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All Journal Jurnal Veteriner Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Dentika Dental Journal Jurnal Ilmiah Mahasiswa Kedokteran Komunitas Al-Bahtsu : Jurnal Penelitian Pendidikan Islam The International Journal of Tropical Veterinary and Biomedical Research Al-Bahtsu: Jurnal Penelitian dan Pendidikan Islam
Zinatul Hayati
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Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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FAKTOR VIRULENSI ASPERGILLUS NIGER DAN CANDIDA ALBICANS: VIRULENCE FACTOR OF ASPERGILLUS NIGER AND CANDIDA ALBICANS Basri Gani; Zinatul Hayati; Abdil lah Imron Nasution; Cut Soraya; Darniati
Dentika: Dental Journal Vol. 16 No. 1 (2011): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v16i1.1886

Abstract

Oral and respiratory diseases have been related with the fungal infections like oral candidiasis caused by Candida albicans and chronic rhinitis caused by Aspergillus niger. Both of these micr oorganisms are including in flora normal in the oral and nasal cavity. Aspergillus niger is rarely reported as aeroalergen in allergy rhinitis cases, but in chronic rhinitis its fungals are A. flavus and A. fumingatus. The aim of this study was to analyze the risk factors that influencing rhinitis and oral candidiasis and its relation. This research used rhinitis mucous identified various fungal used pour plate method.And then, cultured with SDA medium (Sabauraud's Dextrose Agar) to identify fung als morphology usedcultured slide.The results showed that Aspergillus niger was found more dominant than A. fumingatus and A. flavus in chronic rhinitis.In conclusion, Aspergillus niger was proved as an aeroallergen had had an important role in chronic rhinitis a nd could trigger the growth of Candida albicans.
Anti-bacterial activity of rosella flowers extract (Hibiscus sabdariffa linn) in inhibiting bacterial growth methicillin-resistant Staphylococcus aureus Zinatul Hayati; Winda Yulia; T. Fadrial Karmil; Abdullah Azmy
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 2, No 1 (2012): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Infections caused by bacteria Methycillin Resistant Staphylococcus aureus (MRSA) has become a worldwide health problem because of its increasing incidence. Rosella flower (Hibiscus sabdariffa Linn) has been known to have efficacy as an antibacterial. The purpose of this study is to determine the antibacterial activity of rosella flower extract in inhibiting the growth of MRSA. This study is an experimental research laboratory using rosella flower extract as a treatment, vancomycin as a positive control and distilled water as negative control. Fresh and dried rosella flowers crushed and then macerated with 96% ethanol for 24 hours. The filtrate obtained was concentrated by rotary evaporator at a temperature of 35 ˚ C-40 ˚ C and then diluted to a concentration of 12.5%, 25%, 50% and 75%. Phytochemical test is then performed. S.aureus bacteria isolated from clinical specimens in RSUDZA. Test of the antibacterial activity of rosella flower extract performed using Kirby Bauer disc diffusion method. Parameters on the disc were measured in millimeters MRSA. The data obtained were statistically analyzed and grouped into categories of Greenwood (1995). Phytochemical test results indicate the presence of rosella flower extract contains flavonoids, tannins, saponins, triterpenoids and alkaloids. Test results of the inhibition of rosella flower extract concentration of 12.5%, 25%, 50% and 75% of the growth of MRSA each inhibitory zone formed with an average diameter of 14.2 mm, 19.2 mm, 22.8 mm and 24.18 mm, whereas the positive control and negative control respectively of 19.8 mm and 5 mm. The results of data analysis showed that the ethanol extract of rosella flowers significant effect in inhibiting the growth of MRSA by the value of p 0.05. Based on the criteria of Greenwood, rosella flower extract ethanol concentration of 50% and 75% belong to the category of strong inhibitory power in inhibiting the growth of MRSA, a concentration of 25% falls into the category of being and the concentration of 12.5% falls into the category of weak. The results can be concluded that rosella flower ethanol extract can inhibit the growth of MRSA.
AKTIVITAS HIALURONIDASE BAKTERI STREPTOKOKUS GRUP B PADA SUBSTRAT ASAM HIALURONAT THE HYALURONIDASE ACTIVITY OF GROUP B STREPTOCOCCUS IN HYALURONIC ACID SUBSTRATE Zinatul Hayati; Wendy Setiyadi Putranto; Teuku Fadrial Karmil; I Wayan Teguh Wibawan; Sri Budiarti Poerwanto
Jurnal Veteriner Vol 8 No 2 (2007)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Streptococcus agalactiae atau yang juga dikenal dengan Streptokokus grup B (SGB) telah diketahui sebagai agen penyebab pneumonia, septikemia dan meningitis neonatal pada manusia dan hewan. Hialuronidase merupakan produk ekstraseluler dari SGB yang menentukan virulensinya. Penelitian ini dilakukan untuk menguji akitvitas hialuronidase dari 10 isolat SGB yang diisolasi dari kasus komplikase obstetri, serta memurnikan dan mengkarakterisasi hialuronidase yang diisolasi dari SGB SV-14 pada substrat asam hialuronat.
Isolasi Dan Identifikasi Bakteri di Lingkungan Laboratorium Mikrobiologi Klinik RSUDZA Banda Aceh Amiril Arifin; Zinatul Hayati; Kurnia Fitri Jamil
Jurnal Ilmiah Mahasiswa Kedokteran Komunitas Vol 1, No 4 (2016)
Publisher : Jurnal Ilmiah Mahasiswa Kedokteran Komunitas

