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All Journal Majalah Obat Tradisional Smart Medical Journal Journal of Epidemiology and Public Health Indonesian Journal of Medicine Narra J Smart Society Empowerment Journal
SURYAWATI, BETTY
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Risk Factors and Prognosis of Nontuberculous Mycobacteria Infection in a High Prevalence of Tuberculosis Setting Saptawati, Leli; Mashuri, Yusuf Ari; Suryawati, Betty; Harsono, Harsono; Pradiptakirana, Riska
Journal of Epidemiology and Public Health Vol 5, No 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.805 KB)

Abstract

Background: The prevalence and incidence of Non­tuberculous Mycobacteria (NTM) infections in the world in general have continued to in­cre­ase in the last two to three decades. Until now i­den­tification and testing of NTM sensitivity in Indonesia is still very difficult to do in daily health services. Thus, NTM infection is still a ne­glected case and misdiagnosis often occurs. In these conditions, one of the things that is very im­portant to help clinicians in the management of NTM infections is information about patient characteristics and how the relationship of risk factors for NTM infection with prognosis.Subjects and Method: The study was con­duc­ted retrospectively using data on the medical re­cords of patients with positive culture of NTM at the Surakarta Center for Community Lung Health (BBKPM) for 3 years (2016-2018). A total of 134 samples were selected for this study with total sampling. The dependent variable is the prognosis of infection. The independent variables were gender, age, occupation, history of inhaled corticosteroid use, antibiotic therapy, and under­lying disease. Data were analyzed using multiple logistic regression.Results: The number of samples is 143 medical records. Most of the patients in this study were male (62.90%) and aged less than 60 years (79.70%). The majority of patients work not as far­mers (80.40%). Most patients had no history of inhaled corticosteroid use (89.50%). The­ra­pe­utic factors indicate that the majority of patients receive combined antibiotic therapy (68.5%). As many as 42% of patients with NTM infection have an underlying disease. Underlying disease in patients is mostly in the form of diabetes me­l­litus (DM) in 13.3% and in the former tuber­cu­losis in 4.9%. Based on the Chi-Square test, a sig­nificant relationship was found between the­ra­peutic factors, history of inhaled corti­cos­teroid use, and type of work, and the patient's prog­no­sis. Based on mult­ivariable testing, the factor of antibiotic therapy is the most influential variable on a pa­tient's prognosis.Conclusion: Risk factors related to the patient's prog­nosis are occupation, use of inhaled cor­tico­steroids and antibiotic therapy.Keywords: Nontuberculous Mycobacteria, risk factors, prognosis, Center for Community Lung HealthCorrespondence: Leli Saptawati. Department of Microbiology, Fa­culty of Medicine, Universitas Sebelas Maret, In­do­nesia. Jl. Ir. Soetami no. 36A Kentingan Su­ra­karta, Indonesia. Email: llsapt_md@yahoo.­co.­id. Mobile: (0271) 632489.Journal of Epidemiology and Public Health (2020), 5(1): 79-87https://doi.org/10.26911/jepublichealth.2020.05.01.08
Sensitivitas Metode Pemeriksaan Mikroskopis Fluorokrom dan Ziehl-Neelsen untuk Deteksi Mycobacterium tuberculosis pada Sputum BETTY SURYAWATI; LELI SAPTAWATI; ASTARI FEBYANE PUTRI; JATU APHRIDASARI
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.603 KB) | DOI: 10.13057/smj.v1i2.28704

