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All Journal Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Medicine Jurnal Penyakit Dalam Indonesia
Dhani Redhono, Dhani
Sub Division Tropical Medicine & Infectious Disease Faculty of Medicine, Sebelas Maret University, Moewardi Hospital
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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Relationship Between Clinical Manifestations and Antibody Serum in Outbreaks Anthrax Redhono, Dhani
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 5 (2015)
Publisher : Institute of Topical Disease

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Introduction: Anthrax is a zoonotic disease that often affects the grass-eating animals, which occurs due to the entry of spores into the bodies of animals and can be transmitted to humans. This disease often appear in certain seasons and occurs in endemic areas, including Indonesia. Cutaneous anthrax is the clinical manifestations that often arise on outstanding events in the area. This study aims to determine how the relationship between the clinical manifestations of the serum antibodies in people who are exposed to anthrax. Material and methods: This study is an observational cross sectional analytic approach, in people exposed to anthrax to assess the clinical manifestations and antibody serum Anthrax. Results: Obtained in this study respondents were 101 people with a history of contact with animals suffering from anthrax. The number of respondents with the highest age distribution was 31 to 40 years by 42%, and most were female gender, which is 57.7%, the highest level of education is 74% finished elementary school. Forty-four percent of working as a housewife. Risk factors are the most direct contact with and consume the flesh of animals as much as 34.6%. Results of Ig G antibody serum showed 50% negative, 15.4 borderline and 34.6% positive. Clinical manifestations that occur in the skin as much as 13.5%, that is the eschar on all respondents and 92.8% showed positive Ig G. While 86.5% did not show any clinical signs of anthrax, of that number 25.5% with Ig G positive, 16.6% and 57.7% showed borderline negative with p 0.02. Conclusion: There was a significant association between the clinical manifestation with antibody serum anthrax. But also found apositive Ig G without the appearance of clinical signs in the skin.
Anthrax Seroprevalence in Central Java, Indonesia Redhono, Dhani; Dirgahayu, Paramasari
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Anthrax is a zoonotic disease that is caused by Bacillus Anthracis is transmitted to humans through infected animal. The transmission to humans occurs when there is a contact to animals or animal products contracting anthrax. Clinical skin manifestations and anthrax serum Ig G antibody can be used to diagnose infected anthrax animals. This study aimed to determine the prevalence of anthrax based on ELISA serum Ig G antibody and clinical skin manifestations occurring in patients with anthrax.Subjects and Method: This was a descriptive study with cross sectional design conducted in Sragen district, Central, Indonesia, in 2015. A sample of 101 patients infected with anthrax was examined based on clinical skin manifestations and anthrax serum Ig G antibody.Results: 39.6% of the sample was 21 to 40 years of age. 57.4% of the sample was female. 74% of the sample completed primary school. 21% worked as farmers. 30.5% of the sample who cooked and consumed meat showed positive Ig G. Test results showed serum Ig G antibody negative 50%, 15.8% and 33.7% borderline positive. Clinical manifestations in the skin as much as 11.9%, which is the eschar on all respondents and 92.8% showed positive Ig  G. While 88.1% did not show any clinical signs of anthrax.Conclusion: The increase in serum antibody titer Ig G anthrax is not all respondents were exposed, in an area that otherwise outbreak of anthrax, which is only a third of all respondents, and when it comes up eschar will be followed by an increase in Ig G antibody titer.Keywords: cutaneous anthrax, Ig G antibody ELISA, escharCorrespondence: Dhani Redhon. Sub Division Tropical Medicine and Infectious Disease, Internal Medicine.Indonesian Journal of Medicine (2016), 1(2): 129-135https://doi.org/10.26911/theijmed.2016.01.02.07
Cutaneous Anthrax in Gunung Kidul, Yogyakarta: A Case Report Riswanto, Riswanto; Redhono, Dhani; Nurhayatun, Evi
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 3
Publisher : UI Scholars Hub

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Bacillus anthracis is an aerobic, gram-positive, and spore-forming Bacillus species. The most common form of anthrax infection is the cutaneous form. The infection usually develops several days after exposure to products of infected animals and manifest as a black sore with severe swelling on the skin. In this report, a 60-year-old man with a black and swollen lesion on her index finger presented in Gunung Kidul in December 2019. ELISA antibody anthrax serum was performed. The patient was then treated with antibiotics after diagnosis. This patient had a history of contact with the beef of a slaughtered sheep. The patient was treated after making a correct and rapid diagnosis and sufficient antibiotic therapy. We presented this case to update our information about cutaneous anthrax, which are become a current issue again. With appropriate management, cutaneous anthrax can heal with a good result.