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Abstract

One of the roles of Clinical Microbiology Laboratory is a supporting-investigation data provider about bacterial patogens that may cause infection disease to the patients. Hence, it’s accuracy is considered necessary. Living Bacteria in the Clinical Microbiology Laboratory environment is one source of the contaminants to clinical sample, therefore misidentification can occur. Research objectives  were to isolate and identificatebacteriain the Clinical Microbiology Laboratory environment, RSUDZA Banda Aceh,  and to determine  its source. The research type was laboratory observations. The research samples were surfaces such as tables, wall, floor, Biosafety Cabinet (BSC), incubator, handle of door and refrigerator, computer keyboard, laboratory staffs’ nasal mucosa and unwashed palm. Thirty four isolates were obtained from  25 samples. The identification result showed Gram positive rods bacteria,  Pantoea spp, Acinetobacter baumannii, Staphylococcus warneri, Staphylococcus haemolyticus, Staph. hominis spp hominis, Staphylococcus aureus, Staphylococcus epidermidis, Leuconostoc pseudomesenteroides, Citrobacter koseri, Burkholderia cepacia, Sphingomonas paucimobilis, Lactococcus garvieae, and Staphylococcus gallinarum
Hubungan Kualitas Penggunaan Antibiotik dengan Luaran Klinis Pasien Bakteremia yang Disebabkan Methicillin Resistant Staphylococcus aureus (MRSA) Endah Widyastuti1; Zinatul Hayati; Nurjannah Nurjannah; Mudatsir Mudatsir; Irwan Saputra
Jurnal Kedokteran Syiah Kuala Vol 22, No 1 (2022): Volume 22 Nomor 1 Maret 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v22i1.25400

Abstract

AbstrakPenggunaan antibiotik yang tidak rasional akan berisiko pada kegagalan terapi atau resistensi bakteri terutama pada pasien infeksi yang dirawat inap di rumah sakit. Penelitian ini dirancang untuk mengevaluasi kualitas penggunaan antibiotik dan hubungannya terhadap luaran klinis pasien bakteremia yang disebabkan oleh Methicillin Resistant Staphylococcus aureus (MRSA). Jenis penelitian ini adalah  analitik menggunakan rancangan cross sectional dengan pendekatan retrospektif. Data diambil dari rekam medik pasien yang dirawat inap di RSUD Dr. Zainoel Abidin Banda Aceh sejak Januari hingga Desember 2020. Kriteria inklusi yang digunakan adalah pasien dengan hasil kultur darah MRSA. Kualitas penggunaan antibiotik dievaluasi menggunakan metode Gyssens. Luaran klinis diambil dari catatan rekam medis dengan parameter kondisi klinis meninggal atau sembuh. Analisis data untuk karakteristik pasien dan rasionalitas penggunaan antibiotik dilakukan secara deskriptif, sedangkan untuk melihat hubungan rasionalitas penggunaan antibiotik dengan luaran klinis dilakukan dengan uji Chi-square. Hasil penelitian menunjukkan karakteristik pasien bakteremia yang disebabkan oleh MRSA di RSUD Dr. Zainoel Abidin berdasarkan jenis kelamin adalah jumlah pasien perempuan (52,6%) hampir sama dengan jumlah laki-laki (47,4%) dan berdasarkan usia ditemukan rata-rata pasien berada pada usia 52 tahun. Penggunaan antibiotik pasien bakteremia yang disebabkan oleh MRSA yang masuk kategori 0 (rasional) sebanyak 35,1% dan irrasional sebanyak 64,29% (kategori I-V). Luaran klinis pasien bakteremia ysng disebabkan oleh MRSA diperoleh angka mortalitas yang cukup tinggi yaitu sebanyak 38,9% pasien meninggal, sementara yang sembuh sebesar 61,1%. Hasil uji chi-square didapatkan p-value 0,024 yang menunjukkan adanya hubungan yang signifikan antara kualitas penggunaan antibiotik dengan luaran hasil klinis pasien bakteremia yang disebabkan oleh MRSA. Hasil ini menunjukkan bahwa pemberian antibiotik yang tidak tepat pada pasien bakteremia yang disebabkan oleh MRSA akan menyebabkan kegagalan terapi yang berujung pada kematian.Kata Kunci: Methicillin Resistant Staphylococcus aureus (MRSA), luaran klinis, rasionalitas, Gyssens. 
PENCEGAHAN PERILAKU BULLYING MELALUI INTERNALISASI NILAI-NILAI AKHLAK ISLAMI DI MADRASAH IBTIDAIYAH NEGERI 1 KOTA BENGKULU Zinatul Hayati
Al-Bahtsu : Jurnal Penelitian Pendidikan Islam Vol 7, No 2 (2022): DESEMBER
Publisher : IAIN Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29300/btu.v7i2.3506

