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KORELASI JUMLAH FOLIKEL ANTRAL DENGAN KADAR 25(OH)D SERUM PADA PENDERITA SINDROM OVARIUM POLIKISTIK Mustari, Asri Dini; Rostini, Tiene; Indrati, Agnes Rengga; Bayuaji, Hartanto; Rachmayati, Sylvia
Majalah Kedokteran Bandung Vol 50, No 4 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Sindrom ovarium polikistik (SOPK) ditandai oleh hiperandrogenisme, oligo atau anovulasi, dan morfologi ovarium polikistik. Penanda ovarium polikistik, yaitu terdapat ?12 folikel antral dengan diameter 2?9 mm pada pemeriksaan ultrasonografi. Vitamin D (25-hidroksivitamin D; 25(OH)D) berperan pada proses steroidogenesis di sel teka ovarium dan pengaturan ekspresi reseptor follicle stimulating hormone (FSH) di sel granulosa ovarium. Defisiensi 25(OH)D menyebabkan penurunan aktivitas FSH, sehingga folikel antral di ovarium berukuran kecil dan berjumlah banyak. Tujuan penelitian ini mengetahui korelasi jumlah folikel antral dengan kadar 25(OH)D serum pada penderita SOPK. Uji observasional analitik dengan rancangan potong lintang di Rumah Sakit Umum Pusat Dr. Hasan Sadikin (RSHS) Bandung dilakukan selama bulan September 2017?Juni 2018. Subjek penelitian adalah 52 penderita SOPK yang telah didiagnosis oleh klinisi obstetri dan ginekologi RSHS Bandung. Pengambilan darah vena dilakukan untuk pemeriksaan kadar 25(OH)D serum dengan metode ELISA. Hasil penelitian ini mendapatkan 56% subjek memiliki kadar 25(OH)D serum ?20 ng/mL. Hasil uji korelasi Spearman didapatkan korelasi negatif kuat yang bermakna (r = -0,867, p<0,001) jumlah folikel antral dengan kadar 25(OH)D serum. Kadar 25(OH)D serum yang rendah pada penderita SOPK berkorelasi dengan jumlah folikel antral yang banyak. Terdapat korelasi negatif antara jumlah folikel antral dan kadar 25(OH)D serum pada penderita SOPK. Kata kunci: Folikel antral, 25(OH)D serum, sindrom ovarium polikistik Correlation between Antral Follicles Count and Serum 25(OH)D Levels in Polycystic Ovary Syndrome PatientsPolycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo- or anovulation, and polycystic ovarian morphology. Vitamin D (25-hydroxyvitamin D; 25(OH)D) plays a role in the steroidogenesis process in the ovarian theca cells and regulates follicle stimulating hormone (FSH) receptor expression in granulosa cells. In 25(OH)D deficiency there is a decrease in FSH activity that the follicles become small and the antral follicles count in the ovary increases. The aim of this study was to determine the relationship between antral follicles count and serum 25(OH)D levels in PCOS patients. A cross-sectional analytical observational study was conducted in Dr. Hasan Sadikin General Hospital Bandung in September 2017?June 2018. Subjects of this study were 52 PCOS patients diagnosed by obstetricians and gynecologists of the hospital. Blood vein samples were collected to examine serum 25(OH)D levels using ELISA method. Serum 25(OH)D level of ?20 ng/mL was found in 55.8% of the subjects in this study. Analysis using Spearman?s correlation test showed a significant negative correlation (r = -0.867, p <0.001) between antral follicles count and serum 25(OH)D level in patients with PCOS. Lower levels of 25(OH)D serum in PCOS patients correlates with higher number of antral follicles count. There is a negative correlation between antral follicles count and serum 25(OH) D level in PCOS patients.Key words: Antral follicle count, 25(OH)D serum levels, polycystic ovary syndrome

