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REVIEW : POTENSI KOPI ARABIKA (Coffea arabica L.) DARI BERBAGAI AKTIVITAS FARMAKOLOGI & BENTUK SEDIAAN FARMASI: REVIEW : POTENTIAL ARABICA COFFEE (Coffea arabica L.) FROM VARIOUS PHARMACOLOGICAL ACTIVITIES & PHARMACEUTICAL PREPARATION FORMS Firman Muharam; Sriwidodo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.349

Kopi Arabika (Coffea arabica L.) adalah tanaman yang memiliki populasi cukup banyak di Indonesia dan merupakan salah satu komoditas di dunia. Kopi arabika memiliki aktivitas sebagai antiinflamasi, antihiperglikemik, antiselulit, hiperurisemia, antimikroba, dan antioksidan. Hal ini mengindikasikan kopi arabika (Coffea arabica L.) memiliki bahan aktif atau metabolit sekunder seperti kafein dan asam klorogenat yang memberikan aktivitas tersebut. Penggunaan kopi arabika (Coffea arabica L.) pada kalangan masyarakat terbatas pada obat herbal dan juga minuman dengan pengolahan standar sehingga saat ini banyak dikembangkan ulasan mengenai formulasi dan inovasi dari kopi arabika (Coffea arabica L.) sehingga lebih memberikan aktivitas terapi. Pada review artikel ini akan diulas secara lengkap mengenai kopi arabika (Coffea arabica L.) dalam hal kandungan kimia, aktivitas, dan formulasi yang telah dikembangkan pada kopi arabika (Coffea arabica L.). Kopi arabika (Coffea arabica L.) memiliki potensi untuk dikembangkan sebagai bahan aktif berdasarkan tinjauan tentang efektivitas kopi arabika (Coffea arabica L.).

A Case Report VP shunt in Non Communicating Hydrocephalus due to Intracerebral Hemorrhage Firman Muharam; Rully Hanafi Dahlan; Seyline Estethia Ompusunggu
Sumatera Medical Journal Vol. 5 No. 1 (2022): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v5i1.9383

Stroke is one of the top three cause of death and disability globally. Approximately, only 10% to 15% of first-ever stroke are intracerebral hemorrhages (ICHs), but the rates of disability and death are significantly higher. Hydrocephalus may occur in more than 50% of patients with intraventricular hemorrhage (IVH), which is secondary to ICH. Intraventricular hemorrhage (IVH), an accumulation of blood to ventricles that may be cause by extension of ICH, occurs in up to 50% of patients with primary ICH. Hydrocephalus itself may serves as a predictor of poor outcome after ICH.1,2,3 A 71 years old male came to the hospital with the complaint of loss of consciousness, difficulty in communicating, and weakness of extremities on the left side of the body since 12 hours ago. The complaint was preceded by headache that did not alleviate with medication since 1 day before admission and there was history of slurred speech. A head CT scan without contrast was done and the result showed an intracerebral hemorrhage and a suggestive obstructive hydrocephalus. The patient was diagnosed noncommunicating hydrocephalus due to spontaneous intracerebral haemorrhage (ICH) at the right thalamus with intraventricular haemorrhage due to suspect hypertension with differential diagnosis of cerebral amyloid angiopathy with emergency hypertension. The patient was advised to underwent an emergency VP shunt placement. Implantation of a ventriculoperitoneal (VP) shunt is the most widely used treatment of hydrocephalus. Considered to be a major privonce of neurosurgery, it accounts for 70.000 hospital admission in the US. Even though, VP shunting of CSF reduces the morbidity and mortality of post-hemorrhagic. hydrocephalus, it is associated with potential complications requiring multiple surgical procedures, as well as shunt revision due to its failure during the patient’s lifetime.4

