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All Journal Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Obstetrics & Gynecology Science Contagion: Scientific Periodical Journal of Public Health and Coastal Health JOURNAL LA MEDIHEALTICO
Amillia Siddiq
Departemen Obstetri & Ginekologi Universitas Padjadjaran RSUP Dr. Hasan Sadikin Bandung
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : JOURNAL LA MEDIHEALTICO

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Endocrine Control of Fetal Growth, the Delivery Process, and the Physiology of Childbirth Maelissa, Merlin Margreth; Siddiq, Amillia; Islamy, Nurul; Puspitasari, Maya Khaerunnisa; Lumentut, Anastasia Mariane; Wirawan, Wahyudi
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1903

Abstract

Childbirth is a complex physiological process characterized by the expulsion of the fetus from the uterus, marked by uterine contractions and cervical changes. The timing of labor is crucial for favorable pregnancy outcomes and is regulated by the neuroendocrine maturation of the fetus. Hormones like estrogen, progesterone, and human placental lactogen play key roles in fetal growth regulation, with fluctuations influencing birth weight and placental development. Progesterone inhibits labor by relaxing the uterus, while estrogen promotes labor by stimulating uterine contractions and cervical changes. The transition from uterine quiescence to active labor involves multiple stages, from myometrial relaxation to enhanced contractility. Labor progresses through phases, starting with quiescence, followed by the onset of rhythmic contractions, active labor, and concluding with involution. Uterine stretching and the role of fetal lung maturation also contribute to labor initiation, as fetal lung surfactant activates macrophages, leading to inflammation and progesterone withdrawal. This process synchronizes labor timing with fetal lung development. In conclusion, labor is influenced by a combination of endocrine and mechanical factors, including prostaglandins, cytokines, and hormones such as oxytocin and CRH. Proper endocrine regulation ensures timely labor, while disruptions in this system, such as premature or prolonged pregnancies, can lead to increased fetal morbidity and mortality.
Co-Authors Adhi Pribadi Adhi Pribadi Adriansyah, Putri Nadhira Adinda Akhmad Yogi Pramatirta, Akhmad Yogi Alamsyah Aziz Andayani, Aviasti Pratiwi Andhika Yudi Hartono Anita Deborah Anwar Dasopang, Husna Bulkis Dian Tjahyadi Edwin Armawan Erfiandi, Febia Faizal Arif Caropeboka Farhanah, Aninda Yasmin Hanom Husni Syam Hartanto Bayuaji Hartanto, Amadea Ivana Johanes C. Mose Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Kuswandewi Mutyara Lumentut, Anastasia Mariane M. Rizkar Arev Sukarsa Maelissa, Merlin Margreth Muhammad Ilman Muhammad Ilman, Muhammad Nurul Islamy Puspitasari, Maya Khaerunnisa R. M. Sonny Sasotya Raden Tina Dewi Judistiani Rahadyan Aji Sasongko Ratuafni Shafrina Wardani Ritonga, Mulyanusa Amarullah Riva, Salma Nisrina Rotinggo, Rico Setyorini Irianti Tono Djuwantono Tono Djuwantono Udin Sabarudin Wardani, Ratuafni Shafrina Wirawan, Wahyudi Wiwit Widiastuti Wiwit Widiastuti, Wiwit Yenni Zuhairini Yoga Paripurna Yudi Mulyana Hidayat Zulvayanti Zulvayanti Zulvayanti Zulvayanti