Abstract

Background: Detection of fast acid bacteria (FAB) using smear microscopy is used as a primary screening for tuberculosis diagnosis. Previous studies have shown that fluorochrome (Auroamine-rhodamine) staining showed better sensitivity compared to Ziehl-Neelsen (ZN) method in the detection of FAB in sputum. However this method has not been recommended for routine use including in Indonesia. This study aimed to evaluate the sensitivity and specificity of fluorochrome compared to ZN to detect FAB in patient’s sputum.Methods: This study analyzed 60 sputum samples from patients with tuberculosis and suspected pulmonary tuberculosis. Samples were obtained consecutively from microbiology laboratory Moewardi Hospital, Indonesia. Each sample was examined using ZN and fluorochrome staining and cultured in Lowenstein-Jensen (LJ) medium. Data were analyzed using sensitivity and spesificity tests.Results: ZN staining detected FAB in 12 samples (10%), while fluorochrome detected FAB in 17 samples (28%). The sensitivity and specificity of ZN staining were 70% and 90% while these for fluorochrome were 90% and 84%. Conclusions: The sensitivity of fluorochrome staining is better compared to ZN staining. This method can be recommended for early detection of tuberculosis. 
Peningkatan Pengetahuan Kader Posyandu-Lansia Tentang Penyakit Infeksi dan Hipertensi untuk Meningkatkan Promosi Kesehatan pada Masyarakat Lanjut Usia Betty Suryawati; Marwoto Marwoto; Jusuf Soebagyo; Harsini Harsini; Reviono Reviono; Arthrien Adiputri; Brigitta Devi Anindita Hapsari
Smart Society Empowerment Journal Vol 2, No 3 (2022): Smart Society Empowerment Journal
Publisher : Fakultas Kedokteran UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.392 KB) | DOI: 10.20961/ssej.v2i3.66873

Abstract

Pendahuluan: Lanjut usia (lansia) merupakan kelompok masyarakat yang mempunyai resiko tinggi untuk mendapatkan penyakit, baik penyakit degeneratif maupun penyakit infeksi. Salah satu penyakit yang sering terjadi pada usia lanjut adalah hipertensi dan penyakit infeksi. Pengetahuan tentang penyakit sangat penting agar lansia dapat mengenali faktor risiko dan upaya pencegahan penyakit. Kader posyandu lansia mempunyai peranan penting dalam promosi kesehatan pada lansia; sehingga peningkatan pengetahuan dan skill kader posyandu tentang penyakit hipertensi dan infeksi sangat penting dalam pencegahan dan pengurangi risiko penyakit infeksi pada lansia. Tujuan pengabdian masyarakat ini adalah untuk memberikan peningkatan pengetahuan kader posyandu lansia dalam hal penyakit infeksi yang sering terjadi pada lansia dan penyakit hipertensi.Metode: Kegiatan pengabdian kepada masyarakat ini bekerjasama dengan pemerintah Kelurahan Mojo, Kecamatan Pasarkliwon, Kota Surakarta. Metode yang digunakan adalah dengan memberikan ceramah kepada kader lansia di kelurahan Mojo, tentang penyakit infeksi yang sering terjadi pada lansia dan penyakit hipertensi, yang meliputi faktor risiko, tanda dan gejala, dan upaya yang dapat dilakukan untuk pencegahan. Selain itu untuk mengevaluasi kegiatan ini dilakuka pre- dan post-test yang bertujuan untuk mengetahui tingkat pengetahuan kader posyandu lansia tentang penyakit infeksi dan hipertensi.Hasil dan Pembahasan: Jumlah peserta kegiatan adalah sebanyak 80 kader posyandu. Hasil evaluasi menunjukkan bahwa kader lansia sudah mempunyai pengetahuan yang cukup tentang hipertensi dan penyakit infeksi pada lansia, tetapi dalam beberapa hal masih perlu ditingkatkan, terutama dalam pengetahuan tentang klasifikasi hipertensi, cara pengukuran tekanan darah yang benar, dan penyakit infeksi. Didapatkan peningkatan nilai post-test yang menunjukkan peningkatan pengetahuan dari kader posyandu setelah diberikan paparan tentang materi tersebut.Kesimpulan: Terjadi peningkatan pengetahuan tentang hipertensi dan penyakit infeksi pada kader posyandu lansia. Kata kunci: Hipertensi; Infeksi;Usia lanjut; Kader; Posyandu
Effectiveness of Zingiber officinale to reduce inflammation markers and the length of stay of patients with community-acquired pneumonia: An open-label clinical trial Reviono, Reviono; Hapsari, Brigitta DA.; Sutanto, Yusup S.; Adhiputri, Artrien; Harsini, Harsini; Suryawati, Betty; Marwoto, Marwoto; Syaikhu, Akhmad
Narra J Vol. 3 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i1.142

