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All Journal Jurnal Teknologi Dan Industri Pangan CHEMISTRY PROGRESS Jurnal Pangan dan Agroindustri Indonesian Journal of Cancer Food Science and Technology Journal (Foodscitech) Indonesian Journal of Natural Pigments Cermin Dunia Kedokteran Jurnal Ilmiah Berkala: Sains dan Terapan Kimia JURNAL REKAYASA KIMIA & LINGKUNGAN
Renny Indrawati, Renny
Ma Chung Research Center for Photosynthetic Pigments (MRCPP) - Universitas Ma Chung
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Other

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ENKAPSULASI DENGAN KITOSAN-NATRIUM ALGINAT MENGGUNAKAN TEKNIK SPRAY-DRYING DAN FREEZE-DRYING Mulyadi, Naomi Megananda; Widyaningsih, Tri Dewanti; Wijayanti, Novita; Indrawati, Renny; Limantara, Leenawaty
Jurnal Pangan dan Agroindustri Vol 4, No 2 (2016)
Publisher : Jurusan Teknologi Hasil Pertanian, Fakultas Teknologi Pertanian, Universitas Brawijaya

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Abstract

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Perkembangan Sensitizer pada Terapi Fotodinamika Tumor dan Kanker Hingga Penuntunan Nanopartikel (Nanoparticulate Targeting) Dengan Antibodi Monoklonal INDRAWATI, RENNY; KARWUR, FERRY F; LIMANTARA, LEENAWATY
Indonesian Journal of Cancer Vol 4, No 3 (2010): Jul - Sep 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

World Health Organization (WHO) estimates both the number of patients and mortality rates due to cancer will continue to rise. Various researches were conducted in order to prevent and handle the cases of tumors and cancers, including the application of photosynthetic pigment molecules known as photodynamic therapy (PDT). Chlorophylls, the main pigment in photosynthesis, have an ability to capture light energy and control series of photobiology and photochemical processes1. In PDT, chlorophyll or its derivatives compounds act as the sensitizer which have energy excitation by light radiation (visible or near infra red), and generate some reactive oxygen species which triggers the death of cancer cells selectively (through apoptosis and / or necrosis pathway)2. Sensitizer compounds have been progressing from the first to third generation. The development of the third generation sensitizer was influenced by the advances of nanotechnology which lead to the improvement of PDT efficacy. The structure and size of nanoparticles can increase light absorption, and make the sensitizer accumulate in cancer tissues more specifically 3-4. Furthermore, nanoparticulatte targeting also interested to be studied because by conjugate functional groups, i.e. monoclonal antibody, on the sensitizer, it can improve the selectivity of therapy in targeting tumor and cancer tissues.
Effects of pH and Storage Time on the Stability of Papaya and Carrot Extracts Juliana, Juliana; Indrawati, Renny; Yuliati, Leny
Indonesian Journal of Natural Pigments Vol 1 No 1 (2019): February 2019
Publisher : Ma Chung Research Center for Photosynthetic Pigments

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/ijnp.2019.01.1.25

Abstract

Papaya and carrot are rich in natural pigments, especially b-carotene. Unfortunately, in most cases, natural pigments are less stable than the synthetic ones when they are put in a variety of treatment conditions, such as pH. In this work, the stability of the papaya and carrot extracts were evaluated in various pH, which ranges of 1-10 for 7 days. The extracts were obtained by a slow juicer, followed by encapsulation and drying by a freeze dryer. The extracts were then dispersed in buffer solutions and the chroma and color difference (DE) values were calculated from the obtained lightness (L*), redness (a*), and yellowness (b*). The results showed that carrot extract was better than the papaya extract in terms of chroma values. It was also shown that both extracts were not stable under acidic condition, but more stable in neutral to alkaline condition. The acid condition facilitated the cleavage of the conjugated bonds in the b-carotene, which in turn caused the color degradation in the papaya and carrot extracts.
Isolation, Encapsulation, Stability and Characteristics of Thylakoid from Suji Leaves (Pleomele angustifolia) as Natural Food Coloring Agent Chandra, Rosita Dwi; Indrawati, Renny; Heriyanto, Heriyanto; Brotosudarmo, Tatas H.P.; Limantara, Leenawaty
Indonesian Journal of Natural Pigments Vol 1 No 2 (2019): Agustus 2019
Publisher : Ma Chung Research Center for Photosynthetic Pigments

