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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Universa Medicina JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Zainuri Sabta Nugraha, Zainuri Sabta
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Binaural entrainment of 2000-2040 Hz and 2000-2090 Hz increase Glial Fibrillary Acidic Protein (GFAP) expression of astrocytes in the CA1 rat hippocampus during operant learning conditioning Nugraha, Zainuri Sabta; Aswin, Soedjono; Harijadi, Harijadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 03 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (142.092 KB) | DOI: 10.19106/JMedScie004603201401

Abstract

Astrocytes of hippocampus contribute in the learning performance. Entrainment of gamma wavescan improve learning performance by improving the neurons to astrocytes communication. Theaim of this study was to evaluate the effect of binaural entrainment of 2000-2040 Hz and 2000-2090 Hz on Glial Fibrillary Acidic Protein (GFAP) expression in astrocytes of the CA1 region ofrat hippocampus during operant learning conditions. Twenty male Wistar rats aged 4-6 weekswith body weight 100-150 g were devided into 4 groups. Group I was given binaural soundsentrainment at 2000-2040 Hz without learning test. Group II was given entrainment as performedin Group I followed by a learning test. Group III was given binaural sounds entrainment at 2000-2090 followed by a learning test. Group IV was not given entrainment nor learning test. Theentrainment was performed for 30 minutes everyday for 12 days and the learning test wasperformed for 10 minutes everyday for 12 days. The GFAP expression was examinedimminohistochemically. Astrocytes processes and astrocytes histoscore were also calculated.The results showed that the number of the GFAP-positive astrocytes in Group I (70.96 ± 4.86),II (69.76±3.07) and III (63.10±5.85) were significantly higher than Control (47.33±1.33)(p<0.05). The number of the processes astrocytes in Group I (47.64 ± 3.87), II (60.66±2.07)and III (54.17±6.38) was significantly higher than Control (30.87±2.69) (p<0.05). Moreover,the number of the processes astrocytes in Group II was significantly higher than Group I (p=0.016).The astrocytes histoscore index in the Group II (115.58±14.13) and III (78.32±22.23) weresignificantly higher than Group I (28.79 ± 9.61) and Control (16.05±1.64) (p<0.05). Inconclusion, the binaural entrainment of 2000-2040 Hz and 2000-2090 Hz increase GFAP expressionof astrocytes in Cornu Ammonus 1 (CA1) region of rat hippocampus during operant learningconditioning.
Black sugarcane decoction reduces rat brain ischemia Handayani, Ety Sari; Nugraha, Zainuri Sabta; Nurmasitoh, Titis; Kuswati, Kuswati; Ahsani, Dwi N.; Nanda, Ajeng G.
Universa Medicina Vol 35, No 1 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.40-45

Abstract

BackgroundThere are people in Yogyakarta, who use black sugarcane decoction (BSD) to prevent stroke. BSD contains policosanol and antioxidants. It has been proven that policosanol can reduce global ischemia in Mongolian gerbils. This study aims to evaluate the effect of BSD on brain ischemia in a rat stroke model. MethodsA laboratory experiment using eighteen 3-month old male Wistar rats without any defects, of 175-250 g body weight. Brain ischemia was produced by a 20-minute bilateral carotid communis artery oclusion (BCCAO).  Using a rat stroke model, brain ischemia was produced by a 20-minute BCCAO. The rats were randomized into three groups: BSD treated stroke model rats (group 1), non treated stroke model rats (group 2), and sham operated rats (group 3). BSD was administered by gavage for 1 week before BCCAO. Decapitation of rats was performed two hours post BCCAO. Brain tissues were stained with 2,3,5-triphenyltetrazolium chloride (TTC). Ischemic areas were analyzed using Image J softwere. Statistical analysis was conducted by one way ANOVA test.ResultsThe mean percentages of rat brain ischemic area differed between group 3 (0.0 ± 0.0%), group 2 (3.13 ± 0.59%) and group 1 (1.15 ± 0.47%) p =0.001). Post hoc test showed that there was no difference between group 3 with group 1. Instead, there was a significant difference between  group 2 and the other groups.ConclusionThe administration of BSD reduced rat brain ischemia after bilateral carotid artery ligation.
Propolis increases neuronal count in hippocampal area CA1 and prefrontal cortex in stressed rats Nugroho, Kuswati; Handayani, Ety Sari; Nugraha, Zainuri Sabta
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.214-220