Correlation between Body Mass Index and Serum Leptin Level in Patients with Polycystic Ovary Syndrome Erna Jupri; Anna Tjandrawati; Hartanto Bayuaji; Sylvia Rachmayati; Ida Parwati
Majalah Kedokteran Bandung Vol 51, No 3 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n3.1459

Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in reproductive-age women, which is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Some evidence suggested that leptin also causes PCOS due to its role in female reproductive system. The physiological function of leptin controls the balance of energy and suppresses the center of appetite. Patients with PCOS maybe underweight, normoweight, overweight, and obese, based on their body mass index (BMI), but obesity is a common clinical situation in PCOS. Obesity occurs when the level of leptin increases but cannot decrease appetite, resulting in leptin resistance. This study aimed to discover the connection between BMI and the level of leptin in patients with PCOS. This was a cross-sectional observational analytic performed in Dr. Hasan Sadikin General Hospital Bandung between April 25 and July 10, 2018. Subjects included 46 PCOS patients who were diagnosed based on Rotterdam criteria by gynecology obstetricians in the hospital. Enzyme-linked immunosorbent assay (ELISA) was used to examine the leptin serum levels. Leptin level increased 74%, mostly in obese patients that comprised 41% of these subjects. Normal leptin levels was seen in 26% of patients, none of them was obese. The Spearman Rank correlation test showed a significant positive correlation between BMI and leptin levels (r=0.644, p=0.000). Hence, a high body mass index in people with PCOS positively correlates with increased leptin level. Korelasi antara Indeks Massa Tubuh dan Kadar Leptin Serum pada Penderita Sindrom Ovarium PolikistikSindrom Ovarium Polikistik (SOPK) merupakan kelainan endokrin pada wanita reproduktif yang ditandai oleh hiperandrogenisme, anovulasi, dan ovarium polikistik. Terdapat beberapa bukti bahwa leptin turut menyebabkan SOPK karena leptin berperan dalam sistem reproduksi wanita. Fungsi fisiologis leptin mengendalikan keseimbangan energi dan menekan pusat nafsu makan. Penderita SOPK dapat memiliki indeks massa tubuh (IMT) underweight, normoweight, overweight dan obese, namun obesitas merupakan gambaran klinis yang umum terjadi pada SOPK. Obesitas terjadi bila peningkatan kadar leptin, namun leptin tidak mampu bekerja menurunkan nafsu makan sehingga terjadi resistensi leptin. Penelitian ini bertujuan mengetahui hubungan IMT dengan kadar leptin pada penderita SOPK. Penelitian ini berbentuk analitik observasional dengan rancangan potong lintang dan dilakukan di Rumah Sakit Umum Pusat Dr. Hasan Sadikin (RSHS) Bandung pada tanggal 25 April–10 Juli 2018. Subjek penelitian sebanyak 46 penderita SOPK yang didiagnosis berdasar atas kriteria Rotterdam oleh klinisi obstetri ginekologi RSHS. Pemeriksaan kadar leptin serum mengunakan metode Enzyme-linked immunosorbent assay (ELISA). Kadar leptin yang meningkat 74% terbanyak pada IMT obese 41% subjek, dan kadar leptin normal 26% tidak ditemukan pada subjek yang IMT obese. Uji korelasi Rank Spearman menunjukkan korelasi positif kuat yang bermakna antara IMT dan kadar leptin (r=0,644; p=0,000). Indeks massa tubuh yang tinggi pada penderita SOPK berkorelasi positif dengan peningkatan kadar leptin.

