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Variasi Arteri Koronaria Dominan pada Jantung Kadaver di Laboratorium Anatomi Fakultas Kedokteran Universitas Andalas Gusti Revilla
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p130-136.2023

Coronary arteries have a variable distribution in the myocardium of the heart. This condition is also known as dominant coronary arteries. The research that has been done knows that the most common coronary artery variation is the right dominant variation and the co-dominant variation. Objective: to describe the variation of the dominant coronary arteries in the cadaveric heart at the Anatomy Laboratory of the Faculty of Medicine, Andalas University. Method: This study used a descriptive method of looking at the variation of the dominant coronary arteries in the cadaveric heart at the Anatomy Laboratory of the Faculty of Medicine, Andalas University. The population was all existing cadaveric hearts and the entire population was sampled according to the inclusion and exclusion criteria. Results: The number of samples found was 26 hearts. The results obtained were 80.8% were hearts with a right dominant coronary artery, which was the most varied, 7.7% a heart with a left dominant coronary artery, and 11.5% a heart with a co-dominant coronary artery. Conclusion: Variations of the dominant coronary arteries found ptovides information for the need to increase awareness of these risky variations so that morbidity and mortality can be reduced.

DAYA HAMBAT EKTRAK DAUN JARAK PAGAR (Jatropha curcas L) TERHADAP PERTUMBUHAN Candida albicans Susi susi; Gusti Revilla; Fitri Anggini; Putri Ovieza Maizar
Cakradonya Dental Journal Vol 11, No 2 (2019): Agustus 2019
Publisher : FKG Unsyiah

Candida albicans merupakan jamur flora normal bersifat opportunistik didalam rongga mulut yang dapat menyebabkan terjadinya denture stomatitispada daerah rongga mulut. Penelitian ini bertujuan untuk menetapkan potensi hambat ekstrak daun jarak pagar terhadap pertumbuhan Candida albicans (ATCC 10231) pada permukaan akrilik. Desain penelitian eksperimental laboratorium dengan Post test only with control group. Sampel 20 buah pelat resin akrilik heat cured yang dikontaminasikan dengan suspensi Candida albicans (0.5X108 cfu/ mL) dan diinkubasi secara aerob, selama 24 jam. Sampel dibagi menjadi 4 kelompok dan direndam selama 8 jam dalam ekstrak daun jarak pagar konsentrasi 10% (G1), 15% (G2), 20% (G3) dan akuades (G4). Ekstrak daun jarak pagar dibuat secara maserasi dengan etanol 96%. Koloni masing-masing sampel dihitung dengan Tally counter. Data dianalisis dengan One Way Anova (p0,05). Hasil penelitian menunjukkan bahwa jumlah koloni Candida albicans terkecil ditemukan pada kelompok konsentrasi 20% dibandingkan dengan kelompok kontrol. Hasil analisa One Way Anova menunjukkan adanya perbedaan jumlah koloni Candida albicans antar kelompok (p0.05). Hasil Uji Least Significance Different terdapat perbedaan bermakna antara kelompok kontrol dengan kelompok konsentrasi 15%, dan 20% (p0.05). Kesimpulan ekstrak daun jarak pagar dapat menghambat pertumbuhan Candida albicans pada pemukaan akrilikKata kunci: Candida albicans, ekstrak daun jarak pagar, maserasi

Exploring the Effects of Bone Marrow Mesenchymal Stem Cells on Amyloid Plaque Reduction in a Rat Model of Alzheimer's Disease Annita Annita; Gusti Revilla; Hirowati Ali; Almurdi Almurdi
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1036-1044.2023

Objective: This study aimed to evaluate the therapeutic potential of Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) in mitigating amyloid plaque formation in Alzheimer's disease induced by Aluminum Chloride (AlCl3) in rats. Methods: Rats were divided into three groups: negative control, positive control (AlCl3-induced), and treatment (AlCl3 + BM-MSCs). Cognitive function was assessed five days post-induction, and amyloid plaques were quantified using Congo Red staining in the cortex and hippocampus. Results: A significant reduction in amyloid plaque was observed in rats treated with BM-MSCs. The proportion of stained areas decreased from 1.88 to 1.73 in the cortex and from 1.61 to 1.47 in the hippocampus, compared to AlCl3-only controls. Conclusion: BM-MSCs demonstrated a moderate but statistically significant reduction in amyloid plaque in a rat model of Alzheimer's disease, indicating their therapeutic potential.

