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All Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal EduHealth
Linlin Haeni
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Dentistry Health Professions Medicine & Pharmacology Public Health Veterinary

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EFEK EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) SEBAGAI PENCEGAH KERUSAKAN MUKOSA LAMBUNG Linlin Haeni; Ris Kristiana; Inge Lucya
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 5 No 3 (2022): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Ekstrak kulit manggis (Garcinia mangostana L.) mengandung xanthone dengan senyawa utama alfa mangostin dan gamma-mangostin yang berfungsi sebagai antioksidan dalam melindungi mukosa lambung. Tujuan dari penelitian ini ingin mengetahui pengaruh pemberian ekstrak kulit manggis sebagai pelindung mukosa lambung tikus yang diinduksi asam asetilsalisilat (ASA). Penelitian ini menggunakan 24 ekor tikus yang dibagi menjadi empat kelompok perlakuan yang terdiri dari kontrol negatif (K-), kontrol positif (K+), perlakuan dosis ekstrak 750mg/KgBB (P1), dan dosis ekstrak 1000mg/KgBB (P2). Perlakuan diberikan setiap hari selama 7 hari. Pada hari ke-8 tikus di eutanasia, dibedah, diambil organ lambung untuk dibuat sediaan histopatologi dengan pewarnaan HE. Uji Post Hoc Tukey menunjukkan bahwa pemberian ekstrak kulit manggis dengan dosis 750mg/Kgbb (P1) dan dosis 1000mg/KgBB (P2) memiliki perbedaan yang signifikan (p<0.05) terhadap kontrol positif (K+), tetapi (P1) tidak menunjukkan perbedaan yang signifikan (p>0.05) dibandingkan kelompok (P2). Hal ini menunjukkan bahwa pemberian dosis ekstrak kulit manggis 750mg/KgBB efektif dalam mencegah kerusakan mukosa lambung tikus galur Wistar yang diinduksi asam asetilsalisilat dibandingkan dengan dosis ekstrak kulit manggis 1000mg/KgBB. Pada penelitian ini dapat disimpulkan bahwa ekstrak kulit manggis memiliki kemampuan untuk mencegah kerusakan mukosa lambung tikus Wistar. DOI : 10.35990/mk.v5n3.p297-307
Hepatoprotective Effect of Ethanol Extracted Clove Flower (Syzygium Aromaticum) on Wistar Rat’s Hepatocytes Induced by Carbon Tetrachloride (CCl4) Linlin Haeni; Dewi Ratih Handayani; Kautsar Balda Fauzan
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Abstract

Based on WHO, the total death caused only by alcohol causing liver cirrhosis complications was estimated at 637,000 people in 2016. Based on Riskesdas 2018, 3% of Indonesians consumed alcohol 0.3% excessively. One of the liver damage prevention due to alcohol was by consuming plant antioxidants. Ethanol extracted clove flowers (EEBC) contains antioxidant substances such as eugenol and flavonoids which protect hepatocytes from free radicals. The aim of this research was to determine the hepatoprotective effect of ethanol extracted clove flower on hepatocytes induced by carbon tetrachloride (CCl4). Trichloromethyl from CCl4 metabolism by P-450 enzymes caused lipid peroxidation of hepatocyte cell membranes This research was divided into 5 groups with 5 Wistar rats in each group. The group categories were negative control (K1), positive control (K2), 750 mg/KgBW dose EEBC (K3), 875 mg/KgBW dose EEBC (K4), 1000 mg/KgBW dose EEBC (K5). The research procedure was divided into 2 phases. First, administration of extract for 7 days, second, induction of CCl4 on the 8th day. On 9th day, rats were terminated and their livers were taken for histologic preparations. The results showed that K5 had the lesser destruction than positive control but still under negative control, and K3 and K4 almost the same as positive control. In conclusion, ethanol extracted clove flowers had hepatoprotective effect towards hepatocytes of induced CCl4 Wistar rats. Low and moderate doses of EEBC did not have a statistical effect, apparently because the induction of CCl4 was too strong compared to previous studies that used paracetamol.
Co-Authors Dewi Ratih Handayani Emma Mardliyah Inge Lucya Kautsar Balda Fauzan Nabella Meriem Annisa Fitri Ris Kristiana