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All Journal Majalah Obat Tradisional Journal of Indonesian Dental Association
Finsa Tisna Sari, Finsa Tisna
Faculty of Dentistry, Universitas Gadjah Mada
Dentistry Health Professions Medicine & Pharmacology Public Health

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EFEK ANTIINFLAMASI EKSTRAK DAUN SEMBUKAN (Paederia scandens) PADA TIKUS WISTAR Utami, Evy Tri; Kuncoro, Rebecca Azary; Hutami, Islamy Rahma; Sari, Finsa Tisna; Handajani, Juni
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.556 KB) | DOI: 10.14499/mot-TradMedJ16iss2pp95-100

Abstract

Inflamasi merupakan tindakan protektif dalam melawan agen penyebab jejas sel. Tanaman sembukan (Paederia scandens) dengan kandungan glukosida diketahui berpotensi sebagai bahan antiinflamasi. Penelitian ini bertujuan untuk mengetahui efek antiinflamasi ekstrak daun sembukan terhadap edema buatan pada tikus Wistar. Subjek penelitian ini adalah 35 ekor tikus jantan galur Wistar yang dibagi menjadi 7 kelompok, masing-masing berjumlah 5 ekor. Pada kelompok perlakuan dan kontrol yaitu akuades (kontrol negatif), fenilbutazon (kontrol positif), dan perlakuan ekstrak daun sembukan dengan konsentrasi 10mg/kgBB, 20mg/kgBB, 30mg/kgBB, 40mg/kgBB, dan 50mg/kgBB, diberikan secara oral. Telapak kaki belakang kanan tikus disuntikkan secara subkutan karagenan 1% untuk memicu inflamasi. Pengukuran volume edema dilakukan dengan menggunakan pletismometer dalam selang waktu 1 jam selama 5 jam. Data selanjutnya dianalisis menggunakan ANAVA. Hasil penelitian menunjukkan adanya perbedaan bermakna pada pemberian ekstrak daun sembukan 20mg/kgBB dengan kontrol positif dan kontrol negatif. Disimpulkan bahwa ekstrak daun sembukan 20mg/kgBB berpotensi sebagai bahan antiinflamasi.
The Effect of Porphyromonas gingivalis Lipopolysaccharide-Induced Periodontitis in Rats Fed a High-Cholesterol Diet on Macrophage Number Sari, Finsa Tisna; Tandelilin, Regina Titi Christinawati; Rahman, Friska Ani; Mardhiyah, Iffah; Widita, Elastria
Journal of Indonesian Dental Association Vol 4 No 2 (2021): October
Publisher : Indonesian Dental Association

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Abstract

Introduction: Periodontitis is a chronic inflammatory condition of the tooth-supporting tissue. P. gingivalis, which produces virulence factors, including lipopolysaccharide (LPS), is the main pathogenic driver of periodontitis. However, the interaction between the innate immune system and periodontal pathogens in hyperlipidemia remains unclear. Objective: The aim of this study was to investigate the effect of a high-cholesterol diet (HCD) on macrophage activity in P. gingivalis LPS-induced periodontitis. Methods: Twenty-eight male Sprague Dawley rats were divided into four groups (n=7 rats each group): LPS-HCD, saline-HCD, LPS-basal diet (LPS-BD), and saline-BD. HCD group had been being feeding by high cholesterol diet (1% cholesterol (w/w) and 0.5% cholic acid (w/w)) for 30 days before were injected with 0.2 ml of P. gingivalis ATCC 3277 LPS (LPS-HCD group) and saline (saline-HCD group). The other two groups had been being feeding by normal basal diet for 30 days before were injected with 0.2 ml of P. gingivalis ATCC 3277 LPS (LPS-BD group) and saline (saline-BD group). Rats were sacrificed and lower jaws were harvested and embedded in paraffin. Paraffin section of lower right and left incisor were deparaffinized, rehydrated, and stained with hematoxylin & eosin (H&E). The total number of macrophages was counted using a light microscope at a magnification of 400× from 10 fields of view. Results: The number of macrophages in the LPS-HCD group was the highest compare to LPS- BD, saline-HCD, and saline-BD groups. In addition, LPS-BD group had higher number of macrophage than saline-BD group which had the lowest number of macrophages. Conclusion: HCD and P. gingivalis LPS-induced periodontitis can contribute to increasing of macrophage activity in periodontitis. Thus, HCD itself can enhance the process of inflammation in periodontitis.
Co-Authors Elastria Widita Evy Tri Utami Iffah Mardhiyah Islamy Rahma Hutami, Islamy Rahma Juni Handajani Rahman, Friska Ani Rebecca Azary Kuncoro, Rebecca Azary Regina Titi Christinawati Tandelilin