Abstract

Permasalahan dalam penelitian ini adalah bagaimana pelaksanaan strategi internalisasi nilai-nilai akhlak Islami dalam mencegah perilaku bullying di Madrasah Ibtidaiyah Negeri 1 Kota Bengkulu. Permasalahan yang menjadi fokus dalalm penelitian ini menggunakan pendekatan kualitatif, Penelitian kualitatif adalah penelitian yang menghasilkan data deskriptif berupa kata-kata tertulis atau lisan dari orang-orang dan perilaku yang dapat diamati. Hasil penelitian menunjukkan bahwa: Pertama, Strategi internalisasi nilai-nilai agama Islam dalam mencegah perilaku bullying di MI Negeri 1 Kota Bengkulu dilakukan melalui kegiatan akademik maupun non-akademik. Adapaun strategi yang digunakan adalah strategi keteladanan, strategi pembiasaan, strategi pemberian nasihat dan strategi kedisiplinan. Kedua, Pencegahan perilaku bullying di MI Negeri 1 Kota Bengkulu adalah memberikan hukuman-hukuman apabila melakukan perilaku bullying. Seperti hukuman menghafal Surat-surat pilihan, hukuman menulis surat Yasin dan hukuman pelayanan sekolah. Ketiga, Faktor penghambat dari dalam diri siswa sendiri karena karakter Siswa yang berbeda-beda dan dari latar belakang Siswa yang berbeda-bedasehingga dalam proses pembinaan yang dilakukan oleh para guru kadang tidak berjalan baik dengan adanya siswa yang dapat mengerti dan melakukan dengan baik pembinaan tersebut dan adanya Siswa yang tidak dapat melakukan pembinaan tersebut dengan baik
The Role of Gut Microbiota-derived Tryptophan Metabolites in Mycobacterium tuberculosis Infection: A Mini-Review Novi Maulina; Zinatul Hayati; Kartini Hasballah; Zulkarnain Zulkarnain; Baidillah Zulkifli
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 2 (2022): Vol. 7 (2) November 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (911.502 KB) | DOI: 10.21157/ijtvbr.v7i2.30165

Abstract

The gut microbiota has a major contribution in human physiology and influences disease pathogenesis, including in tuberculosis (TB) lung infection. Gut-lung axis has demonstrated the interplay of these two organs, mediated by metabolites produced by the gut microbes or derived from host molecules transformation. Tryptophan (Trp) is one of the essential aromatic amino acids catabolized as kynurenine, serotonin (5-hydroxytryptamine), and indole derivatives, including indole propionic acid (IPA), via 3 pathways. The latter was microbiota-derived Trp catabolism, which has known to have an immunomodulatory role, as ligands for Aryl hydrocarbon Receptor (AhR). Intriguingly, Mycobacterium tuberculosis required Trp as a nitrogen source, especially in CD4+ T cells-generated stress, to survive in the phagosome of macrophage and to cause disease. Recently, IPA is identified as a new anti-mycobacterial compound, which is specific and has broad spectrum of anti-mycobacterial activity. The structural similarity of this gut microbiota-derived metabolite and Trp allows IPA to inhibit the TrpE anthranilate synthase in Trp biosynthesis pathway in Mtb. In this review, we summarize findings from recent work by focusing on the role of Trp metabolites in host cells in TB infection.  A better understanding of this chemical signal could potentially serve as a novel strategy for managing this chronic inflammatory disease.
Isolation Of Extended-Spectrum B-Lactamase (ESBL) Producing Escherichia coli and Klebsiella pneumiae From Dr. Zainoel Abidin General Hospital, Aceh Zinatul Hayati; Syamsul Rizal; Ridhia Putri
The International Journal of Tropical Veterinary and Biomedical Research Vol 4, No 1 (2019): Vol. 4 (1) May 2019
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.033 KB) | DOI: 10.21157/ijtvbr.v4i1.13806

