antipyretic drugs alone. Tepid-water sponging represents a simple, nonsedating method to combat the metabolic impact of shivering and to induce cutaneous vasodilatation that increases heat loss.

Aktivitas Antimikroba Ekstrak Rimpang Jeringau (Acorus calamus) Terhadap Pertumbuhan Candida albicans Nurlaili Susanti
Jurnal Biodjati Vol 1, No 1 (2016): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v1i1.1037

Abstrak. Infertilitas adalah ketidakmampuan seorang wanita berusia lebih dari 35 tahun untuk hamil setelah mencoba kurang lebih selama 6 bulan, dengan hubungan seksual yang normal dan tanpa menggunakan kontrasepsi. WHO memperkirakan bahwa 8-12% dari pasangan di seluruh dunia memiliki masalah dalam kehamilan. Baru-baru ini, manajemen infertilitas dengan cara operasi, obat-obatan, dibantu teknologi reproduksi (fertilisasi in-vitro / IVF) selain mahal, tidak selalu berhasil. Saat ini, banyak orang menggunakan herbal dalam pengobatan berbagai penyakit. Madura dikenal sebagai salah satu etnis yang memiliki pengetahuan tentang obat tradisional atau "herbal" terutama yang berkaitan dengan keharmonisan perkawinan. Rimpang Jeringau (Acorus Calamus) adalah salah satu bahan baku "Jamu Subur Kandungan" yang mengatasi masalah infertilitas perempuan. Penelitian ini menguji aktivitas antimikroba Jeringau Rimpang (Acorus Calamus) untuk menghambat pertumbuhan Candida albicans. Hasil penelitian ini diharapkan menjadi dasar untuk standardisasi dan saintification dari "Jamu Subur Kandungan". Uji aktivitas antimikroba dari ekstrak Jeringau Rimpang (Acorus Calamus) menunjukkan penghambatan pertumbuhan Candida albicans dengan Konsentrasi Hambat Minimum (KHM) sebesar 0,5%.Abstrak : Acorus calamus, Antimicrobial activity, Candida albicans Abstract. Infertility is the inability of a woman over 35 years to pregnant after trying for at least 6 months, with normal sexual intercourse and without use birth control. WHO estimates that 8-12% of couples worldwide have problems in pregnancy. Recently, management of infertility with surgery, medicine, assisted reproductive technology (in-vitro fertilization/IVF) in addition to expensive, not always successfully. Currently, many people use herbs in the treatment of various diseases. Madura is known as one of the ethnic that have knowledge of traditional medicine or "herbal" especially related to marital harmony. Rhizome of Jeringau (Acorus Calamus) is one of the raw materials of "Jamu Subur Kandungan" which overcome the problem of female infertility. This study examined the antimicrobial activity of Jeringau Rhizomes (Acorus Calamus) to inhibit the growth of Candida albicans. The results of this study are expected to be the basic for standardization and saintification of "Jamu Subur Kandungan". Antimicrobial activity test of Jeringau Rhizome Extract (Acorus Calamus) showed inhibition of Candida albicans growth with Minimum Inhibitory Concentration (MIC) at 0.5%.Key words : Acorus calamus, Antimicrobial activity, Candida albicans

Exposure of Murattal Al-Quran Audio Enhances Cisplatin Activity on Growth Inhibition and Cell Cycle Modulation on Hela Cells Roihatul Mutiah; Muhammad Ragib Mustofa; Yen Yen Ari Indrawijaya; Abdul Hakim; Rahmi Annisa; Nurlaili Susanti; Ach Nashichuddin; Muhammad Zainuddin
Indonesian Journal of Cancer Chemoprevention Vol 10, No 2 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss2pp71-79

Cancer is a disease characterized by abnormal cell mechanisms. The development of alternative cancer treatments is still needed. One of them is the music therapy. The music therapy uses sound vibrations to improve healing. Al-Quran, the Holy book of muslims, recites with measured recitation produces beautiful tones. Reading and recitating of Al-Quran is an important form of worship for which a Muslim can expect reward and benefit in the Hereafter. Al-Fatihah is one of surahs in Al-Qur'an that is often read by Muslims and used as a prayer for healing. The purpose of this study was to determine the effect of cytotoxic activity and cell cycle modulation on Hela cells with exposure of murattal Al-Quran and cisplatin combination. Audio exposure murattal Al-Fatihah and its combination with cisplatin to HeLa cells were tested using the MTT method assay. Induction of apoptosis and modulation of cell cycle evaluated by flow cytometry method. Treatment used 30 minutes Audio Murattal (AM), Cisplatin 10 µg/mL (Cis), and the combination of AM + Cis caused a decrease in the viability of HeLa cells respectively 80.14%, 69.86%, and 64.32%. The results of flow cytometry explained that in treatment of AM there was inhibition in the G2-M phase and induction of apoptosis in the M5 phase. Whereas in treatment AM + Cis inhibition occurs in the S, G2-M phase, and induction of apoptosis in the M5 phase. Audio Murattal Al-Quran presents cytotoxic effects on HeLa cells and to provide a synergistic impact on cisplatin so that disclosure therapy murattal can be recommended for supporting therapy in the treatment of cancer (supportive therapy).Keywords: Al-Quran, Audio murottal, HeLa Cells, Cell Viability, Flow cytometry

