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All Journal Jurnal Kedokteran Syiah Kuala The Journal of The Indonesian Medical Students´ Association Jurnal Ilmiah Mahasiswa Kedokteran Komunitas
Kurnia Fitri Jamil
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Health Professions Medicine & Pharmacology

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Role of Fasting on Enteroendokrin Cell Remodelling to Prevent Type 2 Diabetes Mellitus Harapan, Harapan; Fitri Jamil, Kurnia; Hayati, Zinatul; Muhammad, Iqbal
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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Hitherto, there was no study dedicated to analyze the effect of fasting associated enteroendocrine (EE) cell population remodelling on type 2 diabetes mellitus prevention. This article aimed at discussing the molecular and cellular mechanisms of fasting associated EE cell remodelling to type 2 diabetes mellitus prevention and estimating its effectiveness. It was shown that fasting could inhibit EE cell hyperplasia, thus decreased glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) production from K and L cells. Both hormones caused hyperinsulinemia -via enteroinsular axis- and obesity when they interacted with their respective receptors GIPR and GLP-1R in pancreatic beta cell and adipocyte. This would cause insulin resistance through PI-3 kinase and Cb1. Thus, the levels of GIP and GLP-1 are diabetic predisposition factors. Another study also revealed that EE cell remodelling due to fasting had effective target site on type 2 diabetes mellitus prevention - and was also more superior than GIP and GLP-1 analogs. Key words: type 2 diabetes mellitus, fasting, enteroendocrine cell, GIP, GLP-1
Profil Kadar CD4 Terhadap Infeksi Oportunistik pada Penderita Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) di RSUD dr. Zainoel Abidin Banda Aceh Kurnia Fitri Jamil
Jurnal Kedokteran Syiah Kuala Vol 14, No 2 (2014): Volume 14 Nomor 2 Agustus 2014
Publisher : Universitas Syiah Kuala

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Profil Kadar CD4 Terhadap Infeksi Oportunistik pada Penderita Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) di RSUD dr. Zainoel Abidin Banda Aceh
SEMISINTESIS DAN KARAKTERISASI ANTIMALARIA BARU TURUNAN EURIKUMANON Hanifah Yusuf; Kurnia Fitri Jamil; Tristia Rinanda
Jurnal Kedokteran Syiah Kuala Vol 17, No 1 (2017): Volume 17 Nomor 1 April 2017
Publisher : Universitas Syiah Kuala

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Abstrak. Meluasnya penyebaran resistensi Plasmodium terhadap antimalaria merupakan permasalahan utama dalam pemberantasan malaria.Upaya cepat untuk mengatasi masalah tersebut, salah satunya melalui penemuan dan pengembangan antimalaria barudari tumbuhan obat yang secara empiris telah terbukti khasiatnya. Eurikumanon dari akar tumbuhan Eurycoma longifolia, Jack telah terbukti memiliki aktivitas antimalaria. Permasalahan dalam pengembangan eurikumanon dari bahan alam adalah biaya isolasi yang mahal, sehingga perlu usaha kreatif dan inovatif untuk mendapatkan turunannya. Semisintesis turunan eurikumanon merupakan langkah awal pengembangan eurikumanon menuju total sintesis guna memenuhi kebutuhan global. Penelitian ini menggunakan eurikumanon dari akar pasak bumi untuk semisintesis turunannya dengan menggunakan farmakofor tionil klorida, asetil klorida, asam klor asetat, asam triklor asetat dan asam trifluoro asetat. Struktur eurikumanon dan turunan hasil semisintesisditentukan secara analisis spektroskopi. Hasil ekstraksi serbuk akar pasak bumi, diperoleh ± 50 g (5%) ekstrak kental. Fraksinasi terhadap ekstrak tersebut secara kromatografi cair vakum (KCV) diperoleh fraksi terkonsentrasi eurikumanon 20 g (2%). Isolasi eurikumanon dari fraksi ini diperoleh eurikumanon 0,03%. Hasil semisintesis turunan eurikumanon diperoleh eurikumanon diklorida 60,10%, eurikumanon monoasetat55,25% , eurikumanon monoklor asetat 55,25%., eurikumanon monotriklor asetat 53,25% dan eurikumanon monotrifluoro asetat 75,65%.Kata kunci: eurikumanon, semisintesis dan turunan eurikumanon Abstract.The  widespread of resistant Plasmodium to antimalarial is  a mainly  problem in treatment of malaria. The fast effort to overcome the problem is the discovery and development of  new antimalarial from medicinal plant which is empirically proven. Eurycomanone from pasakbumi roots (Eurycoma longifolia, Jack) has been proven  as  antimalaria. The problem in development  of eurycomanone  is the high cost of isolation, therefore needed  the creative and inovative effort for getting its derivatives  by  semisynthesis and total synthesis to fill the need of new antimalarial  drugs globally. This research used isolated eurycomanone for semisynthesize its derivatives by using pharmacophore thionyl chloride, acetyl chloride, chloracetic acid, trichlor acetic acid and trifluoro acetic acid. The chemical stucture of them were determined by spectroscopic analysis. The result of extraction of pasak bumi roots is obtained  ± 50 g (5%) thick extract. The fractination of this extract by vacum liquid chromatography (VLC) is obtained eurycomanone  fraction ± 20 g (2%). Isolation of eurycomanone from this fraction is yielded  eurycomanone ± 0,03%. Semisynthesis of eurycomanone derivatives  were obtained eurycomanone dichloride  60,10%, eurycomanone monoacetic 55,25% , eurycmanone monochlor acetic 55,25%., eurycomanone monotrichlor acetic 53,25% and eurycomanonone monotrifluoro acetic 75,65%.Keywords: eurycomanone, semisynthesis and eurycomanone derivatives
Malaria berat Kurnia Fitri Jamil
Jurnal Kedokteran Syiah Kuala Vol 8, No 2 (2008): Volume 8 Nomor 2 Agustus 2008
Publisher : Universitas Syiah Kuala