The Correlation of Serum Total Testosterone, Sex Hormone Binding Globulin and Free Androgen Index with Athens Insomnia Scale Score in Polycystic Ovary Syndrome Hartanto Bayuaji; Heda Melinda Nazaruddin Nataprawira; Herri Suhari Sastramihardja
The Indonesian Biomedical Journal Vol 10, No 1 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i1.324

BACKGROUND: Polycystic ovary syndrome (PCOS), a common reproductive endocrinologic disorder in woman, was considered to be related to sleep disturbance. This study is aimed to analyze the correlation between excess androgen markers and Athens Insomnia Scale (AIS) in PCOS.METHODS: This observational, cross-sectional study of PCOS was conducted to 31 subjects to evaluate the correlation between serum total testosterone, sex hormone binding globulin (SHBG) and free androgen index with the incidence of sleep disturbance using AIS. Sleep disturbance was present if the score ≥6. The correlation between excess androgen markers and sleep disturbance was analyzed using Pearson’s coefficient of correlation or Spearman’s rho test. Correlation coefficient more than 0.5 with p<0.05 was considered significant.RESULTS: Out of 31 PCOS subjects aged 20-40 years, 39% subjects had AIS score ≥6. Mean serum testosterone in AIS score >6 group was higher than AIS score <6 group but not statistically significant (46.68 vs. 28.49 ng/mL, p>0.05). No significant correlation was found between serum total testosterone, SHBG and free androgen index with AIS score. After adjusting for AIS score, there was the moderate positive correlation between serum total testosterone level although not statistically significant (r=0.54, p=0.07).CONCLUSION: The serum total testosterone level might influence the occurrence of sleep disturbance in PCOS.KEYWORDS: PCOS, androgen excess, testosterone, sleep disturbance, Athens Insomnia Scale

Profil Pasien Kanker Ovarium yang Dilakukan Fertility Sparing Surgery di RSUP Dr. Hasan Sadikin Bandung Tahun 2017-2020 Rania Ramadha Athiyazahra; Ali Budi Harsono; Hartanto Bayuaji
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 1 Maret 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n1.349

Tujuan: Tujuan penelitian ini untuk menggambarkan karakteristik pasien kanker ovarium yang dilakukan tindakan fertility sparing surgery.Metode: Penelitian deskriptif menggunakan data rekam medis pasien kanker ovarium yang dilakukan tindakan fertility sparing surgery di RSUP Dr. Hasan Sadikin Bandung pada tahun 2017-2020. Sampel yang digunakan sebanyak 35 data rekam medis menggunakan metode total sampling. Hasil: Dari 35 pasien, sebagian besar berusia 20-29 tahun (37%),belum menikah (54%), dan nulipara (71%), Tindakan fertility sparing surgery dilakukan pada stadium I-II untuk tipe sel epitel, stadium I-III untuk tipe sel germinal, dan hanya pada stadium I untuk tipe sel sex cord stromal. Pasien usia <20 tahun dilakukan tindakan fertility sparing surgery pada stadium III dengan jenis histopatologi tipe sel germinal sementara pasien dengan usia>20 tahun mayoritas dilakukan tindakan pada stadium I dengan tipe histopatologi terbanyak adalah tipe sel epitel.Kesimpulan: Tindakan fertility sparing surgery bertujuan untuk mempertahankan organ reproduksi. Karakteristik pasien kanker ovarium yang dapat dilakukan tindakan fertility sparing surgery berusia 20-29 tahun dan nulipara. Tindakan fertility sparing surgery pada tipe sel epitel dan tipe sex cord stromal hanya dilakukan pada stadium dini, sementara pada tipe sel germinal dapat dilakukan hingga stadium III. Ovarian Cancer Patient Profile Undergoing Fertility Sparing Surgery at Dr. Hasan Sadikin General Hospital Bandung From 2017 Until 2020Abstract Objective: Aimed to describe the characteristics of ovarian cancer patients underwent fertility sparing surgery between 2017-2020 at Dr. Hasan Sadikin General Hospital Bandung. Methods: A descriptive study that used medical records of ovarian cancer patients that underwent fertility sparing surgery at Dr. Hasan Sadikin General Hospital from 2017-2020. The sample used was 35 data, using the total sampling methods. Result: From a total of 35 patients, most were aged 20-29 years (37%), unmarried (54%), and nulliparous (71%). Fertility sparing surgery was performed at stage I-II for epithelial cell, stage I-III for germ cells, and stage I for sex-cord stromal cells. Patients <20 years underwent fertility sparing surgery at stage III with the most common histopathology type is germ cell while patients >20 years underwent fertility sparing surgery at stage I with the histopathology type is surface epithelial cells.Conclusion: Fertility sparing surgery aimed to maintain the reproductive organs. Characteristics of patients who underwent fertility sparing surgery are aged 20-29 years and nulliparous. Fertility sparing surgery can be performed at an early stage for epithelial cell and sex-cord stromal cells, while germ cell can be performed up to stage III.Key words: ovarian cancer, fertility sparing surgery, characteristics