REVIEW : POTENSI KOPI ARABIKA (Coffea arabica L.) DARI BERBAGAI AKTIVITAS FARMAKOLOGI & BENTUK SEDIAAN FARMASI: REVIEW : POTENTIAL ARABICA COFFEE (Coffea arabica L.) FROM VARIOUS PHARMACOLOGICAL ACTIVITIES & PHARMACEUTICAL PREPARATION FORMS Firman Muharam; Sriwidodo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.349

Kopi Arabika (Coffea arabica L.) adalah tanaman yang memiliki populasi cukup banyak di Indonesia dan merupakan salah satu komoditas di dunia. Kopi arabika memiliki aktivitas sebagai antiinflamasi, antihiperglikemik, antiselulit, hiperurisemia, antimikroba, dan antioksidan. Hal ini mengindikasikan kopi arabika (Coffea arabica L.) memiliki bahan aktif atau metabolit sekunder seperti kafein dan asam klorogenat yang memberikan aktivitas tersebut. Penggunaan kopi arabika (Coffea arabica L.) pada kalangan masyarakat terbatas pada obat herbal dan juga minuman dengan pengolahan standar sehingga saat ini banyak dikembangkan ulasan mengenai formulasi dan inovasi dari kopi arabika (Coffea arabica L.) sehingga lebih memberikan aktivitas terapi. Pada review artikel ini akan diulas secara lengkap mengenai kopi arabika (Coffea arabica L.) dalam hal kandungan kimia, aktivitas, dan formulasi yang telah dikembangkan pada kopi arabika (Coffea arabica L.). Kopi arabika (Coffea arabica L.) memiliki potensi untuk dikembangkan sebagai bahan aktif berdasarkan tinjauan tentang efektivitas kopi arabika (Coffea arabica L.).

Pemberdayaan Santri di Pondok Pesantren Manbaul Huda Seureuh Jawa Cibiuk Kabupaten Garut Dalam Pemanfaatan Limbah Organik Menjadi Ekoenzim Dadang Muhammad Hasyim; STIKES Karsa Husada Garut; Yogi Rahman Nugraha; Nurul; Elang Mohamad Atoilah; Dede Suharta; Firman Muharam
Jurnal Kemitraan Responsif untuk Aksi Inovatif dan Pengabdian Masyarakat Volume 2 Issue No. 2: January 2025
Publisher : Lontara Digitech Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61220/kreativa.v2i2.20252

Pengelolaan limbah organik merupakan tantangan di lingkungan pesantren yang dapat menimbulkan permasalahan lingkungan jika tidak dikelola dengan baik. Program ini bertujuan untuk memberdayakan santri Pondok Pesantren Manbaul Huda di Seureuh Jawa, Cibiuk, Garut, dalam mengolah limbah organik menjadi ekoenzim, sebuah produk hasil fermentasi yang bermanfaat sebagai pupuk organik dan cairan pembersih alami. Program ini dilaksanakan melalui tahap-tahap persiapan, pelatihan, praktik produksi, pemanfaatan produk, dan evaluasi keberhasilan. Hasil pelaksanaan menunjukkan bahwa 90% santri aktif berpartisipasi dalam kegiatan dan memiliki pemahaman yang baik tentang pembuatan ekoenzim, sebagaimana dibuktikan dengan peningkatan skor post-test rata-rata sebesar 85%. Sebanyak 65 liter ekoenzim berhasil diproduksi, melampaui target awal sebesar 50 liter. Produk ekoenzim dimanfaatkan untuk kebutuhan internal pesantren dan mulai dijual ke masyarakat oleh beberapa santri, menunjukkan potensi kewirausahaan yang tumbuh. Kesadaran lingkungan di kalangan santri juga meningkat, dengan 75% santri mulai memilah limbah secara mandiri. Program ini diintegrasikan ke dalam kurikulum pesantren, menjadikannya sebagai kegiatan rutin yang berkelanjutan. Dengan pendekatan kolaboratif dan berbasis praktik, program ini berhasil menciptakan pesantren yang ramah lingkungan, mandiri secara ekonomi, dan berpotensi menjadi model pemberdayaan lingkungan yang dapat direplikasi di wilayah lain.

