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All Journal Medula Biomedical Journal of Indonesia JOURNAL LA MEDIHEALTICO Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Ade Yonata, Ade
Bagian Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Lampung
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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FACTORS AFFECTING THICKENING OF CAROTID INTIMA MEDIA THICKNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE Yonata, Ade; Ali, Zulkhair; Indrajaya, Taufik; Effendi, Ian; Suhaimi, Novadian
Biomedical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10539

Abstract

Chronic kidney disease (CKD) is associated with high mortality rates related to cardiovascular complications. Atherosclerosis, arteriosclerosis and vascular calcification conditions are often found in CKD patients. Carotid intima media thickness (cIMT) thickening is one of the parameters of vascular disorders. A cross sectional study was conducted on patients with chronic kidney disease in the hospital. Mohammad Hoesin Palembang. Patients' blood samples were examined in the hospital laboratory. CIMT thickening was examined using echocardiography. A total of 55 patients with stage 3-5 chronic kidney disease were examined. The median cIMT is 0.8 (0.6-1.45) mm. Spearman's correlation analysis showed a significant correlation between triglyceride levels and thickening of cIMT (r = 0.303, p = 0.025). A significant correlation was also shown between phosphate levels and cIMT thickening (r = 0.290, p = 0.032). There is a significant correlation of triglyceride levels and phosphate levels to cIMT thickening in patients with chronic kidney disease in Palembang
Literature Review: Gagal Ginjal Akut Akibat Nefrotoksisitas Gentamisin Akbar, Dafa Rafiqi; Yonata, Ade; Ratna, Maya Ganda; Darwis, Iswandi
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1312

Abstract

Acute kidney failure or Acute Kidney Injury (AKI) is a sudden decline in kidney function that is often caused by various factors such as sepsis, ischemia, and nephrotoxicity. One of the significant causes of nephrotoxicity is gentamicin, an aminoglycoside antibiotic commonly used to treat Gram-negative bacterial infections. Although effective, gentamicin has nephrotoxic side effects, especially at high doses or long-term use, which can cause damage to the renal tubular epithelium and trigger AKI. This literature review aims to describe and study more deeply the relationship between gentamicin consumption and the incidence of acute kidney failure. Gentamicin works by inhibiting bacterial protein synthesis on the 30S ribosome. Still, its mechanism of action also has the potential to cause nephrotoxicity through drug accumulation in kidney cells, impaired mitochondrial function, increased production of reactive oxygen species (ROS), and mesangial contractions that reduce the glomerular filtration rate. Signs of gentamicin nephrotoxicity include increased serum creatinine levels, blood urea nitrogen, albuminuria, and decreased glomerular filtration rate, accompanied by structural damage such as tubular necrosis and edema in the proximal tubular epithelium. Previous studies have shown that high doses of gentamicin can increase the number of necrotic cells in the kidney and cause renal fibrosis in test animals. In humans, the incidence of gentamicin-induced nephrotoxicity has been reported to reach 10-25% of therapeutic use, with an estimated incidence of AKI of around 15% of total AKI cases. The importance of proper monitoring and management for patients using gentamicin to reduce the risk of nephrotoxicity. Prevention strategies include monitoring kidney function, dose adjustment, adequate hydration, and considering various alternative antibiotic therapies for patients at high risk of nephrotoxicity.
Sepsis and Septic Shock in Pregnancy Islamy, Nurul; Aziz, M. Alamsyah; Yonata, Ade; Lumentut, Anastasia M.; Maelissa, Merlin M.; Khaerunnisa P, Maya; Wirawan, Wahyudi
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1863

Abstract

Sepsis during pregnancy is a critical condition that leads to organ dysfunction due to an abnormal response to infection. It remains a significant cause of maternal morbidity and mortality worldwide. The World Health Organization (WHO) reports a global prevalence of 4.4% of live births affected by maternal sepsis, with varying incidences across countries. Sepsis ranks among the top five causes of maternal deaths globally, contributing to 12.7% of pregnancy-related mortality in the United States. The physiological changes during pregnancy, such as increased blood volume and immune response modulation, create conditions that make pregnant individuals more susceptible to infections, complicating the timely diagnosis of sepsis. Due to these physiological differences, common sepsis screening tools like qSOFA and SOFA are often inadequate in pregnant patients, highlighting the need for specialized diagnostic and management strategies. Early detection and timely treatment are essential to improving maternal outcomes. Several screening tools, such as the Maternal Early Warning Trigger (MEWT) tool, have been designed to aid in the early identification of deteriorating maternal health. Once sepsis is suspected, prompt antibiotic therapy, fluid resuscitation, and vasopressor support are critical to prevent progression to septic shock. Additionally, controlling the infection source through surgical intervention or drainage may be necessary. Despite advances in sepsis management, challenges remain, particularly in identifying and treating sepsis in pregnant patients due to overlapping symptoms with normal pregnancy changes. Therefore, early recognition and appropriate intervention are key to reducing the impact of sepsis during pregnancy.
The Relationship Between Diabetes and Hypertension and Mortality in Chronic Kidney Disease Patients in Indonesia Yonata, Ade; Islamy, Nurul
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 4 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i4.1534

Abstract

Background: Chronic kidney disease (CKD) is a major global health problem that significantly increases morbidity and mortality, mainly due to cardiovascular disease (CVD). In Indonesia, cardiovascular complications account for approximately 42% of deaths among CKD patients. This study aimed to analyze the relationship between diabetes and hypertension with mortality in CKD patients in Indonesia. Objective: To investigate the association between diabetes and hypertension and mortality among chronic kidney disease patients undergoing hemodialysis in Indonesia. Methods: A cross-sectional study was conducted at Dr. H. Abdul Moeloek Regional Hospital, Lampung, from March to May 2024. The study population consisted of end-stage CKD patients undergoing hemodialysis. Data were obtained from medical records and analyzed using the Chi-Square test, with a significance level set at p < 0.05. Results: Of 110 patients, 58% of those with diabetes and 55.1% of those with hypertension died. Both comorbidities showed a significant association with mortality in CKD patients (p = 0.0031 for diabetes, p = 0.019 for hypertension). Conclusion: Diabetes and hypertension significantly increase mortality risk among CKD patients. These findings underscore the importance of comprehensive management of comorbidities to improve survival outcomes in CKD populations
Co-Authors Akbar, Dafa Rafiqi Aziz, M. Alamsyah Effendi, Ian Indrajaya, Taufik Iswandi Darwis Khaerunnisa P, Maya Lumentut, Anastasia M. Maelissa, Merlin M. Nurul Islamy Ratna, Maya Ganda Suhaimi, Novadian Wirawan, Wahyudi Zulkhair Ali