Article Per Year (5 Year)
p-Index From 2021 - 2026
1.776
P-Index
This Author published in this journals
All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Narra J Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia
Endi Novianto
Department Of Dermatology And Venereology, Faculty Of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society Of Dermatology And Venereology
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
The effects of vitamin D on chronic wounds Priyanto, Mufqi Handaru; Miranda, Eliza; Yusharyahya, Shannaz Nadia; Legiawati, Lili; Novianto, Endi; Bramono, Kusmarinah; Krisanti, Roro Inge Ade
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Wounds that fail to proceed through the normal healing process are referred to as chronic wounds, also known as ulcers. Chronic wounds have immeasurable biological, psychological, social, and economic effects, bringing tremendous challenges for patients, doctors, healthcare providers, and healthcare systems. Discussion: This condition is associated with a variety of comorbidities and complex etiologies. The global incidence of chronic wounds is expected to increase with longer life expectancy. Thus, a holistic approach is necessary, such as proper wound management, proper control of comorbidities, and provision of adequate nutrition, including vitamin D supplementation. Vitamin D is an essential pro-hormone for cell differentiation, proliferation, and growth. It affects the skin’s immune response, and is therefore thought to promote wound healing and tissue repair. Many studies have been published on the association between low vitamin D levels and chronic wounds. However, whether or not vitamin D supplementation directly contributes to wound healing still needs to be elucidated. Conclusion: Despite the many reports on vitamin D as an adjuvant treatment for chronic wounds, further large-scale clinical studies are needed to cement the role of vitamin D as an effective standard therapy for chronic wound healing.
TATA LAKSANA TERKINI PENYAKIT SINDROM STEVENS-JOHNSON (SSJ)/ NEKROLISIS EPIDERMAL TOKSIK (NET) Dina Kusumawardhani; Eyleny Meisyah Fitri; Windy Keumala Budianti; Endi Novianto; Evita Halim Effendi
Media Dermato-Venereologica Indonesiana Vol 50 No 1 (2023): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i1.291

Abstract

Sindrom Stevens-Johnson (SSJ) dan nekrolisis epidermal toksik (NET) merupakan penyakit yang mengancam nyawa, ditandai oleh adanya ruam dan lepuh yang nyeri, disertai lepasnya lapisan epidermis, atau ulkus pada mukosa mulut, mata, dan genital. SSJ/NET merupakan spektrum terberat dari reaksi efek simpang obat yang dimediasi imun, terutama oleh sel T, dan termasuk reaksi hipersensitivitas tipe IVc. SSJ dan NET adalah penyakit yang sama, dibedakan berdasarkan persentase permukaan kulit yang terlibat yaitu SSJ (<10%), SSJ/NET overlap (10%-30%), dan NET (>30%). SSJ/NET sering disertai keterlibatan multiorgan dengan rerata mortalitas 1-5% pada SSJ dan 25-35% pada NET. Tata laksana optimal SSJ/NET meliputi diagnosis dini, identifikasi dan penghentian obat tersangka, mempertimbangkan kemungkinan adanya infeksi sebagai pencetus, serta terapi suportif sedini mungkin. Terapi suportif yang dilakukan oleh tim multidisipilin merupakan tata laksana utama. Terapi suportif yang baik terbukti dapat memperbaiki kondisi klinis pasien. Rekomendasi penggunaan terapi sistemik berupa kortikosteroid, siklosporin, intravenous immunoglobulin (IVIg), plasmaferesis, dan terapi target, hingga saat ini sangat bervariasi karena belum terdapat bukti efikasi berdasarkan penelitian randomized controlled trial.
DERMATOMIOSITIS ANTI-MDA5: LAPORAN DUA KASUS SUATU ENTITAS DENGAN MANIFESTASI DAN PROGNOSIS BERAGAM Halim, P. Anthony; Hamdali, Christie; Pranathania, Andravina; Fitri, Eyleny Meisyah; Budianti, Windy Keumala; Novianto, Endi; Indrawati, Luh Ari
Media Dermato-Venereologica Indonesiana Vol 52 No 1 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i1.505

