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All Journal Majalah Obat Tradisional Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Syntax Idea Jurnal Pengabdian Masyarakat (ABDIRA) Proceeding of Mulawarman Pharmaceuticals Conferences AMMA : Jurnal Pengabdian Masyarakat Usadha Journal of Pharmacy Journal of Pharmaceuticals and Natural Sciences Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Al Qodiri: Jurnal Pendidikan, Sosial dan Keagamaan
Hifdzur Rashif Rija’i
Laboratorium Penelitian Dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Isolation and Identification of DPPH Radical (2,2-diphenyl-1-pikrylhidrazyl) Scavenging Active Compound in Ethyl acetat fraction of Piper acre Blume Hifdzur Rashif Rijai; Nanang Fakhrudin; Subagus Wahyuono
Majalah Obat Tradisional Vol 24, No 3 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.48173

Abstract

Piper acre Blume, known as Black Betel (local name), is a plant that is widely used by the people of East Kalimantan, especially in Samarinda, for the treatment of illness. Leaves (3-4 months old) are collected from Samarinda, extracted, fractionated, and monitored by DPPH antiradical activity. The isolation of the Piper acre Blume is performed on the active fraction, and the structure identification is based on spectroscopic data of the compound.  The leaves were dried, pulverized, and macerated with MeOH. Dried MeOH extract was obtained upon evaporation of the solvent. The extract was then fractionated by vacuum liquid chromatography (vlc), eluted gradually by solvents having different polarities (n-hexane, ethyl acetate and methanol). The fractions obtained were monitored using TLC [n-hexane: ethyl acetate (3: 1 v/v)] that was visualized by UV254 nm, UV366 nm and DPPH. The isolation was performed by preparative TLC [SiO2, n-hexane: ethyl acetate (3: 1)] on ethyl acetate fraction that showed the highest DPPH antiradical value. A single compound was obtained, and it appeared as a round spot and pure according to TLC performances at 3 different solvent systems. The isolated Piper acre Blume compound displayed the IC50 value on the anti-radical DPPH (measured at λ 520 nm) as 10.41µg/mL. The IR spectrum (KBr) showed –OH band (3450 cm-1), aliphatic bands [alkene, 3010 cm-1; alkana 2900 cm-1), an aromatic overtone bands (1900-200 cm-1) and a strong C=O band (1725 cm-1). The NMR (1H- and 13C-) (mono and 2D) indicated the present of a p-di-substituted aromatic signals (δ, 7.54 and 7.52, d, J =6 Hz, 1 H each), 2 methyl (δ, 0.96, d, J = 7.0 Hz, 6 Hs), a triplet signal (δ, 4.22 ppm). Other signals of CH- and CH2 were shown as m signals at δ, 1.64 and 1.34 ppm.  Based on those data, the compound was identified as isoamyl p-OH benzoate that is grouped as parabens used as a preservative in the pharmaceutical preparations. In conclusion, the anti-radical (DPPH) active compound present in the leaves of Piper acre Blume is identified as isoamyl p-OH benzoate, having IC50 value anti-radical DPPH 10,41µg/mL.
Uji Kualitatif Aktivitas Radikal Bebas DPPH dari Daun Penggugut (Knema pallens W.J.deWilde): Qualitative Test of DPPH Radical Scavenging Activity from Penggugut Leaves (Knema pallens W.J.deWilde) Annisa Anugrah Putri; Hifdzur Rashif Rija’i; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.916 KB) | DOI: 10.25026/mpc.v14i1.544

Abstract

Penggugut (Knema pallens W.J. deWilde) is an endemic plant from Kalimantan belongs to Myristicaceae or the nutmeg family. Penggugut can be found in habitats like lowland forest, sandy forests and mangroves. The efficacy and activity of penggugut especially the leaves, have not been widely known or studied. So that make the purpose was to know about the percentage yield of extract and fraction from penggugut leaves and to know the activity of Radical Scavenging DPPH from penggugut leaves. The methods used include extraction, liquid-liquid fractination and TLC by spraying DPPH. The results there are percentage of yield : methanol extract is 8,04%, n-hexane fraction is 28,9%, ethyl acetate fraction is 7,83% and n-butanol fraction is 9,8%. In the qualitative test, it was found that the spots have activity of Radical Scavenging were marked with yellow spots on a purple background, there are in the methanol extract have 4 spots with Rf values (0,07; 0,14; 0,29; 0,43), the n-hexane fraction have 3 spots with Rf values ??(0,1; 0,21; 0,43), the ethyl acetate fraction have 5 spots with Rf values ??(0,07; 0,17; 0,29; 0,43; 0,53) and the n-butanol fraction did not get any spots.
Aktivitas Antioksidan Ekstrak Etanol Daun Kelapa Sawit (Elaeis guineensis Jacq.): Antioxidant Activity of Oil Palm Leaf Ethanol Extract (Elaeis guineensis Jacq.) Masrurotin Zumaro; Hifdzur Rashif Rija’i; Angga Cipta Narsa; Riski Sulistiarini; Helmi Helmi
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.534 KB) | DOI: 10.25026/mpc.v14i1.566

