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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Lina Widiyastuti
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Formulation and Antioxidant Activity of Syzygium polyanthum (Salam) Ethanolic Extract with Het-Cam Irritation Assessment Lina Widiyastuti; Siti Fatmawati Fatimah; Athiyyah Najelita Harahap; Leoni Nanda Wulandari; Hajjatuna Hasna Salsabil; Syifa Aulia Nugraheni; Aulia Salsabila Merdeksari
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 2 (2026): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i2.26833

Abstract

Ethanol extract of salam leaves (Syzygium polyanthum) contains flavonoids, tannins, essential oils, citric acid, and eugenol, which are efficacious as antioxidants, anti-cholesterol, antimicrobials, and antidiabetics. Extracts need to be formulated in gel dosage forms to obtain uniform doses, enhance the effectiveness of pharmacological effects, ensure hygiene, and facilitate ease of use. The study aims to develop a gel formula using the physical characteristics ANOVA method with ethanol extract from salam leaves at a 95% confidence level. The results revealed that the salam leaves ethanol extract gel had moderate to strong antioxidant activity. The results of the irritation test indicate that the characteristics have met the requirements for efficacious antioxidant dosage forms that do not cause irritation. The stages of the research method began with the development of a gel dosage form using Design Expert software. The gel formed exhibited physical characteristics, including organoleptic properties, viscosity, homogeneity, pH, adhesion, and spreadability. The gel effectiveness test included an antioxidant test using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and an in vitro irritation test using the Hen's Egg Test Chorioallantoic Membrane (HET-CAM) method, which assessed the presence of lysis, bleeding, or coagulation in the test media.
Co-Authors Agung Endro Nugroho Agung Endro Nugroho Aprilia Kusbandari, Aprilia Athiyyah Najelita Harahap Aulia Salsabila Merdeksari Azis Ikhsanudin Citra Ariani Edityaningrum, Citra Deasy Vanda Pertiwi Fatma Nuraisyah, Fatma Hajjatuna Hasna Salsabil Iis Wahyuningsih Leoni Nanda Wulandari Nilmawati Nilmawati Noorlina, Noorlina Novia Ariani Dewi Novitasari, Putri Rachma Prastyaningrum, Endah Rusdi, Niswa Fadilah Siti Fatmawati Fatimah, Siti Fatmawati Suwidjiyo Pramono Suwidjiyo Pramono Syifa Aulia Nugraheni Widyasari Putranti