Abstract

Infection that occurs in Indonesia has increased more significantly than before, compared to the increasing bacterial multidrug resistance (MDR) as the cause of infection. A study conducted in 5 hospitals in Indonesia in 2013 showed that the prevalence rate of extended-spectrum β-lactamase (ESBL)-producing bacteria reached 32-68%. The objective of this study is to detect the prevalence and resistence pattern of ESBL-producing Escherichia coli and Klebsiella pneumoniae in Dr. Zainoel Abidin General Hospital, Banda Aceh. This study was conducted from 1 September 2016 to 31 December 2016. Specimen types included in this study were blood, sputum, urine, pus, mucosal swab, and another body fluids sample. The sampling method in this study was total sampling that is all clinical specimen examined in Clinical Microbiology Laboratory. Isolation and identification ESBL-producing bacteria was performed by VITEK-2 machine (Biomerieux). The result of this study is that a total 122 E. coli and K. pneumoniae were isolated. That consisted of 48 (39%) E. coli isolates and 74 (61%) K. pneumoniae isolates. From 48 E. coli isolates it was found out that 41 (85%) had ESBL phenotypes and from 74 K. pneumoniae isolates it was found out that 59 (80%) had ESBL phenotypes. In total, 100 (82%) isolates from 122 isolates had ESBL phenotypes. Distribution of ESBL-producing E. coli and K. pneumoniae based on sample was 24 (89%) isolates from the total of 27 urine isolates, 18 (95%) isolates from the total of 19 blood isolates, 28 (78%) isolates from the total of 36 sputum isolates, and 30 (75%) isolates from the total of 40 pus isolates. Antibiotic sensitivity pattern of the E. coli and K. pneumoniae isolates had high sensitivity to amycasin dan meropenem which was above 89%. Meanwhile, it also had sensitivity to Fosfomycin and Piperacyclin-Tazobactam by 80% and 77% respectively. Another antibiotic was less effective
Pencegahan Perilaku Bullying Melalui Internalisasi Nilai-Nilai Akhlak Islami di Madrasah Ibtidaiyah Negeri 1 Kota Bengkulu Zinatul Hayati; Zulkarnain Syapal
Al-Bahtsu: Jurnal Penelitian Pendidikan Islam Vol 8, No 2 (2023): Al-Bahtsu: Jurnal Penelitian Pendidikan Islam
Publisher : UIN Fatmawati Sukarno Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29300/btu.v8i2.5361

Abstract

The problem in this study is how to implement the strategy of internalizing Islamic moral values in preventing bullying behavior at Madrasah Ibtidaiyah Negeri 1 Bengkulu City. The problem that is the focus of this study uses a qualitative approach. Qualitative research is research that produces descriptive data in the form of written words. or word of mouth from people and observable behavior. The results showed that: First, the strategy of internalizing Islamic religious values in preventing bullying behavior at MI Negeri 1 Bengkulu City was carried out through academic and non-academic activities. The strategies used are exemplary strategies, habituation strategies, advice giving strategies and disciplinary strategies. Second, the prevention of bullying behavior at MI Negeri 1 Bengkulu City is to give punishments for bullying behavior. Such as punishment for memorizing selected letters, punishment for writing Yasin letters and punishment for school service. Third, the inhibiting factors from within the students themselves because of the different characters of students and from different backgrounds of students so that the coaching process carried out by teachers sometimes does not go well with students who can understand and do well the coaching and there are students who cannot carry out the coaching properly.
Co-Authors . Darniati Abdil lah Imron Nasution Abdullah Azmy Amiril Arifin Basri Gani Cut Soraya Endah Widyastuti1 I wayan Teguh Wibawan Irwan Saputra Kartini Hasballah Kurnia Fitri Jamil Mudatsir Mudatsir MUHAMMAD AGUS SUPRAYUDI Novi Maulina Nurjannah Nurjannah Ridhia Putri Sri Budiarti Poerwanto Syamsul Rizal T. Fadrial Karmil Teuku Fadrial Karmil Wendy Setiyadi Putranto Winda Yulia Zulkarnain Syapal Zulkarnain Zulkarnain