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/ijnp.2019.01.2.53

Abstract

Suji (Pleomele angustifolia) is one kind of Indonesian typical plants which can be used as natural green food coloring agent. The susceptibility of natural pigment to external environment forces the protection in order to prolong its shelf life. Encapsulation has been known in the art of food preparation to provide protection for several ingredients including food coloring agent. The objective of this study was to observe the method for isolation and encapsulation of thylakoid, and to investigate the stability and characteristics of thylakoid of suji leaves encapsulated in maltodextrin during dark storage at 30 °C, 45 °C, and 60 °C. The degradation of the encapsulated pigments was identified through chromametric analysis which resulted in the increase of L* (lightness), a* (redness), and b* (yellowness) values. In addition, it was also indicated by the decrease of total chlorophyll (TC) which was determined using spectrophotometer. Chromatography analysis confirmed the presence of four major peaks in the fresh encapsulated thylakoid powder and five major peaks in the encapsulated thylakoid powder stored at the highest temperature (60 °C), with Chl a as the dominant pigments in both powder. The vivid green powder was able to preserve its color without any obvious change to an untrained eye up to 60 d of storage at 30 °C, becoming a promising ingredient to replace the synthetic colorants.
KARAKTERISASI METODE PAPER ANALYTICAL DEVICE BERBASIS PENCITRAAN DIGITAL UNTUK DETEKSI KADMIUM Rismiarti, Zuri; Indrawati, Renny
CHEMISTRY PROGRESS Vol 10, No 2 (2017)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.10.2.2017.27744

Abstract

ABSTRAK Logam kadmium merupakan logam yang bersifat toksik dan mencemari lingkungan serta mengalami proses biotransformasi dan bioakumulasi dalam organisme hidup (tumbuhan, hewan dan manusia). Ikan merupakan salah satu biota perairan yang dapat terpapar logam Cd sehingga merupakan sumber masuknya logam Cd ke dalam tubuh manusia. Telah banyak ditemukan keracunan bersifat kronis yang terjadi pada manusia seperti kanker disebabkan paparan logam kadmium. Paper analytical device telah dilaporkan sebagai metode yang efektif, sensitid dan telah banyak diaplikasikan dalam logam berat. Penentuan kadmium dengan metode paper analytical device berbasis kolometri dengan teknik pencitraan digital telah berhasil dikembangkan. Metode ini menggunakan kertas Whatmann yang telah dipreparasi, kemudian diteteskan dengan reagen alizarin red s yang berdifusi melewati kapiler kertas hingga membentuk warna kuning kehijauan. Intensitas warna yang terbentuk difoto dengan kamera kemudian dianalisis secara kolorimetri menggunakan program Image J untuk memperoleh absorbansi pada masing-masing warna komplementer merah, hijau, biru. Penelitian memfokuskan pada karakterisasi metode yang akan dikembangkan meliputi optimasi reagen (alizarin red S dan asam sulfat) serta waktu pengukuran. Hasil penelitian menunjukkan konsentrasi optimum dari Alizarin Red S dan H2SO4 masing- masing sebesar 750 ppm dan 0,05 M dengan waktu pengukuran sebesar 10 menit. Kata kunci: Kertas, analisis, kadmium, alizarin red S, pencitraan, digital     ABSTRACT Cadmium (Cd) in trace amounts as a toxicant and an environmental pollutant. The cadmium metal will undergo biotransformation and bioaccumulation processes in living organisms (plants, animals, and humans). Fish is one of the aquatic biotas that can be exposed to Cd metal which is the source of the Cd into the human body. Chronic poisoning that occurs in humans such as cancer caused by exposure to cadmium metal. Paper analytical device (PAD) has been reported as an attractive tool for analysis with good sensitivity and can apply for heavy metal detection. This research using Alizarin Red S reagent as a chelating agent with Cd metal to produce greenish yellow color complex on paper due to sample movement through the capillary paper. The greenish yellow color complex in a paper was photographed with the digital color camera. To produce absorbance data from each complementary color of Red, Green, Blue by colorimetry analysis using Image J software. This research focuses on optimization of the reagent such as alizarin red s, sulfuric acid, and time of measuring. The result showed that optimum concentration of Alizarin Red S is 750 ppm, sulfuric acid of 0.05 M with stability time for over 10 minutes. Keywords: Paper, analysis, cadmium, alizarin red S, digital color image
Thermal Degradation Kinetics of Encapsulated Palm Carotenes Using Different Combination of Wall Materials Hong, Khoo Mun; Indrawati, Renny; Brotosudarmo, Tatas HP; Limantara, Leenawaty
Indonesian Journal of Natural Pigments Vol 2 No 1 (2020): February 2020
Publisher : Ma Chung Research Center for Photosynthetic Pigments