Analisis Risiko Kejadian Bayi Berat Lahir Rendah (BBLR) pada Pasien Preeklamsi di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Periode Januari–Desember 2019 Tri Karyadi; Hanom Husni Syam; Hartanto Bayuaji
Indonesian Journal of Obstetrics & Gynecology Science Volume 4 Nomor 2 September 2021
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n2.301

Tujuan: Preeklamsi adalah peningkatan tekanan darah (tekanan sitolik ≥140 mmHg atau diastolik ≥90 mmHg) pada wanita yang sebelumnya memiliki tekanan darah normal, dan proteinuria, atau gejala klinis berat. Abnormalitas plasentasi serta perfusi plasenta yang buruk menyebabkan hipoksia pada janin sehingga terjadinya bayi lahir dengan berat rendah. BBLR (Bayi Berat Lahir Rendah) adalah berat lahir <2.500 gram. BBLR diasosiasikan dengan risiko kematian yang tinggi, disabilitas neurologis jangka panjang, perkembangan bahasa yang terhambat, dan peningkatan risiko penyakit-penyakit kronis.Metode: Penelitian ini menggunakan desain penelitian observasional analitik dengan pendekatan cross-sectional (potong lintang). Data dikumpulkan dari data yang tersedia pada rekam medis pasien yang melakukan persalinan di RSUP Dr. Hasan Sadikin pada bulan Januari hingga bulan Desember tahun 2019.Hasil: Terdapat 252 (11,4%) ibu hamil dengan preeklamsi dari seluruh subjek. Prevalensi BBLR pada subjek total adalah 49,2%. Bayi dengan BBLR lebih banyak terjadi pada kelompok preeklamsi dibandingkan dengan kelompok non preeklamsi, yaitu 60,3% dibandingkan 47,8% (p < 0,001). Kelompok preeklamsi memiliki rerata BBL yang lebih rendah secara signifikan dibandingkan kelompok non preeklamsi, yaitu 2.255,6 + 741,5 gram dibandingkan 2.465,5 + 696,2 gram (p <0,001).Kesimpulan: Terdapat hubungan bermakna antara preeklamsi dengan kejadian BBLR di Rumah sakit Hasan Sadikin.Risk Analysis of the Incidence of Low Birth Weight Infants in Preeclampsia Patient in Dr. Hasan Sadikin General Hospital Periode January–December 2019AbstractObjective: Preeclampsia is an increase in blood pressure (systolic pressure 140 mmHg or diastolic 90 mmHg) in women who previously had normal blood pressure, and proteinuria, or severe clinical symptoms. Abnormal placentation and poor placental perfusion cause fetal hypoxia resulting in low birth weight babies. LBW (Low Birth Weight Babies) is birth weight <2,500 grams. LBW is associated with a high risk of death, long-term neurological disability, delayed language development, and an increased risk of chronic diseases.Method: This study used an analytical observational research design with a cross-sectional approach. The data collected is based on the results of the data available in the medical records of patients who gave birth at Dr. RSUP. Hasan Sadikin in January to December 2019.Result: There were 252 (11.4%) pregnant women with preeclampsia from all subjects. The prevalence of LBW in total subjects was 49.2%. Babies with LBW were more common in the preeclampsia group compared to the non-preeclampsia group, namely 60.3% compared to 47.8% (p < 0.001). The preeclampsia group had a significantly lower mean BBL than the non-preeclampsia group, which was 2,255.6 + 741.5 grams compared to 2,465.5 + 696.2 grams (p < 0.001).Conclusion: It can be concluded that there is a significant relationship between preeclampsia and the incidence of LBW at Hasan Sadikin Hospital.Key word: Preeclampsia, LBW

