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Nurhayatun, Evi
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Cutaneous Anthrax in Gunung Kidul, Yogyakarta: A Case Report Riswanto, Riswanto; Redhono, Dhani; Nurhayatun, Evi
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Bacillus anthracis is an aerobic, gram-positive, and spore-forming Bacillus species. The most common form of anthrax infection is the cutaneous form. The infection usually develops several days after exposure to products of infected animals and manifest as a black sore with severe swelling on the skin. In this report, a 60-year-old man with a black and swollen lesion on her index finger presented in Gunung Kidul in December 2019. ELISA antibody anthrax serum was performed. The patient was then treated with antibiotics after diagnosis. This patient had a history of contact with the beef of a slaughtered sheep. The patient was treated after making a correct and rapid diagnosis and sufficient antibiotic therapy. We presented this case to update our information about cutaneous anthrax, which are become a current issue again. With appropriate management, cutaneous anthrax can heal with a good result.
Factor Related to The Incidence of Ascites in Chronic Kidney Disease Patients Undergoing Hemodialysis at RSUD Dr Moewardi Surakarta: A Cross Sectional Study Yusman, Felizia Alika; Dewi, Ratih Tri Kusuma; Mashuri, Yusuf Ari; Nurhayatun, Evi; Giani, Maia Thalia
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
Publisher : UI Scholars Hub

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Introduction. Chronic kidney disease (CKD) is a global health issue with continuously rising prevalence. Fluid overload is a frequent systemic complication which occurs in CKD patients undergoing hemodialysis (HD). One of clinical manifestation of fluid overload in HD patients is ascites. This study aimed to determine the factors related to the incidence of ascites in CKD patients undergoing hemodialysis. Methods. An observational analytic study with a cross-sectional approach was conducted at Dr. Moewardi Hospital, Surakarta from September until October 2019. The subjects were end-stage CKD patients undergoing HD. Subjects were selected by total sampling technique. Data were obtained from medical records tracking. Furthermore, each variable was analyzed using Chi Square and Independent T-test analysis. P value less than 0.05 is considered statistically significant. Results. A total of 116 subjects were recruited in this study. Incidence of ascites was documented in 24 (20.7%) patients. The comorbid of chronic heart failure (CHF) was found in 23 (19.8%) subjects, where this condition was associated with the incidence of ascites [p = 0.003; PR 2.888 (95% CI=1.476–5.650)]. In the subjects with hypoalbuminemia was also related to higher incidence of ascites [p < 0.001; PR 7.800 (95% CI=3.153 – 19.293)]. Meanwhile gender, age, diabetes mellitus, the levels of hemoglobin, ureum, creatinine serum, albumin, hematocrit, and leukocyte were not associated with ascites in CKD patients undergoing HD (p > 0.05). Conclusions. Factors related to the incidence of ascites in patients with chronic kidney disease who have undergone hemodialysis is chronic heart failure and hypoalbuminemia.
Adherence to Antiretroviral Theraphy and Associated Factors Among People Living with HIV in Surakarta Nurhayatun, Evi; Ulfia, Mila; Angelina, Tirsa
JURNAL INFO KESEHATAN Vol 23 No 3 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss3.1660

Abstract

The Human Immunodeficiency virus (HIV) presents a major public health challenge due to its association with high mortality and morbidity rates. Infection HIV occurs when the virus attacks the body’s immune system at a cellular level. Without treatment, this can progress to the most advanced stage, Acquired Immune Deficiency Syndrome (AIDS). For people living with HIV (PLWHIV), lifelong treatment with antiretroviral (ARV) medication is necessary. This continuing therapy works to reduce the amount of virus in the blood, lowering the risk of transmission, preventing secondary infections, and improving the patient's general life quality. The success and effectiveness of ARV therapy depends on PLWHIV adherence. Poor adherence to antiretroviral therapy decreases its effectiveness and increases viral replication. Therapy adherence indicates that the patient understands the value of receiving therapy and follows the instructions. Knowledge is an important role in therapy compliance. This cross-sectional study was conducted at the VCT Polyclinic of the Department of Internal Medicine, Dr. Moewardi General Hospital in Surakarta, between April and July 2024. The target population included all patients who received a positive HIV diagnosis. A total of 60 patients from this group were selected to participate using a purposive sampling strategy. Bivariate analysis was then used to investigate the relationship between variables, with the Spearmean Rank statistical test.  The study result showed that 21 patients with poor level of knowledge had low compliance (92.9%), followed by patients with intermediate level of knowledge with moderate compliance 10 (60.0%), and patients with high level of knowledge with high compliance 29 (69.4%). A statistically significant, moderately strong positive relationship (r=0.572, p < 0.001) was found between patient knowledge and adherence to ARV therapy at the VCT polyclinic of Dr. Moewardi Hospital, Surakarta. This suggests that PLWHIV who receive adequately informed patients are more likely to adhere to their treatment plans. Therefore, improving patient compliance requires implementing robust educational programs and conducting further research to uncover other influencing factors.             
Difference of Cycle Threshold Value, Oxygen Saturation and D-dimer to COVID-19 Vaccination Redhono Harioputro, Dhani; Dasa Ramadhan, Arsyi; Nurhayatun, Evi; Budi Susilo, Satrio; Agung Prabowo, Nurhasan
JURNAL INFO KESEHATAN Vol 21 No 2 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss2.1204

