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All Journal HAYATI Journal of Biosciences Jurnal Biologi Tropis
Andita Ayu Mandasari, Andita Ayu
Departemen Biologi, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Immunology & microbiology

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Impact of Nicotine and Nicotine-Free E-Cigarettes on Body Weight, Erythrocyte Dynamics, Sperm Morphology, and Molecular Outcomes in Mice Mandasari, Andita Ayu; Maryam, Siti Ayu; Firdausi, Chilyatul; Maulana, Muhammad Iqbal; Kurnia, Muhammad Hardi; Widyastuti, Dyah Ayu; Herawati, Dheasy
HAYATI Journal of Biosciences Vol. 32 No. 6 (2025): November 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.6.1466-1475

Abstract

The effect of electric cigarettes (e-cigs) on health should be a concern since their legality has occurred in Indonesia. Young adults use e-cigarettes not as therapy but as a lifestyle. The vapor component contains propylene glycol, vegetable glycerin, flavor, and nicotine, which may harm human health. This study examined the health risks of e-cigarettes on body weight, erythrocytes, and sperm morphology in mice. We used twenty healthy male mice exposed to the cigarette's vapor for thirty days. Mice were divided into room air as the negative control, nicotine-free, and 18 mg nicotine-containing groups. Our results showed that the body weight of the nicotine-free and nicotine-containing groups increased, while micronuclei formation increased after e-cig exposure. Furthermore, abnormal sperm morphology in the nicotine-containing groups increased significantly, yet the nicotine-free group was not significantly different compared to the negative control. These results were supported by the molecular prediction that exposure to e-cigs might increase oxidative stress and decrease the expression of TGF-β. Moreover, studies on it are ongoing to gather scientific evidence.
Wound Healing Potential of Sargassum plagiophyllum Extract on Mice Model with Incision Lesion Mandasari, Andita Ayu; A'isyi, Nadia Rahadatul; Herawati, Dheasy
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8256

Abstract

The skin serves as the body's outer protection against infection and plays an important role in water and electrolyte balance. The skin is often injured which increases the risk of infection if the wound does not close immediately. This study explored the potential of concentrated extract of Sargassum plagyophyllum in healing incision wounds in mice. Mice were given a 1 cm incision wound and then given CaCl2 S. plagyophyllum extract as the treatment group, povidine iodine as the positive control group, while the negative control group was not given anything. Macroscopic results showed that the wounds in the treatment group healed on day 17, while the negative and positive groups healed on days 15 and 16. Microscopic images showed that the inflammatory phase of wound healing was seen on day five in all groups which showed a normal phase of wound healing. These results indicate that the CaCl2 extract of S. plagyophyllum has the same potency as the positive group, but it is very important to consider the right formulation so that the effectiveness can be increased and faster in wound healing in future studies.
Co-Authors A'isyi, Nadia Rahadatul Dyah Ayu Widyastuti Firdausi, Chilyatul Herawati, Dheasy Kurnia, Muhammad Hardi Maryam, Siti Ayu Maulana, Muhammad Iqbal