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Impact of scabies on Indonesian public boarding school students’ quality of life: A mixed-method analysis Menaldi, Sri Linuwih SW; Surya, Danny; The, Valensia Vivian; Marissa, Melani
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Scabies is a neglected tropical disease in which people affected primarily presents with intense pruritus. The disease is often recurrent, especially in people living in close contacts, such as in a community; thus, it negatively impacts their quality of life (QoL).This study analyzes the impact of pruritus in scabies on the QoL of patients living in a public boarding school (PBS) in West Java, Indonesia. Methods: This study is a mixed-method study conducted on 39 subjects. TheQoL was examined using the Indonesian version of the dermatology life quality index (DLQI) questionnaire and in-depth interviews. Results: Most subjects were female, grade 9 students, had a duration of symptoms between six months to one year, had been infected more than twice, and with no family member affected by the same symptoms. We found that sex, duration of symptoms, disease frequency, and affected family members did not significantly affect subjects’ QoL. In-depth interviews revealed that pruritus affected social relationships, quality of learning, and sleeping. Conclusion: Holistic and comprehensive community management is needed to treat and prevent scabies transmission, as its symptoms negatively impact the QoL of students in PBS.
Berbagai Instrumen Penilaian Photoaging dan Karakteristiknya Putu Martha Gerynda Sukma; Shannaz Nadia Yusharyahya; Sri Linuwih SW Menaldi; Lili Legiawati; Rinadewi Astriningrum
Jurnal Kedokteran Meditek Vol 29 No 1 (2023): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v29i1.2454

Abstract

Seiring dengan bertambahnya usia seseorang, kulit sebagai jaringan terluar dari tubuh manusia akan memberikan gambaran paling terlihat dari proses penuaan. Penuaan kulit dipengaruhi oleh dua faktor yaitu faktor intrinsik dan faktor ekstrinsik. Faktor intrinsik terjadi secara alamiah dan berkaitan dengan proses degenerasi seluler. Faktor ekstrinsik berkaitan dengan pajanan sinar matahari, rokok, dan polusi udara. Penyebab utama penuaan kulit akibat faktor ekstrinsik berupa pajanan kronik sinar ultraviolet dikenal sebagai photoaging. Tanda klinis photoaging dapat bervariasi, namun yang sering ditemukan berupa perubahan pigmentasi dan keriput. Saat ini telah tersedia lebih dari 100 instrumen penilaian penuaan kulit menggunakan fotografi, dermoskopi, dan alat diagnostik multifungsi namun masih belum ada yang dianggap sebagai baku emas. Tinjauan pustaka ini bertujuan untuk membahas berbagai instrumen penilaian photoaging yang sering digunakan dalam praktik klinis sehari-hari dan karakteristik dari masing-masing instrumen tersebut.
MANIFESTASI KULIT PADA INFEKSI VIRUS NEW EMERGING DAN RE-EMERGING DI INDONESIA Mufqi Handaru Priyanto; Triana Agustin; Eliza Miranda; Sandra Widaty; Sri Linuwih Menaldi
Media Dermato-Venereologica Indonesiana Vol 50 No 3 (2023): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i3.247

Abstract

Virus merupakan patogen infeksius yang dapat menyebabkan berbagai penyakit life-threatening, dan memiliki kemampuan untuk berevolusi seiring dengan evolusi manusia sebagai pejamu. Virus new-emerging, memiliki patogenitas yang lebih tinggi karena belum terbentuk imunitas alamiah pada pejamu. Selain itu, berbagai virus re-emergingjuga menjadi ancaman tersendiri karena kemampuannya yang tinggi untuk berevolusi, sehingga keberadaan virus emergingini menyebabkan outbreak, epidemi, dan pandemik global. Indonesia dengan letak geografis yang strategis dan habitat fauna yang beragam, berpotensi besar bagi transmisi zoonosis dan tempat berkembang yang ideal bagi vektor pada penyakit virus. Beberapa infeksi virus new emergingcontohnya virus swine fludan SARS-CoV-2, serta virus re-emergingmisalnya virus chikungunya dan measles yang dilaporkan di Indonesia, tidak hanya memberikan gejala klinis yang biasa, namun dapat disertai dengan manifestasi pada kulit. Beberapa manifestasi pada kulit tersebut juga dapat menjadi penanda khas terhadap jenis inveksi virus yang berperan sebagai patogen. Identifikasi terhadap lesi kulit pada penyakit-penyakit akibat infeksi virus penting untuk dilakukan, dan memiliki peran untuk mengarahkan pada kemungkinan diagnosis dan tata laksana yang tepat.
Patogenesis Melasma Riyantia Astrid Diahtantri; Sri Linuwih Menaldi; Fadhli Aulia Mughni
Cermin Dunia Kedokteran Vol 51 No 9 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i9.1514