RELATIONSHIP BETWEEN CLINICAL MANIFESTATIONS AND ANTIBODY SERUM IN OUTBREAKS ANTHRAX Redhono, Dhani
Indonesian Journal of Tropical and Infectious Disease Vol. 5 No. 5 (2015)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.023 KB) | DOI: 10.20473/ijtid.v5i5.303

Abstract

Introduction: Anthrax is a zoonotic disease that often affects the grass-eating animals, which occurs due to the entry of spores into the bodies of animals and can be transmitted to humans. This disease often appear in certain seasons and occurs in endemic areas, including Indonesia. Cutaneous anthrax is the clinical manifestations that often arise on outstanding events in the area. This study aims to determine how the relationship between the clinical manifestations of the serum antibodies in people who are exposed to anthrax. Material and methods: This study is an observational cross sectional analytic approach, in people exposed to anthrax to assess the clinical manifestations and antibody serum Anthrax. Results: Obtained in this study respondents were 101 people with a history of contact with animals suffering from anthrax. The number of respondents with the highest age distribution was 31 to 40 years by 42%, and most were female gender, which is 57.7%, the highest level of education is 74% finished elementary school. Forty-four percent of working as a housewife. Risk factors are the most direct contact with and consume the flesh of animals as much as 34.6%. Results of Ig G antibody serum showed 50% negative, 15.4 borderline and 34.6% positive. Clinical manifestations that occur in the skin as much as 13.5%, that is the eschar on all respondents and 92.8% showed positive Ig G. While 86.5% did not show any clinical signs of anthrax, of that number 25.5% with Ig G positive, 16.6% and 57.7% showed borderline negative with p 0.02. Conclusion: There was a significant association between the clinical manifestation with antibody serum anthrax. But also found a positive Ig G without the appearance of clinical signs in the skin.
The Agreement of Immunoglobulin Gamma Release Assay (IGRA)/ T-SPOT Tuberculosis and Tuberculin Skin Test to Detect Latent TB Infection in Diabetes Mellitus Patients Reviono, Reviono; Sutanto, Yusup Subagio; Harsini, Harsini; Saptawati, Leli; Marwoto, Marwoto; Suryawati, Betty; Redhono, Dhani; Sebayang, Pribadi M
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: WHO identifies diabetes mellitus (DM) as a neglected risk factor for tuberculosis (TB). Currently, there is no gold standard test for latent TB infection (LTBI). Centers for Disease Control and Prevention (CDC) recommends using Tuberculin Skin Test (TST) and Immunoglobulin Gamma Release Assay (IGRA) to diagnose LTBI. TST is an LTBI classic diagnostic tool that has low sensitivity and specificity. But it is still preferred in diagnosing LTBI due to its lower price, and more health facilities can perform the examination compared to IGRA (T-SPOT.TB). The study aimed to measure the agreement of TST and T-SPOT.TB testing in detecting LBTI in DM and the correlation of HbA1c with TST and T-SPOT.TB.Subjects and Method: Subjects were DM patients who underwent TST and T-SPOT.TB testing. If the results of TST and T-SPOT.TB was positive, the test would be continued with Xpert MTB/RIF microbiological testing. TST used PPD RT23 2TU. T-SPOT.TB was performed toward peripheral blood mononuclear cells. The degree of agreement between TST and T-SPOT.TB testing was