POTENSI MINYAK AKAR WANGI SEBAGAI KOSMETIKA.: POTENSI MINYAK AKAR WANGI SEBAGAI KOSMETIKA. Muharam, Firman; Nurul, Nurul; Ekawati, Risrina Nur
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar

The cosmetics industry is experiencing rapid development with a variety of beauty products, and vetiver oil is emerging as a safe and effective natural ingredient with antioxidant, antimicrobial, and anti-aging benefits, and has the potential to overcome health problems caused by synthetic ingredients. Indonesia, as a major producer of vetiver oil, has a great opportunity to develop the market for natural cosmetics, increase the economic value of local agricultural products, and fulfil the global demand for environmentally-friendly natural cosmetics. Method: The article preparation method used literature reviews from international and national journals. The search for articles published online was conducted through PubMed and Google Scholar sites and citation writing using the Mendeley® software application. Result: Vetiver oil exhibits strong antioxidant and antimicrobial activities, able to protect cells from oxidative damage and is effective against various bacteria and fungi, with an IC50 of 0.515 µg for antioxidant activity and a Minimum Inhibitory Concentration (MWC) of 62.5 µg/ml against Bacillus cereus. In addition, the oil has anti-aging effects through increased lipid synthesis, aids in the treatment of acne by inhibiting the growth of Cutibacterium acnes, and reduces oxidative stress and melanin production, making it a potential agent in various skincare and health applications. Conclusion. Vetiver oil exhibits a range of significant health and beauty benefits, including antioxidant activity, antimicrobials, anti-aging effects, acne treatment, and oxidative stress reduction. Research and development of vetiver oil-based products can provide effective natural solutions to a wide range of health and cosmetic concerns.

Systematic Review : Metode dan Aplikasi Mikroenkapsulasi pada Ekstrak Bahan Alam Muharam, Firman; Sriwidodo, Sriwidodo; Amalia, Eri
MAHESA : Malahayati Health Student Journal Vol 5, No 5 (2025): Volume 5 Nomor 5 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i5.17066