Abstract

Examination of the interleukin 6 (IL-6) and procalcitonin levels, and neutrophil-lymphocyte ratio (NLR) might could help to diagnosis and predict the duration of therapy and prognosis of pneumonia cases. Zingiber officinale var rubrum could be used as an adjunct therapy in infectious diseases as it has anti-inflammatory activity. The aim of study was to assess the effect of Z. officinale on levels of IL-6 dan procalcitonin, NLR, and the length of hospitalization of patients with community-acquired pneumonia (CAP). An open-label clinical trial was conducted among CAP cases regardless of the etiology at Dr Moewardi Hospital and Universitas Sebelas Maret Hospital, Surakarta, Indonesia from July to September 2022. A total of 30 inpatient CAP cases were recruited and were randomly divided into two groups: (1) received Z. officinale capsule 300 mg daily for five days in addition to CAP standard therapy; and (2) received CAP standard therapy only, as control group. The data were compared using a paired Student t-test, Chi-squared test, Mann-Whitney test and Wilcoxon signed-rank test as appropriate. In Z. officinale group, the mean difference between post- and pre-treatment as follow: IL-6 level was 9.93 pg/mL, procalcitonin level -471.31 ng/mL, and NLR value -4.01. In control group, the difference was 18.94 pg/mL for IL-6, 339.39 ng/mL for procalcitonin, and 1.56 for NLR. The change of IL-6 was not statistically significant between treatment and control groups with p=0.917. The changes of procalcitonin level and NLR were significant between treatment and control group with p=0.024 and p=0.007, respectively, of which the treatment had better improvement. In addition, our data indicated that the length of stay was not statistically significant between the treatment and control groups (4.13 vs 4.47 days, p=0.361). In conclusion, Z. officinale could reduce serum inflammatory markers such as procalcitonin and NLR but it has little impact in reducing IL-16 level and the length of hospitalization of CAP patients.
Risk Factors and Prognosis of Nontuberculous Mycobacteria Infection in a High Prevalence of Tuberculosis Setting Saptawati, Leli; Mashuri, Yusuf Ari; Suryawati, Betty; Harsono, Harsono; Pradiptakirana, Riska
Journal of Epidemiology and Public Health Vol. 5 No. 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The prevalence and incidence of Non
The Agreement of Immunoglobulin Gamma Release Assay (IGRA)/ T-SPOT Tuberculosis and Tuberculin Skin Test to Detect Latent TB Infection in Diabetes Mellitus Patients Reviono, Reviono; Sutanto, Yusup Subagio; Harsini, Harsini; Saptawati, Leli; Marwoto, Marwoto; Suryawati, Betty; Redhono, Dhani; Sebayang, Pribadi M
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: WHO identifies diabetes mellitus (DM) as a neglected risk factor for tuberculosis (TB). Currently, there is no gold standard test for latent TB infection (LTBI). Centers for Disease Control and Prevention (CDC) recommends using Tuberculin Skin Test (TST) and Immunoglobulin Gamma Release Assay (IGRA) to diagnose LTBI. TST is an LTBI classic diagnostic tool that has low sensitivity and specificity. But it is still preferred in diagnosing LTBI due to its lower price, and more health facilities can perform the examination compared to IGRA (T-SPOT.TB). The study aimed to measure the agreement of TST and T-SPOT.TB testing in detecting LBTI in DM and the correlation of HbA1c with TST and T-SPOT.TB.Subjects and Method: Subjects were DM patients who underwent TST and T-SPOT.TB testing. If the results of TST and T-SPOT.TB was positive, the test would be continued with Xpert MTB/RIF microbiological testing. TST used PPD RT23 2TU. T-SPOT.TB was performed toward peripheral blood mononuclear cells. The degree of agreement between TST and T-SPOT.TB testing was calculated using the Test of Agreement (Kappa Cohen). The degree of correlation between the two variables was calculated by using Pearson correlation.Results: The selected 30 study subjects with DM undergoing antidiabetic therapy showed 6 (20%) detected LTBI and 24 (80%) without LTBI using TST and T-SPOT.TB test. There was a substantial agreement level between TST and T-SPOT.TB testing in detecting LTBI among diabetes mellitus patients undergoing anti-diabetic therapy with kappa value= 0.62 (p<0.001). HbA1c increased T-SPOT (r= 0.07; p= 0.716) and TST (r= 0.11; p= 0.956).Conclusion: TST testing may substitute T-SPOT.TB to detect LTBI among diabetes patients undergoing antidiabetic therapy.Keywords: latent tuberculosis infection, diabetes mellitus, TST, Immunoglobulin Gamma Release Assay (IGRA), T-SPOT.TBCorrespondence: Reviono. Department of Pulmonology and Medical Respiratory, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Indonesia. Email: reviono@staff.uns.ac.id.Indonesian Journal of Medicine (2021), 06(03): 298-306https://doi.­org/10.26911­/theijmed.2021.06.03.07
Antibacterial and Antibiofilm of Cinnamomum burmanii Bark Oil (CbBO) against Klebsiella pneumoniae ATCC 700603: In Vitro Study Inayati, Inayati; Hartono, Hartono; Indarto, Dono; Suryawati, Betty
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97396