calculated using the Test of Agreement (Kappa Cohen). The degree of correlation between the two variables was calculated by using Pearson correlation.Results: The selected 30 study subjects with DM undergoing antidiabetic therapy showed 6 (20%) detected LTBI and 24 (80%) without LTBI using TST and T-SPOT.TB test. There was a substantial agreement level between TST and T-SPOT.TB testing in detecting LTBI among diabetes mellitus patients undergoing anti-diabetic therapy with kappa value= 0.62 (p<0.001). HbA1c increased T-SPOT (r= 0.07; p= 0.716) and TST (r= 0.11; p= 0.956).Conclusion: TST testing may substitute T-SPOT.TB to detect LTBI among diabetes patients undergoing antidiabetic therapy.Keywords: latent tuberculosis infection, diabetes mellitus, TST, Immunoglobulin Gamma Release Assay (IGRA), T-SPOT.TBCorrespondence: Reviono. Department of Pulmonology and Medical Respiratory, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Indonesia. Email: reviono@staff.uns.ac.id.Indonesian Journal of Medicine (2021), 06(03): 298-306https://doi.­org/10.26911­/theijmed.2021.06.03.07
Brixia Score as Predictor of D-Dimer Levels of COVID-19 Patients in Intensive Care Unit Adyanata, Yanuareza Totti; Soewondo, Widiastuti; Arifin, Arifin; Redhono, Dhani
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background:  COVID-19 is caused by a novel virus that can cause lung abnormalities which can be measured with new chest x-ray scoring system named Brixia score. In COVID-19 patients, coagulation disorders are often found that can be seen through D-Dimer levels. This study aimed to prove the Brixia Score as a predictor of D-Dimer levels.Subjects and Method: This study was an observational analytic study with a cross-sectional approach. The subjects were 94 COVID-19 patients which taken from ICU Melati 1 Dr. Moewardi General Hospital, Surakarta from March 2021 to August 2021 who met the exclusion and inclusion criteria. The independent variable is the Brixia score performed by radiologists and the dependent variable is D-Dimer levels taken from laboratory results. Sampling was obtained by purposive sampling and the data were investigated using the receiver operating characteristic (ROC) curve.Results: 94 samples were obtained for analysis. The average Brixia Score of patients with D-Dimer <2 µg/mL was Mean= 15.85; SD= 1.43 and D-Dimer ≥2 µg/mL was Mean= 17.29; SD= 0.96. There was a significant difference between the Brixia Score of patients with D-Dimer <2 µg/mL and D-Dimer ≥2 µg/mL (p<0.001). Analysis with the ROC curve shows an area under the curve (AUC) of 0.793. The optimal cutoff value of the Brixia Score for predicting D-Dimer levels was 16.5 (sensitivity 77.9%, specificity 73.1%).Conclusion: Brixia Score proved to be a predictor of D-Dimer levels of COVID-19 patients in ICU care.Keywords: COVID-19, ICU, brixia score, predictor, D-Dimer.Correspondence: Widiastuti Soewondo, Radiology Department, Faculty of Medicine, Universitas Sebelas Maret. JL. Ir. Soetami No. 36A, Surakarta 57126, Indonesia. E-mail: widiastuti.sprad56@staff.uns.ac.id. Mobile: 082134368592Indonesian Journal of Medicine (2023), 08(01): 92-99https://doi.org/10.26911/theijmed.2023.08.01.09
Co-Authors Adyanata, Yanuareza Totti Arifin Arifin Leli Saptawati marwoto marwoto Mochammad Imron Awalludin Nurhayatun, Evi Paramasari Dirgahayu Reviono Reviono riswanto riswanto Sebayang, Pribadi M Soewondo, Widiastuti SURYAWATI, BETTY Yusup Subagio Sutanto