Abstract

Melasma is a chronic skin pigmentation disorder caused by sunlight exposure. Melasma is a multifactorial disease with various pathways that can induce hyperpigmentation. Exposure to ultraviolet (UV) light as a source of reactive oxygen species (ROS) and free radicals plays a role in the pathogenesis of melasma. Another mechanism is the role of ROS on melanogenesis and melanocyte cells as well as the signaling pathway for melanin synthesis. Concentration of antioxidants as a skin defense against ROS, namely superoxide dismutase (SOD), catalase, and glutathione peroxidase, also influences the occurrence of melasma.
PIODERMA FASIALE: DERMATOSIS AKIBAT INFEKSI ATAU AKIBAT ETIOLOGI LAIN? SUATU KASUS JARANG Priyanto, Mufqi Handaru; Miranda, Eliza; Sirait, Sondang Pandjaitan; Menaldi, Sri Linuwih SW
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.261

Abstract

Pioderma fasiale merupakan kondisi kelainan kulit yang jarang terjadi. Kelainan ini secara klasik ditandai dengan munculnya erupsi inflamatori berupa papul, pustul, nodul, bahkan kista pada wajah, terutama mengenai perempuan usia 15-46 tahun. Kondisi tersebut saat ini disebut sebagai rosasea fulminan, suatu varian rosasea yang berat dengan etiologi yang belum diketahui jelas sampai sekarang. Diduga terdapat hubungan antara pioderma fasiale dengan faktor imunologi, hormonal, dan vaskular. Dilaporkan satu kasus yang sepengetahuan penulis belum pernah dilaporkan di Indonesia. Perempuan usia 15 tahun dalam terapi lupus eritematosus sistemik, datang dengan erupsi pustul multipel di atas plak eritematosa disertai beberapa telangiektasis pada wajah. Kondisi ini awalnya dipikirkan sebagai suatu pioderma yang membaik dengan antibiotik sistemik  amoksisilin/asam klavulanat, namun mengalami rekurensi. Kultur dari pustul tidak didapatkan pertumbuhan isolat bakteri, dan biopsi jaringan menunjukkan sebukan sel polimorfonuklear di sekitar pembuluh darah, jaringan interstitial, dan folikel rambut. Pasien kemudian diterapi dengan kombinasi asam retinoat dan eritromisin topikal yang memberikan respons sangat baik dalam 3 minggu sejak dimulainya terapi.
PERKEMBANGAN TERKINI MANIFESTASI KLINIS FRAMBUSIA Natasha, Joanne; Menaldi, Sri Linuwih SW; Irawan, Yudo; Novianto, Endi
Media Dermato-Venereologica Indonesiana Vol 51 No 2 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i2.338

Abstract

Yaws, a neglected tropical disease, is still become the health problem in several countries. World Health Organization has proposed 2030 goals for yaws eradication after the previous target has not been achieved. Indonesia is still one of the largest contributors to yaws cases in Southeast Asia. The variety of lesions and the development of atypical clinical features make the yaws diagnose as a challenge. WHO guideline is used as a reference to determine the clinical manifestations, divided into early stage (infectious) lesions to advanced (non-infectious) yaws lesions. Yaws clinical features should be mastered by health workers in Indonesia, considering that the establishment of suspected cases begin with a clinical examination then confirmed by serological test. Several recent clinical surveillance had not reported early-stage lesions as the most common clinical finding, but rather had scars which was previously removed from the modified WHO guidelines. Missed diagnosis causes continually transmission.
The spectrum of cutaneous manifestations in COVID-19 patients at Dr. Cipto Mangunkusumo Hospital Widaty, Sandra; Menaldi, Sri Linuwih Susetyo Wardhani; Miranda, Eliza; Marissa, Melani; Nilasari, Hanny; Melinda, Thong Felicia; Cornain, Emilina Faradila
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

