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Function after Wrist Arthrodesis with Non-Vascularized Fibular Graft in Distal Radius Giant Cell Tumor: Case Series Rahmadhany, Heru
Cermin Dunia Kedokteran Vol 49, No 1 (2022): Bedah
Publisher : PT. Kalbe Farma Tbk.

Giant cell tumor (GCT) of bone, the most common benign locally aggressive bone tumor, accounts for 4% to 5% of all primary bone neoplasmsand 20% of benign bone tumors. The distal radius is the third commonest site of involvement in about 10% of GCT cases. Due to the highrecurrence rate after curettage of the more progressed lesions, most surgeons prefer en bloc resection followed by reconstruction. Cases: Threedistal radius GCT Campanacci III cases underwent en bloc resection and wrist arthrodesis with non-vascularized fibular graft. The mean follow-upperiod was nine months (6-12 months). Patients were evaluated with the Disabilities of the Arm, Shoulder, and Hand (DASH) Score. Results: Unionhad been achieved in 2 patients, and implant removal was done. One patient needs cancellous bone grafting after implant removalâ€”no sign ofrecurrence after one year. DASH score showed moderate disability. Conclusion: Autogenous non-vascularized fibular graft reconstruction canbe considered a reasonable option after en bloc resection of distal radius GCT.Â Giant Cell Tumor (GCT) adalah tumor tulang jinak yang paling sering dijumpai, bersifat agresif secara lokal, merupakan 4-5% dari seluruhneoplasma tulang primer dan 20% dari seluruh tumor tulang jinak. Radius distal merupakan lokasi GCT terbanyak ketiga, mencakup 10% kasusGCT. Mengingat tingginya rekurensi setelah prosedur kuretase, lebih disukai reseksi en bloc diikuti rekonstruksi. Kasus: Tiga pasien GCT padaradius distal (Campanacci III) menjalani reseksi en bloc disertai arthrodesis pergelangan tangan. Follow-up rata-rata selama 9 bulan (range 6-12bulan). Pasien dinilai menggunakan skor Disabilities of the Arm, Shoulder, and Hand (DASH). Hasil: Union tulang tercapai pada 2 pasien, dan implantelah dicabut. Satu pasien membutuhkan graft dari tulanag cancellous setelah pencabutan implan. Tidak didapatkan rekurensi pada periodefollow-up satu tahun. Skor DASH menunjukkan disabilitas sedang pada ketiga pasien. Simpulan: Prosedur rekonstruksi menggunakan nonvascularized fibular graft baik dilakukan setelah reseksi en bloc pada pasien GCT radius distal.

Function after Wrist Arthrodesis with Non-Vascularized Fibular Graft in Distal Radius Giant Cell Tumor: Case Series Heru Rahmadhany
Cermin Dunia Kedokteran Vol 49, No 1 (2022): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.1642

Giant cell tumor (GCT) of bone, the most common benign locally aggressive bone tumor, accounts for 4% to 5% of all primary bone neoplasmsand 20% of benign bone tumors. The distal radius is the third commonest site of involvement in about 10% of GCT cases. Due to the highrecurrence rate after curettage of the more progressed lesions, most surgeons prefer en bloc resection followed by reconstruction. Cases: Threedistal radius GCT Campanacci III cases underwent en bloc resection and wrist arthrodesis with non-vascularized fibular graft. The mean follow-upperiod was nine months (6-12 months). Patients were evaluated with the Disabilities of the Arm, Shoulder, and Hand (DASH) Score. Results: Unionhad been achieved in 2 patients, and implant removal was done. One patient needs cancellous bone grafting after implant removal—no sign ofrecurrence after one year. DASH score showed moderate disability. Conclusion: Autogenous non-vascularized fibular graft reconstruction canbe considered a reasonable option after en bloc resection of distal radius GCT. Giant Cell Tumor (GCT) adalah tumor tulang jinak yang paling sering dijumpai, bersifat agresif secara lokal, merupakan 4-5% dari seluruhneoplasma tulang primer dan 20% dari seluruh tumor tulang jinak. Radius distal merupakan lokasi GCT terbanyak ketiga, mencakup 10% kasusGCT. Mengingat tingginya rekurensi setelah prosedur kuretase, lebih disukai reseksi en bloc diikuti rekonstruksi. Kasus: Tiga pasien GCT padaradius distal (Campanacci III) menjalani reseksi en bloc disertai arthrodesis pergelangan tangan. Follow-up rata-rata selama 9 bulan (range 6-12bulan). Pasien dinilai menggunakan skor Disabilities of the Arm, Shoulder, and Hand (DASH). Hasil: Union tulang tercapai pada 2 pasien, dan implantelah dicabut. Satu pasien membutuhkan graft dari tulanag cancellous setelah pencabutan implan. Tidak didapatkan rekurensi pada periodefollow-up satu tahun. Skor DASH menunjukkan disabilitas sedang pada ketiga pasien. Simpulan: Prosedur rekonstruksi menggunakan nonvascularized fibular graft baik dilakukan setelah reseksi en bloc pada pasien GCT radius distal.