Karakteristik Pasien Adenomiosis dengan Gambaran Ultrasonografi di Rumah Sakit Dr. Hasan Sadikin Bandung Periode 2015-2016 Meice Fitrina; Hartanto Bayuaji; Tita Husnitawati Madjid; Edwin Armawan
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Abstrak Tujuan: Karakteristik pasien dan hasil pemeriksaan ultrasonografi penting untuk menegakkan diagnosis adenomiosis, dapat diketahui terkait dari usia, gejala dan paritas serta pemeriksaan patologi anatomi. Metode: Deskriptif retrospektif menganalisis gejala klinis dan ultrasonografi adenomiosis. Data demografi (usia dan paritas), gejala klinis, hasil pemeriksaan ultrasonografi, dan hasil pemeriksaan patologi anatomi.Hasil: Dari 116 kasus, rata-rata usia adalah 39 tahun, paritas 1 - 4 (51,7%), infertilitas sekunder (35,3%), dengan gejala klinis yang terbanyak adalah massa pada abdomen (45,7%). Hasil pemeriksaan ultrasonografi yang terutama adalah miometrium heterogen (63,8%), kista miometrium (59,5%), dan subendometrial linear striae (56,0%). Diskusi: Hasil pemeriksaan USG transvaginal yang paling banyak ditemukan gambaran miometrium heterogen (63,8%) dan kista miometrium (59,5%). Kesimpulan: Adenomiosis umum terjadi pada usia reproduktif dan multiparitas dengan gejala utama massa pada abdomen dan hasil ultrasonografi yang terutama ditemukan adalah miometrium heterogen. Characteristics Overview of Adenomyosis Patients with Ultrasonographic at Dr. Hasan Sadikin Bandung General Hospital during 2015–2016Abstract Objective: Characteristic patient and ultrasonography findings are important to make a diagnosis of adenomyosis. To describe common and uncommon characteristics patients which is include age, symptoms, and parity with ultrasonographic findings and histopatolgic examination of adenomyosis.Method: This study was a descriptive restrospective study in adenomyosis cases. Patients with clinical symptoms and confirmed with ultrasonographic was an adenomyosis were analyzed. Results: Out of 116 cases, mean age was >35 years old (70,7%), parity was 1 - 4 (51,7%), related to secondary infertility (35,3%), with most common symptom is abdominal mass (45,7%). Most common findings of ultrasonographic were heterogenous myometrium (63,8%), myometrium cyst (59,5%), and subendometrial linear striae / shadowing (56,5%).Discussion: Sign transvaginal ultrasound were the heterogeneous myometrium (63.8%) and myometrial cyst (59.5%). Conclusion: Adenomyosis usually happen in reproductive age, multiparity with main symptoms is abdominal mass and the most common sonographic findings is heterogenous myometrium.Key words: adenomyosis, ultrasonographic, transvaginal ultrasonography.