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Background: Cutaneous manifestations are identified in 0.2%–20% of COVID-19 cases, both in adult and pediatric patients. They can occur before, simultaneously with, or after the systemic symptoms of COVID-19. This study aims to analyze the association between cutaneous manifestations, severity, and outcomes of patients with COVID-19. Methods: This observational study was conducted from April 2020 to April 2021 in Dr. Cipto Mangunkusumo Hospital, a referral center for COVID-19 in Jakarta, Indonesia. Medical records were used to collect demographic, clinical, and laboratory data. Results: A total of 0.61% (31/5070) of COVID-19 cases showed cutaneous manifestations, consisting of maculopapular (80.6%), vesicular (16.1%), livedoid (6.4%), pseudo-chilblain (3.2%), and urticarial (3.2%) lesions, with three patients showing more than one cutaneous manifestation. In the present study, only 2,001 out of 5,070 patients were appropriately confirmed to suffer from COVID-19 infection. Multisystem inflammatory syndrome in children (MIS-C) was identified in one out of eleven patients under 21 years old. Laboratory examinations showed an increased neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), procalcitonin, D-dimer, and creatinine alongside a decreased albumin level. Conclusion: We reported various cutaneous manifestations and diagnostic test results associated with COVID-19. More than one cutaneous manifestations are present in several COVID-19 patients in our study. Several contradictory findings relative to previous publications indicate the necessity of collecting more data regarding the cutaneous manifestation of COVID-19.
A Multidimensional Welfare Status of Leprosy Patients Living in a Suburban Area Irawati, Yunia; Menaldi, Sri Linuwih SW; Harini, Melinda; Wahyuni, Luh Karunia; Alwin, Wanarani; Dwiranti, Astari; Menaldi, Adhityawarman; Luzanil, Sonny Tirta; Matsurah, Qaishum; ., Dadun; Kurniawan, Rico; Ruwaida, Ida; Wicaksono, Gunawan; Sahid, Muhammad Hidayat; Rahmayanti, Febrina; Priscilia, Florentina; Fitriana, Anis; Rahayu, Tri; Susiyanti, Made; Andayani, Gitalisa; Bani, Anna Puspitasari; Daniel, Hisar; Lestari, Yeni Dwi
ASEAN Journal of Community Engagement Vol. 5, No. 1
Publisher : UI Scholars Hub

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Abstract

Leprosy has a high incidence of physical complications that will impact directly the physiological, economic, and social status of patients. Indonesia has a high burden of the disease, and several leprosy settlements are still spread in the country. Neglasari Village, Sitanala, Tangerang serves as one of the places of residence of people who have had leprosy. A health service initiative known as Identifikasi Tanda-Tanda Mata, Ekstremitas, dan Kulit pada Kusta (KATAMATAKU) was launched as a collaboration of health services among multi-departments (ophthalmology, dermatovenereology, and medical rehabilitation). Sitanala has a relatively high incidence of people who have had leprosy with disabilities of the hand, foot, and eye. As a continuation of this health service and combined with the efforts to improve the welfare of leprosy patients, in November 2019, a multidisciplinary program titled KATAMATAKU Universitas Indonesia, was conducted. This program aimed to determine the demographic data regarding the health, psychological, social, and economic status of the leprosy population at Sitanala The project consisted of a collaborative anti-stigma program by the Faculty of Psychology, Public Health, Social and Political Sciences, Cultural Sciences, Administrative Sciences, and Vocational Educational Program; thematic health program, which supports the improvement of physical abilities and empowerment of former leprosy patients, by the Faculty of Medicine, Dentistry, Nursing, and Pharmacy; thematic economics program, which aims to increase the economic capacity of the leprosy community, by the Faculty of Economics and Business, Mathematics and Natural Sciences, and Engineering. This program enabled the construction of a multidimensional management model, in which every aspect plays important roles to improve the patients’ quality of life.
Difficulties in diagnosing primary cutaneous mucormycosis: Excluding mycobacterium other than tuberculosis Indah, Chinda Liaska; Menaldi, Sri Linuwih Susetyo Wardhani; Sirait, Sondang Pandjaitan; Widaty, Sandra
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

