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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Jurnal Kesehatan Andalas Jurnal Pengabdian Kesehatan Biomedika
Ilhami Romus, Ilhami
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Biomedika

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EFFECT OF INULIN EXTRACT FROM DAHLIA TUBER (dahlia variabilis) ON CORONARY ARTERY HISTOPATHOLOGY IN RATS WITH TYPE 2 DIABETES MELLITUS (DM) Hopi, Zikrilla mayuli; Ismawati, Ismawati; Saryono, Saryono; Romus, Ilhami; Putri, Veni Dayu; Yanti, Sri; Dyna, Fitri
Biomedika Vol 17, No 1 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.3734

Abstract

Atherosclerosis in diabetes mellitus (DM) patients is prevented by using inulin to increase glucose metabolism and reduce cholesterol synthesis. Therefore, this research aimed to analyze dahlia tuber inulin extract to determine the effect on coronary artery histopathology in type 2 DM rats. A total of 20 male Wistar rats were divided into five groups, namely negative control without treatment, DM, DM + 0.5 mg/gBW/day inulin extract, DM + 1 mg/gBW/day inulin extract, and DM + 1.5 mg/gBW/day inulin extract. Furthermore, DM induction was carried out by administering 60 mg/kgBB streptozotocin and 120 mg/kgBB nicotinamide. The results of coronary artery histopathology readings showed that the highest and lowest scores of atherosclerosis were in Groups II (0,91±0,17) and V (0,08±0,1), respectively. Data analysis using Kruskal Wallis test reported significant results (p<0.05), while Mann-Whitney test showed differences between control and DM, DM, and inulin groups (III, IV, V). In this context, the administration of dahlia tuber inulin extract to rats induced by Type 2 DM prevented atherosclerosis in histopathological image of coronary artery.
Co-Authors A.A. Ketut Agung Cahyawan W Aufa, Athiatul Dyna, Fitri Esy Maryanti Fiatiningsih, Istiana Fran, Jimy Hopi, Zikrilla mayuli Ismawati ismawati Ismawati Ismawati Luthfianty, Elfiah Mukhyarjon Paramitha, Sonia Dinda Permatasari, Nopi Saryono Saryono Sri Yanti Veni Dayu Putri