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All Journal Program Kreativitas Mahasiswa - Penelitian Jurnal ORTOPEDAGOGIA Jurnal Penelitian Pendidikan IPA (JPPIPA) Acta Biochimica Indonesiana Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat
Andreas Budi Wijaya
Pendididikan dokter, Fakultas kedokteran, Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Materials Science & Nanotechnology Physics Social Sciences

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KIT DETEKSI KANKER LEHER RAHIM BERBASIS ANTIBODI TELOMERASE: PENDEKATAN SECARA IMMUNOMOLEKULAR Hidayatullah, Furqan; Wijaya, Andreas Budi; Gersom, Camoya; Pahlevi, Faizal Reza; Setyabudhi, Veronica Verina
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.633 KB)

Abstract

Cervical cancer is the first leading cause of cancer death in Indonesia. About 95% telomerase activity is associated with cervical cancer’s malignancy. Therefore, telomerase is very potential as a biomarker for cervical cancer detection. This research’s purpose is to produce  cut-off point of cervical cancer telomerase. Telomerase antibody is produced and detected using Western Blotting and ELISA, 15 samples of each cancer and normal patients were collected from RSSA. ELISA Absorbance value of antibody and antigen binding were collected and analyzed using independent t-test and ROC. cut off point is found at 0.092 with 81,25% specificity and 80% sensitivity. Keywords: Cervical Cancer, Telomerase, Telomerase Antibody, Cut-Off point
Enhancement of Teachers' Knowledge in Gamification for Improving Reading Skills in Students with Autism Spectrum Disorder Kurniawan, Agung; Ariesaka, Kiky Martha; Fukata, Editya; Wijaya, Andreas Budi; Putri, Angelica Igsanti; Prasetya, Ahmada Viosepta; Devi, Athaayaa Nastiti Ulayya
Jurnal ORTOPEDAGOGIA Vol 10, No 2 (2024): November
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um031v10i22024p75-82

Abstract

Autism Spectrum Disorder (ASD) is a developmental disorder characterized by challenges with social interaction, communication, and repetitive behaviors. Students with ASD often struggle with reading skills due to deficits in language comprehension, attention, and social communication. Gamification, applying game-design elements in non-game contexts, has emerged as a promising approach to enhance learning for these students. This study aimed to develop and implement a gamification-based learning application to improve the reading skills of students with ASD in special schools. The initiative sought to empower teachers through comprehensive training and support, enabling them to effectively use gamified educational tools. The method followed the ADDIE model: Analysis involved a needs assessment; Design included creating a training program and evaluation instruments; Development involved creating training materials and preparing for pilot testing; Implementation included conducting the training for teacher and administering pre-tests and post-tests; Evaluation consisted of analyzing test data and feedback. The training session was conducted on July 17, 2024, at SLB Autis Lab UM. Paired t-test results showed a significant increase in mean scores from pre-test (78.67±11.87) to post-test (88.00±10.14), with a P-value of 0.014, indicating effective training. Participant feedback highlighted the gamification application’s appealing interface, ease of use, and positive impact on student motivation, participation, and reading skills. The gamification-based learning application effectively improves reading skills in students with ASD and enhances teachers’ knowledge and skills in using such tools. Ongoing support and professional development for educators are crucial for integrating innovative tools into teaching practices, fostering academic success and overall development for students with ASD.
Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases Aulanniam; Rudijanto, Achmad; Wijaya, Andreas Budi
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.182

Abstract

The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is linked to hypothyroidism. Advances in understanding TPO and TSHR as biomarkers over recent decades have enhanced their clinical application. This review explores the molecular basis of TPO and TSHR as biomarkers, highlighting their importance in diagnosing AITD and their potential to guide effective therapeutic strategies. Additionally, it discusses the development of lateral flow assay (LFA) kits developed by the authors, which show promise as rapid and reliable diagnostic tools for AITD.
Characterization of TPO Enzyme and its Immunogenecity in New Zealand White Rabbits (Oryctolagus cuniculus) Ramadani, Devi; Wijaya, Andreas Budi; Srihardyastutie, Arie; Wuragil, Dyah Kinasih; Rosandi, Rulli; Rudijanto, Achmad; Aulanni'am, Aulanni'am
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9539

