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All Journal E-Jurnal Medika Udayana Medula JURNAL PENELITIAN PERAWAT PROFESIONAL
Ratna, Maya Ganda
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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PENGARUH TINGKAT PENYANGRAIAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI ASPIRIN ananti, anggini tasyakurillah; Rudiyanto, Waluyo; Ratna, Maya Ganda; Windarti, Indri
E-Jurnal Medika Udayana Vol 13 No 8 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i08.P03

Abstract

Abstract Background: Coffee is a plant that widely consumed by the community. It contains antioxidant-rich compounds such as caffeine, chlorogenic acid, trigonelin, kafestol, and kahweol. Coffee quality related to the roasting process. This study aimed to determine the effect of different roasting level of robusta coffee extract (Coffea canephora) on liver histopathology of male Sprague Dawley strain white rats (Rattus norvegicus) induced by aspirin. Methods: This research is an experimental study with Post-Test Only Control Group design for 15 days. This research used 30 rats in 5 groups, K(-) (aquadest); K(+) (aspirin 90mg/day); P1 (aspirin and robusta coffee extract Light roast 25mg/kgBW/day); P2 (aspirin and robusta coffee extract Medium roast 25mg/kgBW/day); and P3 (aspirin and robusta coffee extract Dark roast 25mg/kgBW/day). Assessment of liver cell damage using modified Suzuki scoring. Results: Mean score of hepatocyte damage on the histopathological findings was K(-)=0,44; K(+)=1,92; P1=1,28; P2=1,20; and P3=1,68. Data analysis performed using One-Way ANOVA test followed by Post-Hoc LSD and obtained significant results between all groups. Conclusion: There is an effect of roasting level of robusta coffee extract (Coffea canephora) with the roasting level is Medium Roast on liver histopathology of male Sprague Dawley strain white rats (Rattus norvegicus) induced by aspirin. Key Words: aspirin, coffee roasting, liver histopathology, robusta coffee extract.
Literature Review: Gagal Ginjal Akut Akibat Nefrotoksisitas Gentamisin Akbar, Dafa Rafiqi; Yonata, Ade; Ratna, Maya Ganda; Darwis, Iswandi
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1312

Abstract

Acute kidney failure or Acute Kidney Injury (AKI) is a sudden decline in kidney function that is often caused by various factors such as sepsis, ischemia, and nephrotoxicity. One of the significant causes of nephrotoxicity is gentamicin, an aminoglycoside antibiotic commonly used to treat Gram-negative bacterial infections. Although effective, gentamicin has nephrotoxic side effects, especially at high doses or long-term use, which can cause damage to the renal tubular epithelium and trigger AKI. This literature review aims to describe and study more deeply the relationship between gentamicin consumption and the incidence of acute kidney failure. Gentamicin works by inhibiting bacterial protein synthesis on the 30S ribosome. Still, its mechanism of action also has the potential to cause nephrotoxicity through drug accumulation in kidney cells, impaired mitochondrial function, increased production of reactive oxygen species (ROS), and mesangial contractions that reduce the glomerular filtration rate. Signs of gentamicin nephrotoxicity include increased serum creatinine levels, blood urea nitrogen, albuminuria, and decreased glomerular filtration rate, accompanied by structural damage such as tubular necrosis and edema in the proximal tubular epithelium. Previous studies have shown that high doses of gentamicin can increase the number of necrotic cells in the kidney and cause renal fibrosis in test animals. In humans, the incidence of gentamicin-induced nephrotoxicity has been reported to reach 10-25% of therapeutic use, with an estimated incidence of AKI of around 15% of total AKI cases. The importance of proper monitoring and management for patients using gentamicin to reduce the risk of nephrotoxicity. Prevention strategies include monitoring kidney function, dose adjustment, adequate hydration, and considering various alternative antibiotic therapies for patients at high risk of nephrotoxicity.
Systematic Review: Faktor-faktor yang Mempengaruhi Sectio Caesarea Putri, Tiara Triwansa; Sari, Ratna Dewi Puspita; Ratna, Maya Ganda; Zuraida, Reni
Jurnal Penelitian Perawat Profesional Vol 7 No 3 (2025): Juni 2025, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v7i3.6673

Abstract

Tingkat persalinan melalui section caesarea (SC) menunjukkan peningkatan yang signifikan secara global, termasuk di Indonesia. Berdasarkan data Riset Kesehatan Dasar Tahun 2018, prevalensi persalinan dengan SC di Indonesia mencapai 17,6%. Angka ini meningkat 9,8% dibandingkan dengan tahun 2013. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis faktor-faktor yang mempengaruhi keputusan pelaksanaan SC pada ibu bersalin. Penelitian ini penting untuk tenaga kesehatan dalam melakukan analisis faktor tersebut dalam mendukung suatu persalinan. Metode yang digunakan dalam penelitian ini adalah systematic review dengan pencarian artikel melalui Google Scholar, GARUDA, Pubmed, dan Scopus dengan rentang tahun 2020-2025. Hasil penelitian menunjukkan dari 2.751 artikel yang diidentifikasi, sebanyak 1.021 artikel pada rentang tahun 2020-2025. Sebanyak 520 artikel dikecualikan karena tidak memenuhi kriteria inklusi yang sudah ditetapkan. Setelah dilakukan analisis, didapatkan 6 artikel yang diteliti dan didapatkan hasil bahwa usia ibu, obesitas, jarak kehamilan, jumlah persalinan, kelainan posisi janin, persalinan yang lama, pecah ketuban dini, plasenta previa, kehamilan berisiko, riwayat operasi atau persalinan, dan kondisi gawat darurat yang dapat mengharuskan pasien menjalani tindakan sectio caesarea. Kesimpulannya adalah faktor-faktor yang mempengaruhi sectio cesarea terdapat dari faktor ibu, janin, dan persalinan itu sendiri.
Co-Authors Ade Yonata, Ade Akbar, Dafa Rafiqi ananti, anggini tasyakurillah Indri Windarti Iswandi Darwis Putri, Tiara Triwansa Ratna Dewi Puspita Sari Reni Zuraida Rudiyanto, Waluyo