Abstract

Background Stress induces neuronal cell damage in the hippocampus and prefrontal cortex. Propolis has a neuroprotective effect that can inhibit apoptosis and decrease neuronal cell count. This study aimed to determine the effect of propolis on neuronal cell count in hippocampal area CA1 and prefrontal cortex in Sprague Dawley rats with induced stress.MethodsA study of laboratory experimental design was conducted involving 24 male Sprague-Dawley Rattus norvegicus. The animals were randomly divided into 4 groups, i.e. controls (K), and stress groups P1, P2 and P3. Controls did not receive treatment, stress group (P1) received stress treatment, groups P2 and P3 received stress and propolis at 100 and 200 mg/kgBW, respectively. Stress and propolis were given for 14 days, followed by termination. The number of neurons in the hippocampal area CA1 and prefrontal cortex were counted. One way ANOVA was used to analyze the data.Results The neuronal count in the hippocampal area CA1 and prefrontal cortex in the stress group (P1) was lower than in groups K, P2 and P3. There were significant differences in the neuronal count of the hippocampal area CA1 between P1 and P3 and P1 and K (p=0.019) and also in the neuronal count of the prefrontal cortex between P1 and P2, P3 and K (p=0.002).Conclusions This study strongly suggest that propolis inhibits the decrease in neuronal count in in the hippocampal area CA1 and prefrontal cortex of Sprague Dawley rats with induced stress. The present study suggests a potential neuroprotective effect of propolis in the prevention of neurodegenerative disorders.
Propolis inhibited Bax expression and increased neuronal count of hippocampal area CA1 in rats receiving sodium nitrite Kuswati, Kuswati; Handayani, Ety Sari; Nugraha, Zainuri Sabta; Rahmanti, Fishella Aprista; Wicaksana, Zulfikar Loka; Zhafirrahman, Muhammad
Universa Medicina Vol 38, No 2 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (702.491 KB) | DOI: 10.18051/UnivMed.2019.v38.73-80

Abstract

BackgroundSodium nitrite induces hypoxia and oxidative stress in the hippocampus, decreasing the number of neurons in the hippocampus and cognitive function. Propolis contains chrysin that has antioxidant effects that are expected to inhibit neuronal damage in the hippocampus. This study aims to determine the effects of propolis on the expression Bcl-2-associated X protein (Bax) and the number of neurons in the rat hippocampus receiving sodium nitrite.MethodsThis study of laboratory experimental design was conducted on 18 male Wistar strain rats (Rattus norvegicus), they were randomized into 3 groups: one control group (K) received sodium nitrite and two intervention groups  (P1 and P2) received sodium nitrite and propolis at doses of 100 and 200 mg/kgBW. Treatment with sodium nitrite and propolis were given for 60 days, followed by termination. The number of neurons and Bax expression in the hippocampal CA1 area were measured. One-way ANOVA was used to analyze the data.ResultsThere were significant differences in Bax expression between group K and groups P1 and P2 (p<0.001). The lowest number of neurons in the hippocampal CA1 area was in the K group. There were significant differences in the number of neurons between control (K) group and groups P1 and P2 (p<0.001).ConclusionPropolis inhibited the expression of Bax and decreased the number of neurons in the hippocampal CA1 area of rats receiving sodium nitrite. This study provides information about the benefits of propolis as an antioxidant in the brain.
Correlation of Total Body Fat and Physical Fitness Index in Medical Students of Universitas Islam Indonesia Firdaus, Lidya Sabilla; Pramaningtyas, Miranti Dewi; Nugraha, Zainuri Sabta
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): December 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.119 KB) | DOI: 10.30659/sainsmed.v12i2.7733

Abstract

The World Health Organization suggests that total body fat is one of the main risk factors for metabolic syndrome which is the most significant cause of morbidity and mortality in the world. The excessive fat mass harms the function of the heart, lowers the oxygen uptake by working muscles. Excess of body fat may decrease physical fitness. This research aims to know the correlation of total body fat with physical fitness index in medical students of Universitas Islam Indonesia. This research used a cross-sectional study design. The research subjects consisted of 45 male medical students of Universitas Islam of Indonesia under 25 years old. Total body fat of its subject is measured by Bioelectrical impedance analysis method (Karada scan), while physical fitness index is measured by the Harvard Step Test. This study is tested by Spearman correlation. Mean of TBF (%) value was 23.68 ± 6.29. Mean of physical fitness index levels was 60.05 ± 31.27. Spearman correlation test has a result r = -0.314 with a significance of p = 0.038 (p<0.05), that means total body fat and physical fitness index has a significant negative correlation. There was a significant negative correlation between total body fat and physical fitness index
Hubungan Aktivitas Fisik Terhadap Risiko Terjadinya Sindroma Metabolik Pada Pegawai Kantor PT. PLN Unit Pelaksana Pelayanan Pelanggan (UP3) Daerah Istimewa Yogyakarta Al-Ghozi, Yasfi Suryalfihro Al-Ghozi; Sukarno, Rizky Triutami; Nugraha, Zainuri Sabta; Pramaningtyas, Miranti Dewi
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol2.iss2.art6