Correlation between Age and Body Mass Index (BMI) with Histopathological Features of Breast Cancer Patients in RSUP Haji Adam Malik Medan Harisa Mardiah; Radita Nur Anggaeni Ginting; Heru Rahmadhany; Esther Reny Deswani Sitorus
Indonesian Journal of Cancer Vol 15, No 2 (2021): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Breast cancer is influenced by various risk factors, including age and obesity. Older women who are overweighted and obese have a higher risk of developing breast cancer. This study aims to find the correlation between age and body mass index (BMI) with histopathological features of breast cancer patients in RSUP Haji Adam Malik Medan.Methods: This research is an analytical study using a cross-sectional design with 103 samples obtained from medical record data by random sampling. The data obtained were then adjusted to the research criteria and grouped based on predetermined variables.Results: The majority of the age group was 41-50 years (36.9%), obesity BMI (40.8%), histopathological subtype of invasive carcinoma of no special type (NST) (85.4%), and grade II (46.6%). Kruskal-Wallis test result between histopathological subtypes and breast cancer grading based on age, respectively, obtained p=0.503, r=.325; (α>0.05), and p=0.207, r=0.393; (α>0.05), while based on BMI obtained p=0.017, r=0.021; (α<0.05), and p=0.018, r=0.018; (α<0.05). The OR value (95% CI) obtained on overweight-obese BMI with invasive carcinoma NST subtype was 7.63 (7.27–14.90) and other subtypes were 2.40 (1.14–13.75), and for grades II and III, they were respectively 3.57 (1.32–8.09) and 3.27 (1.17–9.91).Conclusions: There was a correlation between BMI with histopathological subtypes and breast cancer grading, but the correlation tended to be weak. Whereas, with age, there was no correlation. BMI overweight-obese were more likely to have invasive carcinoma NST subtype and higher-grade of breast cancer.

Risk Factor Analysis of Low Back Pain in Employees of Drinking Water Store in Medan Selayang Sub-District Andri Josua Barutu; Heru Rahmadhany
Sumatera Medical Journal Vol. 5 No. 3 (2022): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v5i3.8040

Background. Low back pain is defined as feeling of pain and discomfort in the area between the costal margin and inferior gluteal fold, with or without radiating pain. In Indonesia, LBP was fifth ranks in term of disability-adjusted life years (DALYs). Aim. This study aims to determine risk factors for LBP in employees of drinking water store in Medan Selayang sub-District, Medan. Method. This research is an observational analytic study with cross-sectional design. This study used consecutive sampling method. Minimum sample size in this study was 97 samples. Subjects in this study were employees of drinking water store in Medan Selayang sub-District. Data used in this study was primary data from samples through filling out questionnaires. Analysis used in this study was univariate analysis, bivariate with chi-square, and multivariate with logistic regression. Result. From 100 samples, 39 respondents (39%) experienced LBP. Based on bivariate analisis, p value ≤ 0.05 was found for age, body mass index, and duration of work. P value ≥ 0.05 was obtained for years of work and lifting frequency. Based on multivariate analysis with regression logistic, p value ≤ 0.05 was obtained for body mass index (p = 0.089) and work duration (p = 0.011) which indicated that work duration was the most dominant risk factor. Conclusion. There’s a relationship between age, body mass index, and work duration with the work duration being the most dominant risk factor for the incidence of low back pain in water gallon worker. .