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Abstrak.Seorang  pria,  26  tahun  masuk   ke Rumah  Sakit  dengan  keluhan   demam  selama  I    minggu   terns menerus, disertai mata kuning   clan kencing  warna hitam.  Tanda vital, sensorium koma, tensi  140/70 mmHg,  nadi  100 kali/menit   reguler, frekuensi  nafas 40 kali/menit,    suhu 39,6°C.  Pada pemeriksaan  lisik dijumpai  konjungtiva anemis,  sklera  ikterik, hepatosplenornegali.    Pada  hari pertama rawatan produksi  urin  hanya 300  cc per 4 jam. Pada pemeriksaan  laboratorium,   Hb 6,1   gr/di,  Lekosit 3400/mm3,  Eritrosit  2 juta/  mrrr',  Trombosit  62.000/ mrrr', LED  180  mm/jam. Dari dasar anamnesis,   pemeriksaan  lisik  dan perneriksaan laboratorium   ditcgakkan diagnosa  Malaria   Berat. Penatalaksanaan  dengan Tirah   Baring,  diet   ginjal,   Kina,   kuinin   dan  hemodialisa. Pada hari ke 10 pasien  dapat pulang  berobat jalan.  (JKS2008; 2: 97~102) Katakunci  :  malaria berat Abstract.   A man,  26 years old came to the hospital   because  of fever for l week, continous,  with  yellow eyes and  dark  urine   color.   The  vital   sign,   Comrnma  sensoriurn,     blood   pressure    140/70   mmHg,   pulse   ratel OOtime/minutes,  regular,  respiratory  rate  40times/minutes,    temperature  39,6°C.   On  physical   examination found  conjungtiva   anemic,   sclera  icteric   and  hepatosplenomegali.     On  the  first  day  of  treatment,  win production  only 300 cc io 4 hours.  On laboratory   examination,   Hb 6, l gr/di,  leucocytes  3400/mm3,    eritrosit2.106/mm3,    thrombocytes,    62.000/mm3.       Based   on   anamnesis,   physical    examination    and   laboratory examination, this patient  got severe  malaria.  The treatment was bed rest, renal  doet, and pharmacology.  In the lO'h treatment, the patient  could go home and control  to internist  later.  (JKS2008; 2:97-102) Keyword:severe malaria
Isolasi Dan Identifikasi Bakteri di Lingkungan Laboratorium Mikrobiologi Klinik RSUDZA Banda Aceh Amiril Arifin; Zinatul Hayati; Kurnia Fitri Jamil
Jurnal Ilmiah Mahasiswa Kedokteran Komunitas Vol 1, No 4 (2016)
Publisher : Jurnal Ilmiah Mahasiswa Kedokteran Komunitas

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One of the roles of Clinical Microbiology Laboratory is a supporting-investigation data provider about bacterial patogens that may cause infection disease to the patients. Hence, it’s accuracy is considered necessary. Living Bacteria in the Clinical Microbiology Laboratory environment is one source of the contaminants to clinical sample, therefore misidentification can occur. Research objectives  were to isolate and identificatebacteriain the Clinical Microbiology Laboratory environment, RSUDZA Banda Aceh,  and to determine  its source. The research type was laboratory observations. The research samples were surfaces such as tables, wall, floor, Biosafety Cabinet (BSC), incubator, handle of door and refrigerator, computer keyboard, laboratory staffs’ nasal mucosa and unwashed palm. Thirty four isolates were obtained from  25 samples. The identification result showed Gram positive rods bacteria,  Pantoea spp, Acinetobacter baumannii, Staphylococcus warneri, Staphylococcus haemolyticus, Staph. hominis spp hominis, Staphylococcus aureus, Staphylococcus epidermidis, Leuconostoc pseudomesenteroides, Citrobacter koseri, Burkholderia cepacia, Sphingomonas paucimobilis, Lactococcus garvieae, and Staphylococcus gallinarum
Co-Authors Amiril Arifin HANIFAH YUSUF Harapan Harapan Iqbal Muhammad Tristia Rinanda Zinatul Hayati Zinatul Hayati