Tata Laksana Infertilitas yang Rasional dan Efisien untuk Mempersingkat "Time to Pregnancy" Hartanto Bayuaji
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 2 September 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Memberikan pandangan kepentingan melakukan penatalaksanaan infertilitas yang efisien untuk mempersingkat time to pregnancy.Metode: Telaah pustaka dan basis bukti.Hasil: Kunci mempersingkat time to pregnancy pada penanganan infertilitas adalah melakukan work-up yang efisien dan rasional. Terdapat beberapa pemeriksaan yang mempunyai manfaat jelas berdasarkan basis bukti. Hari-hari tertentu pada siklus menstruasi seorang wanita dapat dimanfaatkan untuk melakukan beberapa pemeriksaan terpilih. Fokus pemeriksaan adalah identifikasi latar belakang kesehatan suami dan istri, mengetahui adanya ovulasi dan cadangan ovarium, tes patensi tuba, evaluasi anatomik uterus dan peritoneum, serta analisis sperma. Setelah data dasar tersebut diperoleh, dilakukan evaluasi komprehensif untuk mengetahui program penanganan yang sesuai. Saat ini telah terdapat panduan nasional praktik kedokteran penanganan infertilitas sebagai dasar untuk dapat menangani infertilitas secara efisien.Kesimpulan: Time to pregnancy dapat dipersingkat dengan proses diagnostik dan penanganan yang berbasis bukti dengan memanfaatkan waktu-waktu tertentu dari siklus menstruasi.Rational and Efficient Infertility Management Improve Shortening "Time to Pregnancy"AbstractObjective: Provide an insight of the importance of conducting efficient and rational infertility management to shorten time to pregnancy.Method: Literature and evidence base review.Results: The key to shortening time to pregnancy in infertility management is to do an efficient and rational work-up. There are several examination that have clear benefits. Certain days of a woman's menstrual cycle can be used to do some selected examinations. The focus of the examination is identification of the health background of husband and wife, ovulation documentation and ovarian reserve assay, tubal patency tests, anatomic evaluation of the uterus and peritoneum, and sperm analysis. After the basic data is obtained, a comprehensive evaluation is carried out to find out the appropriate management program. Currently there is a national guide to the practice of medical treatment of infertility as a basis for infertility management efficiently.Conclusion: Time to pregnancy can be shortened by an evidence-based diagnostic and treatment process by utilizing certain times of the menstrual cycle.Key words: Infertility, time to pregnancy, infertility management, referral system.

Korelasi Indeks Massa Tubuh dengan Pertambahan Berat Badan Menurut The Institute of Medicine (IOM) selama Kehamilan terhadap Kejadian Persalinan Ekstraksi Vakum dan Persalinan Normal Yeni Komala; Tita Husnitawati Madjid; Hartanto Bayuaji
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 1 Maret 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n1.310

Tujuan: Mengetahui korelasi indeks massa tubuh (IMT) dan penambahan berat badan menurut The Institute of Medicine (IOM) beserta besaran risiko terjadinya persalinan dengan ekstraksi vakum.Metode: Desain penelitian menggunakan metode case control dengan menggunakan data sekunder dari rekam medis pasien yang bersalin dengan bantuan ekstraksi vakum dan spontan pada empat rumah sakit di Kota Bandung tahun 2016–2020 secara random sampling sebanyak 460 responden.Hasil: Karakteristik pada persalinan ekstraksi vakum maupun persalinan spontan tidak berbeda. Rerata usia ibu saat bersalin pada kelompok persalinan ekstraksi vakum lebih tinggi dibandingkan dengan persalinan spontan (29 tahun vs 27 tahun). Pada kelompok persalinan ekstraksi vakum, proporsi primigravida lebih tinggi dibandingkan persalinan spontan, namun tidak bermakna secara statistik (p=0,217). Skor APGAR <7 pada menit pertama lebih banyak didapatkan dari bayi yang lahir dengan bantuan ekstraksi vakum (28,1%). Terdapat 3% bayi pada kelompok ekstraksi vakum dengan berat lahir di atas 4000 gram, kondisi ini bermakna secara statistik. Kesimpulan: IMT gemuk saat awal kehamilan bersifat protektif 0,27 kali terhadap persalinan ekstraksi vakum, sedangkan penambahan berat badan diatas rekomendasi IOM selama kehamilan meningkatkan risiko 9,76 kali untuk terjadinya persalinan dengan bantuan ekstraksi vakum.Relationship between Body Mass Index and Gestational Weight Gajn According to the Institute of Medicine on the Incidence of Vacuum ExtractionAbstractObjective: To determine the correlation between body mass index (BMI) and pregnancy weight gain according to the Institute of Medicine (IOM) and the magnitude of the risk of delivery by vacuum extraction.Methods: This was a case control study using secondary data from medical records of 460 patients who gave birth with vacuum extraction and spontaneous delivery at four hospitals in Bandung West Java in 2016–2020.Results: The characteristic were similar in both groups. The mean maternal age at delivery in the vacuum extraction group was higher than in the spontaneous delivery group (29 years vs. 27 years). In the vacuum extraction group, the proportion of primigravida was higher than that of spontaneous labor, but it was not statistically significant (p=0.217). The APGAR score <7 in the first minute was obtained more from babies born with vacuum extraction (28.1%). There were 3% of babies in the vacuum extraction group with birth weight above 4000 grams, this condition was statistically significant. Conclusion: Mothers with obese BMI during early pregnancy are 0.27 times protective against vacuum extraction deliveries, while mothers whose weight gain is above the IOM recommendation during pregnancy have a 9.76 times risk of having vacuum extraction deliveries. Key words : Body mass index, pregnancy weight gain, the institute of medicine, vacuum extraction delivery

