Article Per Year (5 Year)
p-Index From 2020 - 2025
1.116
P-Index
This Author published in this journals
All Journal e-Journal Pustaka Kesehatan Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Indonesia Journal of Agropharmacy
Eka Deddy Irawan
Fakultas Farmasi Universitas Jember
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Library & Information Science Medicine & Pharmacology

Published : 24 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 24 Documents
Search

 1   2   3 
UJI TOKSISITAS AKUT DARI EKSTRAK ETANOL HERBASEREH (ANDROPOGON CITRATUS D.C ) PADA MENCIT PUTIH SEBAGAI BAHAN PEMBELAJARAN TOKSIKOLOGI Irawan, Eka Deddy; Ruma K. S., Lusia Oktora; Untari, Sri
Jurnal Pengembangan Pendidikan Vol 2, No 2 (2005)
Publisher : Jurnal Pengembangan Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.853 KB)

Abstract

Sereh Herb have been proven to have effect asanalgetic at mice which have been induced by acetic acid. In order to develop Sereh herb as  fitofarmaka, it requires acute toxicity testfrom sereh herb to know it’s safety level. Result of this research is expectedto become a studied material of Toxicology. In acute toxicity test of aethanolextract from sereh herb, mice divided into 5 groups which consist of 1 negativecontrol group and 4 dose levels with 2 times interval dose, 200 mg / kg BW, 400mg / kg BW, 800 mg / kg BW, and 1600 mg / kg BW. Up to maximum volume which maybe given to mice, the highest dose given to mice did not caused death,therefore the highest dose expressed as apparent LD50 ( LD0).Thereby, aethanol extract from sereh herb have LD0 value equal to1600 mg / kg BW. If converted to human being with 50 kg BW , LD0aethanol extract from sereh herba become 443,6 g / kg BW. Aethanol extract from sereh herb does not have LD50, this indicate that aethanol extract from sereh herbdoesnt have potention to make toxic effect, this matter is also shown by noany clinical symptom at mice. Thereby acute toxicity potention of Aethanolextract of sereh herb can be classified to relativelynot dangerous (> 15 g / kgBW ). In conclution, safety levelof Aethanol extract from sereh herb relatively safe to be consumed by human being.
STUDI IN VITROHUBUNGAN LOGARITMA KOEFISIEN PARTISI DENGAN IKATAN PROTEIN PLASMA DARIANTIDIABET TURUNAN SULFONIL UREA SEBAGAI BAHAN PEMBELAJARAN MATA KULIAH FARMASIFISIK Irawan, Eka Deddy
Jurnal Pengembangan Pendidikan Vol 3, No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.221 KB)

Abstract

Abstract. This paper shows that oral antidiabeticSulfonil Ureic derivates (The first generation: Chlorpropamide, and the secondgeneration : Gliclazide, Glibenclamide & Glipizide) have logaritmicpartition coefficient value increased. The increased value in logaritmiccoeficient partition due to modification of chemical structure of suchcompounds. Such modification caused the polarity property of such compoundincreases, which in turn, increasing the logaritmic coeficient partition value.According to this paper that the chemical structure of antidiabet sulfunil ureicderivates play important role in protein plasm bonding in drug. This articlecan be used as laboratory practice or studied material on Physical Pharmacy. Keyword : InVitro Study, Oral antidiabetic Sulfunil Ureic derivates, logaritmic partitioncoeficient, protein plasm bonding.
OPTIMASI KOMPOSISI KARBOPOL DAN NATRIUM KARBOKSIMETILSELULOSA SEBAGAI SISTEM BUCCAL MUCOADHESIVE TABLET PROPRANOLOL HIDROKLORIDA Irawan, Eka Deddy; Munawaro, Siti; Sari, Lusia Oktora Ruma Kumala
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 2 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The purpose of this study is to provide controlled release dosage by avoiding first pass metabolism and enzymatic degradation. Propranolol hydrochloride mucoadhesive buccal tablets was prepared by direct compression method using carbopol and CMC Na as buccal mucoadhesive polymer. Buccal mucoadhesive strength measured using buccal mucosa of gout. Testing the release of propranolol hydrochloride was determined by dissolution test using phosphate buffer solution pH 6,8 for 8 hours. Dissolution efficiency (DE) was calculated to describe the overall release profiles and used in determining the optimum response. The optimum region is determined using factorial design with the design criteria of response force for 20-40 grams of mucoadhesive buccal and DE480 between 45-55%. The amount of carbopol that can provide the optimum response is between the range of 53,27-55 mg while the amount of CMC Na can provie the optimum response range is between 70-100 mg.
Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet Irawan, Eka Deddy; Fudholi, Achmad
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.204 KB) | DOI: 10.14499/indonesianjpharm0iss0pp231-238