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Background: Mucormycosis is a rare fungal infection caused by a group of opportunistic fungi from the class Zygomycetes. Primary cutaneous mucormycosis is the most common type of mucormycosis in immunocompetent patients. This study reported a case of primary cutaneous mucormycosis with nonspecific clinical characteristics and various supporting examinations. The patient was successfully treated with in toto excision and oral ketoconazole. Case Illustration: A 40-year-old female presented with purplish-red spots and painless lumps on the second finger of her right hand, which had been present for a year. She had a history of frequent fish tank cleaning and gardening but denied any known injury. Physical examination revealed multiple well-circumscribed and confluent erythematous-violaceous plaques and nodules. An in toto excisional biopsy was performed for histopathological examination, culture, and a rapid molecular test (RMT) using the Xpert MTB/RIF® test (Cepheid, USA). Histopathological examination revealed granulomatous suppurative inflammation, and fungal culture revealed growth of Mucor species. Discussion: Clinical findings in cutaneous mucormycosis are nonspecific. The diagnosis is confirmed by identifying the organism through biopsy and histopathological examination, as well as culture. Histopathology will reveal granulomas in the dermis and subcutis containing numerous macrophages and Langhans giant cells, often with phagocytosed fungal elements. Fungal culture yields positive results in 72–89% of cases of skin mucormycosis conducted on Sabouraud and potato dextrose agar media. Conclusion: This case emphasizes the need for broad differential consideration and thorough diagnostic workup in nonspecific cutaneous mucormycosis and supports surgical excision with systemic antifungal therapy for chronic, localized primary disease.
Tingkat Kesesuaian Gambaran Klinik dan Histopatologik Serta Positivitas CD4 dan CD8 pada Spektrum Penyakit Kusta Menurut Klasifikasi Ridley-Jopling . Lenti Perangin Angin*, Sri Linuwih Menaldi**, Santoso Cornain*, Mpu Kanoko
Majalah Patologi Indonesia Vol. 20 No. 2, Mei 2011
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRAK Latar Belakang Kusta adalah suatu penyakit kronik yang disebabkan oleh Mycobacterium leprae. Manifestasi penyakit kusta bergantung kepada respon imun seluler seseorang. Ridley-Jopling membuat klasifikasi menjadi Tuberculoid leprosy (TT), Borderline tuberculoid (BT), Mid-borderline (BB), Borderline lepromatous (BL), Lepromatous leprosy (LL) berdasarkan gambaran klinik, histopatologik, bakteriologik dan imunologik. Pada umumnya Pusat Kesehatan Masyarakat di Indonesia belum memiliki fasilitas pemeriksaan histopatologik dan imunologik, sehingga diagnosis kusta hanya ditegakkan berdasarkan jumlah lesi dan jumlah kuman. Tujuan penelitian ini adalah untuk mengetahui tingkat kesesuaian antara gambaran klinik dan histopatologik penyakit kusta dan melihat gambaran respon imun penderita melalui pemeriksaan CD4+ dan CD8+ pada limfosit sel T, serta korelasi antara indeks bakteriologik pada masing-masing tipe kusta. Bahan dan Cara Penelitian potong lintang terhadap 159 kasus kusta baru tanpa reaksi tahun 2007-2009 di Departemen Ilmu Kesehatan Kulit dan Kelamin RSUPN Dr. Cipto Mangunkusumo. Secara sistematic sampling dilakukan pemeriksaan Hematoksilin-Eosin, Fite Faraco dan immunohistokimia CD4 dan CD8 pada 30 kasus masing-masing mewakili tipe kusta. Hasil Dari 159 kasus kusta baru tanpa reaksi terdiri atas 88 laki-laki dan 71 perempuan, dengan kelompok umur paling banyak pada rentang 16-30 tahun. Tingkat kesesuaian diagnosis kusta secara klinik dan histopatologik adalah 52.2%, dengan ketidaksesuaian mayor ditemukan 22% dan ketidaksesuaian minor 25.8%. Tidak terdapat hubungan yang bermakna antara positivitas CD4 dan CD8 dengan tipe kusta sedangkan Indeks Bakteriologik memiliki hubungan yang bermakna