Abstract

Latar Belakang: Sindrom Metabolik (SM) dan kurang aktivitas fisik memiliki prevalensi cukup tinggi di Indonesia, termasuk di wilayah perkantoran Daerah Istimewa Yogyakarta (DIY). SM merupakan sekelompok gangguan metabolisme, sedangkan kurang aktivitas fisik merupakan kondisi seseorang kurang melakukan aktivitas fisik. Kondisi kurangnya aktivitas fisik dapat berisiko untuk terjadinya sindrom metabolik. Tujuan: Mengetahui hubungan Aktivitas Fisik Terhadap Risiko Terjadinya Sindroma Metabolik pada Pegawai Kantor PT. PLN Unit Pelaksana Pelayanan Pelanggan (UP3) Daerah Istimewa Yogyakarta. Metode: Penelitian ini merupakan penelitian kuantitatif observasional dengan desain cross sectional. Sampel pada penelitian ini menggunakan purposive sampling dengan perhitungan uji hipotesis dua proporsi didapatkan sebanyak 49 sampel untuk desain penelitian cross sectional. Pengambilan data didapatkan dari Medical Check up dan pengisian kuisioner Bouchard di Unit Pelaksana Pelayanan Pelanggan (UP3) PLN Yogyakarta. Hasil: Hasil uji chi-square untuk variabel aktivitas fisik menunjukkan nilai p-value sebesar 0,915, yang berarti bahwa p>0,05. Dengan demikian, dapat disimpulkan bahwa tidak terdapat hubungan yang signifikan pada variabel aktivitas fisik. Namun didapatkan pada variabel jenis kelamin nilai p-value sebesar 0,000 yang artinya p<0,05 sehingga hasil signifikan. Sebaliknya, pada variabel umur, nilai p-value sebesar 0,136, yang berarti p>0,05, mengindikasikan bahwa tidak terdapat hubungan yang signifikan pada variabel umur. Simpulan: Tidak terdapat hubungan bermakna antara tingkat aktivitas fisik dengan risiko terjadinya sindrom metabolik pada Pegawai Kantor PT. PLN Unit Pelaksana Pelayanan Pelanggan (UP3) Daerah Istimewa Yogyakarta.
Pola Sidik Jari Anak-anak Sindrom Down di SLB Bakhti Kencana dan Anak Normal di SD Budi Mulia Dua Yogyakarta Ainur, Annisa; Hastuti, Janatin; Nugraha, Zainuri Sabta
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol1, No 1, (2009)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dermatoglyphics is not only used to identify criminal, but also useful in clinical field. There are some evidence that people with chromosome abnormalities like Down Syndrome (trisomy 21), have abnormality in dermatoglyphics pattern compared to normal people. It can be used to help confirming the diagnose.  The goals are to study the variation and distribution difference of dermatoglyphics and also the difference of Total Ridge Count (TRC) on children with Down Syndrome at SLB Bakhti Kencana and normal children at SD Budi Mulia Dua Yogyakarta. This research use cross sectional study with 2 groups of subject that consist of 10 person. The dermatoglyphics was taken by sticking both hands that had been marked with purple ink on the paper. Gathered data was analyzed with descriptive analysis and statistic analysis using Chi Square test, Fisher test and independent sample T-test with SPSS 14 for windows. The results show that the highest mean percentage of dermatoglyphics on Down Syndrome children is whorl (55%), on the otherhand the highest mean percentage of dermatoglyphics on normal children is loop ulna (53%). There is significant difference (pKeyword : dermatoglyphics, Down Syndrome, normal children
Co-Authors Ainur, Annisa Ajeng G. Nanda, Ajeng G. Al-Ghozi, Yasfi Suryalfihro Al-Ghozi Dwi N. Ahsani, Dwi N. Ety Sari Handayani Firdaus, Lidya Sabilla Harijadi Harijadi Janatin Hastuti Kuswati Kuswati Kuswati Nugroho, Kuswati Miranti Dewi Pramaningtyas Nurmasitoh, Titis Rahmanti, Fishella Aprista Soedjono Aswin Sukarno, Rizky Triutami Wicaksana, Zulfikar Loka Zhafirrahman, Muhammad