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All Journal HAYATI Journal of Biosciences Jurnal Biologi Tropis Eduvest - Journal of Universal Studies
Andita Ayu Mandasari, Andita Ayu
Departemen Biologi, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Neuroscience Social Sciences

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Impact of Nicotine and Nicotine-Free E-Cigarettes on Body Weight, Erythrocyte Dynamics, Sperm Morphology, and Molecular Outcomes in Mice Mandasari, Andita Ayu; Maryam, Siti Ayu; Firdausi, Chilyatul; Maulana, Muhammad Iqbal; Kurnia, Muhammad Hardi; Widyastuti, Dyah Ayu; Herawati, Dheasy
HAYATI Journal of Biosciences Vol. 32 No. 6 (2025): November 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.6.1466-1475

Abstract

The effect of electric cigarettes (e-cigs) on health should be a concern since their legality has occurred in Indonesia. Young adults use e-cigarettes not as therapy but as a lifestyle. The vapor component contains propylene glycol, vegetable glycerin, flavor, and nicotine, which may harm human health. This study examined the health risks of e-cigarettes on body weight, erythrocytes, and sperm morphology in mice. We used twenty healthy male mice exposed to the cigarette's vapor for thirty days. Mice were divided into room air as the negative control, nicotine-free, and 18 mg nicotine-containing groups. Our results showed that the body weight of the nicotine-free and nicotine-containing groups increased, while micronuclei formation increased after e-cig exposure. Furthermore, abnormal sperm morphology in the nicotine-containing groups increased significantly, yet the nicotine-free group was not significantly different compared to the negative control. These results were supported by the molecular prediction that exposure to e-cigs might increase oxidative stress and decrease the expression of TGF-β. Moreover, studies on it are ongoing to gather scientific evidence.
Wound Healing Potential of Sargassum plagiophyllum Extract on Mice Model with Incision Lesion Mandasari, Andita Ayu; A'isyi, Nadia Rahadatul; Herawati, Dheasy
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8256

Abstract

The skin serves as the body's outer protection against infection and plays an important role in water and electrolyte balance. The skin is often injured which increases the risk of infection if the wound does not close immediately. This study explored the potential of concentrated extract of Sargassum plagyophyllum in healing incision wounds in mice. Mice were given a 1 cm incision wound and then given CaCl2 S. plagyophyllum extract as the treatment group, povidine iodine as the positive control group, while the negative control group was not given anything. Macroscopic results showed that the wounds in the treatment group healed on day 17, while the negative and positive groups healed on days 15 and 16. Microscopic images showed that the inflammatory phase of wound healing was seen on day five in all groups which showed a normal phase of wound healing. These results indicate that the CaCl2 extract of S. plagyophyllum has the same potency as the positive group, but it is very important to consider the right formulation so that the effectiveness can be increased and faster in wound healing in future studies.
Prevention of Iron Deficiency Anemia Through Blood Immunochemical Detection in Improving the Quality of Life of Elderly Wiwis Wijayanti, Christina Destri; Herawati, Dheasy; Mandasari, Andita Ayu; Mawarti, Herin
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52272

Abstract

The increase in the elderly population poses challenges to health services in Indonesia, particularly regarding degenerative diseases and malnutrition due to reduced physical activity and dietary changes. Supporting the Asta Cita program for elderly assistance, it is essential to monitor elderly health to maintain wellness and functionality in old age. This study used descriptive analytical observation on 25 women aged 55 to 75 years. Results showed that hemoglobin levels declined below the normal range of 12–15 g/dL. Serum iron levels and lactate dehydrogenase (LDH) enzyme activity were measured using a spectrophotometer to assess anemia potential, while immune status was evaluated through vitamin D levels by immunofluorescence. Statistical analysis with SPSS software using Spearman’s correlation test revealed no significant relationships between hemoglobin and serum iron (p = 0.520), hemoglobin and LDH (p = 0.615), or serum iron with LDH (p = 0.543) and vitamin D (p = 0.138). Pearson correlation showed no association between hemoglobin and vitamin D (p = 0.885). These findings indicate weak or no correlation among these parameters in this sample. Factors such as small sample size and measurement limitations suggest that using more precise biomarkers, like Ferritin levels, could improve future research. This study contributes to understanding Prevention of Iron Deficiency Anemia Through Blood Immunochemical Detection in Improving the Quality of Life of Elderly—a valuable approach to elderly health monitoring.
Co-Authors A'isyi, Nadia Rahadatul Dyah Ayu Widyastuti Firdausi, Chilyatul Herawati, Dheasy Herin Mawarti Kurnia, Muhammad Hardi Maryam, Siti Ayu Maulana, Muhammad Iqbal Wiwis Wijayanti, Christina Destri