dengan spektrum tipe kusta. Kesimpulan Tingkat kesesuaian penegakan diagnostik secara klinik dan histopatologik adalah 52.2%. Terdapat korelasi dengan kekuatan sedang pada hubungan diagnosis klinik dan indeks bakteriologik sedangkan pada diagnosis histopatologik terdapat korelasi kuat dengan indeks bakteriologik. Kata Kunci : Mycobacterium leprae, kusta, indeks bakteriologik, diagnosis klinik, diagnosis histopatologik, klasifikasi Ridley-Jopling, CD4+, CD8+. ABSTRACT Background Leprosy (Hansen’s Disease) is a chronic infectious disease caused by Mycobacterium leprae. The varied manifestations of the disease might depend on the immune status of the host. Ridley-Jopling classified cases based on clinical, histopathological, bacteriological and immunologicalfeatures as TT (tuberculoid leprosy), BT (borderlinetuberculoid), BB (mid-borderline), BL (borderline lepromatous), LL (lepromatousleprosy). Because many centres of health in this country lack the fascility to perform laboratory diagnostic, so clinical diagnostic based on WHO (World Health Organization) classification Paucibacillary and Multibacillary dichotomy may be sufficient. The purpose of this study is to analyze the concordance level between clinical and histopathological diagnosis and correlation of the immunological respons represented by the expression of CD4+ and CD8+T lymphocyte among the spectrum of leprosy. Material and methods A cross sectional study was performed in 159 new leprosy patients with no reaction phase in the National General Central Hospital, Jakarta during 2007-2009 and the archival slides were reviewed. They were stained with Hematoxylin dan Eosin and modified Fite- Faraco staining for identification of Mycobacterium leprae. Immune status of the patients was determined by immunohistochemistry staining with expression of CD4+ and CD8+ T cell lymphocyte. Results 159 new cases of leprosy with no reaction phase consisted of 88 males and 71 females. Discrepancy between clinical and histopathological diagnosis was seen in 47.8% of cases. Major discrepanciescomprised 22%, and minor discrepancies 25.8%. There was no statistically significant relationship between positivity of CD4+ (p>0.05) and CD8+ (p>0.05) with respect to leprosy spectrum.There was statistically significant relationship between Bacteriological Index (BI) and spectrum of leprosy (p
Co-Authors ., Dadun Adriono, Gitalisa Andayani Aldri Frinaldi Alwin, Wanarani Amitya Kumara Amitya Kumara Anggraini, Ika Aria Kekalih Astari Dwiranti Bani, Anna Puspitasari Chinda Liaska Indah Cornain, Emilina Faradila Daniel, Hisar Danny Surya Danny Surya Dennely Yulisa Dewi Sumaryani Soemarko Edbert Wreksoatmojo Eliza Miranda Eliza Miranda Endi Novianto Erdina H. D. Pusponegoro Fadhli Aulia Mughni Fakhrina Fahma Febrina Rahmayanti Felaza, Estivana Fifinela Raissa Fitriana, Anis Githa Rahmayunita Hanny Nilasari Harini, Melinda Henry Lim Henry W. Lim Henry Wan-Peng Lim Ida Ruwaida, Ida Ika Anggraini Inadia Putri Chairista Indah, Chinda Liaska Inosensia Diajeng Kusumo Irawan, Yudo Irawati, Yunia Iwan Dwiprahasto Iwan Dwiprahasto Lili Legiawati Luddwi Achmad Rizky Luh Karunia Wahyuni, Luh Karunia Luzanil, Sonny Tirta Made Susiyanti Marissa, Melani Matsurah, Qaishum Melani Marissa Melani Marissa Melani Marissa Melinda Harini Melinda, Thong Felicia Menaldi, Adhityawarman Mufqi Handaru Priyanto Nanda L. Prasetya Natalia Putri Handayani Natasha, Joanne Ova Emilia Priscilia, Florentina Priyanto, Mufqi Handaru Putu Martha Gerynda Sukma Rahadi Rihatmadja Rico Kurniawan Rinadewi Astriningrum Riyantia Astrid Diahtantri Roni Zakaria R Sahid, Muhammad Hidayat Sandra Widaty Satyanaya Widyaningrum Shannaz Nadia Yusharyahya Sirait, Sondang Panjaitan Siti Farida Sondang P. Sirait Sondang Pandjaitan Sirait Steven Setiono Surya, Danny The, Valensia Vivian Tiara Aninditha Tri Rahayu Triana Agustin Valensia Vivian The Valensia Vivian The Wicaksono, Gunawan Yayi Suryo Prabandari Yeni Dwi Lestari