Abstract

Hypothyroidism is characterized by inadequate production of thyroid hormones, chiefly thyroxine (T4) and triiodothyronine (T3). Thyroid peroxidase (TPO), is an enzyme and crucial for producing thyroid hormones, and also serves as a primary autoantigen in autoimmune thyroid conditions, such as Hashimoto's thyroiditis and Graves' disease. The existence of anti-thyroid peroxidase antibodies (anti-TPO) indicates an autoimmune response in which the immune system TPO which is normally recognized as part of the body (self), begins to be identified by the immune system as a something foreign (non-self). This study aimed to characterize, measure TPO activity, and evaluate the immunogenicity of TPO protein derived from patient serum and its ability to induce TPO antibody production in New Zealand White Rabbits. TPO protein isolation was achieved through SDS-PAGE and confirmed by western blot technique have molecular weight of 52 kDa. In samples from normal patients, the average TPO enzyme activity was 31.34 U/mL, while in hypothyroid patients, the average activity increased to 49.46 U/mL. TPO polyclonal antibody production in rabbits indicated its immunogenicity, peaking in week eight post-immunization, with an ELISA absorbance of 0.555. Dot blot analysis further confirmed anti-TPO sensitivity at various dilutions, anti-TPO has a high sensitivity at 1:80 dilution still detects TPO in sera patient.
Peningkatan Kapasitas Guru Sekolah Luar Biasa tentang Diet Gluten Free Casein Free (GFCF) pada Anak dengan Autism Spectrum Disorder Kurniawan, Agung; Fukata, Editya; Ariesaka, Kiky Martha; Wijaya, Andreas Budi; Putri, Angelica Igsanti; Prasetya, Ahmada Viosepta; Devi, Athaayaa Nastiti Ulayya; Putra, Alvino Ramadhany; Khodijah, Khodijah; Auliarahma, Zhafirah
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 10 No. 4 (2025): December
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/dfr7v968

Abstract

Salah satu intervensi non-farmakologis pada anak dengan Autism Spectrum Disorder (ASD) adalah diet Gluten Free Casein Free (GFCF), namun pengetahuan guru Sekolah Luar Biasa (SLB) tentang diet ini masih sangat terbatas. Program pengabdian ini bertujuan meningkatkan pemahaman guru mengenai konsep dan implementasi diet GFCF di sekolah. Metode yang digunakan adalah pelatihan berbasis model ADDIE (Analysis, Design, Development, Implementation, Evaluation) yang melibatkan 29 guru SDLB melalui pendekatan partisipatif. Evaluasi dilakukan dengan pre-test dan post-test yang dianalisis menggunakan uji paired T-test. Hasil menunjukkan adanya peningkatan signifikan pada skor pengetahuan guru setelah pelatihan (p=0,021), dengan rata-rata peningkatan 4,83 poin. Analisis kualitatif juga memperlihatkan partisipasi aktif, sikap positif terhadap penerapan diet GFCF, serta kepuasan tinggi terhadap proses pelatihan. Kegiatan ini merupakan pelatihan pertama di Indonesia yang menggunakan pendekatan model ADDIE untuk meningkatkan kapasitas guru SLB dalam menerapkan diet GFCF secara terstruktur. Temuan ini menunjukkan bahwa pelatihan terstruktur efektif meningkatkan kapasitas guru dalam mendukung tatalaksana holistik anak dengan ASD, sekaligus berkontribusi pada pengembangan ilmu pengetahuan terapan di bidang pendidikan khusus dan pencapaian Sustainable Development Goals (SDGs), khususnya pada aspek kesehatan dan pendidikan berkualitas. Enhancing Special School Teachers’ Capacity on Gluten Free Casein Free (GFCF) Diet for Children with Autism Spectrum Disorder Abstract One of the non-pharmacological interventions for children with Autism Spectrum Disorder (ASD) is the Gluten Free Casein Free (GFCF) diet; however, teachers in special schools (SLB) still have very limited knowledge about this dietary approach. This community service program aimed to improve teachers’ understanding of the concept and implementation of the GFCF diet in schools. The method used was training based on the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), involving 29 special elementary school teachers. Evaluation was carried out using pre- and post-tests analyzed with a paired t-test. The results showed a significant increase in teachers’ knowledge scores after the training (p=0.021), with an average improvement of 4.83 points. Qualitative analysis also revealed active participation, positive attitudes toward the application of the GFCF diet, and high satisfaction with the training process. These findings demonstrate that structured training is effective in enhancing teachers’ capacity to support the holistic management of children with ASD, while also contributing to the advancement of applied science in special education and the achievement of the Sustainable Development Goals (SDGs), particularly in the areas of health and quality education.
Co-Authors Achmad Rudijanto Agung Kurniawan Arie Srihardyastutie Aulanni'am, Aulanni'am Aulanniam Auliarahma, Zhafirah Camoya Gersom Devi, Athaayaa Nastiti Ulayya Editya Fukata Faizal Reza Pahlevi Furqan Hidayatullah Khodijah Khodijah Kiky Martha Ariesaka Prasetya, Ahmada Viosepta Putra, Alvino Ramadhany Putri, Angelica Igsanti Ramadani, Devi Rulli Rosandi Veronica Verina Setyabudhi Wuragil, Dyah Kinasih