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/ijnp.2020.02.1.21

Abstract

Palm oil is known as one of the richest sources of carotenes. Carotenes concentrate could be prepared from crude palm oil and possessing potency to be used as nutraceutical materials. Due to the susceptibility of carotenes against heat, the encapsulation procedure might be applied to provide protections. The present study was aimed to learn the influence of using different combination of wall materials toward the thermal degradation kinetics of palm carotenes. Maltodextrin was used as primary wall material, being combined with various surface-active agents, i.e. Tween-80 (A), Tween-20 (B), and Arabic gum (C). The carotenes concentrate was encapsulated through emulsification steps, and the vivid yellow powder was obtained after freeze drying process. Then, encapsulated palm carotenes were stored in 200C, 350C, and 500C for several days, and the color, carotenes spectrum, as well as water content were monitored periodically. The kinetics of thermal degradation of carotenes were estimated using Arrhenius equation. The results showed that the use of different combination of wall materials exhibited distinct degradation rate. The combination of maltodextrin and Tween-80 gave preferable protection compared to the others, being half-degraded after 51 days in 200C.
Humans’ Body Immunity and Natural Pigments Indrawati, Renny; Limantara, Leenawaty; Brotosudarmo, Tatas H.P.
Indonesian Journal of Natural Pigments Vol 2 No 2 (2020): Agustus 2020
Publisher : Ma Chung Research Center for Photosynthetic Pigments

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/ijnp.2020.02.02.26

Abstract

The emerging pandemic of Corona Virus Disease (COVID-19) has attracted special concerns regarding the case of very contagious viral infection. Besides the profound waiting toward vaccine development, public awareness was also addressed into the effort of increasing humans’ body immunity. Nowadays, the people are encouraged to consume adequate amount of vitamin C and increase the consumption of fruits and vegetables. In addition, various kinds of food supplements are offered and claimed to give us protection and prevention against viral infection by boosting our immune system. However, the communities are actually lack of proper information regarding the true mechanism of immune system. How is the infection developed in our body? How does the immune system work? Could it be modulated by consuming the bioactive compounds? Here, the stages of infection, the immune system, as well as the role of natural pigments to support the humans’ body immunity will be briefly discussed.
Color Alteration of Encapsulated Beetroot (Beta vulgaris L.) Extract Upon Dissolving in Various pH Treatment Lukitasari, Diah Mustika; Indrawati, Renny; Chandra, Rosita Dwi; Heriyanto, Heriyanto; Limantara, Leenawaty
Indonesian Journal of Natural Pigments Vol 2 No 2 (2020): Agustus 2020
Publisher : Ma Chung Research Center for Photosynthetic Pigments

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/ijnp.2020.02.02.48

Abstract

It has been known that most natural pigments are unstable upon exposure against several environmental factors, such as thermal treatment, light, oxidizing or reducing agents, as well as acid or alkaline compounds. Encapsulation procedures is often adopted to adjust the solubility and provide protection to the natural pigments. Here, we prepared an encapsulated beetroot extract as the candidate of red bio-colorant. The primary aim of the present study is to investigate color alteration of encapsulated beetroot (Beta vulgaris L.) extract upon dissolving in various pH adjustment and prolonged storage. The McIllvainne buffer was prepared in various pH range, i.e. from 2 to 11. The encapsulated extract (0.1% w/v) was dissolved and the color of the solutions were measured regularly until 3 days storage under darkness at 200C. Any degradation or structural changes will cause color alteration, which were monitored through L*, a*, b* values, the hue angle (H°), chroma values (C), as well as color difference (DE). The results showed that pH 4 was the most favorable condition that brings least impact to the color alteration, even when the colored solution was kept in prolonged storage until 9 days.
Product Characterization and Marketing Strategy of “BREM UNGU”: Rejuvenation of Indonesian Traditional Food with Local Purple Sweet Potato as the Source of Natural Colorant Jatiyati, Greta; Jessica, Benedieta Prytania; Indrawati, Renny
Indonesian Journal of Natural Pigments Vol 3 No 1 (2021): February 2021
Publisher : Ma Chung Research Center for Photosynthetic Pigments

