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KERAGAMAN GENETIK DRINGO (Acorus calamus L.) YANG DIGUNAKAN SEBAGAI TUMBUHAN OBAT PADA BEBERAPA ETNIS DI INDONESIA BERDASARKAN INTER-SIMPLE SEQUENCE REPEATS (ISSR) Subositi, Dyah; Mujahid, Rohmat; Widiyastuti, Yuli
Buletin Kebun Raya Vol 18, No 2 (2015): Buletin Kebun Raya Vol. 18 (2) July 2015
Publisher : Center for Plant Conservation Bogor Botanic Garden, Indonesian Institute of Sciences

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Dringo (Acorus calamus L.) used as medicinal plant in Indonesian ethnic groups. Those information based on Ristoja 2012 research. The objective of Ristoja was to provide a database of local ethnomedicine knowledge, herbal formula and medicinal plant in Indonesia. Inter Simple Sequence Repeats (ISSR) markers were used to assess the genetic diversity of Dringo from 20 selected ethnic groups in Indonesia. Ten selected ISSR primers generated 82 amplified fragments with 51,2% were polymorphic. Dice coefficient was used to calculate similarity index and UPGMA was used to construct a dendogram. The genetic similarity index among accessions ranged from 76,7-100% thus indicating that low level of genetic diversity in dringo. Genetic diversity database can be useful for medicinal plant mapping and conservation especially for in situ conservation.

Karakterisasi Genetik Tempuyung (Sonchus arvensis L.) Berdasarkan Penanda Molekuler Sequence-Related Amplified Polymorphism Subositi, Dyah; Mujahid, Rohmat
JURNAL BIOLOGI INDONESIA Vol 9, No 2 (2013): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Tempuyung (Sonchus arvensis L.) is known as an important medicinal plant used as a diuretics andantihypertensives. This plant is widely distributed in Indonesia. Genetic diversity of tempuyung is importantinformation as a database for further research especially in medicinal plant standardization. The objective of thisstudy was to analyse genetic characterization of tempuyung based on SRAP (Sequence-related amplifiedpolymorphism) molecular markers. Thirteen samples were collected from 8 different locations and amplified using5 primer SRAP combinations. Similarity matrix was calculated using Dice coefficient. Unweighted Pair GroupMethod Using Arithmetic Mean (UPGMA) cluster analysis was performed to develop a dendrogram. The resultindicates that there was a genetic variation among tempuyung accessions and divided into 4 clusters with similarityindex of 0,7719. Citeureup and Turen3 accessions were the most closely similar with similarity index of 0,8936. Inconclusion, SRAP markers may serve as an efficient and effective tools to analyze the genetic diversity amongtempuyung accessions.Keywords: genetic characterization, tempuyung (Sonchus arvensis L.), SRAP

Observasi Klinik Ramuan Jamu untuk Menurunkan Berat Badan Pamadyo(, Sunu; Novianto, Fajar; Mujahid, Rohmat
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

The prevalence of overweight (obesity) has increased significantly in the world. During this decade, obesity will become a health problem. Even today, obesity is referred to as the New World Syndrome, where it is continuity increasing the number of events almost all over the world. Based on Riskesdas in 2010, the prevalence of adult obesity in Indonesia had reached 21.7%, significantly increasing if it was compared to the previous Riskesdas in 2007 which were 10.3%. Obesity in the younger people was associated with the increased of the incident risk of coronary heart disease, hypertension, hypercholesterolemia, diabetes mellitus and metabolic disorders. Obesity has a strong correlation with morbidity and mortality, and received serious attention on the causes, prevention and treatment efforts. Until now, there has been no specific drugs used for weight loss. People saw fitoterapi as a weight loss (besides diet)drug, because it has been considered relatively safe and without significant side effects. Jamu consisting of Jati Belanda, Kemuning, Kelembak and tempuyung was used in Saintifikasi Jamu Clinic. The results in this jamu showed that capsule weight loss has gave lower Body Mass Index (BMI) for 2 months but it has not lowered the BMI category of overweight to normal. The jamu could significantly reduce the weight of research subyek after administration for 28 days, with an average decline of 3.9 Kg and a highly significantly decrease after 56 days administration, with an average decrease of 6.7 Kg, compared to the initial weight. Medicinal herb could reduce the waist 41.1 cm, after 56 days administration. The herbs could not reduce the upper arm circumference, after 56 days administration.

