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All Journal Natural Science: Journal of Science and Technology Biocelebes Jurnal Kedokteran Universitas Palangka Raya
Musjaya M. Guli
Jurusan Biologi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Tadulako
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Immunology & microbiology Medicine & Pharmacology Public Health

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PATOGENESIS PENYAKIT KOLERA PADA MANUSIA Musjaya M. Guli
Biocelebes Vol. 10 No. 2 (2016)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.639 KB)

Abstract

Vibrio cholerae is the causative agent of cholera is characterized by continuous diarrhea in patients. V.cholerae strains that have ctx genes that can produce cholera toxin (cholera toxin = CT), which is a toxigenic strain. The toxigenic strain responsible for an outbreak of cholera. Pathogenic V. cholerae is due to two main factors, namely cholera toxin (CT) and TCP pili (toxin coregulatedpilus), which is responsible for the ability of V. cholerae attaches to epithelial cells intestinal. The mechanism of bacterial infection generally consists of 2 phases, the first phase of bacterial will latch preceded by pili to host cells that are anchoring, after that proceed with sticking through the outer membrane cell attachment is doching. After the invasion and colonization, V. cholerae which will remove pathogens and toxin coregulated CT philus (TCP). Type IV pili are found in V. cholerae are important in the formation of colonies, biofilms, and adhesion and secretion of proteins in the outer membrane. V. cholerae can invade macrophage phagocytosis surrounded by a membrane that V. cholerae can damage the membrane and spread into the cytoplasm. Keywords: Cholera, Pathogenicity, Cholera toxin (CT), toxin coregulatedpilus (TCP), Vibrio cholerae
RESPON IMUN HOSPES TERHADAP INFEKSI Vibrio cholerae Musjaya, M Guli
Biocelebes Vol. 15 No. 2 (2021)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/bioceb.v15i2.15777

Abstract

The immune sistem is a way of the body’s defense sistem to save the host from the invasion of outside pathogen. Based on how respon to disease, that differentiated into two immune system are innate and adaptive system. Because it an cant throgh the stomach, these pathogenic bacteria go to the small intestin as a site infection. In the intestine, V. cholerae bactesia adhere and colonize and invasion to intestinal epihelial cells. Protection mechanism to V. cholerae are the natural defense presence of tick mucosa on the surface of epithelial cells can inhibit pathogene to adhere tointestinal epithelial cells. One anothet defense namely innate immune system did by phagocytic cells to attac pathogen agent and adaptive immune system involves IgA to opsonization so that can increase intestinal mucosal immune system
PERBANDINGAN EKSTRAKSI AKAR KUCING (ACALYPHA INDICA L.) DENGAN EKSTRAK ETANOL 96% DAN EKSTRAK AKUADES TERHADAP PERTUMBUHAN EPEC DAN CANDIDA ALBICANS M. Guli, Musjaya; Zahra, Yuyun Jannatul; Ardiputra, Muh. Akbar; Toemon, Agnes Immanuela
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 2 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i2.11038

Abstract

The root of the cat (Acalypha indica L.) was used as the object of research and extraction was carried out to determine the antimicrobial activity of 96% ethanol extract and distilled water against EPEC (Enterophatogenic Escherichia coli) bacteria and the fungus Candida albicans. The method used for plant sampling is purposive sampling method. Extraction of active compounds using maceration method. The antimicrobial potency test used the agar-diffusion method using two types of microbial pathogens, namely the bacteria EPEC and the fungus Candida albicans. Each paper disk was given 50 µL of bacterial isolate, incubated at 37 0C for 24 hours and continued for 48 hours. The observed parameter is the clear zone formed around the paper disk. The results showed that cat root (A. indica L.) contains compounds that can inhibit the growth of EPEC bacteria and the fungus C. albicans. A good solvent to extract the active compounds contained in the cat root plant (A. indica L.) is distilled water. Treatment with aquadest extract with a concentration of 100% had the widest inhibition zone among other treatments, namely 6.8 mm against the growth of EPEC bacteria and ethanol extract with a concentration of 100% which was 3.8 mm against the growth of the fungus Candida albicans.
Uji aktivitas antimikroba ekstrak daun tumbuhan akar kucing (Acalypha indica l.) terhadap mikroba patogen manusia M. Guli, Musjaya; Darmiyati; Ardiputra, Muh.Akbar; Toemon, Agnes Immanuela
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 2 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i2.11040

Abstract

The leaves of Acalypha indica L. were used as the object that are easily found around the home contain secondary metabolites as antimicrobials for Meticillin Resistant Staphylococcus aureus (MRSA) and Candida albicans. The method used for plant sampling is purposive sampling method. Extraction of active compounds using maceration method. The antimicrobial potency test used the agar-diffusion method using two types of microbial pathogens: Meticillin Resistant Staphylococcus aureus (MRSA) and C. albicans. Each paper disk was given 50 L of bacterial isolate and incubated at 370 C for 24 hours and continued for 48 hours. The parameter observed is the clear zone formed around the paper disk. The results showed that the leaves of contained compounds that could inhibit the growth of MRSA bacteria and the fungus. A good solvent to extract the active compounds contained in the leaves of is distilled water. The extract - distilled water treatment with a concentration of 100% had the widest inhibition zone among other treatments, which was 4.5 mm against the growth of the fungus
Uji efektivitas antibakteri ekstrak daun kayu hitam (Diospyros celebica Bakh.) terhadap bakteri Staphylococcus aureus dan Salmonella typhi M. Guli, Musjaya; Priyandini, Nabila; Lambui, Orryani; Ardiputra, Muh.Akbar; Toemon , Agnes Immanuela
Jurnal Kedokteran Universitas Palangka Raya Vol 12 No 1 (2024): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v12i1.13189

