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All Journal Program Kreativitas Mahasiswa - Penelitian Narra J Bioinformatics and Biomedical Research Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Camoya Gersom
Pendididikan dokter, Fakultas kedokteran, Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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KIT DETEKSI KANKER LEHER RAHIM BERBASIS ANTIBODI TELOMERASE: PENDEKATAN SECARA IMMUNOMOLEKULAR Hidayatullah, Furqan; Wijaya, Andreas Budi; Gersom, Camoya; Pahlevi, Faizal Reza; Setyabudhi, Veronica Verina
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cervical cancer is the first leading cause of cancer death in Indonesia. About 95% telomerase activity is associated with cervical cancer’s malignancy. Therefore, telomerase is very potential as a biomarker for cervical cancer detection. This research’s purpose is to produce  cut-off point of cervical cancer telomerase. Telomerase antibody is produced and detected using Western Blotting and ELISA, 15 samples of each cancer and normal patients were collected from RSSA. ELISA Absorbance value of antibody and antigen binding were collected and analyzed using independent t-test and ROC. cut off point is found at 0.092 with 81,25% specificity and 80% sensitivity. Keywords: Cervical Cancer, Telomerase, Telomerase Antibody, Cut-Off point
Arrangement of Burn Status for Emergency Management, Monitoring, and Evaluation of Burns in Saiful Anwar General Hospital in Malang, East Java, Indonesia Wihastyoko, Herman Yosef Limpat; Agustina, Wilma; Gersom, Camoya
Bioinformatics and Biomedical Research Journal Vol. 1 No. 3 (2018): Volume 1 Issue 3
Publisher : Future Science

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Abstract

The article proposes an arrangement of burn status for the management of severe based on a review of management of burns. More than 95% of burns are associated with fatal fires and occur in low to middle income countries. A coordination between health officers within health facilities is crucial to provide proper management for severe burns. There is no standard yet for burn status in Indonesia. Burn status may provide better management of patients who are admitted with burns. In this article, the set of burn status was arranged for the management of patients with burns in the Saiful Anwar General Hospital. There are 3 types of burn status in this paper each for the respective use of emergency management, burn unit monitoring, and wound care evaluation. The purpose of this burn status is to facilitate a better coordination between health officers regarding management of burns in Saiful Anwar General Hospital. This paper can also become the basis of further studies regarding burns as a tool to collect data or as a basis to pioneer the standard of burn status in Indonesia to further improve the general quality of burn care and research in Indonesia. The system of medical record for patients is generally carried out to keep a record of the patient's disease progression, including the diagnosis and treatment plans carried out by doctors and medical personnel which are involved.
Incidence Rate of Myocardial Infarction in HIV–Infected Individuals: A System-atic Review and Meta–Analysis Gersom, Camoya; Thirza, Savannah Quila
Bioinformatics and Biomedical Research Journal Vol. 1 No. 3 (2018): Volume 1 Issue 3
Publisher : Future Science

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Abstract

Background: The incidence rate of myocardial infarction has been reportedly higher in human immunodeficiency virus (HIV)–infected individuals compared to in uninfected individuals. HIV infection is suggested to have increased the risk of myocardial infarction (MI). To review the incidence rate of myocardial infarction in HIV–infected individuals compared to in uninfected individuals in its relation to HIV infection as a potential risk factor of MI incident. A literature search was performed in Google Scholar, PubMed, and Cochrane databases with keywords “HIV risk myocardial infarction” and “myocardial infarction in HIV” ranging from 2013 to 2019. Inclusion criteria wasfull-text observational studies that reported the incidence rate of myocardial infarction in HIV–infected individuals compared to in uninfected individuals. A total of 6 studies were eligible for review. We performed the meta–analysis with Review Manager 5.3 in May 2019. We reviewed several studies that discussed the association between HIV infection and myocardial infarction. The incidence rate of MI is higher in HIV–infected individuals compared to in non–infected individuals. It is suggested that Framingham Risk Score does not directly contribute to the higher incidence of MI in patients with HIV. Several studies also reported that low CD4 cell count and HIV–1 RNA levels less than 500 copies/mL contribute directly to the risk of myocardial infarction. There is a higher incidence rate of myocardial infarction among HIV–infected individuals compared to among non–infected individuals. Several suggested factors include low CD4 cell count and HIV–1 RNA levels less than 500 copies/mL. Thus, it may be suggested that HIV infection is a potential risk factor of MI. Further studies are needed to better understand the mechanism of HIV infection as a risk factor of MI incident.
Global prevalence and contributing factors of transplant renal artery stenosis in renal transplant recipients: A systematic review and meta-analysis Tamara, Fredo; Fajar, Jonny K.; Gersom, Camoya; Wicaksono, Ramadi S.; Tupamahu, Alvira R.; Huda, Fariz N.; Sari, Fitria R.; Dela, Jamaludin A.; Putri, Irawati E.; Sutrisno, Muhammad A.; Putra, Riyantono; Dwinata, Michael; Friatna, Yudha; Albaar, Thoha M.; Susanto, Agung; Dewi, Ratih TK.; Suseno, Aryo; Samsu, Nur
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1782