Pengaruh Human Bone Marrow Mesenchymal Stem Cells Terhadap Penyembuhan Luka Bakar Pada Pembentukan Jaringan Granulasi Tikus DM Dini Nurhasanah; Gusti Revilla; Deddy Saputra
VitaMedica : Jurnal Rumpun Kesehatan Umum Vol. 2 No. 3 (2024): Juli : VitaMedica : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/vitamedica.v2i3.109

Background: Burns with diabetes mellitus conditions can interfere with the wound healing process. Mesenchymal stem cells have been studied to heal burns, one of which originates from the bone marrow Objective: Determine the effect of human bone marrow mesenchymal stem cells on burn wound healing in the formation of granulation tissue DM rats. Methods: Research is experimental research with post-test only control group design. The research subjects were 30 rats divided into two groups, the control group was given NaCl and the treatment group was given hBM-MSCs. Mice were induced by alloxan to cause hyperglycemia, burns were made using a heated plate. Tissue collection was carried out after termination of the experimental animals on the 3rd, 7th, 14th days and then made histological preparations to assess the formation of granulation tissue. Data were analyzed using Two Way Anova Test. Results: Increase in the number of macrophages, fibroblasts and new blood vessels after hBM-MSCs were given. There were no increase on the 14th day neutrophils and 3rd day lymphocytes. Statistical analysis showed a significant increase in the number of lymphocytes, macrophages, fibroblasts and new blood vessels. Conclusion: The is study concludes that human bone marrow mesenchymal stem cells can increase the formation of granulation tissue by increasing macrophages, fibroblasts and new blood vessels in DM rats.

DAYA HAMBAT EKTRAK DAUN JARAK PAGAR (Jatropha curcas L) TERHADAP PERTUMBUHAN Candida albicans Susi susi; Gusti Revilla; Fitri Anggini; Putri Ovieza Maizar
Cakradonya Dental Journal Vol 11, No 2 (2019): Agustus 2019
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v11i2.16153

Candida albicans merupakan jamur flora normal bersifat opportunistik didalam rongga mulut yang dapat menyebabkan terjadinya denture stomatitispada daerah rongga mulut. Penelitian ini bertujuan untuk menetapkan potensi hambat ekstrak daun jarak pagar terhadap pertumbuhan Candida albicans (ATCC 10231) pada permukaan akrilik. Desain penelitian eksperimental laboratorium dengan Post test only with control group. Sampel 20 buah pelat resin akrilik heat cured yang dikontaminasikan dengan suspensi Candida albicans (0.5X108 cfu/ mL) dan diinkubasi secara aerob, selama 24 jam. Sampel dibagi menjadi 4 kelompok dan direndam selama 8 jam dalam ekstrak daun jarak pagar konsentrasi 10% (G1), 15% (G2), 20% (G3) dan akuades (G4). Ekstrak daun jarak pagar dibuat secara maserasi dengan etanol 96%. Koloni masing-masing sampel dihitung dengan Tally counter. Data dianalisis dengan One Way Anova (p0,05). Hasil penelitian menunjukkan bahwa jumlah koloni Candida albicans terkecil ditemukan pada kelompok konsentrasi 20% dibandingkan dengan kelompok kontrol. Hasil analisa One Way Anova menunjukkan adanya perbedaan jumlah koloni Candida albicans antar kelompok (p0.05). Hasil Uji Least Significance Different terdapat perbedaan bermakna antara kelompok kontrol dengan kelompok konsentrasi 15%, dan 20% (p0.05). Kesimpulan ekstrak daun jarak pagar dapat menghambat pertumbuhan Candida albicans pada pemukaan akrilikKata kunci: Candida albicans, ekstrak daun jarak pagar, maserasi

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