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All Journal Proceeding of Mulawarman Pharmaceuticals Conferences Journal of Tropical Pharmacy and Chemistry
Helmi Helmi
Pharmaceuticals Research And Development Laboratory Of Farmaka Tropis, Faculty Of Pharmacy, Universitas Mulawarman, Samarinda 75123, East Kalimantan, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Aktivitas Antioksidan Ekstrak Etanol Daun Kelapa Sawit (Elaeis guineensis Jacq.): Antioxidant Activity of Oil Palm Leaf Ethanol Extract (Elaeis guineensis Jacq.) Masrurotin Zumaro; Hifdzur Rashif Rija’i; Angga Cipta Narsa; Riski Sulistiarini; Helmi Helmi
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.534 KB) | DOI: 10.25026/mpc.v14i1.566

Abstract

Indonesia is a country with abundant natural wealth and almost all types of plants can grow in the territory of this country. One of them is oil palm leaf (Elaeis guineenis Jacq.) containing terpenoid compounds, steroids, alkaloids, flavonoids, glycosides, tannins and saponins and also this plant among the community has benefits that can be used for the treatment of skin infections. Purpose of this study was to determine the yield obtained as well as the antioxidant activity of ethanol extract of oil palm leaves. Oil palm leaves were extracted using 96% ethanol as solvents and using the maceration method. Testing the antioxidant activity of the ethanol extract of oil palm leaves was carried out using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), where the absorbance was measured at max 515 nm using a UV-vis spectrophotometer. The results showed that the yield of oil palm leaf ethanol extract obtained as much as 5.44 % and obtained that the ethanolic extract of oil palm leaves had antioxidant activity against DPPH radicals with an IC50 value of 133.58 ppm. It could be concluded that the ethanolic extract of oil palm leaves (Elaeis guineensis Jacq.) had antioxidant activity in the moderate category because the IC50 value was between 100- 150 ppm.
Optimasi Konsentrasi VCO Terhadap Stabilitas Fisik Facewash dan Uji Antibakteri Ekstrak Daun Kelapa Sawit (Eleais Guineensis Jacq.) pada Bakteri Penyebab Jerawat: Optimization of VCO Concentration on Physical Stability of Facewash and Antibacterial Test of Oil Palm Leaf Extract (Eleais Guineensis Jacq.) on Acne-causing Bacteria Selin Cenora Aritonang; Wisnu Cahyo Prabowo; Angga Cipta Narsa; Riski Sulistiarini; Helmi Helmi
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (354.444 KB) | DOI: 10.25026/mpc.v14i1.586

Abstract

Palm oil leaves (Elaeis guineensis Jacq.) is a waste from oil palm plantations which contain flavonoid, steroid, and alkaloid compounds that function as an antibacterial that causes acne. The purpose of this research was to identify determine the concentration of ethanolic extract of oil palm leaves which is effective in inhibiting acne-causing bacteria and to determine the best formulation that can produce a facewash base that fulfill the requirements for stability of the preparation according to SNI. Antibacterial test of oil palm leaf extract was using the pitting method against acne-causing bacteria. The results of the antibacterial test showed that the extract concentration of 75% had antibacterial activity against the growth of acne-causing bacteria. The facewash base was obtained by varying the VCO with concentrations of 17.5%, 20%, and 22.5%. The results of the evaluation of the facewash base formula for 28 days, namely F2 (20%) produced good characteristics and stability, namely a distinctive aroma, cream color, semi-solid form, pH 6,25 – 6,37, viscosity 0,904 -2,700 Pa.s, high foam stability. 89% - 100% and good homogeneity. The three base formulas have fulfill requirements for facewash according to SNI.
Profil Kadar Malondialdehida, Glukosa dan Kolesterol Pada Tikus Putih yang Terpapar Asap Rokok Lizma Febrina; Helmi Helmi; Laode Rijai
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 4 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i4.115