Serum Nephrin Levels in Severe Preeclampsia: A Cross-Sectional Study : Kadar Nephrin Serum pada Preeklamsia Berat: Sebuah Studi Potong Lintang Meice Fitrina; Sofie R. Krisnadi; Hartanto Bayuaji
Indonesian Journal of Obstetrics and Gynecology Volume 9 No. 1 January 2021
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v9i1.1191

Abstract Objective: To determine differences in serum nephrin levels in severe preeclampsia compared to normal pregnancy and also its correlation with systolic and diastolic blood pressure and proteinuria.Methods: This study is an analytical observational with cross sectional study. The observation group consisted of severe preeclampsia (n= 30) and normal pregnancy group as a control (n= 30). Both groups measured systolic and diastolic blood pressure, proteinuria and serum nephrin using the Human NPHN (Nephrin) ELISA Kit. Statistical test were performed with Mann-Whitney test and the Spearman’s rank test. A value of p<0.05 was considered significant. The study was conducted in the Obstetric Clinic Inward and Laboratorium Department of Clinical Pathology Dr. Hasan Sadikin General Hospital/Faculty of Medicine Universitas Padjadjaran on March–May 2019.Results: Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies (6.4 ng/mL vs 4.2 ng/mL; p= 0.014). There is a positive weak correlation but statistically significant between serum nephrin with systolic blood pressure (r= 0.36; p= 0.02) but not significant to diastolic blood pressure (r= 0.3; p= 0.05). There is no significant correlation was found between serum nephrin levels and proteinuria (r= 0.18; p= 0.54).Conlusions: Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies and there is a correlation between serum nephrin with systolic blood pressure. Keywords: blood pressure, proteinuria, serum nephrin, podocyte, severe preeclampsia. Abstrak Tujuan: Untuk mengetahui perbedaan kadar nephrin serum pada preeklamsia berat dibandingkan dengan kehamilan normal dan juga hubungannya dengan tekanan darah sistolik dan diastolik serta proteinuria.Metode: Penelitian ini bersifat analitik observasional dengan pendekatan potong silang. Kelompok pengamatan terdiri dari kelompok preeklamsia berat (n= 30) dan kelompok kehamilan normal sebagai kontrol (n= 30). Pada kedua kelompok dilakukan pengukuran tekanan darah sistolik dan diastolik, proteinuria serta pengukuran kadar nephrin serum menggunakan Human NPHN (Nephrin) ELISA Kit. Uji statistik dilakukan dengan uji Mann-Whitney dan uji rank Spearman. Nilai p<0,05 dianggap bermakna. Penelitian dilakukan di ruang perawatan obstetri FKUP/RSHS dan Laboratorium Patologi Klinik FKUP/RSHS pada bulan Maret-Mei 2019.Hasil: Rerata kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi secara bermakna dibandingkan kehamilan normal (6,4 ng/mL vs 4,2 ng/mL; p= 0,014). Terdapat korelasi positif dengan derajat lemah namun bermakna secara statistik antara nephrin serum dengan tekanan darah sistolik (r= 0,36; p= 0,02) namun tidak signifikan terhadap tekanan darah diastolik (r= 0,3; p= 0,05). Tidak ditemukan korelasi yang bermakna antara kadar nephrin serum dengan proteinuria (r= 0,18; p= 0,54). Kesimpulan: Kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi dibandingkan kehamilan normal dan terdapat korelasi antara nephrin serum dengan tekanan darah sistolik. Kata kunci: nephrin serum, podosit, preeklamsia berat, proteinuria, tekanan darah