Abstract

Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captopril mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimum formula of mucoadhesive tablet for captopril using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were perfomed to establish composition of chitosan, sodium CMC and Mg stearat. Such composition could produce mucoadhesive strength with a zero order release kinetics. A 23 factorial design has been applied to systematically optimize the formula. The amounts of chitosan (XA), sodium CMC (XB), and Mg stearat (XC) were selected as independent variables. Mucoadhesive strength and dissolution efficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70 %) chitosan at low to middle level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low to middle level (4-6 mg).Key words : mucoadhesive, factorial design, DE480 , chitosan, CMC Na, Mg stearat, contour plot
Optimasi Konsentrasi Etil Selulosa dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida Sukmaningrum, Ninda; Sari, Lusia Oktora Ruma Kumala; Irawan, Eka Deddy
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 3 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (885.452 KB) | DOI: 10.15416/ijpst.v4i3.13190

Abstract

Metformin hidroklorida (MH) merupakan obat pilihan pertama yang digunakan dalam terapi diabetes mellitus tipe 2, namun dapat menimbulkan efek samping pada saluran pencernaan sehingga MH tepat dipreparasi menjadi sediaan microspheres. Banyak faktor yang mempengaruhi hasil preparasi microspheres di antaranya adalah konsentrasi etil selulosa (EC) dan lama pengadukan yang digunakan. Penelitian ini bertujuan untuk mengetahui komposisi terbaik konsentrasi EC dan lama pengadukan yang dapat menghasilkan microspheres MH-EC dengan entrapment efficiency (EE) tertinggi menggunakan optimasi desain faktorial. MH digunakan sebagai bahan aktif, EC digunakan sebagai polimer serta non-aqueous solvent evaporation method sebagai teknik yang dipilih dalam preparasi microspheres. Hasilnya microspheres yang menggunakan konsentrasi EC sebanyak 4.500 mg dan lama pengadukan selama 2 jam menghasilkan EE sebesar 84,6 ± 0,557% dengan nilai verifikasi EE sebesar 98,1%, drug loading sebesar 12,7 ± 0,173% dan yield sebesar 95,1 ± 0,612%. Microspheres memiliki bentuk sferis dan morfologi permukaan yang relatif halus dan cerah serta ukuran partikel sebesar 173,8 ± 4,41µm. Hasil analisis FTIR menunjukkan bahwa tidak ada perubahan gugus fungsi spesifik pada MH sebagai bahan aktif. Kata kunci:    microspheres, metformin hidroklorida, etil selulosa
STUDI IN VITROHUBUNGAN LOGARITMA KOEFISIEN PARTISI DENGAN IKATAN PROTEIN PLASMA DARIANTIDIABET TURUNAN SULFONIL UREA SEBAGAI BAHAN PEMBELAJARAN MATA KULIAH FARMASIFISIK Irawan, Eka Deddy
Jurnal Pengembangan Pendidikan Vol 3 No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract. This paper shows that oral antidiabeticSulfonil Ureic derivates (The first generation: Chlorpropamide, and the secondgeneration : Gliclazide, Glibenclamide & Glipizide) have logaritmicpartition coefficient value increased. The increased value in logaritmiccoeficient partition due to modification of chemical structure of suchcompounds. Such modification caused the polarity property of such compoundincreases, which in turn, increasing the logaritmic coeficient partition value.According to this paper that the chemical structure of antidiabet sulfunil ureicderivates play important role in protein plasm bonding in drug. This articlecan be used as laboratory practice or studied material on Physical Pharmacy. Keyword : InVitro Study, Oral antidiabetic Sulfunil Ureic derivates, logaritmic partitioncoeficient, protein plasm bonding.
UJI TOKSISITAS AKUT DARI EKSTRAK ETANOL HERBASEREH (ANDROPOGON CITRATUS D.C ) PADA MENCIT PUTIH SEBAGAI BAHAN PEMBELAJARAN TOKSIKOLOGI Irawan, Eka Deddy; Ruma K. S., Lusia Oktora; Untari, Sri
Jurnal Pengembangan Pendidikan Vol 2 No 2 (2005)
Publisher : Jurnal Pengembangan Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sereh Herb have been proven to have effect asanalgetic at mice which have been induced by acetic acid. In order to develop Sereh herb as  fitofarmaka, it requires acute toxicity testfrom sereh herb to know it’s safety level. Result of this research is expectedto become a studied material of Toxicology. In acute toxicity test of aethanolextract from sereh herb, mice divided into 5 groups which consist of 1 negativecontrol group and 4 dose levels with 2 times interval dose, 200 mg / kg BW, 400mg / kg BW, 800 mg / kg BW, and 1600 mg / kg BW. Up to maximum volume which maybe given to mice, the highest dose given to mice did not caused death,therefore the highest dose expressed as apparent LD50 ( LD0).Thereby, aethanol extract from sereh herb have LD0 value equal to1600 mg / kg BW. If converted to human being with 50 kg BW , LD0aethanol extract from sereh herba become 443,6 g / kg BW. Aethanol extract from sereh herb does not have LD50, this indicate that aethanol extract from sereh herbdoesn't have potention to make toxic effect, this matter is also shown by noany clinical symptom at mice. Thereby acute toxicity potention of Aethanolextract of sereh herb can be classified to relativelynot dangerous (> 15 g / kgBW ). In conclution, safety levelof Aethanol extract from sereh herb relatively safe to be consumed by human being.
Optimization of chitosan and sodium carboxymethylcellulose as mucoadhesive system in theophylline tablet Irawan, Eka Deddy; ., Farhana
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.37 KB) | DOI: 10.14499/indonesianjpharm0iss0pp92-97

