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All Journal Majalah Kedokteran Andalas Cakradonya Dental Journal Vitamedica: Jurnal Rumpun Kesehatan Umum
Gusti Revilla
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Dentistry Health Professions Medicine & Pharmacology Public Health

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Journal : Majalah Kedokteran Andalas

 1 
Variasi Arteri Koronaria Dominan pada Jantung Kadaver di Laboratorium Anatomi Fakultas Kedokteran Universitas Andalas Gusti Revilla
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p130-136.2023

Abstract

Coronary arteries have a variable distribution in the myocardium of the heart. This condition is also known as dominant coronary arteries. The research that has been done knows that the most common coronary artery variation is the right dominant variation and the co-dominant variation. Objective: to describe the variation of the dominant coronary arteries in the cadaveric heart at the Anatomy Laboratory of the Faculty of Medicine, Andalas University. Method: This study used a descriptive method of looking at the variation of the dominant coronary arteries in the cadaveric heart at the Anatomy Laboratory of the Faculty of Medicine, Andalas University. The population was all existing cadaveric hearts and the entire population was sampled according to the inclusion and exclusion criteria. Results: The number of samples found was 26 hearts. The results obtained were 80.8% were hearts with a right dominant coronary artery, which was the most varied, 7.7% a heart with a left dominant coronary artery, and 11.5% a heart with a co-dominant coronary artery. Conclusion: Variations of  the dominant  coronary arteries  found ptovides information for the need to increase awareness of these risky variations so that morbidity and mortality can be reduced.
Exploring the Effects of Bone Marrow Mesenchymal Stem Cells on Amyloid Plaque Reduction in a Rat Model of Alzheimer's Disease Annita Annita; Gusti Revilla; Hirowati Ali; Almurdi Almurdi
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1036-1044.2023

Abstract

Objective: This study aimed to evaluate the therapeutic potential of Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) in mitigating amyloid plaque formation in Alzheimer's disease induced by Aluminum Chloride (AlCl3) in rats. Methods: Rats were divided into three groups: negative control, positive control (AlCl3-induced), and treatment (AlCl3 + BM-MSCs). Cognitive function was assessed five days post-induction, and amyloid plaques were quantified using Congo Red staining in the cortex and hippocampus. Results: A significant reduction in amyloid plaque was observed in rats treated with BM-MSCs. The proportion of stained areas decreased from 1.88 to 1.73 in the cortex and from 1.61 to 1.47 in the hippocampus, compared to AlCl3-only controls. Conclusion: BM-MSCs demonstrated a moderate but statistically significant reduction in amyloid plaque in a rat model of Alzheimer's disease, indicating their therapeutic potential.
Co-Authors Almurdi Almurdi Annita Annita Deddy Saputra Dini Nurhasanah Fitri Anggini Hirowati Ali Putri Ovieza Maizar susi susi Susi Susi