Abstract

Indonesia is a country with abundant natural wealth and almost all types of plants can grow in the territory of this country. One of them is oil palm leaf (Elaeis guineenis Jacq.) containing terpenoid compounds, steroids, alkaloids, flavonoids, glycosides, tannins and saponins and also this plant among the community has benefits that can be used for the treatment of skin infections. Purpose of this study was to determine the yield obtained as well as the antioxidant activity of ethanol extract of oil palm leaves. Oil palm leaves were extracted using 96% ethanol as solvents and using the maceration method. Testing the antioxidant activity of the ethanol extract of oil palm leaves was carried out using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), where the absorbance was measured at max 515 nm using a UV-vis spectrophotometer. The results showed that the yield of oil palm leaf ethanol extract obtained as much as 5.44 % and obtained that the ethanolic extract of oil palm leaves had antioxidant activity against DPPH radicals with an IC50 value of 133.58 ppm. It could be concluded that the ethanolic extract of oil palm leaves (Elaeis guineensis Jacq.) had antioxidant activity in the moderate category because the IC50 value was between 100- 150 ppm.
Kajian Efektivitas Pengobatan pada Pasien Stroke Iskemik di Instalasi Rawat Inap RSUD Nunukan: Study of Treatment Effectiveness in Ischemic Stroke Inpatients Instalation Nunukan Hospital Rida Wahda Maulida Tahir; Hifdzur Rashif Rija’i; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.211 KB) | DOI: 10.25026/mpc.v14i1.581

Abstract

Ischemic stroke occurs due to obstruction of the blood vessels that supply the brain. Obstruction occurs due to increased fat lining the blood vessels or atherosclerosis. Atherosclerosis will cause cerebral thrombosis and cerebral embolism. This study aims to examine effectiveness of the use of drugs in ischemic stroke patients hospitalization at Nunukan Hospital. This study is a non-experimental study with a descriptive analysis design using medical record data collected retrospectively and the number of samples in this study was 70 patients. The sample selection of this research was using purposive sampling technique. The results showed tthe highest characteristics of ischemic stroke patients by gender were male (54.29%), based on age group 45-65 years (64.29%), based on diagnoses with comorbidities (64.70%), and the length of treatment the most occurred in 5-10 days (72.55%). The most used drugs single therapy for ischemic stroke are antiplatelet drugs, namely aspirin (28.57%) and the most used combination therapy is piracetam and citicoline (50%). The most frequent drug interactions were aspirin and clopidogrel (48.57%). While the accuracy of drug use includes the right indication (100%), the right drug (94.29%), the right dose (97.14%), and the right frequency (97.14%). Thus, it was concluded that the treatment of ischemic stroke at the inpatient installation the Nunukan General Hospital was effective.
Uji Aktivitas Penghambatan Radikal Bebas DPPH dari Ekstrak Etil Asetat Batang Penara (Myristica Iners Blume.): DPPH Free Radical Scavenging Activity Test Of Ethyl acetate Extract of Stem Penara (Myristica iners Blume.) Faizah Hanan Lestari; Hifdzur Rashif Rija’i; Herman Herman
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.619

Abstract

Optimalisasi Induksi Hiperglikemik pada Zebrafish dan Skrining Fitokimia Infusa Daun Salam (Syzygium polyanthum) dengan Buah Belimbing Wuluh (Averrhoa bilimbi) sebagai Antidiebetes: Optimization of Hyperglycemic Induction in Zebrafish and Phytochemical Screening of Bay Leaf (Syzygium polyanthum) with Starfruit (Averrhoa bilimbi) as Antidiebetic Yusri Yusri; Riski Sulistiarini; Hifdzur Rashif Rija’i
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.644