KARAKTERISASI GENETIK TEMPUYUNG (SONCHUS ARVENSIS L.) BERDASARKAN PENANDA MOLEKULER SEQUENCE-RELATED AMPLIFIED POLYMORPHISM Subositi, Dyah; Mujahid, Rohmat
JURNAL BIOLOGI INDONESIA Vol 9, No 2 (2013): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v9i2.163

Tempuyung (Sonchus arvensis L.) is known as an important medicinal plant used as a diuretics andantihypertensives. This plant is widely distributed in Indonesia. Genetic diversity of tempuyung is importantinformation as a database for further research especially in medicinal plant standardization. The objective of thisstudy was to analyse genetic characterization of tempuyung based on SRAP (Sequence-related amplifiedpolymorphism) molecular markers. Thirteen samples were collected from 8 different locations and amplified using5 primer SRAP combinations. Similarity matrix was calculated using Dice coefficient. Unweighted Pair GroupMethod Using Arithmetic Mean (UPGMA) cluster analysis was performed to develop a dendrogram. The resultindicates that there was a genetic variation among tempuyung accessions and divided into 4 clusters with similarityindex of 0,7719. Citeureup and Turen3 accessions were the most closely similar with similarity index of 0,8936. Inconclusion, SRAP markers may serve as an efficient and effective tools to analyze the genetic diversity amongtempuyung accessions.Keywords: genetic characterization, tempuyung (Sonchus arvensis L.), SRAP

Analysis of Curcumin Contents in Curcuma xanthorrhiza using FTIR Spectroscopy and HPLC-UV in Combination with Multivariate Calibration Kusumadewi, Awal P.; Mujahid, Rohmat; Martien, Ronny; Purwanto, Purwanto; Styawan, Anita A.; Irnawati, Irnawati; Rohman, Abdul
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.82220

Curcuma xanthorrhiza Roxb. or Java Turmeric with the local name of Temulawak is one of herbal medicines used in Indonesia. This plant is believed to prevent some degenerative diseases due to its active compounds, especially curcumin (CUR) contained in Java Turmeric. Therefore, analysis of active components including CUR is very urgent. This study highlighted the development of FTIR spectroscopy coupled with PLSR for the determination of CUR in Java Turmeric powders. The levels of CUR in Java Turmeric powders were determined using HPLC with UV detectors, and the obtained results were used as actual values to be predicted using FTIR spectroscopy-multivariate calibrations. The results revealed that the levels of CUR ranged from 0.6741 ± 0.0705% (g/100 samples) to 2.1062 ± 0.0095%. PLSR modeling for the relationship between the actual value of CUR as determined using HPLC and calculated values as predicted using FTIR spectroscopy provide the value of R2 of 0.9990 with RMSEC of 0.0028. The developed method offers reliable results providing a green analytical method due to the use of minimum solvent and reagent and does not involve extensive sample preparation.

Medicinal Plants used for Antihypercholesterolemia in Ethnic Groups of Celebes Island, Indonesia: Pemanfaatan Tumbuhan Obat sebagai Antihiperkolesterolemia di Berbagai Etnis di Pulau Sulawesi, Indonesia Rahmawati, Nuning; Haryanti, Sari; Yanti Marfuatush Sholikhah, Ika; Subositi, Dyah; Widodo, Harto; Mujahid, Rohmat; Widiyastuti, Yuli
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.1025

This study aimed to identify the utilization of medicinal plants used by selected traditional healers who met inclusion criteria to treat high cholesterol levels in ethnic groups of Celebes Island, Indonesia. Data collection was carried out through interviews, observation, and sample collection. This study revealed 67 concoction information and identified the use of 48 plant species distributed in 32 families among 39 healers in 20 ethnic groups in Celebes Island. Peperomia pellucida (L.) Kunth (UV=0.21), lamiaceae (15.63%), and leaves (57.35%) were determined as the most prominent species, family, and plant part used. The most widely prescribed rule of use is internal administration (94.03%) with a frequency of 3x1 per day (44.78%) for a week to a month (56.72%). However, conservation efforts need to be initiated immediately since more than 50% of healers made no cultivation efforts

ANTIMALARIAL MEDICINAL PLANTS USED BY TRADITIONAL HEALERS IN BENGKULU PROVINCE OF INDONESIA Susanti, Dian; Putra, Aditya Dwi Permana; Safrina, Devi; Wijaya, Nur Rahmawati; Adi, M Bakti Samsu; Mujahid, Rohmat; Rukmana, Rizal Maarif; Subositi, Dyah; Haryanti, Sari; Siswanto, Usman; Widiyastuti, Yuli
BIOTROPIA Vol. 31 No. 3 (2024): BIOTROPIA Vol. 31 No. 3 December 2024
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2024.31.3.2318

Article Highlights- This research provides information on the use of medicinal plants for treating malaria among ethnic groups in Bengkulu Province.- This research was part of RISTOJA (Research on Medicinal Plants), national research conducted by the Ministry of Health of the Republic of Indonesia.- Several compounds found in medicinal plants used by traditional healers in the Bengkulu Province have been scientifically proven to be effective as antimalarial medication.AbstractMalaria is a disease with a high mortality rate and is still a significant problem in Indonesia and globally. One of the provinces in Indonesia that uses a diversity of medicinal plants to treat malaria is Bengkulu Province. This research aims to inventory and evaluate the use of medicinal plants as malaria drugs in Bengkulu Province. The research methods used were observation, interviews, and the collection of samples. Respondents were traditional healers from seven ethnic groups in Bengkulu. Plant species, use value (UV) parameters, fidelity level (FL), family use value (FUV), relative frequency of citation (RFC), and plant parts value (PPV) were analyzed. This study found 32 specific herbal concoctions and identified the use of 47 plant species in 28 families used by 20 healers in 6 ethnic groups of Bengkulu. The species Carica papaya, Peronema canescens, and Tinospora crispa have the highest use value, fidelity level, and relative frequency of citation. The Lamiaceae and Caricaceae families have the highest family use value (0.15). The leaves (43.9%) and barks (13.6%) were the most frequently utilized parts of medicinal plants to overcome malaria. Decoction was the method most widely used by traditional healers in Bengkulu to prepare conventional medicine formula.