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/ijnp.2021.03.1.10-15

Abstract

Solid brem is an indigenous fermented food of Indonesia, which often has typical form of long thick bar, white to yellow in color, sweet-sour taste with cooling sensation, and it is easy to crumble by the presence of water. These unique characteristics are generated through alcoholic fermentation of glutinous rice, followed by filtration, concentration, whipping and dehydration. Although it is continuously produced and sold as regional specialties of Madiun, East Java, most people refuse to consume this solid brem due to its high sugar content and lack of information that describes its potential health benefits. The present study is attempting the possibility of combining glutinous rice with another local material having well-known health benefit. Here, we utilize the potency of local purple sweet potato (Ipomoea batatas var. Gunung Kawi), being rich in carbohydrate and anthocyanines, to partly substitute the glutinous rice while adding the health benefits of the final product. The present anthocyanins in sweet potato has been well-studied, exhibiting antioxidant, anti-inflammation, and hepatoprotective activities. The raw materials were subjected to yeast fermentation for 7 days, and subsequently extracted using manual mechanical press. A series of materials ratio (extract of fermented glutinous rice: purple sweet potato = 30:1, 15:1, 15:2) was determined prior to dehydration of brem, and then the color, sugar content, pH, antioxidant activity, and sensory properties of the resulted product were analyzed. Moreover, the competitive analysis and marketing strategy will also be discussed in order to make sure the sustainability of this new innovation.
Terapi Alternatif Penyakit Kardiovaskuler dengan Pigmen Alami Salim, Katarina Purnomo; Indrawati, Renny; Limantara, Leenawaty
Cermin Dunia Kedokteran Vol 43, No 11 (2016): Kesehatan Ibu - Anak
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.693 KB) | DOI: 10.55175/cdk.v43i11.893

Abstract

Pola diet dan gaya hidup kurang sehat menyebabkan berbagai kasus hiperkolesterol dan obesitas. Berbagai pengobatan untuk mengatasi permasalahan tersebut masih terus diperbaharui, tak hanya dengan obat-obatan sintetik namun juga obat alam berbasis senyawa bioaktif tumbuhan tingkat tinggi. Sejumlah studi juga menunjukkan bahwa pigmen alami, yang diproduksi oleh tumbuhan tingkat tinggi maupun rendah, juga mampu memberikan manfaat terapi hampir serupa untuk membantu menurunkan prevalensi penyakit kardiovaskular. Beberapa pigmen seperti fukosantin, astasantin, lutein, dan fikosianin dibuktikan memiliki sifat antioksidan alami serta bioaktivitas spesifik dalam metabolisme lemak tubuh, sehingga dapat digunakan untuk terapi penyakit yang disebabkan oleh kerusakan oksidatif, termasuk penyakit kardiovaskular.The unhealthy life style and poor diet become the reason of most hypercholesterol and obesity cases. Numerous studies are still continuously conducted to overcome heart conditions, not only with synthetic drugs but also natural herbals from bioactive compounds of higher plants. Several natural pigments studies showed comparable activities in decreasing cardiovascular disease prevalence. Fucoxanthin, astaxanthin, lutein, and phycocyanin are natural antioxidants, playing beneficial role in the metabolism of body fats. They can be applied for diseases associated with oxidative stress, including cardiovascular problems.
Co-Authors Amelia Myristi Lolita Diah Mustika Lukitasari Diah Mustika Lukitasari, Diah Mustika Ferry Fredy Karwur Hana Susanti Maleta Hong, Khoo Mun Jatiyati, Greta Jessica, Benedieta Prytania Juliana Juliana Juliana Katarina Purnomo Salim Leenawaty Limantara Leny Yuliati Lidwina Angelica Soetantijo Maleta, Hana Susanti Naomi Megananda Mulyadi, Naomi Megananda Novita Wijayanti Ratna Yulianti Wijaya Rosita Dwi Chandra Rosita Dwi Chandra, Rosita Dwi Salim, Katarina Purnomo Tatas H.P. Brotosudarmo Tri Dewanti Widyaningsih Yundari, Yundari Yuyun Yuniati Zuri Rismiarti _ Heriyanto