Abstract

Skrining Fitokimia dan Profil KLT Antioksidan Ekstrak Metanol dan Ekstrak Partisi N-Heksana Akar Bajakah (Uncaria nervosa Elmer): Phytochemical Screening and Antioxidant TLC Profile and Methanol Extracts And N-Hexana Partition Extracts Root Bajakah (Uncaria nervosa Elmer) Elisabeth James Randan; Hifdzur Rashif Rija’i; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 17 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v17i1.682

Abstract

Tumbuhan Bajakah dengan nama ilmiah Uncaria nervosa Elmer merupakan salah satu tumbuhan yang berasal dari pulau Kalimantan, dan digunakan oleh masyarakat Dayak sebagai obat tradisonal. Telah dilakukan berbagai penelitian yang menyajikan infomasi aktivitas tumbuhan akar bajakah dapat mengobati berbagai penyakit degeneratif. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder yang terkandung pada ekstrak metanol dan ekstrak partisi n-heksan akar Bajakah melalui skrining fitokimia dan profil KLT. Ekstraksi dilakukan menggunakan metanol dengan cara maserasi dan nilai rendemen sebesar 1,64%. Kemudian dilakukan partisi cair-cair dengan pelarut n-heksan dan nilai rendemen sebesar 12,5%. Dilakukan skrining fitokimia dan profil KLT golongan metabolit sekunder pada ekstrak metanol ialah alkaloid, fenol, terpenoid, flavonoid, dan saponin dan ekstrak partisi n-heksan ialah Terpenoid. Kemudian dilakukan uji kualitatif antioksidan dengan metode DPPH ekstrak metanol dan ekstrak partisi n-heksan memiliki aktivitas antioksidan yang ditandai dengan 4 noda berwarna kuning dengan nilai RF 0,4; 0,6; 0,8 dan 0,96 pada plat KLT yang disemprotkan DPPH.
Optimasi Basis Sediaan Masker Gel Peel off dan Skrining Fitokimia Ekstrak Etanol Bunga Telang (Clitoria ternatea L.): Optimization of Gel Mask Preparation Base Peel off and Phytochemical Screening of Telang Flower Ethanol Extract (Clitoria ternatea L.) Nor Sinta Hidayati; Hifdzur Rashif Rija’i; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 17 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v17i1.684

Abstract

Bunga telang (Clitoria ternatea L.) merupakan tumbuhan merambat yang masuk ke dalam suku Febaceae. Masker gel peel off adalah sediaan kosmetik berbentuk gel yang dioleskan pada kulit wajah dan dibiarkan hingga mengering. Tujuan penelitian ini adalah untuk mengetahui formula optimum dari basis masker gel peel off dan metabolit sekunder yang terkandung dalam ekstrak etanol bunga telang. Metode penelitian ini menggunakan metode kualitatif dan eksperimental laboratorium. Optimasi basis masker gel peel off dilakukan dengan membuat variasi konsentrasi PVA yaitu 10%, 12,5% dan 15%. Hasil penelitian menunjukan bahwa formula dengan konsentrasi PVA 12,5% memenuhi kriteria sediaan yang optimum dengan hasil evaluasi organoleptik berwarna bening, tekstur kental dengan aroma yang khas, pH sediaan 5,43. Uji homogenitas menunjukan bahwa sediaan homogen dengan viskositas 20,930 Pa.s, daya lekat 6,334 cm, waktu kering 22 menit, dan uji sineresis menunjukan tidak adanya lapisan air pada permukaan sediaan. Hasil skrining fitokimia menunjukan ekstrak etanol bunga telang positif mengandung senyawa alkaloid, flavonoid, tannin, terpenoid, saponin, steroid dan antosianin.
Upaya Preventif Hipertensi Dan Hiperkolesterolemia Melalui Penyuluhan Gizi-Farmasi Dan Pembuatan Empon-Empon Di Desa Argo Mulyo Fahrul Rozi; Putri Anggraeni; Laode Rijai; Hifdzur Rashif Rijai; Venna Shintary
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 9 : Oktober (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension and hypercholesterolemia are diseases whose prevalence is still relatively high in Indonesia. One of the provinces with the highest incidence of hypertension and hypercholesterolemia in Indonesia is East Kalimantan. Treatment and prevention of hypertension and hypercholesterolemia can be done modernly or traditionally. However, traditional treatment is considered cheaper and safer to use. One of the traditional efforts to prevent hypertension and hypercholesterolemia can be done by using family medicinal plants (TOGA). In order to be effective and efficient, prevention of hypertension and hypercholesterolemia must be equipped with sufficient knowledge. One source of knowledge is obtained from education about hypertension and hypercholesterolemia. Counseling is one part of community service activities. Therefore, this activity was carried out with the aim of increasing public awareness of hypertension and hypercholesterolemia, so that people can carry out treatment and prevention by utilizing potential plants around the house independently. This activity involved 40 people from Argo Mulyo Village, Sepaku District, North Penajam Paser Regency, East Kalimantan Province. The results of this activity show that the community has increased knowledge related to hypertension and hypercholesterolemia as indicated by higher posttest results compared to the pretest. The community was also very enthusiastic and responded well during the counseling and demonstration on making empon (herbal drink).
Pembuatan Teh Celup Kombinasi Daun Jambu Biji (Psidium Guajava) dan Daun Sirsak (Annona Muricata L.) Sebagai Antioksidan Salsabila Jat Dwiningrum; Hajrah Hajrah; Hifdzur Rashif Rijai
Syntax Idea 2618-2837
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/syntax-idea.v6i6.3455