Integrasi Nilai Islam dalam Kurikulum Pendidikan Kedokteran Nurlaili Susanti; Riskiyah Riskiyah
Journal of Islamic Medicine Vol 6, No 1 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i1.15693

Background: Medical education has a strategic role in producing professional doctors who will provide quality health services to the community. A medical education curriculum that integrates Islamic content is needed to strengthen professionalism as a Muslim doctor. Objective: This study examines the implementation of Islamic integration in several Islamic Medical Faculties in Indonesia. Methods: This research is qualitative research with a phenomenological approach. The research subject was taken by purposive sampling. The research subjects are the Faculty of Medicine under the State Islamic Religious College (PTKIN). Data collection techniques were carried out through document studies and interviews. Results: Each Faculty of Medicine has the concept of implementing Islamic integration in medical education with different approaches and ways. Conclusion: The implementation of the integration of Islam in medical science is reflected in curriculum development, learning activities, and assessments Keyword :Medical education, muslim doctor, Islamic value, integration, curriculum.

Efek Diet Tinggi Fruktosa terhadap Profil Lipid Tikus Rattus Rattus norvegicus Strain Wistar Nurlaili Susanti; Ermin Rachmawati; Risma Aprinda Kristanti
Journal of Islamic Medicine Vol 3, No 1 (2019): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Sejak beribu tahun yang lalu, orang mengonsumsi fruktosa dalam jumlah terbatas dari buah-buahan segar dan sayuran. Fruktosa yang terdapat dalam bahan alami ini tidak membahayakan kesehatan. Akan tetapi saat ini, fruktosa banyak digunakan sebagai pemanis oleh industri makanan dan minuman dalam bentuk high fructose corn syrup (HFCS). Fruktosa sangat efisien menginduksi lipogenesis. Penelitian ini dilakukan untuk membuktikan pengaruh konsumsi fruktosa terhadap profil lipid pada hewan coba. Penelitian ini merupakan penelitian eksperimental laboratoris dengan desain postest only controle group. Sampel dibagi dalam 4 kelompok perlakuan dengan masing-masing 6 ekor tikus terdiri dari tikus diet normal (K), tikus diet fruktosa 10% (P1), tikus diet fruktosa 30% (P2), dan tikus diet fruktosa 60% (P3). Fruktosa diberikan secara peroral dengan menggunakan sonde selama 8 minggu. Pada akhir penelitian, dilakukan pengambilan sampel darah untuk pengukuran profil lipid dengan spektrofotometer. Hasil penelitian pada tikus yang diberikan diet fruktosa menunjukkan kadar kolesterol total, LDL, dan trigliserida yang signifikan lebih tinggi dibandingkan kontrol, sedangkan kadar HDL lebih rendah dibandingkan kontrol. Dapat disimpulkan bahwa diet tinggi fruktosa dapat menginduksi terjadinya dislipidemia. Kata Kunci: fruktosa, profil lipid.

Efek Diet Tinggi Fruktosa terhadap Profil Lipid Tikus Rattus Rattus norvegicus Strain Wistar Nurlaili Susanti; Ermin Rachmawati; Risma Aprinda Kristanti
Journal of Islamic Medicine Vol 3, No 2 (2019): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Sejak beribu tahun yang lalu, orang mengonsumsi fruktosa dalam jumlah terbatas dari buah-buahan segar dan sayuran. Fruktosa yang terdapat dalam bahan alami ini tidak membahayakan kesehatan. Akan tetapi saat ini, fruktosa banyak digunakan sebagai pemanis oleh industri makanan dan minuman dalam bentuk high fructose corn syrup (HFCS). Fruktosa sangat efisien menginduksi lipogenesis. Penelitian ini dilakukan untuk membuktikan pengaruh konsumsi fruktosa terhadap profil lipid pada hewan coba. Penelitian ini merupakan penelitian eksperimental laboratoris dengan desain postest only controle group. Sampel dibagi dalam 4 kelompok perlakuan dengan masing-masing 6 ekor tikus terdiri dari tikus diet normal (K), tikus diet fruktosa 10% (P1), tikus diet fruktosa 30% (P2), dan tikus diet fruktosa 60% (P3). Fruktosa diberikan secara peroral dengan menggunakan sonde selama 8 minggu. Pada akhir penelitian, dilakukan pengambilan sampel darah untuk pengukuran profil lipid dengan spektrofotometer. Hasil penelitian pada tikus yang diberikan diet fruktosa menunjukkan kadar kolesterol total, LDL, dan trigliserida yang signifikan lebih tinggi dibandingkan kontrol, sedangkan kadar HDL lebih rendah dibandingkan kontrol. Dapat disimpulkan bahwa diet tinggi fruktosa dapat menginduksi terjadinya dislipidemia. Kata Kunci: fruktosa, profil lipid.

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