Abstract

Many factors can affect the prognosis of COVID-19 patients, and Cycle Threshold value can be used to estimate the amount of virus in the body. Oxygen saturation and D-dimer are important components in determining the severity. This study aims to analyze the difference of CT value, oxygen saturation, D-dimer, and degree of severity on vaccination state. This study is the observational analytic study of patients admitted to the isolation ward of a referral hospital in Surakarta, Indonesia. The analysis covered assessing the normality of the data, the Kruskal-Wallis correlation test, and ANOVA to assess the differences between variables. A total of 154 patients with, 65.6% of them did not participate in the full vaccination program. The results of the analysis showed a significant difference between the D-dimer and the degree of severity with a p-value of < 0.05, while the CT value and oxygen saturation had no significant difference with the vaccination state. Vaccination showed a significant difference with D-dimer and the degree of severity of COVID-19 infection, so giving a complete vaccine can reduce the severity of COVID-19 patients, and we recommended to be able to complete the vaccine for the whole community.
The Correlation of D- Dimer and Neutrophil Lymphocyte Ratio (NLR) Levels on COVID-19 Mortality Nurhayatun, Evi; Ayu Safira, Meilani; Nurudhin, Arief
JURNAL INFO KESEHATAN Vol 21 No 3 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss3.1207

Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by a novel coronavirus or a new type of corona virus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). D-dimer and Neutrophil Lymphocyte Ratio are parameters that can be used as a predictor of mortality in COVID-19, so this study aims to determine the relationship between D-dimer levels and NLR with mortality in COVID-19 patients. The study used an analytic observational method with a cross sectional approach from medical record data at UNS Hospital. The population in this study were COVID-19 patients at UNS Hospital who had their D-dimer and NLR levels checked in the period November 2020-January 2021. The sample was taken using a simple random sampling technique. Bivariate data analysis with Spearman Rank Correlation Test. Obtained 72 samples. 46 male patients and 26 female patients with the highest age range of 40-59 years as many as 34 patients. Patients who experienced mortality as many as 24 people while the rest survived. Spearman's Rank test obtained p-values of D-dimer and neutrophil lymphocyte ratio (NLR) with mortality of COVID-19 patients 0.009 and <0.001, respectively. While the correlation coefficients for D-dimer and NLR on mortality were 0.308 and 0.515, respectively. There is a relationship between D-dimer and NLR levels with mortality in COVID-19 patients with a positive correlation.
Comparison of Severity in Diabetic Ulcer Patients with and Without Sepsis Maydiana, Siti Roisya Aga; Nurhayatun, Evi; Putri, Desy Puspa
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1221

Abstract

Diabetes mellitus patients in Central Java grow yearly. According to data provided by the Central Java Health Department in 2019, Diabetes mellitus ranks second as the largest non-communicable disease (NCD), covering 13,4% of the total NCD patients. The prevalence of diabetic ulcers is 15-25% of all diabetes mellitus patients in Indonesia, which concerns the author regarding the possible increase of the diabetic ulcer population in Central Java. The severity of diabetic ulcers depends on various factors, including infection and complications. The most common complication is sepsis, a systemic infection often arising from local infections that are not appropriately treated, causing progressive damage and increasing mortality rates. This study aims to examine the comparison of ulcer severity in diabetic ulcer patients with sepsis and non-sepsis complications using Meggitt Wagner's criteria. This study utilizes an analytic observational study using a cross-sectional approach. The author sampled 126 patients diagnosed with Diabetic Ulcers in 2022 at Dr. Moewardi General Hospital for this study, using a purposive sampling method. The research was conducted by looking at the patient's medical record data, and data analysis using SPSS software. The test used in this research includes a Parametric T-independent test and a Pearson bivariate relationship test. This study shows that the comparison of ulcer severity in diabetic ulcer patients with sepsis and without sepsis was statistically significant (p-value = 0.000002). The mean of the group with sepsis (3.4127) was greater than the group without sepsis (2.5238). In conclusion, the comparison of ulcer severity in diabetic ulcer patients with sepsis and without sepsis is significant. We recommend future researchers include patients’ comorbidities, total hospitalization time, and detailed information on drug use and patient adherence to treatment in their research for more nuanced findings.                 
Co-Authors Agung Prabowo, Nurhasan Angelina, Tirsa Arief Nurudhin Ayu Safira, Meilani Budi Susilo, Satrio Dasa Ramadhan, Arsyi Dhani Redhono, Dhani Giani, Maia Thalia Mashuri, Yusuf Ari Maydiana, Siti Roisya Aga Putri, Desy Puspa Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Redhono Harioputro, Dhani riswanto riswanto Ulfia, Mila Yusman, Felizia Alika