Abstract

Mucoadhesive  tablet  for  asthma  treatment  were  prepared  by  mixing theophylline  with  two  variations  of  polymers.  The  purpose  of  this  research  was to  controlled  drug  release  from  the  dosage  form.  Theophylline  mucoadhesive tablets  were  prepared  by  direct  compression  using  chitosan  and  sodium carboxymethylcellulose  as  mucoadhesive  polymers.  Mucoadhesive  strength measured  using  rabbit  gastric  mucosa  and  in  vitro  drug  dissolution  was subjected  in  a  hydroclorid  acid  buffer  pH  1.2  for  10  hours.  The  optimized formula  was  obtained  by  analyzing   both  evaluation  using  factorial  design. Formula  with  5.4  %  of  chitosan  and  14.5  %  of  sodium carboxymethylcellulose followed zero order kinetics. The optimized formulation showed by 8.38-10.91% of  chitosan  and  28.84-29.09%  of   sodium  carboxymethylcellulose  with mucoadhesive strength between 25-40 gram and 43.5%-55% drug was released in 10 hours.Key words: Mucoadhesive, chitosan, CMC Na, E, factorial design. 
Optimasi Konsentrasi Etil Selulosa dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida Ninda Sukmaningrum; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 3 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (885.452 KB) | DOI: 10.15416/ijpst.v4i3.13190

Abstract

Metformin hidroklorida (MH) merupakan obat pilihan pertama yang digunakan dalam terapi diabetes mellitus tipe 2, namun dapat menimbulkan efek samping pada saluran pencernaan sehingga MH tepat dipreparasi menjadi sediaan microspheres. Banyak faktor yang mempengaruhi hasil preparasi microspheres di antaranya adalah konsentrasi etil selulosa (EC) dan lama pengadukan yang digunakan. Penelitian ini bertujuan untuk mengetahui komposisi terbaik konsentrasi EC dan lama pengadukan yang dapat menghasilkan microspheres MH-EC dengan entrapment efficiency (EE) tertinggi menggunakan optimasi desain faktorial. MH digunakan sebagai bahan aktif, EC digunakan sebagai polimer serta non-aqueous solvent evaporation method sebagai teknik yang dipilih dalam preparasi microspheres. Hasilnya microspheres yang menggunakan konsentrasi EC sebanyak 4.500 mg dan lama pengadukan selama 2 jam menghasilkan EE sebesar 84,6 ± 0,557% dengan nilai verifikasi EE sebesar 98,1%, drug loading sebesar 12,7 ± 0,173% dan yield sebesar 95,1 ± 0,612%. Microspheres memiliki bentuk sferis dan morfologi permukaan yang relatif halus dan cerah serta ukuran partikel sebesar 173,8 ± 4,41µm. Hasil analisis FTIR menunjukkan bahwa tidak ada perubahan gugus fungsi spesifik pada MH sebagai bahan aktif. Kata kunci:    microspheres, metformin hidroklorida, etil selulosa
Optimasi dan Formulasi Tablet Mengapung - Mucoadhesive Glimepirid dengan Kombinasi Polimer Karbopol dan HPMC K4M (Optimization and Formulation Floating - Mucoadhesive Glimepiride Tablet with Combination Carbopol and HPMC K4M) Hery Diar Febryanto; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Glimepiride is one of the preferred drug for the treatment of type II diabetes mellitus. Diabetes can affect gastric emptying time. Incomplete absorption of drugs often result in small bioavailability. Glimepiride was chosen as model drug because it has incomplete absorbtion due to less gastric residence time. Tablet make by direct compression using polymer carbopol, HPMC K4M and other additives. This study used factorial design. Factors that are optimazed are carbopol and HPMC K4M and responses used are floating lag time, floating duration time, mucoadhesive, dan DE 720. tablet were evaluated for invitro release characteristic for 12 hours. Area optimum obtained on the composition of the combination of Carbopol 69.20 to 70.60 mg and HPMC K4M 10.66 to 24.67 mg.   Keywords: glimepiride, floating mucoadhesive tablet, release kinetics, carbopol, HPMC K4M
Co-Authors ., Farhana Achmad Fudholi Amalia Fadila Ameliana, Lidya Barikah, Kuni Zu’aimah Cahyaningrum, Nitta Christyn Novita S Dwi Nurahmanto Eryani, Mikhania Christiningtyas Eunike Aprilianio Eva Setyorini Farkha, Fara Sukma Firdatus Sholehah Hanif, Mohammad Ainul Fakhruddin Hery Diar Febryanto Laily, Aisyah Prida Lina Winarti Lusia Oktora Ruma K. S. Lusia Oktora Ruma Kumala Sari Ninda Sukmaningrum Siti Munawaro Siti Munawaro, Siti Sri Untari Sukmaningrum, Ninda Taffana Windy Hananta Tiara Berlianti Tintia Lintang Pratiwi Viddy Agustian Rosyidi Yudi Wicaksono Yudistirawati Khusna