Abstract

Many cases of multidrug-resistant (MDR) bacterial infections are caused by Klebsiella pneumoniae (K.pn), an infectious disease bacterium. Hospital inpatients can be exposed to this occurrence; MDR has transformed 26.96% of infections at Klaten Hospital into highly infectious biofilms, while 54.49% of infections have produced biofilms. Approximately 80% of bacterial illnesses resistant to antibiotics are caused by biofilm-forming bacteria. To reduce biofilm formation, antibacterial compounds, one of which comes from natural products, are necessary. Renowned for its essential oil, Cinnamomum burmanii Bark Oil (CbBO) has been utilized extensively in herbal medicine to combat pathogenic bacteria such as Pseudomonas aeruginosa, Candida albicans, Enterobacter spp., and Staphylococcus aureus. This study aims to evaluate CbBO’s antibacterial capabilities using the microdilution method and its antibiofilm properties against K. pneumoniae ATCC 700603 using the MTT test. A CbBO minimum bactericidal concentration (MBC) of 0.25 mg/mL and a minimum inhibitory concentration (MIC) of 0.125 mg/mL were employed for antibacterial activity. The antibiofilm potential was determined by measuring the minimum biofilm eradication concentration (MBEC) at 0.5 mg/mL and the minimum biofilm inhibition concentration (MBIC) at 0.25 mg/mL. In conclusion, CbBO demonstrated antimicrobial and antibiofilm qualities. However,                   a greater concentration of CbBO was required for antibiofilm formation than for antibacterial purposes.
Co-Authors Adhiputri, Artrien Akhmad Syaikhu Arthrien Adiputri ASTARI FEBYANE PUTRI Brigitta Devi Anindita Hapsari Dhani Redhono, Dhani Dono Indarto Hapsari, Brigitta DA. Harsini Harsini Harsono Harsono Hartono Hartono Inayati Inayati JATU APHRIDASARI Jusuf Soebagyo Leli Saptawati LELI SAPTAWATI Marwoto Marwoto marwoto marwoto Mashuri, Yusuf Ari Mochammad Imron Awalludin Pradiptakirana, Riska Reviono Reviono Reviono Reviono Sebayang, Pribadi M Sutanto, Yusup S. Yusup Subagio Sutanto