KARAKTERISTIK PENDERITA FRAKTUR FEMUR AKIBAT KECELAKAAN LALU LINTAS DI RSUP HAJI ADAM MALIK MEDAN PADA TAHUN 2016-2018 Sembiring, Tasya Epifania; Rahmadhany, Heru
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 21 No. 1 (2022): Januari 2022
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Di Indonesia angka kejadian fraktur cukup tinggi, dimana sekitar delapan juta orang mengalami fraktur femur yang diakibatkan oleh kecelakaan lalu lintas. Penelitian ini menggunakan metode deskriptif observasional dengan desain cross sectional. Sampel penelitian adalah seluruh populasi yang mengikuti kriteria inklusi dan ekslusi. Pemilihan sampel dilakukan dengan metode total sampling. Penelitian ini dilakukan dengan melihat data sekunder, yaitu rekam medis pasien fraktur femur akibat kecelakaan lalu lintas di RSUP H. Adam Malik pada tahun 2016-2018. Data kemudian dianalisis dengan program perangkat lunak statistik. Angka kejadian fraktur femur akibat kecelakaan lalu lintas di RSUP H. Adam Malik Medan tahun 2016-2018 didapatkan sebanyak 104 kasus. Prevalensi fraktur femur akibat kecelakaan lalu lintas terbanyak terjadi pada laki-laki sebanyak 81 kasus (77,9%), rentang usia 18-60 tahun yaitu sebanyak 84 kasus (80,8 %), tingkat pendidikan SMA sebanyak 51 kasus (49%), dengan fraktur femur tertutup sebanyak 70 kasus (67,3%) dan lokasi pada shaft femur sebanyak 70 kasus (67,3%). Kesimpulan: Karakteristik dari fraktur femur akibat kecelakaan lalu lintas di RSUP H. Adam Malik pada tahun 2016-2018 lebih banyak terjadi pada laki-laki, dengan kelompok usia paling banyak 18-60 tahun, tingkat pendidikan terakhir SMA, jenis fraktur terbanyak adalah fraktur tertutup, serta lokasi terbanyak adalah shaft femur.

Function after Wrist Arthrodesis with Non-Vascularized Fibular Graft in Distal Radius Giant Cell Tumor: Case Series Heru Rahmadhany
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.186

Giant cell tumor (GCT) of bone, the most common benign locally aggressive bone tumor, accounts for 4% to 5% of all primary bone neoplasms and 20% of benign bone tumors. The distal radius is the third commonest site of involvement in about 10% of GCT cases. Due to the high recurrence rate after curettage of the more progressed lesions, most surgeons prefer en bloc resection followed by reconstruction. Cases: Three distal radius GCT Campanacci III cases underwent en bloc resection and wrist arthrodesis with non-vascularized fibular graft. The mean follow-up period was nine months (6-12 months). Patients were evaluated with the Disabilities of the Arm, Shoulder, and Hand (DASH) Score. Results: Union had been achieved in 2 patients, and implant removal was done. One patient needs cancellous bone grafting after implant removal—no sign of recurrence after one year. DASH score showed moderate disability. Conclusion: Autogenous non-vascularized fibular graft reconstruction can be considered a reasonable option after en bloc resection of distal radius GCT. Giant Cell Tumor (GCT) adalah tumor tulang jinak yang paling sering dijumpai, bersifat agresif secara lokal, merupakan 4-5% dari seluruh neoplasma tulang primer dan 20% dari seluruh tumor tulang jinak. Radius distal merupakan lokasi GCT terbanyak ketiga, mencakup 10% kasus GCT. Mengingat tingginya rekurensi setelah prosedur kuretase, lebih disukai reseksi en bloc diikuti rekonstruksi. Kasus: Tiga pasien GCT pada radius distal (Campanacci III) menjalani reseksi en bloc disertai arthrodesis pergelangan tangan. Follow-up rata-rata selama 9 bulan (range 6-12 bulan). Pasien dinilai menggunakan skor Disabilities of the Arm, Shoulder, and Hand (DASH). Hasil: Union tulang tercapai pada 2 pasien, dan implan telah dicabut. Satu pasien membutuhkan graft dari tulanag cancellous setelah pencabutan implan. Tidak didapatkan rekurensi pada periode follow-up satu tahun. Skor DASH menunjukkan disabilitas sedang pada ketiga pasien. Simpulan: Prosedur rekonstruksi menggunakan nonvascularized fibular graft baik dilakukan setelah reseksi en bloc pada pasien GCT radius distal.

