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Plasma Malondialdehid and Histopatology Healing Score Differences in Incised Old and Young Mice Zinc with Zinc Administration Moniq W. Aryantie; Rizqy D. Monica; Andri Rezano; Sudigdo Adi; Kiki A. Rizki; Yenni Zuhairini
Journal of Medicine and Health Vol. 2 No. 1 (2018)
Publisher : Universitas Kristen Maranatha

Free radical plays role in wound healing. This study was conducted to determinedifferences in level of plasma malondialdehyde (MDA), and histopathological score of woundhealing by administering zinc in old and young mice. We used 24 old mice and 24 young miceincision wound model, randomized into two groups, with and without zinc administration. Wefound plasma MDA level was lower in old mice with zinc administration but not statisticallysignificant. The plasma MDA level was significantly higher by administering zinc in young mice(p=0.004). The plasma MDA level of young mice was higher than old mice in zincadministration group (p=0.010). Reepitelialization, inflammatory cells, fibroblasts andangiogenesis did not differ by administering zinc both in old mice and young mice.Reepitelialization, inflammatory cells and angiogenesis did not differ between old and youngmice in mice that were given zinc; while fibroblast of young mice is more than old mice(p=0.010). We concludedÂ plasma MDA level is higher in young mice with zincadministration. Plasma MDA level in young mice is higher than old mice with zincadministration. Young mice with zinc administration have higher fibroblast than oldmice.Keywords: aging, free radical, histopathologic score, malondialdehid, wound healing, zinc

REDUCED BODY MASS INDEX BUT NOT FAT MASS IN ANTHRACYCLINE-BASED CHEMOTHERAPY OF LOCALLY ADVANCED BREAST CANCER PATIENTS Isma Rachmawati; Raden Yohana; Bambang Amam; Yenni Zuhairini
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.174

Background: Breast cancer is a cancer disease with the highest proportion of new cases and the proportion of deaths it causes is quite high at 6.9%. Cancer patients who use anthracycline-based chemotherapy experience loss of body weight, muscle, body cell mass, distribution of extracellular fluid expansion and reduced intracellular air. This study was to determine the change of the Body Mass index (BMI) and body composition of patients with locally advanced breast cancer (stage IIIA, IIIB and IIIC) who had undergone anthracycline-based chemotherapy.Methods: This anthracycline-based observational analytical study of pre and post chemotherapy was conducted with a cross-sectional approach. Subjects were measured height by microtoise; weight, body composition, daily calorie intake (DCI) and basal metabolic rate (BMR) as measured by Bioelectrical Impendance Analysis (BIA).Results: 47 locally advanced breast cancer patients underwent anthracycline-based chemotherapy. Based on the Wilcoxon statistical test, 6 variables with a 95% confidence level (p<0.05) showed a decrease in the value 5 variables, namely BMI, total body water (TBW), visceral fat, skeletal muscle mass and skeletal bone mass. Meanwhile, body fat showed a p value=0.224. The changes of variable confounding, DCI decrease (p=0.004), but BMR increase not significantly (p=0.795).Conclusion: There is an effect of chemotherapy on nutritional status of BMI, TBW, visceral fat, skeletal muscle mass and bone mass in patients with locally advanced breast cancer who underwent anthracycline-based chemotherapy, which may the result of the calorie intake decreased, but not on body fat

Relationship between age, occupation, education, and parity with the chronic energy deficiency among pregnant women Auranissa, Aliefia; Zuhairini, Yenni; Nurdiawan, Windi
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23525

Maternal and child health quality depends on maternal nutrition during pregnancy. Chronic energy deficiency (CED), a malnutrition condition common in pregnant women, increases the risk of the mother experiencing postpartum hemorrhage and the fetus experiencing intrauterine growth restriction (IUGR). The prevalence of CED risk among pregnant women in Sukabumi City, West Java, Indonesia is unstable and has not significantly decreased. This study aimed to determine the relationship between age, occupation, education, and parity with the risk of CED among pregnant women in Sukabumi City. An analytical observational study with a case-control approach using cluster sampling was conducted on 126 pregnant women with and without CED risk, respectively. The population for this study was pregnant women who checked at the primary health center in Sukabumi City in 2021. Data were collected from maternity health record and analyzed using Chi-square. The results showed that age had a significant relationship (p=0.000). In contrast, occupation (p=0.162), education (p=0.127), and parity (p=0.313) did not have a significant relationship with the risk of CED among pregnant women in Sukabumi City. Age was associated with the risk of CED among pregnant women in Sukabumi City.