Perbedaan Capaian Kontrasepsi Pascasalin Jangka Panjang Sebelum dan Saat Pandemi Covid-19 Dave Orlando Gumay; Dini Pusianawati; Hartanto Bayuaji
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.393

Tujuan: Mengetahui perbedaan capaian kontrasepsi pascasalin jangka panjang sebelum dan saat pandemi COVID-19 di RSUP dr. Hasan Sadikin Bandung. Metode: Penelitian ini adalah studi analitik observasional dengan pendekatan potong silang menggunakan data sekunder dari rekam medik subjek penelitian selama masa pengamatan yakni sebelum pandemi (1 Maret 2019–28 Februari 2020) dan saat pandemi (1 Maret 2020–28 Februari 2021). Dilakukan analisis perbedaan capaian kontrasepsi pascasalin jangka panjang sebelum dan saat pandemi COVID-19, serta perbedaan capaian penggunaan kontrasepsi pascasalin jangka panjang berdasarkan status infeksi COVID-19 menggunakan uji chi-square. Nilai P <0,05 dianggap bermakna secara statistik.Hasil: Selama periode pengamatan didapatkan proporsi subjek yang mendapatkan layanan kontrasepsi pascasalin pada periode pandemi lebih tinggi secara bermakna dibandingkan dengan kelompok sebelum pandemi (38,8% vs 27,7%, P<0,001). Tidak didapatkan perbedaan bermakna sebaran penggunaan metode kontrasepsi pada kelompok saat pandemi yang terinfeksi dan tidak terinfeksi COVID-19.Kesimpulan: Capaian pemberian kontrasepsi pascasalin jangka panjang saat pandemi lebih tinggi secara bermakna dibandingkan dengan sebelum pandemi. Tidak didapatkan perbedaan yang bermakna capaian kontrasepsi pascasalin jangka panjang saat pandemi pada subjek yang terinfeksi dan tidak terinfeksi COVID-19.Differences in Long-Term Postpartum Contraception Achievements Before and During The Covid-19 PandemicAbstractObjective: To find out the difference in the achievement of long-term postpartum contraception before and during the COVID-19 pandemic at dr. Hasan Sadikin Bandung.Methods: This research is an observational analytic study with a cross-sectional approach using secondary data from the medical records of the research subjects during the observation period before the pandemic (1 March 2019–28 February 2020) and during the pandemic (1 March 2020–28 February 2021). An analysis of the difference in the achievement of long-term postpartum contraception before and during the COVID-19 also differences in achievement of long-term postpartum contraceptive use was carried out based on the status of COVID-19 infection was conducted using the chi-square test. P-value < 0.05 was considered statistically significant.Results: During the observation period, there were the proportion of subjects who received postpartum contraceptive services during the pandemic period was significantly higher than the group before the pandemic (38.8% vs 27.7%, P<0.001). Postpartum contraceptive use in the group during the pandemic infected with COVID-19 was lower than in the uninfected subjects (32.4% vs. 39.4%, P=0.07). There was no significant difference in the distribution of contraceptive methods used in the infected and uninfected groups during the COVID-19 pandemic.Conclusion: The achievement of long-term postpartum contraception during the pandemic was significantly higher than before the pandemic. There was no significant difference in the achievement of long-term postpartum contraception during the pandemic in subjects who were infected and not infected with COVID-19.Key words: COVID-19, postpartum contraception, pandemic.

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