Abstract

Asap rokok merupakan salah satu sumber radikal bebas eksogen yang dapat melemahkan pertahanan antioksidan sehingga kadar radikal bebas dalam tubuh meningkat. Peningkatan kadar radikal mempercepat kerusakan sel sehingga mengganggu metabolisme di dalam tubuh. Penelitian ini bertujuan untuk mengetahui apakah radikal bebas dari asap rokok dapat mempengaruhi kadar glukosa dan kolesterol pada hewan coba. Tikus wistar jantan dengan berat ±200 gram dipergunakan sebagai hewan coba dan dipaparkan asap rokok sebanyak 1 batang setiap pagi dan sore. Setelah tujuh hari, semua tikus diambil darahnya untuk analisis MDA, glukosa dan kolesterol. MDA dianalisis menggunakan metode TBARS (Thiobarbituric Acid Reactive Substance )yang diukur dengan spektrofotometer UV-Vis pada χ = 531 nm, sedangkan glukosa dan kolesterol diukur menggunakan test strip. Hasil yang didapat kadar MDA meningkat 6x lipat setelah dipaparkan asap rokok, disertai kenaikan glukosa sebanyak 1,5x lipat sementara kolesterol menurun 0,25x lipat dibandingkan sebelum dipaparkan. Kata Kunci : Malondialdehida, glukosa, kolesterol ABSTRACT Cigarette smoke is one of the potential of exogenous free radicals which can weaken antioxidant system so that can increase free radicals levels in the body. The increasing of free radicals can accelerating damage to cells that interfere with the metabolism in the body. This study aimed to determine whether free radicals from cigarette smoke can affect glucose and cholesterol levels in experimental animals. This research used male-2-old-month-rats that have weigth ± 200 grams and exposed to cigarette smoke as much as 1 stick every morning and afternoon for 7 days . The MDA levels was analyzed with Thiobarbituric Acid Reactive Substance (TBARS) method by spectrophotometer UV-Vis in χ =531 nm, whereas glucose and cholesterol were measured using a test strip. The results of MDA increased 6x first level after exposed to cigarette smoke, glucose level increase 1,5x frist level and cholesterol deacrease 0,25x after exposed to cigarette smoke. Keywords: Malondialdehyde glucosa, cholesterol
The Potency of the Genus Uncaria from East Borneo for Herbal Medicine Purposes: A Mini-review Maria Almeida; Supriatno Salam; Agung Rahmadani; Helmi Helmi; Angga Cipta Narsa; Sri Agung Fitri Kusuma; Sriwidodo Sriwidodo
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.457

Abstract

Uncaria is a genus of plants that are widely distributed in the tropics. There are about 5 of the 38 species of this genus growing in the tropical rain forests of East Borneo, Indonesia. For a long time, Uncaria is commonly used as a traditional medicine to treat various diseases by the Dayak tribe in Kalimantan, traditional people believe that Uncaria may be cured cancer, tumors, mioms, and cycts. Based on previous studies, the activity of the genus Uncaria has been widely reported such as cytotoxic, antimicrobial, antioxidant, antidiabetic, and thrombolytic activities. This article aims to summarize the potential of the Uncaria genus, focusing on 5 species from East Borneo, namely Uncaria nervosa, Uncaria longiflora, Uncaria gambir, Uncaria tomentosa and Uncaria cordata. The method used in this article is a literature study by collecting previous research articles related to the Uncaria genus. The results of the literature study show that the Uncaria genus in East Borneo has many secondary metabolites with diverse chemical structures that show good biological potential so that they can be used as broad and promising insights for drug discovery and development. This paper is also expected to provide input for the policy of conservation of medicinal plants in the forests of East Borneo.
Co-Authors Almeida, Maria Angga Cipta Narsa Hifdzur Rashif Rija’i Laode Rijai Lizma Febrina Masrurotin Zumaro Rahmadani, Agung Selin Cenora Aritonang Sri Agung Fitri Kusuma Sriwidodo Sriwidodo Sulistiarini, Riski Supriatno Salam Wisnu Cahyo Prabowo