Effects of Vitamin C Supplementation on Histology of Callus Diameter and Osteoblast Number in Male Wistar Rats With Complete Femur Bone Fracture Rambe, Syahrul Ramadan; Putra, Reza Mahruzza; Rahmadhany, Heru
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.25888

Background: The role of nutritional factors, particularly vitamin C, in bone repair has been extensively studied. However, despite this research, the specific impact of vitamin C on bone fracture healing remains unclear. While some studies suggest that vitamin C supplementation may enhance bone repair, others report no significant benefits.Objective: This study aimed to investigate the effects of different doses of vitamin C on callus formation and osteoblast proliferation in a rat femur fracture model.Methods: A post-test-only control group design was employed in this study, involving 27 male Wistar rats that were randomly divided into three groups. The first and second groups received daily intramuscular injections of vitamin C at doses of 200 mg/kg body weight (BW) and 500 mg/kg BW, respectively, following femur bone fracture and fixation. The control group did not receive vitamin C and underwent no fixation. After 14 days, all rats were euthanized, and their femur bones were histologically examined for callus diameter and osteoblast count.Results: Vitamin C supplementation significantly increased the callus diameter in rats with complete femoral fractures. Both the 200 mg and 500 mg doses proved effective, demonstrating a clear dose-response relationship. Additionally, Vitamin C significantly elevated the number of osteoblasts, which play a crucial role in bone formation. However, there was no statistically significant difference in osteoblast count between the 200 mg and 500 mg doses.Conclusion: In conclusion, vitamin C supplementation has been shown to positively influence bone fracture healing in rats by promoting an increase in callus diameter and enhancing osteoblast proliferation. This study indicates that vitamin C could serve as a beneficial adjunct therapy for facilitating bone fracture healing, particularly by improving callus formation. Physicians should consider integrating vitamin C into treatment plans for patients with fractures, using doses similar to those applied in this study, adjusted appropriately for human use.

Knowledge and Behavior of the Tembung Village Community about Sunscreen to Prevent Melanoma Ali, M. Fakhri; Utama Pohan, Pimpin; Prayugo, Bambang; Rahmadhany, Heru
Sumatera Medical Journal Vol. 6 No. 2 (2023): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v6i2.11092

Background: Indonesia is one of the tropical countries in the world that is illuminated by the sun all year round. High sun exposure requires Indonesian people to be more concerned about skin protection, especially melanoma. The risk factor for melanoma is exposure to UV radiation so melanoma can be prevented by reducing exposure to UV rays, one of them by using sunscreen. The use of sunscreen with SPF 15+ every day can reduce the risk of developing melanoma by 50%. Objective: This study aims to obtain information about the level of knowledge and behavior of people in Tembung about the use of sunscreen to prevent melanoma. Methods: The research design used is descriptive research using a cross-sectional study. The Data was obtained through the distribution of online questionnaires with 100 people. Furthermore, the data obtained will be processed using SPSS. Results: 41 people had sufficient knowledge about melanoma, 67 people had less knowledge about sunscreen, and 38 people had good behavior. Conclusion: Most of people in Tembung have sufficient knowledge about melanoma, lack knowledge about sunscreen, and have a good behavior in using sunscreen.

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