Abstract

Antioksidan merupakan suatu senyawa yang dapat menangkap radikal bebas dengan cara reaksi oksidasi dihambat lajunya yang berfungsi untuk memberi perlindungan endogen Penelitian ini bertujuan untuk mengetahui karakteristik sediaan teh celup kombinasi daun jambu biji dan daun sirsak, dan mengetahui aktivitas antioksidan pada sediaan teh celup daun daun jambu biji, sediaan teh celup sirsak, dan sediaan kombinasi teh celup daun jambu biji dan daun sirsak. Data kadar air pada daun jambu biji 7,196% dan pada daun sirsak 7,043%. Data kadar abu total daun jambu biji 5,733% dan daun sirsak 5,933%. Data kadar abu larut dalam air didapatkan daun jambu biji sebesar 3,513% dan daun sirsak sebesar 2,842%. Data kadar abu tidak larut asam didapatkan daun jambu biji sebesar 0,43% dan daun sirsak 0,44%. Data uji pH pada seduhan teh formula 1:3 didapatkan pH 6,55; seduhan teh formula 1:1 didapatkan pH 6,21; seduhan teh formula 3:1 didapatkan pH 6,25. Hasil penelitian yang telah dilakukan didapatkan aktivitas antioksidan sediaan teh celup daun jambu biji sebesar 41,877 ppm, sediaan teh celup daun sirsak sebesar 48,759 ppm, sediaan teh celup kombinasi daun jambu biji dan daun sirsak pada perbandingan 1:3, 1:1, dan 3:1 berturut yaitu sebesar 27,214 ppm; 26,914 ppm; 23,536 ppm. Hal ini menunjukkan bahwa sediaan teh celup kombinasi daun jambu biji dan daun sirsak mempunyai aktivitas antioksidan yang sangat kuat
Co-Authors A. Yuki Angraini Putri Nabila Almeida, Maria Angga Cipta Narsa Angga Cipta Narsa Annisa Anugrah Putri Arfiani Arifin Arfina Sukmawati Arifin Arman Rusman Arman Rusman Arsyik Ibrahim Arsyik Ibrahim Arsyik Ibrahim Aulia Rahmadita Baso Didik Hikmawan Baso Didik Hikmawan Dea Reggina Elisabeth James Randan Erwin Samsul Erwin Samsul Erwin Samsul Fahrul Rozi Faizah Hanan Lestari Fatur Rahman Azmi Hajrah Hajrah Hanggara Arifian Hanggara Arifian Harra Ismi Farah Harra Ismi Farrah Helmi Helmi Herman Herman Islamudin Ahmad Islamudin Ahmad Islamudin Ahmad Islamudin Ahmad Iswahyudi Iswahyudi Junaidin Junaidin Laode Rijai Lizma Febrina Lizma Febrina Lizma Febrina M. Arifuddin M. Arifuddin M. Arifuddin Arifuddin Mahfuzun Bone Masrurotin Zumaro Muhammad Romi Adipasa Pratama Nanang Fakhrudin, Nanang Nanda Silvana Alfin Ni Kadek Ria Astini Niken Indriyanti Nor Sinta Hidayati Nur Dwi Martini Putri Anggraeni Rezti Amanda Rida Wahda Maulida Tahir Riki Riki Riki Riki Rolan Rusli Rolan Rusli Rusman, Arman Salsabila Jat Dwiningrum Subagus Wahyuono Sulistiarini, Riski Venna Shintary Vina Maulidya Vincentcia Chrisanta Roentoe Wina Andriani Yusri Yusri