Plasma Malondialdehid and Histopatology Healing Score Differences in Incised Old and Young Mice Zinc with Zinc Administration Moniq W. Aryantie; Rizqy D. Monica; Andri Rezano; Sudigdo Adi; Kiki A. Rizki; Yenni Zuhairini
Journal of Medicine and Health Vol 2 No 1 (2018)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i1.743

Free radical plays role in wound healing. This study was conducted to determinedifferences in level of plasma malondialdehyde (MDA), and histopathological score of woundhealing by administering zinc in old and young mice. We used 24 old mice and 24 young miceincision wound model, randomized into two groups, with and without zinc administration. Wefound plasma MDA level was lower in old mice with zinc administration but not statisticallysignificant. The plasma MDA level was significantly higher by administering zinc in young mice(p=0.004). The plasma MDA level of young mice was higher than old mice in zincadministration group (p=0.010). Reepitelialization, inflammatory cells, fibroblasts andangiogenesis did not differ by administering zinc both in old mice and young mice.Reepitelialization, inflammatory cells and angiogenesis did not differ between old and youngmice in mice that were given zinc; while fibroblast of young mice is more than old mice(p=0.010). We concludedÂ plasma MDA level is higher in young mice with zincadministration. Plasma MDA level in young mice is higher than old mice with zincadministration. Young mice with zinc administration have higher fibroblast than oldmice.Keywords: aging, free radical, histopathologic score, malondialdehid, wound healing, zinc

Pengaruh Perubahan Iklim Terhadap Pemenuhan Hak Anak Zuhairini, Yenni; Fauzan, Ahmad Asyraf; Dhamayanti, Meita
Sari Pediatri Vol 25, No 6 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.6.2024.414-9

Perubahan iklim memengaruhi berbagai kebutuhan dasar kehidupan manusia. Anak-anak lebih rentan dibandingkan orang dewasa terhadap perubahan lingkungan, baik langsung maupun tidak langsung. Hak anak untuk bertumbuh kembang, mendapat pelayanan kesehatan yang baik, kesejahteraan, pendidikan, dan gizi sebagaimana tercantum dalam Konvensi Hak Anak akan dipengaruhi oleh perubahan iklim, krisis pola cuaca, dan dampak jangka pendek dan jangka panjangnya. Kelangsungan hidup anak sebagai generasi penerus menjadi terancam oleh perubahan iklim, terutama, mereka yang rentan akan menanggung beban penyakit yang sangat besar akibat perubahan iklim ini, Kesenjangan sosial dan edukasi di antara negara miskin dan maju sangat menentukan dampak perubahan iklim terhadap anak-anak. Negara paling berisiko terdampak merupakan negara berkembang minim sumber daya dan infrakstruktur untuk menanggulangi perubahan iklim. Anak-anak yang kurang beruntung akan menanggung beban kesehatan yang sangat tinggi dan tidak adil akibat perubahan iklim ini.

Penyuluhan Gizi dan Stunting serta Pemanfaatan Tepung Kulit Telur pada Kader Kesehatan di Kabupaten Sumedang Zuhairini, Yenni; Diana, Aly; Luftimas, Dimas Erlangga; Rizqi, Haidar; Jihadillah, Ayunda; Purnamasari, Afini Dwi; Haq, Dearly Ayu Zahrotun; Sakinah, Ana Dina; Puspita, Dina Novtyana; Affandy, Yeni Intan Kusuma Dewi
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2024): Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.10.3.404-411

Sumedang still struggles with a stunting problem; based on the 2022 Indonesian Nutrition Status Survey (SSGI), the percentage of stunted children in Sumedang is the highest among all cities in West Java. Health Cadres have a very potential role in stunting prevention from an early age, providing education about the importance and selection of healthy and balanced nutrition food during pregnancy and breastfeeding, and the utilization of alternative food ingredients to improve the quality of nutrition in family food when conducting activities carried out at the Posyandu. This activity aims to enhance health cadres' knowledge through nutrition and stunting education and encourage the utilization of eggshell flour in creating family food innovations to prevent stunting from an early age. This activity uses pre-test and post-test questionnaires for measuring cadres’ knowledge about balanced nutrition and stunting prevention and a food creation competition based on eggshell flour, which is evaluated based on five criteria: creativity, nutritional facts, taste, texture, and presentation/serving. This activity effectively enhanced the knowledge regarding balanced nutrition and stunting prevention, as indicated by a significant increase in the average score before and after the intervention, with a p-value of 0.005. Furthermore, the food creation competition demonstrated the substantial potential of eggshell flour in preparing a diverse range of nutritious family food, including both savory and sweet dishes/snacks. This activity improved health cadres' knowledge and expanded the variety of healthy food through the innovative utilization of eggshell flour.

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