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Budidaya dan Pengolahan Pascapanen Berenuk, serta Pembuatan Ekoenzim: Upaya Kegiatan Laudato Si’ di Paroki Wates To'bungan, Nelsiani; Patricius Kianto Atmodjo; Exsyupransia Mursyanti; Boy Rahardjo Sidharta; Junedi, Sendy; Ines Septi Arsiningtyas
Jurnal Atma Inovasia Vol. 5 No. 2 (2025)
Publisher : Lembaga Penelitian dan Pengabdian pada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/jai.v5i2.10291

Kegiatan pengabdian masyarakat ini dilakukan di Paroki St. Maria Bunda Penasihat Baik, Wates. Tujuan kegiatan adalah meningkatkan kesadaran dan pemahaman masyarakat tentang prinsip-prinsip Laudato Si' serta pemanfaatan dan budidaya tanaman berenuk (Crescentia cujete) serta pembuatan ekoenzim sebagai salah satu bentuk pengolahan sampah organik. Metode yang digunakan meliputi survei lokasi, sosialisasi, pelatihan, dan evaluasi. Pelatihan mencakup pembuatan produk berbasis berenuk seperti sari buah, masker-jelly, teh daun berenuk, serta pemanfaatan sampah organik menjadi ekoenzim. Hasil kegiatan menunjukkan peningkatan pengetahuan warga gereja tentang pemanfaatan tanaman berenuk sebagai sumber senyawa fitokimia yang bermanfaat serta metode pengolahan sampah menjadi produk bernilai guna. Evaluasi menunjukkan tingkat kepuasan masyarakat yang tinggi terhadap pelaksanaan kegiatan ini. Program ini tidak hanya meningkatkan kesadaran lingkungan tetapi juga memberikan keterampilan baru yang aplikatif kepada masyarakat setempat.

The Doxorubicin-Induced G2/M Arrest in Breast Cancer Cells Modulated by Natural Compounds Naringenin and Hesperidin Junedi, Sendy; Hermawan, Adam; Fitriasari, Aditya; Setiawati, Agustina; Susidarti, Ratna Asmah; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 12, No 2 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss2pp83-89

Doxorubicin as the common drug for breast cancer has been widely proposed to use in combine with a natural compound in order to overcome its side effects such as cardiotoxicity and resistance. Previously, we reported that naringenin and hesperidin, the abundant flavanons in citrus fruit peel, increased cytotoxic and apoptosis activities of doxorubicin in doxorubicin resistant breast cancer cells (T47D and MCF-7 cells). Since doxorubicin arrests G2/M phase in most cancer cells, both flavanons are speculated to affect the similar phase in breast cancer cells. Cell cycle distributions were determined by flowcytometry using propidium iodide (PI) to stain DNA of the cells. Combination of naringenin or hesperidin with doxorubicin increased accumulation of T47D cells in G2/M phase, while in MCF-7 cells, accumulated cells in G2/M phase were decreased, accompanying with slightly increased in G1 phase. Naringenin itself had no effect on cell cycle of both cells. Whereas, hesperidin arrested G2/M and G1 phases in T47D and MCF-7 cells, respectively. The different effect of naringenin and hesperidin in T47D and MCF-7 cells is most likely caused by difference of p53 status. In p53 mutant, T47D cells, naringenin and hesperidin supported mechanism of doxorubicin to arrest at G2/M that to be considered via p53-independent pathway. Whereas, in p53 wild-type MCF-7 cells, naringenin and hesperidin decreased G2/M arrest, suggesting that both flavanons do not utilize cell cycle arrest for their anticancer activity with doxorucibin. This study revealed that potential co-chemoterapeutic agents, naringenin and hesperidin distinctly modulated cell cycle arrest induced by doxorubicin according to the characteristic of breast cancer cells.Keywords: naringenin, hesperidin, doxorubicin, cell cycle, breast cancer cells.