ABSTRACT Natural extracts have potential in the pharmaceutical industry, cosmetics, and clinical applications because they are safe, non-toxic, and have relatively low side effects. Unfavorable taste and odor and stability problems are their disadvantages. The solution to these problems is microencapsulation technology. Microencapsulation is a technology that involves covering or coating a core substance with a polymer wall layer, resulting in micro-sized particles. The benefits of microencapsulation can protect compounds from various environmental factors such as oxidation, degradation, temperature, humidity, and light, thereby extending the shelf life of the product, improving the stability of active ingredients, preventing loss of activity, masking aromatic flavors and odors, improving the stability of volatile compounds and increasing bioavailability. The purpose of this review is to gather information about the application of microencapsulation to natural extracts and what the results of microencapsulation are. The literature review was conducted through Google Scholar and PubMed databases, and the literature selection was done using the PRISMA Flow Chart. This review results in microencapsulation technology for natural extracts made by ionic gelation, spray wet microencapsulation (SWM), solvent evaporation, freeze drying, fluid bed, and spray drying. Each method has a unique way of protecting the core substance with a polymer layer, resulting in useful microcapsules such as to reduce moisture, obtain suitable physicochemical characteristics, good flow rate, retain bioactive compounds, lower hygroscopicity, improve stability, increase shelf life, increase solubility, taste masking, maintain antioxidant content and pharmacological activity of natural ingredient extracts. This means the use of microencapsulation technology promises to improve the utilization of natural extracts in various pharmaceutical industries, cosmetics, and clinical applications. Keywords: Microencapsulation, Natural extracts, Methods, Applications ABSTRAK Ekstrak bahan alam memiliki potensi dalam industri farmasi, kosmetik dan aplikasi klinis karena aman, tidak beracun dan efek samping relative rendah. tetapi kelemahannya yaitu rasa dan bau yang tidak disukai serta masalah stabilitas. Solusi untuk masalah ini adalah teknologi mikroenkapsulasi. Mikroenkapsulasi adalah teknologi yang melibatkan penyalutan atau pelapisan zat inti oleh lapisan dinding polimer, menghasilkan partikel-partikel dengan ukuran mikro. Keunggulan mikroenkapsulasi dapat melindungi senyawa dari berbagai faktor lingkungan seperti oksidasi, degradasi, suhu, kelembaban, dan cahaya, sehingga dapat memperpanjang umur simpan produk, meningkatkan stabilitas bahan aktif, mencegah penurunan aktivitas, menutupi bau dan rasa, stabilitas dan bioavabilitas senyawa meningkat. Tujuan riview ini yaitu mengumpulkan informasi terkait aplikasi mikroenkapsulasi terhadap ekstrak bahan alam serta apa hasil dari mikroenkapsulasi tersebut. Kajian literatur dilakukan melalui database Google Scholar dan PubMed dengan seleksi literatur menggunakan Flow Diagram PRISMA. Hasil dari riview ini teknologi mikroenkapsulasi pada ekstrak bahan alam bisa dibuat dengan metode ionic gelation, spray wet microencapsulation (SWM), solvent evaporation, freeze drying, fluid bed, dan spray drying. Setiap metode memiliki cara unik dalam melindungi zat inti dengan lapisan polimer, sehingga menghasilkan mikrokapsul yang berguna seperti untuk mengurangi kelembaban, mendapatkan karakteristik fisikokimia yang sesuai, laju alir yang baik, mempertahankan senyawa bioaktif, menurunkan higroskopisitas, meningkatkan stabilitas, meningkatkan umur simpan, meningkatkan kelarutan, menutupi rasa, menjaga kandungan antioksidan dan aktivitas farmakologi ekstrak bahan alam. Penggunaan teknologi mikroenkapsulasi menjanjikan peningkatan dalam pemanfaatan ekstrak bahan alam dalam berbagai industri farmasi, kosmetik dan aplikasi klinis. Kata Kunci: Aplikasi, Ekstrak Bahan Alam, Metode, Mikroenkapsulasi.

SKRINING FITOKIMIA MINYAK ATSIRI AKAR WANGI (Vetiveria zizanioides (L.) Nash) ASAL KABUPATEN GARUT Nurul, Nurul; Sujana, Dani; Nugraha, Yogi Rahman; Muharam, Firman; Puspitasari, Siva; Syswianti, Desy
Jurnal Medika Cendikia Vol 11 No 01 (2024): Jurnal Medika Cendikia
Publisher : Karsa Husada Health Institute Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmc.v11i01.246

Indonesia is uniquely positioned among the countries in the world where most of the land consists of tropical forests. Besides Haiti and the Bourbon Pacific, Indonesia is among the three largest producers of vetiver oil in the world. Garut Regency is the center of vetiver oil production in Indonesia. Vetiver root (Vetiveria zizanoides L. Nash), is known to contain terpenoid compounds that have antioxidant bioactivity, especially ?-vetivena, ?-vetivenon, and ?-vetivenon compounds. Phytochemical screening is a way to determine the content of secondary metabolites in a natural material. This study aims to determine the content of secondary metabolites in vetiver essential oil from Garut Regency. This research is qualitative in nature using a descriptive design of laboratory experiment method. The vetiver essential oil produced by the steam distillation method was tested for secondary metabolite content using thin-layer chromatography by looking at the stains that appeared on the chromatogram and the Rf value of the tested compounds. Secondary metabolite compounds tested include alkaloids, flavonoids, tannins, steroids, terpenoids, and saponins. Vetiver essential oil contains steroid compounds characterized by the onset of blue stains with an Rf of 0.9 and terpenoid compounds characterized by the onset of bright blue stains with an Rf of 0.54.

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