Abstract

Transplant renal artery stenosis (TRAS) is a serious complication of renal transplantation, with its prevalence and associated factors remaining inconclusive. The aim of this study was to assess the global prevalence and risk factors associated with TRAS incidence in renal transplant recipients. We conducted a meta-analysis by collecting data on the prevalence and factors associated with TRAS from articles in Scopus, Embase, and PubMed. The prevalence of TRAS was determined using a single-arm meta-analysis. The factors associated with TRAS were determined using Mantel-Haenszel analysis or inverse variance analysis. Out of 28,599 articles from the searches, 31 of them were included in the analysis. The global prevalence of TRAS was 6% among renal transplant recipients. Diabetes mellitus, hypertension, longer duration of dialysis before transplant, deceased donor, acute rejection, delayed graft function, longer cold ischemic time, and prolonged peak systolic velocity were associated with an increased risk of TRAS. Age, gender, peripheral artery disease (PAD) comorbidity, causes of end-stage renal disease (ESRD), previous dialysis modality, and cytomegalovirus infection were not associated with TRAS incidence. In conclusion, the global prevalence of TRAS in renal transplant recipients is relatively high, and some of the contributing factors to the development of TRAS are preventable. These findings could serve as a guideline for informing the management of TRAS in the future.
Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review Mustika, Syifa; Gersom, Camoya; Kongkam, Pradermchai
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202559-67

Abstract

This review article provides a comprehensive examination of liver injury patterns, specifically focusing on hepatocellular and cholestatic patterns, and their respective diagnostic approaches. It highlights the importance of differentiating between these patterns through detailed clinical evaluations and the use of specific liver enzymes, including aminotransferases, bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, 5'-nucleotidase, and lactate dehydrogenase. The review further explores liver function tests, such as albumin and prothrombin time, which are crucial in assessing liver function and guiding clinical management. A wide range of liver diseases is discussed, with a focus on those exhibiting hepatocellular patterns, such as viral hepatitis, acute liver failure, fatty liver disease (both alcoholic and non-alcoholic), and drug-induced liver injury (DILI), as well as other conditions like ischemic and autoimmune hepatitis. Cholestatic illnesses such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), bile duct blockages, and genetic cholestatic syndromes are also investigated. This study seeks to improve physicians' and researchers' awareness of liver diseases, serve as a valuable resource for future research and teaching, and contribute to the improvement of diagnostic and therapeutic techniques in hepatology.Keywords : Cholestatic, hepatocellular, liver enzymes, liver functions
Co-Authors Agustina, Wilma Albaar, Thoha M. Andreas Budi Wijaya Dela, Jamaludin A. Dewi, Ratih TK. Dwinata, Michael Faizal Reza Pahlevi Fredo Tamara, Fredo Friatna, Yudha Furqan Hidayatullah Huda, Fariz N. Jonny K. Fajar Kongkam, Pradermchai Nur Samsu Putra, Riyantono Putri, Irawati E. Sari, Fitria R. Susanto, Agung Suseno, Aryo Sutrisno, Muhammad A. Syifa Mustika Thirza, Savannah Quila Tupamahu, Alvira R. Veronica Verina Setyabudhi Wicaksono, Ramadi S. Wihastyoko, Herman Yosef Limpat