In Vitro Anti-Photoaging Properties of Phylanthus urinaria L. Herb Extract Arsiningtyas, Ines Septi; Simamora, Desy Damayanti; Palimbongan, Angela Merici; Widianingtyas, Fabiana Disa; Junedi, Sendy
Indonesian Journal of Cancer Chemoprevention Vol 15, No 1 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss1pp26-39

The overexposure to ultraviolet (UV) radiation from sunlight is related to photoaging of the skin and high risk of skin cancer. Sunscreen material and antioxidants are commonly used to protect skin from harmful UV. However, the application of synthetic compounds in sunscreen products is regulated to a limited amount because it can produce photosensitizers, inducing adverse reactions in the skin, and also harmful to the environment. Ethanol extract of Phyllanthus urinaria L. herb possesses a strong antioxidant activity similar to ascorbic acid, which makes it potential to substitute the synthetic compound in sunscreen products. Therefore, this research was conducted on the 70% ethanol extract of P. urinaria herb to analyze its in vitro anti-photoaging properties, i.e., antioxidant, protein antiglycation and antiinflammation, also to determine the Sun Protection Factor (SPF) and the quantitative composition of the metabolites. The extract exhibited a strong antioxidant activity IC50 of 3.01 mg/L, a higher moderate antiglycation activity IC50 of 216.67 mg/L, but low anti-inflammatory activity IC50 of 86.61mg/L. The presence of saponin, phenolic compounds, flavonoids, tannins, and methyl linoleates is suggested to contribute to the anti-photoaging properties. According to the anti-inflammatory assay, the extract may not inhibit signaling pathways that follow cytokine expression but possibly inhibit those that precede cytokine expression due to its antioxidant activity. An SPF value of 5.95 at 50 mg/L meets the recommended range for the skin phototypes of Southeast Asian, dark-skinned Asian, and African people. These results indicate that P. urinaria extract has potential as an anti-photoaging material for sunscreen products.Keywords: antiglycation, antiinflammation, antioxidation, Phyllanthus urinaria L., SPF.

THE VAPOR OF LEMONGRASS (Cymbopogon nardus) ESSENTIAL OIL FROM THE DIFFUSER AS MOSQUITO REPELLENT AND TRANQUILIZER Junedi, Sendy; Renanda, Salsa Billa Putri; Callista, Evelin Erlinda Elma; Nahak, Gabriella Ayu Chintya Velania
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.14193

The COVID-19 pandemic and dengue fever present significant health challenges, especially in tropical regions such as Indonesia. This study aimed to explore the potential of citronella essential oil (Cymbopogon nardus) vapor, delivered via a diffuser, as both a tranquilizer and mosquito repellent. Citronella oil was isolated by water distillation and analyzed through GC-MS and TLC. The tranquilizing effect was evaluated using the Depression Anxiety and Stress Scale (DASS), while the mosquito repellent activity was tested against Aedes aegypti. Results showed that citronella oil contains key compounds such as citronellal, eugenol, cytronellol acetate and geraniol acetate. DASS scores decreased after exposure to citronella oil vapor, indicating its tranquilizing effect. In the mosquito repellent test, citronella oil caused a 68% mortality rate in Aedes aegypti after 60 minutes. These findings suggest that citronella essential oil vapor from diffusers is effective as both a tranquilizer and mosquito repellent.

THE VAPOR OF LEMONGRASS (Cymbopogon nardus) ESSENTIAL OIL FROM THE DIFFUSER AS MOSQUITO REPELLENT AND TRANQUILIZER Junedi, Sendy; Renanda, Salsa Billa Putri; Callista, Evelin Erlinda Elma; Nahak, Gabriella Ayu Chintya Velania
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.14193

The COVID-19 pandemic and dengue fever present significant health challenges, especially in tropical regions such as Indonesia. This study aimed to explore the potential of citronella essential oil (Cymbopogon nardus) vapor, delivered via a diffuser, as both a tranquilizer and mosquito repellent. Citronella oil was isolated by water distillation and analyzed through GC-MS and TLC. The tranquilizing effect was evaluated using the Depression Anxiety and Stress Scale (DASS), while the mosquito repellent activity was tested against Aedes aegypti. Results showed that citronella oil contains key compounds such as citronellal, eugenol, cytronellol acetate and geraniol acetate. DASS scores decreased after exposure to citronella oil vapor, indicating its tranquilizing effect. In the mosquito repellent test, citronella oil caused a 68% mortality rate in Aedes aegypti after 60 minutes. These findings suggest that citronella essential oil vapor from diffusers is effective as both a tranquilizer and mosquito repellent.

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