Abstract

Pendahuluan: Dermatomiositis anti-melanoma differentiation-associated protein 5 (DM-MDA5) adalah penyakit autoimun sistemik langka yang memiliki temuan klinis bervariasi dan banyak dipelajari dalam satu dekade terakhir. Subtipe tersebut umumnya bermanifestasi sebagai DM amiopatik atau hipomiopatik, sering disertai intersitial lung disease (ILD) berpotensi fatal. Dalam makalah ini, kami melaporkan untuk pertama kalinya di Indonesia, variasi gambaran klinis, radiologis, laboratorium, dan prognosis dua kasus DM-MDA5. Kasus: Pasien pertama, seorang perempuan 25 tahun dengan ruam kemerahan khas DM, kelemahan otot ringan, artralgia, dan alopesia. Pasien kedua, seorang perempuan 43 tahun dengan ruam kemerahan khas DM, ulserasi kulit, rambut rontok, kelemahan otot, nyeri sendi, dan sesak nafas. Diagnosis DM ditegakkan sesuai kriteria Sontheimer dan American College of Rheumatologist/European League Against Rheumatism (ACR/EULAR) 2017. Pada kedua pasien terdeteksi anti-MDA5 dengan titer positif kuat. Rontgen toraks dan CT scan menunjukkan ILD pada pasien kedua. Tata laksana kombinasi menggunakan kortikosteroid dan imunosupresan sistemik, kortikosteroid topikal, penghambat kalsineurin topikal, dan fotoproteksi ketat memperbaiki gejala klinis pada kedua pasien. Diskusi: Pasien DM-MDA5 dapat digolongkan menjadi beberapa fenotipe klinis sesuai temuan klinis dan laboratorium, dengan prognosis beragam terkait insidensi ILD. Kasus pertama memiliki prognosis baik, sedangkan kasus kedua cenderung memiliki prognosis sedang. Hingga kini, belum terdapat tata laksana spesifik DM-MDA5, tetapi terapi antifibrotik dapat bermanfaat pada kasus dengan ILD. Kesimpulan: Klinisi perlu mengenali subtipe DM ini karena memiliki manifestasi yang bervariasi namun cukup khas, dengan prognosis yang beragam. Evaluasi dan tata laksana dini secara multidisiplin pada pasien DM-MDA5 dapat mencegah progresivitas penyakit dan kematian akibat komplikasi.
Penggunaan Anti TNF-α Dalam Bidang Dermatologi Suprapto, Novita; Novianto, Endi; Hoemardani, Aida Sofiati Dachlan
Majalah Kedokteran Indonesia Vol 72 No 5 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.5-2022-719

Abstract

Tumor necrosis factor-α (TNF-α) merupakan sitokin pleiotropik penting pada patogenesis berbagai kelainan inflamasi dalam bidang dermatologi. Beberapa contoh penyakit tersebut adalah psoriasis, hidradenitis supuratif, dermatosis neutrofilik, sarkoidosis, granuloma anulare, toxic epidermal necrolysis, penyakit Behçet, pitiriasis rubra pilaris, skleroderma, sklerosis sistemik, dan eritema nodosum leprosum. Penggunaan anti TNF-α menjadi strategi terapi untuk menghambat progresivitas berbagai penyakit tersebut. Terdapat lima anti TNF-α yang telah diuji secara klinis, yaitu etanercept, adalimumab, certolizumab pegol, infliximab, dan golimumab. Masing-masing obat memiliki profil farmakologi, indikasi, serta efikasi yang berbeda untuk setiap penyakit. Penggunaan anti TNF-α juga berisiko menimbulkan berbagai efek samping, baik bersifat lokal maupun sistemik, termasuk secara paradoks meningkatkan risiko psoriasis.
PERKEMBANGAN TERKINI MANIFESTASI KLINIS FRAMBUSIA Natasha, Joanne; Menaldi, Sri Linuwih SW; Irawan, Yudo; Novianto, Endi
Media Dermato-Venereologica Indonesiana Vol 51 No 2 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i2.338