Abstract

Diospyros celebica leaf extract can inhibit the growth of Staphylococcus aureus and Salmonella typhi bacteria. This research aims to determine the ability of D. celebica leaf extract to inhibit the growth of S. aureus and S. typhi bacteria. S. aureus and S. typhi were grown in NA media and then given leaf extract with concentrations of 10%, 20%, 30% and 40% using the well method. 2% chloramphenicol added to the bacterial growth medium was used as a control. The results showed that the leaf extract from D. celebica has a strong inhibitory power to inhibit the growth of S. aureus and S. typhi bacteria.
Pengaruh Faktor Sosial Ekonomi dan Lingkungan Terhadap Prevalensi Demam Berdarah Dengue di Wilayah Kerja Puskesmas Sangurara, Bulili dan Birobuli Kota Palu M. Guli, Musjaya; Nita; Yuniati, Eny; Ardiputra, Muh.Akbar; Toemon, Agnes Immanuela
Jurnal Kedokteran Universitas Palangka Raya Vol 12 No 2 (2024): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v12i2.13102

Abstract

Dengue fever is one of the diseases that is still a problem in Indonesia. The incidence of DHF cases in Central Sulawesi, especially Palu City, has increased every year. Environmental and socio-economic factors affect the breeding of Aedes Aegypti mosquitoes. This study aims to determine the effect of socio[1]economic and environmental conditions on the incidence of DHF in the working areas of Sangurara, Bulili and Birobuli health centers in Palu City, Central Sulawesi. The method used quantitative with cross sectional research design. Sampling using Simple Random Sampling technique. The number of samples was 51 cases and 51 controls. Analysis technique used Chi- Square. From the results of the study, the variables that significantly influenced the incidence of DHF were education (p-value = 0.012), occupation (p-value = 1.000), income (p-value = 0.029), frequency of draining containers (p-value = 0.008), habit of hanging clothes (p-value = 0.031), home environment conditions (p-value = 0.005). While the variables that did not affect the incidence of DHF were the availability of lids on containers (p-value = 1.000), and the presence of larvae in containers (p-value = 0.127). This study concluded that education, income, frequency of container draining, habit of hanging clothes and home environmental conditions had a significant influence on the incidence of DHF and there was no influence between occupation, availability of container lids and the presence of larvae in containers.
Skrining Fitokimia Tumbuhan Potensi Obat Kanker Kolorektal Begonia Medicinalis Ardi & D.C. Thomas Ardiputra, Muh. Akbar; Musjaya M. Guli; Andi Saifah; Santi; Bambang Sardi; Wafiq Nurfadilah; Mohammad Rivaldi Putra Pratama; Afifah Islamia
Jurnal Kedokteran Universitas Palangka Raya Vol 12 No 2 (2024): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v12i2.13207

Abstract

Cancer is a condition in which cells or tissues undergo abnormal progressive growth. Colorectal cancer is cancer that occurs in the colon to rectum organs of humans. Alternative therapy for colorectal cancer treatment is the use of herbs such as Begonia medicinalis Ardi & D.C. Thomas. This study aimed to screen the bioactive compounds in the Begonia medicinalis Ardi & D.C. Thomas. extract and its potential as a colorectal cancer drug. This research consists of two stages, namely the extraction stage using the maceration method and the screening stage. The results showed that the extract of Begonia medicinalis Ardi & D.C. Thomas. positively contains flavonoids, alkaloids, and saponins. These bioactive compounds have potential activity as preventive and curative agents for colorectal cancer through several mechanisms, including suppressing oxidative stress, inhibiting CDK activity, suppressing intestinal inflammation, and increasing floranormal diversity and probiotic barrier activity in the intestine.
Literature Review: Comparative Analysis of Sputum Cytology Examination Methods & Fine Needle Aspiration (Fnab) For Lung Cancer Khairunnisa; Guli, Musjaya M.
Jurnal Kedokteran Universitas Palangka Raya Vol 13 No 1 (2025): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v13i1.18678

Abstract

Cancer remains one of the biggest medical challenges, with high mortality rates due to late detection and limited treatment. In 2020, Indonesia saw 396,914 new cancer cases and 234,511 cancer deaths. The purpose of this paper is to provide a strong foundation for the research being conducted, by utilizing knowledge and findings from previous studies related to the FNAB method and sputum cytology in patients with lung cancer. The sources used in this writing are Google, NIH, NCBI, and other national journals. The selection of methods must be adjusted to the patient's condition, risk factors, and the availability of medical facilities, with the main objective of achieving a rapid, accurate, and precise diagnosis, so as to determine the most appropriate therapy for lung cancer patients. This study shows that FNAB and sputum cytology have their respective advantages in the diagnosis of lung cancer. FNAB is highly effective for diagnosing small lung nodules, especially in high-risk patients, due to its high accuracy and ability to provide more detailed diagnostic information. In contrast, sputum cytology is more suitable for early detection and screening in high-risk populations, although its accuracy is lower and limited to certain types of cancer
Co-Authors Afifah Islamia Andi Saifah Ardiputra, Muh. Akbar Ardiputra, Muh.Akbar Astini Dewi Sari Bambang Sardi Darmiyati Endang Suerni Eny Yuniati Fahri Fahri Ika Merdeka Wati Khairunnisa Miswan Miswan Mohammad Rivaldi Putra Pratama Muhammad Alwi Murni Ria Nelky Suriawanto Nita Nur Indang Orryani Lambui Prita Permatasari Priyandini, Nabila Rahmat Pangestu Santi Toemon , Agnes Immanuela Toemon, Agnes Immanuela Umrah Umrah Wafiq Nurfadilah Yuni Tiara Zahra, Yuyun Jannatul