Observasi Klinik Ramuan Jamu untuk Menurunkan Berat Badan Pamadyo(, Sunu; Novianto, Fajar; Mujahid, Rohmat
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.698

The prevalence of overweight (obesity) has increased significantly in the world. During this decade, obesity will become a health problem. Even today, obesity is referred to as the New World Syndrome, where it is continuity increasing the number of events almost all over the world. Based on Riskesdas in 2010, the prevalence of adult obesity in Indonesia had reached 21.7%, significantly increasing if it was compared to the previous Riskesdas in 2007 which were 10.3%. Obesity in the younger people was associated with the increased of the incident risk of coronary heart disease, hypertension, hypercholesterolemia, diabetes mellitus and metabolic disorders. Obesity has a strong correlation with morbidity and mortality, and received serious attention on the causes, prevention and treatment efforts. Until now, there has been no specific drugs used for weight loss. People saw fitoterapi as a weight loss (besides diet)drug, because it has been considered relatively safe and without significant side effects. Jamu consisting of Jati Belanda, Kemuning, Kelembak and tempuyung was used in Saintifikasi Jamu Clinic. The results in this jamu showed that capsule weight loss has gave lower Body Mass Index (BMI) for 2 months but it has not lowered the BMI category of overweight to normal. The jamu could significantly reduce the weight of research subyek after administration for 28 days, with an average decline of 3.9 Kg and a highly significantly decrease after 56 days administration, with an average decrease of 6.7 Kg, compared to the initial weight. Medicinal herb could reduce the waist 41.1 cm, after 56 days administration. The herbs could not reduce the upper arm circumference, after 56 days administration.

Medicinal Plants used for Antihypercholesterolemia in Ethnic Groups of Celebes Island, Indonesia: Pemanfaatan Tumbuhan Obat sebagai Antihiperkolesterolemia di Berbagai Etnis di Pulau Sulawesi, Indonesia Rahmawati, Nuning; Haryanti, Sari; Yanti Marfuatush Sholikhah, Ika; Subositi, Dyah; Widodo, Harto; Mujahid, Rohmat; Widiyastuti, Yuli
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.1025

This study aimed to identify the utilization of medicinal plants used by selected traditional healers who met inclusion criteria to treat high cholesterol levels in ethnic groups of Celebes Island, Indonesia. Data collection was carried out through interviews, observation, and sample collection. This study revealed 67 concoction information and identified the use of 48 plant species distributed in 32 families among 39 healers in 20 ethnic groups in Celebes Island. Peperomia pellucida (L.) Kunth (UV=0.21), lamiaceae (15.63%), and leaves (57.35%) were determined as the most prominent species, family, and plant part used. The most widely prescribed rule of use is internal administration (94.03%) with a frequency of 3x1 per day (44.78%) for a week to a month (56.72%). However, conservation efforts need to be initiated immediately since more than 50% of healers made no cultivation efforts

Kandungan Logam Berat Kadmium (Cd) dan Timbal (Pb) dalam Tempuyung (Sonchus arvensis L.) Mujahid, Rohmat; Subositi, Dyah
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2020: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.684 KB)

Sonchus arvensis L. merupakan salah satu tanaman yang digunakan dalam beberapa ramuan, khasiat dan keamanannya telah terbukti dalam uji preklinis, observasi klinis maupun uji klinis yang dilakukan di Klinik Saintifikasi Djamoe “Hortus Medicus”. Pemenuhan kebutuhan Sonchus arvensis L. di Klinik Saintifikasi Djamoe Hortus Medicus dari hasil budidaya, namun pemakaian oleh masyarakat umumnya berasal dari tumbuhan liar, yang banyak tumbuh di pekarangan, lahan kosong maupun pingir jalan. Luasnya sebaran Sonchus arvensis L. menimbulkan potensi cemaran logam berat terutama yang tumbuh disekitar jalan/jalan raya. Telah dilakukan pengambilan 20 sampel Sonchus arvensis L. yang dibagi dalam 5 kelompok berdasar potensi cemaran logam berat. Kandungan logam berat ditetapkan secara Spektrofotometri Serapan Atom pada panjang gelombang 217,0 nm timbal (Pb) dan 228,8 nm kadmium (Cd). Kandungan kadmium tidak terdeteksi dalam semua sampel (LOD 0,04 ppm), sedangkan kandungan timbal sangat bervariasi mulai dari tidak terdeteksi (6 sampel) hingga 4,34 ppm (LOD 0,01 ppm), terdapat kecenderungan makin dekat tempuyung tumbuh dengan jalan/jalan raya makin besar kandungan timbalnya.

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