Abstract

Yaws, a neglected tropical disease, is still become the health problem in several countries. World Health Organization has proposed 2030 goals for yaws eradication after the previous target has not been achieved. Indonesia is still one of the largest contributors to yaws cases in Southeast Asia. The variety of lesions and the development of atypical clinical features make the yaws diagnose as a challenge. WHO guideline is used as a reference to determine the clinical manifestations, divided into early stage (infectious) lesions to advanced (non-infectious) yaws lesions. Yaws clinical features should be mastered by health workers in Indonesia, considering that the establishment of suspected cases begin with a clinical examination then confirmed by serological test. Several recent clinical surveillance had not reported early-stage lesions as the most common clinical finding, but rather had scars which was previously removed from the modified WHO guidelines. Missed diagnosis causes continually transmission.
Biomarkers for diagnosis, disease progression, and therapeutic response in psoriasis vulgaris: A mini-review Edwar, Sarah Q.; Irawan, Yudo; Budianti, Windy K.; Novianto, Endi; Fitri, Eyleny M.
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3017

Abstract

Psoriasis vulgaris is a chronic immune-mediated inflammatory disease with substantial clinical, psychosocial, and public health impact. Despite advances in therapeutic options, disease management continues to rely predominantly on clinical assessment, which remains limited in its ability to detect early disease, quantify subclinical inflammation, monitor disease progression, and anticipate long-term outcomes. These limitations are further compounded by marked interindividual heterogeneity in disease course, systemic inflammatory burden, comorbidity risk, and treatment response. Although a growing body of research has identified numerous candidate biomarkers related to genetic susceptibility, epidermal pathology, immune activation, and systemic inflammation, their clinical relevance and integration into routine practice remain unclear. A comprehensive synthesis that bridges molecular biomarkers with clinically meaningful applications is therefore needed. This review critically examines the current landscape of biomarkers in psoriasis vulgaris and explores their potential roles in diagnosis, assessment of disease progression, and prediction of therapeutic response. This review discusses genetic biomarkers associated with disease susceptibility and immune pathway regulation, tissue-associated biomarkers reflecting epidermal dysfunction and local inflammatory activity, and soluble biomarkers indicative of systemic inflammation and metabolic dysregulation. By organizing existing evidence across these biomarker domains, this review seeks to highlight conceptual frameworks, unresolved challenges, and future directions for biomarker-informed psoriasis management.
Co-Authors Aldri Frinaldi Anis Irawan Arlha Aporia Debinta Arlha Aporia Debinta Benny Effendi Wiryadi Budianti, Windy K. Cita R. S. Prakoeswa Dina Kusumawardhani Edwar, Sarah Q. Eliza Miranda Erdina H. D Pusponegoro Evita Halim Effendi Eyleny Meisyah Fitri Eyleny Meisyah Fitri Fitri, Eyleny M. Fitri, Eyleny Meisyah Githa Rahmayunita Halim, P. Anthony Hamdali, Christie Harijono Kariosentono Hoemardani, Aida Sofiati Dachlan Indrawati, Luh Ari Irawan, Yudo Jacoeb, Tjut N.A. Krisanti, Roro Inge Ade Kusmarinah Bramono Lili Legiawati Lis Surachmiati Suseno Menaldi, Sri Linuwih SW Natasha, Joanne Pranathania, Andravina Priyanto, Mufqi Handaru Pusponegoro, Erdina H.D. Puti Rineska Meilinda Putu Martha Gerynda Sukma Rahadi Rihatmadja Rahadi Rihatmadja Retno Widowati Soebaryo Shafira Anindya Shafira Anindya Purnawan Shannaz Nadia Yusharyahya Suprapto, Novita Triana Agustin Windy Keumala Budianti Windy Keumala Budianti Windy Keumala Budianti Wresti Indriatmi B. Makes